Half life is a videogame series made by valve, It uses this term for its series name, And uses many other scientific terms aswell, like blue shift and opposing force.
Please correct me if I'm wrong as I am not a doctor/pharmacist. At 0:33, it should be 3 hours only after "intravenous" and possibly "transdermal" administration, implying that peak plasma concentration is achieved immediately. For oral administration for example, we'd have to account for the time it takes for the drug to reach it's peak plasma concentration, only then we start the half life count.
@NaserAloqab you're on to something here - absorption of a drug, distribution of a drug through the tissues of the body, metabolism of a drug, and other factors - like drug interactions and patient age and organ function- make a BIG difference in how long a drug stays in the body. So, let's use the example propranolol (used for blood pressure, tremors, and other conditions) - the half life will change based on the route it is administered, the patient factors of who's getting it, etc. For propranolol: *IV formulation will have a half-life of about 2.5 hrs. *Give that same drug to an neonate, and that half life is now 15 hours. *Give the same drug to an adult as an ORAL Extended Release tablet: up to 20 hrs! Different drugs - AND different routes of administration - AND different patient populations - have different half-lives, but overall they all follow this rule: after one half-life has passed, 50% of the initial drug amount is removed from the body. I hope that helps!
Thanks more,As i understand from your lecture lisinopril is administered at 1half life but captopril is administered at 2 half life how? (When we administere at 5 half life mean attain Cpss )please make it more clarify
How do we determine what effects on our spirit is with long term planning of pharmaceuticals. Ie: losing track of the bigger picture because of drugs or losing a sense of connection to nature.
This is a great question - but variable based on what type of drug interaction it is. It is only sometimes possible to eliminate the interaction by separating the two drugs by a specific # of half-lives, but this is a good place to start.
So what’s the math formula to figure the amount you should take or dose and what’s the time frame? Say for example I take something with a longer half-life than you are showing as an example. What if my half-life is 60 hours what would be the dosing schedule or formula for that?
@AmnestyGG the formula doesn't change with a longer half life, just the time it takes to be eliminated. If the half life is 60 hours, then it will take 60 hrs for 50% to be eliminated, and 120 hrs for 75% to be eliminated, etc. 👍
Wait what @ :38 seconds, “3 hour half life means 3 hours after administering 50% is gone and than another 3 hrs another 50% gone? how tho that’s all 100% of the drug
3hrs = 50%, 6hrs=25%, 9hrs=12.5%, 12hrs=6.25%, 15hrs=3.125% and so forth. it seems like each time 3 hours has past you are dividing 1/2 of the previous eliminated drug. so after 6 hours, 75% of the drug is eliminated.
Half life is a videogame series made by valve, It uses this term for its series name, And uses many other scientific terms aswell, like blue shift and opposing force.
And rely heavily on a crow bar to maintain scientific order.
Wow you explained everything better than my doctor in less than two minutes,Well done.
Please correct me if I'm wrong as I am not a doctor/pharmacist. At 0:33, it should be 3 hours only after "intravenous" and possibly "transdermal" administration, implying that peak plasma concentration is achieved immediately. For oral administration for example, we'd have to account for the time it takes for the drug to reach it's peak plasma concentration, only then we start the half life count.
@NaserAloqab you're on to something here - absorption of a drug, distribution of a drug through the tissues of the body, metabolism of a drug, and other factors - like drug interactions and patient age and organ function- make a BIG difference in how long a drug stays in the body.
So, let's use the example propranolol (used for blood pressure, tremors, and other conditions) - the half life will change based on the route it is administered, the patient factors of who's getting it, etc.
For propranolol:
*IV formulation will have a half-life of about 2.5 hrs.
*Give that same drug to an neonate, and that half life is now 15 hours.
*Give the same drug to an adult as an ORAL Extended Release tablet: up to 20 hrs!
Different drugs - AND different routes of administration - AND different patient populations - have different half-lives, but overall they all follow this rule: after one half-life has passed, 50% of the initial drug amount is removed from the body.
I hope that helps!
Thanks more,As i understand from your lecture lisinopril is administered at 1half life but captopril is administered at 2 half life how? (When we administere at 5 half life mean attain Cpss )please make it more clarify
Thank you for the example! It helps me get half-life down a little better
You are so welcome! Glad it was helpful!
It really does I’m glad is helping you I can say the same it’s just better
@@JayywavySurfingLaughs4Days awesome and glad to hear it! Let us know if there are other clinical topics you want a Rundown for!
The science behind the medicine. Great info
Thanks! Sometimes it helps to review the reasons why medications are dosed differently.
How do we determine what effects on our spirit is with long term planning of pharmaceuticals.
Ie: losing track of the bigger picture because of drugs or losing a sense of connection to nature.
Is half life reduced, if we take sublingual?
Thank you i understand now
So glad you found it helpful!
So if you wanted a drug to not interact with a new one you start taking, would you wait until two half lives or one?
This is a great question - but variable based on what type of drug interaction it is.
It is only sometimes possible to eliminate the interaction by separating the two drugs by a specific # of half-lives, but this is a good place to start.
So what’s the math formula to figure the amount you should take or dose and what’s the time frame? Say for example I take something with a longer half-life than you are showing as an example. What if my half-life is 60 hours what would be the dosing schedule or formula for that?
@AmnestyGG the formula doesn't change with a longer half life, just the time it takes to be eliminated.
If the half life is 60 hours, then it will take 60 hrs for 50% to be eliminated, and 120 hrs for 75% to be eliminated, etc. 👍
But why formula does not change if half life longer like 60 hours . Can it be taken alternate days? Why or why not
Wait what @ :38 seconds, “3 hour half life means 3 hours after administering 50% is gone and than another 3 hrs another 50% gone? how tho that’s all 100% of the drug
3hrs = 50%, 6hrs=25%, 9hrs=12.5%, 12hrs=6.25%, 15hrs=3.125% and so forth. it seems like each time 3 hours has past you are dividing 1/2 of the previous eliminated drug. so after 6 hours, 75% of the drug is eliminated.