Thanks guys. This is so encouraging. For someone with MS it provides hope 🙏🏻 Dr Jen Massey, my neuro, got a mention. I’ll mention this to her when I have my next consultation next month.
Glad you liked the video! I was lucky enough to spend a bit of time chatting with Dr Massey after her presentation, which was incredibly interesting. I've known her quite a while and we will certainly be looking to feature her more over the coming months. Please do let her know about the video, I'm sure she will be interested to know! Thanks - Brett
Thanks for the question! Here is a link to an article discussing the study: news.harvard.edu/gazette/story/2023/08/engineered-probiotic-developed-to-treat-multiple-sclerosis/
@@MStranslate1 this is absolutely fascinating! I have read quite a few publications about gut microbiome and MS - interesting that there seems to be such a definitive link between species dysbiosis and those with MS. From what I can tell it is largely coupled to a lack of bacteria producing SCFA and an increase in IL17 inducing bacteria. Currently I am on DMF - this also seems to act directly on SCFA abundance of gut bacteria. This gut-brain interaction may be one piece of the puzzle imo as there are even neurons in our gut (from my understanding). Perhaps inflammation / damage to our microbiomes leads to some form of biomimicry resulting in a faulty immune system. I hope they can provide targeted treatment. Perhaps a FMT treatment or specific supplementation of crucial missing species.
Was NVG-291 or Lucid MS discussed this year? They have shown the most promise at getting close to a cure so far. The reprogramming of our immune cells sounds really good, too.
Sorry to hear that this was problematic for you. We will take that feedback on board for our future videos. Hopefully it wasn't too off-putting and you were able to watch the rest of the video and found it informative and interesting. Thanks - Brett
I think I hit the unlucky jackpot for MS statistics - Male, never smoked, not overweight, have always been active, lived in area with decent air quality, tried to get outside as much as possible for a bit of vit D... just very unlucky I suppose. Perhaps genetic or induced by EBV/C19/pesticides/forever chemicals - I suppose I will never really know. It is apparent though that food contamination and poor quality is causing a ton of problems world wide - cancer rates are continuing to climb for instance... (up 80% in 3 decades) We are poisoning the earth and I suppose like with insects these chemicals can cause neurological problems/damage most likely...
Thanks for the comment and for sharing your experience. While we continue to learn more about potential triggers, it is still clear that there is a lot that we don't know! Unfortunately, as you say, some people seem to just be unlucky. It is great that we are continuing to learn more about these environmental factors, as they are potentially things that we can investigate to minimise risks and also to better understand what causes MS to start in the first place. Thanks - Brett
@@MStranslate1 definitely seems to be a complex web of interconnected factors at play that is for certain! Perhaps a series of dominos that line up to trigger an underlying genetic vulnerability. Vit D, gut dysbiosis & gut permeability, chemical exposure, smoking, virus interaction, biomimicry (dairy in mice found to impact mouse model of MS), hormonal balance (? interesting how female rates of MS are far higher than male), stresses etc. Likely a permutation of several factors I suppose. Hopefully they can indeed cure this horrific disease. I am still relatively young (not 30 yet) however every day there is the fear in the back of my mind lingering. Is today the day I lose my vision completely? Or perhaps my ability to walk, speak, go to the bathroom etc? The sword of Damocles, for life.
The theme of "treat early with highly effective therapies" was certainly constant at the meeting! A few years ago, this was a topic of debate, but I feel like there is consensus on it now. Thanks - Brett
Being diagnosed in 08/2000, I have been seeking the best treatment from early diagnose... Tysabri in 2008 but advocating for it since 2004/2005, Lemtrada in 2019/2020. Right treatment's but many years delay... lemtrada
Thanks for the videos of ECTRMS 2023.
Thank you for the great work much appreciated
Thanks guys. This is so encouraging. For someone with MS it provides hope 🙏🏻
Dr Jen Massey, my neuro, got a mention. I’ll mention this to her when I have my next consultation next month.
Glad you liked the video! I was lucky enough to spend a bit of time chatting with Dr Massey after her presentation, which was incredibly interesting. I've known her quite a while and we will certainly be looking to feature her more over the coming months. Please do let her know about the video, I'm sure she will be interested to know! Thanks - Brett
Is it also known which prebiotics? (is there a link to the publication? :) ) Would definitely be interested in reading more about it!
Thanks for the question! Here is a link to an article discussing the study: news.harvard.edu/gazette/story/2023/08/engineered-probiotic-developed-to-treat-multiple-sclerosis/
And here is a link to the publication, although you can only access the abstract: www.nature.com/articles/s41586-023-06409-6
@@MStranslate1 thank you for providing the links! :) going to ask my Dr. friends for access ;)
@@MStranslate1 this is absolutely fascinating! I have read quite a few publications about gut microbiome and MS - interesting that there seems to be such a definitive link between species dysbiosis and those with MS. From what I can tell it is largely coupled to a lack of bacteria producing SCFA and an increase in IL17 inducing bacteria. Currently I am on DMF - this also seems to act directly on SCFA abundance of gut bacteria. This gut-brain interaction may be one piece of the puzzle imo as there are even neurons in our gut (from my understanding). Perhaps inflammation / damage to our microbiomes leads to some form of biomimicry resulting in a faulty immune system. I hope they can provide targeted treatment. Perhaps a FMT treatment or specific supplementation of crucial missing species.
Was NVG-291 or Lucid MS discussed this year? They have shown the most promise at getting close to a cure so far.
The reprogramming of our immune cells sounds really good, too.
opening music is too loud
Sorry to hear that this was problematic for you. We will take that feedback on board for our future videos. Hopefully it wasn't too off-putting and you were able to watch the rest of the video and found it informative and interesting. Thanks - Brett
I think I hit the unlucky jackpot for MS statistics - Male, never smoked, not overweight, have always been active, lived in area with decent air quality, tried to get outside as much as possible for a bit of vit D... just very unlucky I suppose. Perhaps genetic or induced by EBV/C19/pesticides/forever chemicals - I suppose I will never really know. It is apparent though that food contamination and poor quality is causing a ton of problems world wide - cancer rates are continuing to climb for instance... (up 80% in 3 decades) We are poisoning the earth and I suppose like with insects these chemicals can cause neurological problems/damage most likely...
Thanks for the comment and for sharing your experience. While we continue to learn more about potential triggers, it is still clear that there is a lot that we don't know! Unfortunately, as you say, some people seem to just be unlucky. It is great that we are continuing to learn more about these environmental factors, as they are potentially things that we can investigate to minimise risks and also to better understand what causes MS to start in the first place. Thanks - Brett
@@MStranslate1 definitely seems to be a complex web of interconnected factors at play that is for certain! Perhaps a series of dominos that line up to trigger an underlying genetic vulnerability. Vit D, gut dysbiosis & gut permeability, chemical exposure, smoking, virus interaction, biomimicry (dairy in mice found to impact mouse model of MS), hormonal balance (? interesting how female rates of MS are far higher than male), stresses etc. Likely a permutation of several factors I suppose. Hopefully they can indeed cure this horrific disease. I am still relatively young (not 30 yet) however every day there is the fear in the back of my mind lingering. Is today the day I lose my vision completely? Or perhaps my ability to walk, speak, go to the bathroom etc? The sword of Damocles, for life.
if you have AI genes..you just need EBV trigger...see many families with
3 or 4 ms cases...some going for 2-3
generations...
Epigenetic, treat early, treat with immune reconstitution therapies! Change doctors (not all of them) mindset!
Eli5 for me please
The theme of "treat early with highly effective therapies" was certainly constant at the meeting! A few years ago, this was a topic of debate, but I feel like there is consensus on it now. Thanks - Brett
Being diagnosed in 08/2000, I have been seeking the best treatment from early diagnose...
Tysabri in 2008 but advocating for it since 2004/2005,
Lemtrada in 2019/2020.
Right treatment's but many years delay...
lemtrada