Beautiful talk! Very refreshing. A putative answer to the apt question asked by the person at 55:18 could be: for each 1000 molecules of protein or sub-unit delivered to the cell, the numbers of spike protein remain the same. Whereas for each 1000 molecules of mRNA delivered, there are at least 50000 protein molecules synthesized by the cell. Thus a lower dose of mRNA can elicit a higher protein production and concomitantly, a higher immune response. Moreover, the mRNA is short lived so very soon it will be degraded and would render less cytotoxicity and potential side effects.
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Beautiful talk! Very refreshing.
A putative answer to the apt question asked by the person at 55:18 could be: for each 1000 molecules of protein or sub-unit delivered to the cell, the numbers of spike protein remain the same. Whereas for each 1000 molecules of mRNA delivered, there are at least 50000 protein molecules synthesized by the cell. Thus a lower dose of mRNA can elicit a higher protein production and concomitantly, a higher immune response. Moreover, the mRNA is short lived so very soon it will be degraded and would render less cytotoxicity and potential side effects.