I love AK lectures' videos. I've been coming back to them to years for learning or refreshing knowledge on various topics. Absolutely class content, I am grateful!
Hi! I have a question. Which is the paper of the histidine at the 64th position in this process? My teacher talked about this particular aminoacid but you don't mention it so I don't understand the paper of it in the process. Thank you!!!
Since you wrote this a month ago, you probably found out the answer... but for anyone else who needs it: His-64 is involved in the proton shuttle, which helps regenerate the active form of the enzyme. A nitrogen in His-64 accepts a proton from the H2O molecule that has bound to the Zinc. The zinc is now bound to an OH- (this is the active form of carbonic anhydrase). The OH- goes on to attack the CO2 in a nucleophilic attack, which is what is explained in this video. The protonated His-64 donates its proton to the buffer (bicarbonate), which concludes the proton shuttle.
I love AK lectures' videos. I've been coming back to them to years for learning or refreshing knowledge on various topics. Absolutely class content, I am grateful!
fantastic. i love your style of teaching, straight forward info and detailed. thank you!
finally someone who explains everything !
When I watch your videos, I assimilate everything, and it's crafted forever.
Thank you so much.
excellent video, gives a better understanding by introducing a more detailed theory
it helps me a lot to understand the mechanism,
thank u
Very informative, nicely explained
I dont know you..... but I love you, thank you soo much this was so helpful
Thank you very much I love the way you explain stuff....saying what's the problem in each part and how the body faces that problem
Thank you sir
Very useful video 👍
And easily understood
Awesome lecture... thankyou sir....
Thank you sir, I'll pass my biochemistry course with your knowledge :)
You're the best teacher I've ever had!
Thank you very much man
God bless you
My instructor needs to play your videos and talk a lot less.
Man your videos are so awesome !
Amazingly explained.
Wonderfully preached, sir. Thank you!
Please what is the role of specific amino acids residue in the catalysis of carbonic anhydrase
So helpful!! Thank you!!
SLAYYY King! I wish professors and books really broke it down the way you do!
Thank you!
You should think about doing a video on Human Arginase, I'd really appreciate it!
very clear explanation...
Great teaching
Thanks man!!
Great explanation, very well done
you are my best teacher ever///////..........................thank you
Hi! I have a question. Which is the paper of the histidine at the 64th position in this process? My teacher talked about this particular aminoacid but you don't mention it so I don't understand the paper of it in the process. Thank you!!!
Since you wrote this a month ago, you probably found out the answer... but for anyone else who needs it:
His-64 is involved in the proton shuttle, which helps regenerate the active form of the enzyme. A nitrogen in His-64 accepts a proton from the H2O molecule that has bound to the Zinc. The zinc is now bound to an OH- (this is the active form of carbonic anhydrase). The OH- goes on to attack the CO2 in a nucleophilic attack, which is what is explained in this video. The protonated His-64 donates its proton to the buffer (bicarbonate), which concludes the proton shuttle.
How come oxygen has 3 bond in the start (one with zinc and two with H) and he dont carry a net charge?
H2O is acting like a ligand instead of forming a Covalent Bond, no need to show any charge
Thanks!
very helpful & explanation,thank you.
What about carboxypeptidase enzyme.can u plz upload the video on carboxypeptidase
is this an example of nucleophilic catalysis by a metal ion?
Make one video on protolytic enzyme
Awesome bruh!
GOOD LUCK IN YOUR MED SCHOOL!!!
Where are the videos for Enzyme 3 & 4 (Restriction Enzymes EcoRV and Myosin mechanisms?)
A M A Z I N G
I LOVE YOU
clean explanation
I need a vedio on carboxypeptidase A and it's structure and it's functioning
holy shit amazing
You explain very well but your. accent will not satisfied me. So please addon you sentence in the video.
Stop moving around ffs