Hi. Wondering if IGF-1 effects on reducing gluconeogenesis by inhibition of glucocorticoids. I understand that inhibition of glucocorticoids prevent Amino Acid from changing to glucose. But that does not mean that gluconeogenesis is reduced. As far as i know with GH, gluconeogenesis increases for the utilization of glycerol and fatty acids changing to glucose. 3:23
Nah man. With GH, gluconeogenesis is reduced is since glucose uptake goes down. Fatty acids are what are used primarily, and the amino acids aren't really broken down, but rather their utilisation for protein synthesis goes up
@@bodi.a.r Thanks for replying. However, The major role of insulin-like growth factor-1 (IGF-1) in the liver is to mediate glucose uptake in hepatocytes to synthesize glycogen and maintain blood glucose homeostasis. Wang J, Zhu X, Chen C, Li X, Gao Y, Li P, Zhang Y, Long M, Wang Z, Liu G. Effect of insulin-like growth factor-1 (IGF-1) on the gluconeogenesis in calf hepatocytes cultured in vitro. Mol Cell Biochem. 2012 Mar;362(1-2):87-91. doi: 10.1007/s11010-011-1130-9. Epub 2011 Oct 21. PMID: 22015655.
@@bodi.a.r Like I mentioned, “Glucocorticoids’s” role is to catabolize the protein while glucogenesis is to change the carb, protein and fat to glucose. GH plays critical roles in regulating somatic growth and the metabolism of carbohydrates, lipids, and protein. GH increases insulin secretion and glucose uptake. Hope this helps. Nishad, R., Mukhi, D., Menon, R.K., & Pasupulati, A.K. (2018). Growth Hormone and Metabolic Homeostasis.
I think you might be wrong on the inhibition or impairment of gluconeogenesis. It sounds like it’s a good thing for muscle growth but you absolutely need to have glycogen in your muscles in order for them to work, especially if you are training hard. So IGF1 almost certainly requires you to intake a lot more carbohydrates to counteract this effect in order to not impair muscle recovery from hard/chronic training.
Bro he is not talking about glycogen there. He is talking about inhibiting the function of turning proteins into glucose which can include muscle breakdown.
I been cycling IGF1 LR3 for a few years now add a full blood test panel and a colonoscopy (i have grand father and father who had and died of colon cancer) everything came back clean.. I use the peptide 2-3 times per year at 1 month at a time.
@@healer246 DHEA is literally closer to estrogen conversion. People use it as a test booster and then just spoke their estrogen because it converts to estrogen if you have an above 500 (tolerable) test lvl.
@@healer246 that’s interesting because I have lab results that say the opposite of what you’re saying. Every cardiovascular system is different ig 🤷♂️ to each their own
Bro I have a question So in the end it's IGF-1 which directly increase height (elongation of the bones)/making you tall) not GH, I mean GH makes you tall but it does that indirectly right? The hormone that does the interstitial growth it is IGF-1 not GH is that correct or am I wrong?
Bro I have a question So in the end it's IGF-1 which directly increase height (elongation of the bones)/making you tall) not GH, I mean GH makes you tall but it does that indirectly right? The hormone that does the interstitial growth it is IGF-1 not GH is that correct or am I wrong?
Doctor please tell me how long does HGH/IGF1 stay elevated in my body after I stopped fasting? Does it last 8-24 hours after a fast to see it’s effects?
Glucocosteroids helps with inflammation, reduce pain, etc. Helps with stress. Why would you want to inhibit this? Unless this is referring to cortisol?
Igf 1 can be raised to extremely high levels according to my experince. I ate huge quantities of white rice before sleeping and and at day time, bcoz white rice raise insulin so it also increase igf1. What happened was 1inch height increase in 1month and 5kg weight gain. I wanaa ask you is that does insulin raise igf1?
@@xNutted ruclips.net/video/1z_HxrZiUAw/видео.html To increase size/thickness of bones = start strongman training (in the above video... U can see his bone size before and after) To increase height = start playing basketball (, check if growth plates are not fused by some tests)
Bro I have a question So in the end it's IGF-1 which directly increase height (elongation of the bones)/making you tall) not GH, I mean GH makes you tall but it does that indirectly right? The hormone that does the interstitial growth it is IGF-1 not GH is that correct or am I wrong?
![Seungmin "그렇게, 천천히, 우리(As we are)" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/kAzmhLHePqU/mqdefault.jpg)
I and my sister have ALS and we are going through Gene Therapy with this IGF-1
Such a simple video. I now understand way more than I knew. Thank you
You are a fantastic teacher brother. Great vid
Sauna 5-7 times per week @ 180F has been shown to increase natural IGF-1 by 600% (covered in detail by Dr. Rhoda Patrick).
Very clear explanation. Please do more vids on peptides
Making a comment so maybe you get more traffic and more in depth videos.
Appreciate it my friend!
Thank you for making it so clear and simple!
I like your training of IGF-1. IS GOOD.
Great explanation dude! Thank you!
Will you grow faster if u have more igf 1 in your system?
If growth plates are not closed yet yes
U also risk getting cancer if ur intake is too much
Yes. Your muscles literally feel like they’re going to explode
@@jaya3597cancer is only a risk if you've already been thorough puberty.
@@jimbone9558how have you found to increase igf1 to grow taller?
Hi. Wondering if IGF-1 effects on reducing gluconeogenesis by inhibition of glucocorticoids. I understand that inhibition of glucocorticoids prevent Amino Acid from changing to glucose. But that does not mean that gluconeogenesis is reduced. As far as i know with GH, gluconeogenesis increases for the utilization of glycerol and fatty acids changing to glucose. 3:23
Nah man. With GH, gluconeogenesis is reduced is since glucose uptake goes down.
Fatty acids are what are used primarily, and the amino acids aren't really broken down, but rather their utilisation for protein synthesis goes up
@@bodi.a.r Thanks for replying. However, The major role of insulin-like growth factor-1 (IGF-1) in the liver is to mediate glucose uptake in hepatocytes to synthesize glycogen and maintain blood glucose homeostasis.
Wang J, Zhu X, Chen C, Li X, Gao Y, Li P, Zhang Y, Long M, Wang Z, Liu G. Effect of insulin-like growth factor-1 (IGF-1) on the gluconeogenesis in calf hepatocytes cultured in vitro. Mol Cell Biochem. 2012 Mar;362(1-2):87-91. doi: 10.1007/s11010-011-1130-9. Epub 2011 Oct 21. PMID: 22015655.
@@bodi.a.r Like I mentioned, “Glucocorticoids’s” role is to catabolize the protein while glucogenesis is to change the carb, protein and fat to glucose. GH plays critical roles in regulating somatic growth and the metabolism of carbohydrates, lipids, and protein. GH increases insulin secretion and glucose uptake. Hope this helps.
Nishad, R., Mukhi, D., Menon, R.K., & Pasupulati, A.K. (2018). Growth Hormone and Metabolic Homeostasis.
Good point. Both IGF-1 and HGH increase glucose up-take.
Another study onboard dihyrdotestosterone vs regular testosterone and it’s effect on body composition and ferritin levels.
Will taking a IGF 1 supplement cause you to get an enlarged prostate?
So what happens to the body once you stop taking it?
It’s produced in the liver
@@GhostOfRT300so your liver will adjust and possibly make less. Much like an Addison crisis , I assume
I think you might be wrong on the inhibition or impairment of gluconeogenesis. It sounds like it’s a good thing for muscle growth but you absolutely need to have glycogen in your muscles in order for them to work, especially if you are training hard. So IGF1 almost certainly requires you to intake a lot more carbohydrates to counteract this effect in order to not impair muscle recovery from hard/chronic training.
Bro he is not talking about glycogen there. He is talking about inhibiting the function of turning proteins into glucose which can include muscle breakdown.
He wasn't paying attention
Love your work!
Thank you!
Good topic!
Thanks!
Thank you for this video.
Brilliant explanation
Good summary and presentation. Thank you 🌟
thnx Mathew. good video...
Excellent info. Thanks
Great information 👍👍👏👏
I been cycling IGF1 LR3 for a few years now add a full blood test panel and a colonoscopy (i have grand father and father who had and died of colon cancer) everything came back clean.. I use the peptide 2-3 times per year at 1 month at a time.
Hey how are you going?
What benefits have you see, in terms of muscle growth, skin, tendons and ligaments
This was informative and comprehensive. Thank you 🙏🏽
wonderful video!!!
clear and complete!! 👏👏🤩
Doesn't high levels cause organ and tumour growth??and research shows people with lower igf live longer??
Helpful A lot
Do they sell this in GNC stores
Which one better creatine or igf-1🤔
take both
@@dayyyyyyyyyyyy will do
@@R512_ unless you’re competing, creatine is one of those things you can (and should) take 24/7 365
nice work!
Thank you
You’re welcome
Damn bro fr you killed it
I currently take this.its slow but it works.
Any effectiveness on Ligaments?
Great information 👍🏾💪🏾👌🏾🇬🇧
Wouldn't insulin sensitivity result in diabetes?
Great video bro!! Just started taking an IGF-1 anabolic spray. Definitely helped shed some light on the benefits of IGF
That won’t do shit. DHEA literally elevated IGF1 and it’s cheap.
@@healer246 DHEA is literally closer to estrogen conversion. People use it as a test booster and then just spoke their estrogen because it converts to estrogen if you have an above 500 (tolerable) test lvl.
@@devynsixx3273 I personally have taken it and have lab results that don’t confirm what you are saying
@@healer246 that’s interesting because I have lab results that say the opposite of what you’re saying. Every cardiovascular system is different ig 🤷♂️ to each their own
Bro I have a question
So in the end it's IGF-1 which directly increase height (elongation of the bones)/making you tall) not GH, I mean GH makes you tall but it does that indirectly right?
The hormone that does the interstitial growth it is IGF-1 not GH is that correct or am I wrong?
Can I use this while on blood thinners?
Can insulin resistance cause an elevation of igf-1?
How to use it? I have the spray one
can i take it for fat loss?
Can low IGF-1 result in muscle soreness after workouts...like more than normal?
I'm not sure. I don't believe it is related to soreness though
Bro I have a question
So in the end it's IGF-1 which directly increase height (elongation of the bones)/making you tall) not GH, I mean GH makes you tall but it does that indirectly right?
The hormone that does the interstitial growth it is IGF-1 not GH is that correct or am I wrong?
Does glycine lower IGf1. I need something to lower IGf1.
Does going to bed late effect hgh, I get 8 hours quality sleep.
Doctor please tell me how long does HGH/IGF1 stay elevated in my body after I stopped fasting? Does it last 8-24 hours after a fast to see it’s effects?
I'm pretty sure fasting decreases igf1 significantly
@@vvltures yes but when you start eating and insulin is introduced it sky rockets above baseline
If im supplementing with IGF 1 is there risk to insulin gets very low? And can I get diabetic because of that?
What is IGF made from?
What’s the result for people who are T1D who use a insulin pump, but also wish to intake smaller doses of igf1-lr3
Glucocosteroids helps with inflammation, reduce pain, etc. Helps with stress. Why would you want to inhibit this? Unless this is referring to cortisol?
bros goated
i got hair loss does it help
What does IGF-1 do in bone remodelling.
Hobart Shoal
Rolfson Corners
Is IGF1 DES only for IM injections or sub q
Casien protein release IGF1 Aswell
Is there any side effects if I stop taking after a while?
This is just about normal production of IGF1 in the body naturally. Not about supplementation
My daughter IGF-1 is 17.2 and her age is 4 years 2 months.I don't know what can I do.Please tell me.
Igf 1 now 500 how to reduce pls help me
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Periodization for thin person to mass building bodybuilding
Help, my IGF-1 is high. Im an active healthy 70 yr old. Please
Monty Green
Cruz Orchard
Igf 1 can be raised to extremely high levels according to my experince.
I ate huge quantities of white rice before sleeping and and at day time, bcoz white rice raise insulin so it also increase igf1. What happened was 1inch height increase in 1month and 5kg weight gain.
I wanaa ask you is that does insulin raise igf1?
No you didn’t
Sorry dude but this sounds like complete rubbish. No way the average person gain an inch of height from eating white rice everyone would be tall asf
@@xNutted ruclips.net/video/1z_HxrZiUAw/видео.html
To increase size/thickness of bones = start strongman training
(in the above video... U can see his bone size before and after)
To increase height = start playing basketball (, check if growth plates are not fused by some tests)
@@xNutted I grew
@@xNutted then Chinese would have been the tallest race of the world
Traduscalo al español please¡¡¡¡¡
Anibal Dale
Tristin Circle
Is it safe
This video is just about the natural production of IGF-1 in the body not supplementation.
Is it possible can stack igf lr3 together with rapid acting insulin after workout ? Or just wait for 1hr taking igf then go for Insulin post workout ?
Bro I have a question
So in the end it's IGF-1 which directly increase height (elongation of the bones)/making you tall) not GH, I mean GH makes you tall but it does that indirectly right?
The hormone that does the interstitial growth it is IGF-1 not GH is that correct or am I wrong?
Julius Neck
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Morissette Valleys
Are there not negative side effects or trade offs to IGF1such as a shortened life span?
This is just about the natural production of IGF1 not supplementing
There most certainly are
Maxime Cape
So we are gonna see a drop in blood sugar. That’s not always good
Rogan takes this
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Stone Ramp
🔥💪🏼😬
Georgianna Path
Is it good to have high igf? Mine is over the range is that good or bad?
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EXPLICA en español para que sudamerica te escuche
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Is IGF1 the same as MK677 essentially???
I’m not sure
I bet if you take NAC with IGF-1 it will work even better.
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