DNA polymerase 1

This lecture explains about the DNA polymerase 1 structure and function and also the role of DNA polymerase 1 in DNA replication.
DNA polymerase enzyme has both polymerization and exonuclease activity that helps in DNA replication process.
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Thanku for your good explanation

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[@suganyasivakumar6972]

please elaborate 5' to 3' exonuclease activity of DNA polymerase with reference to nick translation and strand displacement activity

[@SkyviewKEducation]

Clear concept each and every point right now.

[@shomusbiologyofficial]

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[@alyaaalmery7939]

What's meant by nick translation that you said in the video?

[@sakshishukla1523]

What is exactly that point sir where you mentioned about a free 3- OH' ?? Not exactly getting abt it. Could u plz help me with it ??

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[@xlemmyxlemmy4493]

Question!!!! If the DNA polymerase 1 in a given cell were non-functional,how would that affect the synthesis of a leading strand?

[@shyworthacademy4151]

So nice...I am going to make Hindi version of it.😃

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Glad it helped

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[@zarrahosainy1508]

thanks but i don't know what u said about the couses. the subtitle cant read it too what would the couses be plz its after u said mutation?

[@ashajha8558]

Umullbanin Hosainy

[@lavanyaduvvuri2611]

At the end of the DNA replication Rna primers are replaced by Dna material by DNA polymerase-1.
And we know that DNA and RNA simply Differ in only 2'OH grp.
My question is instead of simply Removing that 2' OH grp why cell completely replaces that RNA primers with DNA material??
And at 11.2 min u mentioned that Pol-1 performs nick translation. but it is performed by LIGASE???

[@suganyasivakumar6972]

please address this as fast as you can , as imagining this activity is difficult for me .... please

[@minchan9522]

tbt time when ur voice not so husky and deep and could be heard clearly
cuz i can't seem picture the function of exonuclease removing primers from which end 3/ but how
and why doesn't oakazaki fragments join together

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You're welcome

[@maimoonaafridi8771]

If exonuclease has to perform cleavage and cleave wrong nucleotides which is same activity peformed by POL 3 that does proof reading, how are they different?

[@shyworthacademy4151]

DNA pol 1 and 3 both have same 3'->5' exonuclease activity, which is also called proof reading activity

[@AGMP9]

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[@emilioconde8782]

Thank you! one question though I read that ligase was in charge of removing RNA primer...

[@shomusbiologyofficial]

+emilio Conde no. Ligand only seals nick.

[@emilioconde8782]

Shomu's Biology Oh now that I re-read I realized I missed some steps. So RNAse H detects the RNA primase, Poly 1 replaces RNA with DNA complementary to the strand and then Ligase fills the nicks!! thank you for commenting so quickly and showing me what I don't know.

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[@FatimaKhazaal534]

Thank you

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[@ayeshanadeem2416]

sir i have a question ... if dna polymerase can onlu polymerize off an available 3' end, then from where does dna polymerase 1 get 3' end for replacing rna primer?

[@shomusbiologyofficial]

3' end was free there

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[@shomusbiologyofficial]

Thank you

[@leenalalson7777]

Sir, which polymerase polymerise okazaki fragments? I or III

[@shyworthacademy4151]

Pol 3

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Okay

[@sangtruongtan5585]

Can you help me this question ? Why does DNA polymerase I not form phosphodiester bonds between new and old circuits
?

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Biochemistry?

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Sir translation process

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Will make it soon

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Sure

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It was discovered in 1957

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It was discovered in 1956 by Arthur Kornberg

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