Had Optic Neuritis in 2008, was finally DX'ed in 2023 with MS after a major flare in my spine at C1-C2 gave me this intractable spasticity. Was given Clemastine (because I begged for it) in August 2023. Took 6 weeks worth and noticed a noticeable change in the center field of vision in the affected eye. Completed my 2nd year of discontinuous DMT with Mavenclad last month. Started up with Clemastine again at the beginning of this month. It's important to mention that I have had an eye exam after the first round and the correction in my left eye had to be reduced. If cog fog doesn't get me, I'll work to remember to come back here and tell you all what my anecdotal experience is/was.
@@DrBrandonBeaber ..my wife Mary (former Dr. Weiner patient) would be interested in Clemastine and the ReCOVER trial. You may recall she is 30yr+ diagnosed and now secondary progressive. Sounds promising ..we will schedule time. Thank you for your commitment and passion.
Always appreciate hearing about potential MS treatments that treat the damage done by MS. I am hopeful to recover some of what I have lost to MS. Thank you for sharing.
@@DrBrandonBeaber can you please explain if it is possible to have the OCT results improve?(as far as I know Optical coherence tomography) shows the neuronal volume and its loss, so it is more precise than MRI. Is it possible to get better results? Since I had done 2 OCTs which have different results of RNFL(retinal nerve fiber layer).
@@arr2820 I don't think improvement of retinal nerve fiber layer thinning is very common. Are you saying is it "possible" with remyelination therapies? It may be possible, but there is no evidence of this yet.
@@DrBrandonBeaber I have had two OCTs i which the second one had better results. I was really confused. It is more about neurogenesis I guess much more complex than remyelination.
This is a beautiful discovery and I hope it follows through and helps re-myelination and reversing damage caused by that whole multiple sclerosis process, hopefully big Pharma does this new gain in medicine and turn it into some other money game and we still suffer, this is where God will prevail just Gotta keep the faith!!
LDN helps get rid of plaques in the brain. Vit B12 methylcobalamin shot with folate/progesterone/lecithin and more may help once gluten/dairy/soy/sugar/GMO are stopped. Vit D3/sunlight may help.
Clemastine fumarate, initially included in the TRAP-MS trial for CSF remyelination insights, unexpectedly increased disability accumulation, leading to trial discontinuation.Mar 2, 2024
I've tried metformin and it helped me a lot. Im on tecfidera and i was in a very bad place. My MS is mainly characterized by severe anxiety (partially treatment resistance), heavy fatigue, and imbalance. After the metformin, everything improved. Im still suffering and will switch soon from tecfidera to ocrevus........I take 1 pill of metformin 750 MG Extended release, somedays i take 2. No hypoglycemia thankfully. Peace to all
Thank you for sharing. There is some preliminary evidence in rats that metformin may have an effect on remyelination as well: multiplesclerosisnewstoday.com/news-posts/2019/10/11/diabetes-drug-metformin-promotes-myelin-repair-in-rats/
yes doctor beaber, there is a good body of evidence for its anti neuroinflammation/regenerative effects.......I was in a bad place anxiety/leg weakness and fatigue wise. Now, my head is above the water. Overall improvements, i'd say everything got better by 30-35%. Been on it for 5 months and I'm excited for the ocrevus switch. I think ocrevus + metformin will help keep the illness at bay. My case is moderate though. Compared to others patients I've seen, i'd say my MS is level is about 6/10, but the nastiness comes from it's comorbidity with an anxiety disorder also do intermittent fasting 16/8, take fish oil and flaxseed oil (which lower some inflammatory markers especially flaxseed oil) Peace :D
My thoughts exactly! I’m trying to find it - OTC unavailable EVERYWHERE - and even the animal versions at the online pet stores have them as “unavailable” - not even out of stock. Something smells fishy! Makes me more determined to get it…
Thank you so much for making these videos. They are supremely intelligent and helpful. What are your thoughts on whether there are alternative therapies that may help demyelination, such as NAD+ infusions, or oral or sublingual ND/NMN? I would be interested in a video on this. Thanks again Doc!
100,000 IU PLUS VITAMIN K2... Lots of exercise... Stay away from all processed food.. laugh laugh.. family family.. stay active.. do not let your drop foot or your fatigue discourage you from keeping your body from moving. IT'S EITHER YOU WIN OR MS
Lithium does, just look up images of it between controls and Lithium. Lithium does all kinds of wonderful things below the toxic doses and really isn't even that bad. -Raises WBC -Jacks up the proliferation of stems cells in the brain and elsewhere -Acts as a powerful broad-spectrum antiviral -and of course regenerates myelin.
I've taken no special drugs, but MRI late last year showed hints of remyelination - older lesions are less pronounced or gone. However, my condition is getting worse. Seems like contradiction, right? My doctor expressed saspirinos, that the damage by 2019 flare-up was so extensive, some isolated nerves in my spinal cord are still dying off, thus connection is getting worse.
And suddenly it is no longer available OTC….wonder why? AND the NIH funded a study (not peer-reviewed) to supposedly debunk Clemastine’s myelin repairing ability and instead says it actually causes progression and weight gain…..….right.
Thats what i said...and weird now the new finding pipe 307 for remylination and guess what they are using clemestine the drug they dissapeared supposedly bacause it was bad hmmmm.??
Is there any work to be done with clamastine? Please let me know. Thanks for making these videos, I was feeling depressed earlier, but your video gavee hope to live! Thanks doctor Beaber!
I'm glad you found the video encouraging. The Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) trial is still ongoing: www.clinicaltrials.gov/ct2/show/NCT02521311?term=clemastine&draw=2&rank=3
My wife was diagnosed with MS around 1998. She has only had two attacks of which one caused optic neuritis, which she recovered from. Her main issues involve poor mobility (walking and balance). Recent MRIs from 2017 and 2020 show no changes. Most demyelination is in her spine. She has never taken any of the traditional MS drugs. In 2017 she began seeing a doc at Mayo here in AZ. She only recently saw him again in 2020, hence the new MRIs. She has mostly been cared for by natural paths. No one has ever discussed the potential of re-myelination or Clementine with her. Any advice from you Doctor? My wife is 56 and a successful business executive who walks with my assistance and uses a cane. She has no pain but does have occasional spasticity.
So if we grow Mylan over the lesions, which are scar tissue how can that even work? Doesn’t the damage have to be cleared up before you can Re-Mylanate?
My hubby always says, “how many hotel rooms can you rent for the price of that property?” He’s right - we can travel farther that way and won’t own a place used by others that we have to fix and maintain vs enjoy,
Clemastine, me with Optic disabilities also thinks its the very first step in the right direction of mutliple sklerosis research, all other drugs have the function to prove that they dont work.
Very interesting that anticholinergic drugs can have this effect, yet they also have been linked with cognitive decline, at least in the elderly. Have the studies of clemastine evaluated for changes in cognitive function as well? Is clemastine and anticholinergic? Would love to hear your thoughts on this! Thanks Dr.!
Clemastine is anticholinergic, but it can actually be shown that it is the antimuscarinic effects which drive remyelination. Cognitive side effects are a consideration with clemastine.
As far as I know, cause and effect has never been proven for anticholinergic drugs and cognitive decline. There are correlations. It is just as likely that people who have symptoms of cognitive decline, happen to use benadryl often. People with early dementia have insomnia so it makes sense that they would use things like benadryl to sleep.
Excellent video. I knew of this study a while ago, brought it up to dr. Who was familiar. Too soon to recommend using it! Also in the study on humans, they were receiving above recommended dose? I live in San Jose, may look at the study you mentioned. Is that the phase 3 study i hope? Or something else?
The phase III trial is the "Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) study" which you can find here: clinicaltrials.gov/ct2/show/NCT02521311 The contact information is near the bottom. The dose they are using is 12mg (4mg 3x/day) clemastine for 7 days followed by 8mg clemastine (4mg 2x/day) until 3 months. This is a relatively dose which could be sedating for many people when taking during the day.
Great video and thanks. I'd really like to be able to walk normally (after a few blocks) again and run because after about 100 meters my legs just lose coordination and I can't lift them. I can't run because of drop foot. Do you know of any way to cure this? I'm trying a lot of different things but have to wait and see if they have any effect. Thanks a lot. 😎✌
It's a very inexpensive pill. The availability may be limited because it's not generally used in modern times, but I can't speak for insurance companies.
My neuroimmunologist and MS specialist at UCI filled me in that clemastine is a bit of a dirty substance, has toxic effects and really only showed a reduction in latency for the VEP test in the studies. I decided to pass on it until they clean it up. He has published recent research on N-acetylglucosamine for remylination, fair warning, it will make you gassy! I volunteered to try it at 12 grams a day and have since been advised to sip that throughout the day instead of 3 big doses of 4 grams each. It doesn't affect A1c either. "NAG" not regular glucosamine.
Thank you for making this video I have Multiple Sclerosis so see that resurrection has been done with this issue is the best thing to finding out a cure against this Multiple Sclerosis sickness. ( like a piece to this puzzle that needs to be found )Thank you
@Dr. Brandon Beaber - Could you please comment or make a video on Clemastine vs. Metformin vs. Alpha-Lipoic Acid? And thank you for all these great videos!
@@DrBrandonBeaber When I saw your list of the most effective MS drugs, I thought something similar could be done for the remyelination. I've found only this, but I don't feel qualified enough to comment on that - www.researchgate.net/publication/346858325_Systematic_approach_to_selecting_licensed_drugs_for_repurposing_in_the_treatment_of_progressive_multiple_sclerosis
I enjoyed this video and found the research intriguing! I participated in the CombiRx Phase Iii trial circa 2005-2012. Wo hi of you be able to review the results of this study please? I did receive both treatments in the study and feel that the course of my disease was dramatically slowed because of early and aggressive treatment. I understand that DMTs are very expensive and no insurance company probably would not cover two therapies. However, I wasn’t able to find the results of this study. Thank you!
The Combi-Rx study did not show any benefit of combining the two medications (copaxone and avonex). Copaxone was slightly superior in efficacy to avonex. I am actually going to do a video shortly looking at head-to-head trials which you may be interested in. This is the full publication of the combi Rx study if you would like to take a look: www.ncbi.nlm.nih.gov/pubmed/23424159
They have tested people with MS and gotten remyelinaton. The myelin has grown back thinner that it orginally was. Would this be because of scar tissue on the nerve being a issue?
The whole question is not how to restore myelin, but how to remove the connective tissue (plaque) in the place where the myelin used to be. Whenever I read that scientists have learned to restore myelin, I understand that this is a scam for the dull. They don't understand what MS is. And why can’t myelin be restored where the plaque was.
Hi, Is it possible to know how the current experiment is going on in humans, as well as a possible date for the end of the experiment? Also, regarding the experiment, in case it has positive results, would the treatment be valid for all types of Multiple Sclerosis or only those that suffer from Acute Optic Neuritis? Thank you very much, it was a very interesting video. Kind regards.
I don't know how the ReCOVER trial is going. Generally speaking, the results are not released until it is completed or for a planned interim analysis. In theory, the beneficial effects would be in general for multiple sclerosis and not just for acute optic neuritis. They chose to study optic neuritis because there are a lot of good paraclinical markers of optic nerve function (visual evoked potentials, ocular computed tomography). You can take a look at the ReCOVER trial on the USCF website here: greenlab.ucsf.edu/recover-trial You could also try contacting the coordinator Tracy Tran by email (listed on the website)
Interesting. Dr. are you aware of any MS Neurologists, who have or are currently, prescribing Clemastine as an off label use to treat MS? I ask because this theory has been around for a few years although the studies had not been done to support it until now.
Would this be prescribed in addition to your DMT? It’s exciting to hear and I’ve heard this about a few of the newer DMTs. Personally, I wouldn’t want to drop one for the other. Thanks for your great videos! 🤗❤️❤️
Hello doctor I recently heard that intake of alpha-lipolic acid (300-600mg daily) can reconstruct the damaged nerve. Do you have any information regarding this? What about the side effects associated?
ALA is sometimes used for neuropathic pain (there is some evidence in diabetic neuropathy), but I am not aware of any good evidence in regrowing nerve tissue.
Thankyou Dr Beaber for this information. You mentioned that it may help those with optic neuritis but would it help at all with mobility issues? Thanks again for your time.
@@DrBrandonBeaber it seems that there are two parts of the phase 2 in which the trial was conducted...one is REBUILD trial which assesses remyelination in general and measures Visual Evoked Potential as primary outcome measure and measures Myelin Water Volume, Magnetization Transfer Ratios, tolerability and EDSS score as secondary outcome measures... The other part of the trial is ReCOVER which is for acute optic neuritis... Regards.
@@DrBrandonBeaber sir, as you mentioned in one of your comments that it is unlikely to get an FDA approval for MS as it is an already approved drug, then how can we know if the drug Is really effective in humans and at what dose (so that we could start taking it off label)?
Thanks for the amazing information! The only problem is I am from Europe and Clemastine itself doesn't seem to be so readily accessible (also, I wonder that if it is proven to be effective, it will be taken off the market and then re-sold as an expensive MS drugh). Towards the end you mention that what's key is the muscaranate antagonist function. I wonder if I can fnd a list of available muscaranate antagonist drugs marketed in Europe...
You may be right about the marketing strategy, but clemastine is generic, so there should be multiple formulations available. Often, a pharmaceutical company will market a specific unusual dose or extended release formulation and then pretend the drug is brand new. You can look at the wikipedia article for muscarinic antagonists, but taking a drug just because it is in the same class as a drug which isn't even proven in humans with MS is somewhat dubious: en.wikipedia.org/wiki/Muscarinic_antagonist#:~:text=A%20muscarinic%20receptor%20antagonist%20(MRA,of%20the%20muscarinic%20acetylcholine%20receptor.&text=Besides%20responding%20to%20their%20primary,a%20variety%20of%20other%20molecules.
Hi Dr Brandon. I suffer from a disease called AMN. It is a rare genetic nerve disorder. At present, there are 0 treatment options, and breakdowns of myelin are the big issue. Do you think this treatment might be a possibility for this disease?
Can you do a video of Lemtra VS HSCT comparing treatment and long-term risks? I have been curious about which is better but haven't found much information comparing the two.
Can you make a video about how to talk to your neurologist about getting on these medications? I tried to get on the one for neurogenic bladder, and even mentioned it by name, but she prescribed me something else and I'm frustrated.
Wtf? Are you telling me that I just have to buy some hay fever tablets, that may be old-fashioned but are still available, and there might be some re-myelination? ... I wonder what they'll say if I buy this in January. Not that I care.
There should be more collaboration and study's done with ms. It seems like there are many people willing to sign waivers for experimental treatments and other countrys that have proven treatments which are like a fairy tail in other places. I've heard many of these remil stories from accredited people in the medical field about the same subject of remilination. This is where the trail runs dry. It goes into clinical trials purgatory.
@@pattischmitz2680 there's a few I've heard about when the covid vaccine was being experimented with. Then of course stem cells but that's a serious procedure and price that may take several times to work and no one knows if any lasting effects come from it. There are others I forget, TBI.
Greetings from India 🇮🇳, My brother is diagnosed with MS, Can we provide him with Tavegyl tablet, It's available in India. Please advice, I am glad to share his medical reports for your opinion. Thanks in advance.
Sorry, I can't give your brother personalized medical advice. Clemastine is currently unproven, but some people do take it. It can be sedating and cause other side effects sometimes.
It seems like this is very promising! I want to know what your opinion is on how close we can find a cure to MS. I'm not expecting it to be soon by any chance. Promising data like Clemastine didn't just occur overnight. As always, I'm very thankful for your videos as an MS patient myself.
I may do a video speculating on the possibility of a cure for multiple sclerosis. It is a little bit of a complicated topic because it depends exactly what is meant by "cure."
They have been working on this for almost 30 yrs! But lately scientists guided to assist humanity with autoimmune condition… between 5 to 10 yrs… I just can’t!
Hi Doc do you see this being effective for myelin repair across all nerves or more just vision? I have vertical nystagmus from MS hoping this will prove to be an effective treatment post clinical trials.
I'm having neuropathy like feelings in my feet and in the last couple months its moved up my legs and in my hands and arms ...it could be ms? Im losimg my mind dealing with this what can i do ?
What about aspirin? I think I heard it has remyelination possibilities. I have found while taking aspirin to combat headache from nystagmus that I walk significantly better...still bad but much better from adding aspirin to everything else I take (not relating to demyelination of course) . I’d be interested in you doing a similar aspirin use in MS!
Dr. Brandon Beaber Tsau et al. Bcm medicine (2015) 13:153 but doesn’t directly address my walking improvement. Could be that as a pain inhibitors that opens up some amount of neural plasticity? Thoughts? Additionally I exhibit noticeable walking improvement immediately after Ocrevus treatment, my suspicion is the solumedrol? It doesn’t last. Could low grade inflammation be a component to my daily walking difficulty that is lowered with various anti inflammatory agents ? This strays from the remyelination but I’m equally interested in both because intimately I just want to walk straight again or at least keep walking! Love your work on RUclips you are help the suffering searchers!
Thank you Mr. Brandon for the amazing explanation! I will start. to use "Betaferon" on next weeks and do you think that it's gonna be a trouble to use both "Betaferon" and "Tavegly" together? Also, there's an only "1mg tablet" is available for sale in my country but in text, you mentioned appx. 5mg a day.. Do you have any recommendation about dosing? Best Regards and thanks again!
Hayir oyle kafama gore baslamak cok yanlis bu klinik calismalarin hepsinin dozu, kullanim araligi gibi detaylar var. İlaclarinizi duzgun kullanin, pozitif dusunun ve mutlaka doktorunuza da danisarak fonksiyonel tip ile ilgilenin, paleo diyeti yapiyorum ben tum problemler geride kaldi :) sevgiler
Thank you so much for your videos. Can you please make an update video. I noticed in a comment that you have prescribed clemastine before. I would like to talk to my neurologist about replacing my sleep aid with it. How much should I use?
I can't give you personal advice, but these are doses which have been used previously. The dose used in the RECOVER trial was very high and would likely be sedating (12mg (4mg 3x/day) clemastine for 7 days followed by 8mg clemastine (4mg 2x/day)). For the ReBUILD trial, the dose is 5·36 mg orally twice daily. I think a practical approach is to take a lower dose only at night until there is real evidence.
@@DrBrandonBeaber Thank you for the reply. I know you can't give personal advice. I was just curious how you prescribed it. How many mg at bedtime do you think it's a good dose? Do you have a video on Metformin? I read that it actually showed improvement on MRI. I wonder if it will be safe for those with normal blood sugars to use for MS in the future.
Possibly. the peripheral nervous system is myelinated by schwann cells rather than oligodendrocytes, so this research doesn't really apply, but the underlying muscarinic receptor target may be the same. In general, the peripheral nervous system has greater potential for remyelination.
Is there any studies that connect Central Pontine Myelinosis with protocols being used/researched fir MS? My son got this in 2014 in connection with treatment from a hospital for very low sodium by raising it too fast. Is there a chance that this protocol could be helpful?
Doctor Beaber, I have been digging into the histamine and MS connection a little deeper. Seems like the data is mixed and lacking at this point. Many of the drugs shown to promote Remyelination appear to be antagonist against Muscarinic Receptors. So an anti-histamine such as clemastine seems highly probable to be effective. Do you know if they studied diphenhydramine as a possible remyelinating agent? It is non-specific to the M receptors and has known access to the CNS. Also it is widely available over the counter and very cheap.
I am having trouble finding a list of medications they screened, but they used a 1,000-compound library screen, so I'm sure some antihistamine agents were screened. I'm not sure if diphenhydramine was included.
@@DrBrandonBeaber That was my thoughts as well, I will try to dig and find the entire list, even if it means scraping through the entire publication haha. Thanks for your response, I watch every video, and love your content. The MS world is so incredibly thankful for you!
@@charlespatton7402 Thanks Charles. That really means a lot to me. Let me know if you have any video suggestions. I would like to do more videos like this in the future, and I am going to interview Professor Dwight Bergles about his work with OPC soon
I have a specific video on biotin: ruclips.net/video/CS6CWPBHKGM/видео.html I don't think there is any clinical data on NVG-291. It is still in phase 1 trials, so it is years away, but certainly we would see it in our lifetime (easily within 5-10 years) if it is effective.
What are the side effects of this medication? And how is it administered? I imagining it’s a little pill that makes your tired and prevents allergies like Benadryl. If so that sounds worth a try to take before bed every night. Unless their are further side effects or precautions on long term use?
This is a pill, and most people take it at night because it can be sedating. It is an old antihistamine just like Benadryl, so it has similar side effects. It has been reported that long term use of benadryl for insomnia may actually be linked to dementia, but I don't think Tavist is generally speaking likely to cause serious side effects.
"A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination" it is stronger and two in one relieves inflammation and activates opc. even potentially for secondarily progressive.
Hello! Greetings from Iraq! I only have one question. Generally speaking, would Zeposia help a patient who is 57, female, with psoriasis and JC Virus? And please, if you don't know the answer to that, could you please connect me with someone who can? Thanks in advance 😊
Please do a follow up on this?
Had Optic Neuritis in 2008, was finally DX'ed in 2023 with MS after a major flare in my spine at C1-C2 gave me this intractable spasticity. Was given Clemastine (because I begged for it) in August 2023. Took 6 weeks worth and noticed a noticeable change in the center field of vision in the affected eye.
Completed my 2nd year of discontinuous DMT with Mavenclad last month. Started up with Clemastine again at the beginning of this month. It's important to mention that I have had an eye exam after the first round and the correction in my left eye had to be reduced. If cog fog doesn't get me, I'll work to remember to come back here and tell you all what my anecdotal experience is/was.
how was it ? how are you doing today ?
Update?
That seems very promising. As someone who has damage from prior optic neuritis, this seems like a step in the right direction.
I definitely look forward to the results of the ReCOVER trial with Dr. Ari Green and his team at UCSF.
Me podría enviar información
@@DrBrandonBeaber ..my wife Mary (former Dr. Weiner patient) would be interested in Clemastine and the ReCOVER trial. You may recall she is 30yr+ diagnosed and now secondary progressive. Sounds promising ..we will schedule time. Thank you for your commitment and passion.
@@DrBrandonBeaber what about immunocal? Have you seen the trial done by NIH for this PROTEIN and Lou Gehrig's disease?
Have you started using it in the last two years since this video came out?
Always appreciate hearing about potential MS treatments that treat the damage done by MS. I am hopeful to recover some of what I have lost to MS. Thank you for sharing.
This is indeed an exciting aspect of MS research. I will try to do more videos of this type in the future.
Try looking into immunocal
@@DrBrandonBeaber can you please explain if it is possible to have the OCT results improve?(as far as I know Optical coherence tomography) shows the neuronal volume and its loss, so it is more precise than MRI. Is it possible to get better results? Since I had done 2 OCTs which have different results of RNFL(retinal nerve fiber layer).
@@arr2820 I don't think improvement of retinal nerve fiber layer thinning is very common. Are you saying is it "possible" with remyelination therapies? It may be possible, but there is no evidence of this yet.
@@DrBrandonBeaber I have had two OCTs i which the second one had better results. I was really confused. It is more about neurogenesis I guess much more complex than remyelination.
This is a beautiful discovery and I hope it follows through and helps re-myelination and reversing damage caused by that whole multiple sclerosis process, hopefully big Pharma does this new gain in medicine and turn it into some other money game and we still suffer, this is where God will prevail just Gotta keep the faith!!
LDN helps get rid of plaques in the brain. Vit B12 methylcobalamin shot with folate/progesterone/lecithin and more may help once gluten/dairy/soy/sugar/GMO are stopped. Vit D3/sunlight may help.
It would be nice to see some interviews with patients with MS who microdose with magic mushrooms. It is incredible how many go into remission.
Clemastine fumarate, initially included in the TRAP-MS trial for CSF remyelination insights, unexpectedly increased disability accumulation, leading to trial discontinuation.Mar 2, 2024
I've tried metformin and it helped me a lot. Im on tecfidera and i was in a very bad place. My MS is mainly characterized by severe anxiety (partially treatment resistance), heavy fatigue, and imbalance. After the metformin, everything improved. Im still suffering and will switch soon from tecfidera to ocrevus........I take 1 pill of metformin 750 MG Extended release, somedays i take 2. No hypoglycemia thankfully. Peace to all
Thank you for sharing. There is some preliminary evidence in rats that metformin may have an effect on remyelination as well: multiplesclerosisnewstoday.com/news-posts/2019/10/11/diabetes-drug-metformin-promotes-myelin-repair-in-rats/
yes doctor beaber, there is a good body of evidence for its anti neuroinflammation/regenerative effects.......I was in a bad place anxiety/leg weakness and fatigue wise. Now, my head is above the water. Overall improvements, i'd say everything got better by 30-35%. Been on it for 5 months and I'm excited for the ocrevus switch. I think ocrevus + metformin will help keep the illness at bay. My case is moderate though. Compared to others patients I've seen, i'd say my MS is level is about 6/10, but the nastiness comes from it's comorbidity with an anxiety disorder
also do intermittent fasting 16/8, take fish oil and flaxseed oil (which lower some inflammatory markers especially flaxseed oil)
Peace :D
Ayushprana best for ms
Are you RRMS or PPMS?
Also....PLASMA! (huge Earthworm Jim fan, here :)
Hi, I know this post is old. My MS is also very severe treatment resistant anxiety and some other things. How are you doing these days?
This is probably why it hasn’t been available otc for years
My thoughts exactly! I’m trying to find it - OTC unavailable EVERYWHERE - and even the animal versions at the online pet stores have them as “unavailable” - not even out of stock. Something smells fishy! Makes me more determined to get it…
We are waiting for the updates doctor concerning the advances in this particular research.
I will make a video if there is a major update
One year after, where are we?
Thanks from Algeria Doctor.
Thank you so much for making these videos. They are supremely intelligent and helpful. What are your thoughts on whether there are alternative therapies that may help demyelination, such as NAD+ infusions, or oral or sublingual ND/NMN? I would be interested in a video on this. Thanks again Doc!
100,000 IU PLUS VITAMIN K2... Lots of exercise... Stay away from all processed food.. laugh laugh.. family family.. stay active.. do not let your drop foot or your fatigue discourage you from keeping your body from moving. IT'S EITHER YOU WIN OR MS
Lithium does, just look up images of it between controls and Lithium.
Lithium does all kinds of wonderful things below the toxic doses and really isn't even that bad.
-Raises WBC
-Jacks up the proliferation of stems cells in the brain and elsewhere
-Acts as a powerful broad-spectrum antiviral
-and of course regenerates myelin.
…and charges our batteries.
I've taken no special drugs, but MRI late last year showed hints of remyelination - older lesions are less pronounced or gone. However, my condition is getting worse. Seems like contradiction, right? My doctor expressed saspirinos, that the damage by 2019 flare-up was so extensive, some isolated nerves in my spinal cord are still dying off, thus connection is getting worse.
And suddenly it is no longer available OTC….wonder why? AND the NIH funded a study (not peer-reviewed) to supposedly debunk Clemastine’s myelin repairing ability and instead says it actually causes progression and weight gain…..….right.
Thats what i said...and weird now the new finding pipe 307 for remylination and guess what they are using clemestine the drug they dissapeared supposedly bacause it was bad hmmmm.??
Is there any work to be done with clamastine? Please let me know. Thanks for making these videos, I was feeling depressed earlier, but your video gavee hope to live! Thanks doctor Beaber!
I'm glad you found the video encouraging. The Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) trial is still ongoing: www.clinicaltrials.gov/ct2/show/NCT02521311?term=clemastine&draw=2&rank=3
My wife was diagnosed with MS around 1998. She has only had two attacks of which one caused optic neuritis, which she recovered from. Her main issues involve poor mobility (walking and balance). Recent MRIs from 2017 and 2020 show no changes. Most demyelination is in her spine. She has never taken any of the traditional MS drugs. In 2017 she began seeing a doc at Mayo here in AZ. She only recently saw him again in 2020, hence the new MRIs. She has mostly been cared for by natural paths. No one has ever discussed the potential of re-myelination or Clementine with her. Any advice from you Doctor? My wife is 56 and a successful business executive who walks with my assistance and uses a cane. She has no pain but does have occasional spasticity.
Unfortunately, I can't give you medical advice here. Clemastine is currently unproven in actual humans with MS, but some people with MS do take it.
@@DrBrandonBeaber yes I understand your position, however if you had MS and mobility issues and have the knowledge you have; would you try Clemestine?
@@stevenordberg maybe
I know exactly what you are saying… i have MS from 1998 and nobody said anything about, maybe because I have RRMS but the sickness is there!!!😢
Not a dr in anyway nor a medical professional. I’m taking Clemastine for my allergies. I’m personally satisfied.
The "Old Mouse" that couldn't walk miraculously walks again drug. I've heard this for over 10 years now. HSCT for real results
That's a fair point. We will have to wait and see if it pans out in humans with MS.
This is very fascinating! What do you know about us who got HSCT and the ability to take this drug?
So if we grow Mylan over the lesions, which are scar tissue how can that even work? Doesn’t the damage have to be cleared up before you can Re-Mylanate?
I will be asking my neurologist about this
My hubby always says, “how many hotel rooms can you rent for the price of that property?” He’s right - we can travel farther that way and won’t own a place used by others that we have to fix and maintain vs enjoy,
why this comment on a video about remyelination?
Clemastine, me with Optic disabilities also thinks its the very first step in the right direction of mutliple sklerosis research, all other drugs have the function to prove that they dont work.
Look into immunocal
Very interesting that anticholinergic drugs can have this effect, yet they also have been linked with cognitive decline, at least in the elderly. Have the studies of clemastine evaluated for changes in cognitive function as well? Is clemastine and anticholinergic? Would love to hear your thoughts on this! Thanks Dr.!
Clemastine is anticholinergic, but it can actually be shown that it is the antimuscarinic effects which drive remyelination. Cognitive side effects are a consideration with clemastine.
@@DrBrandonBeaber I thought that had to do with the “D” option that was removed from the market?
As far as I know, cause and effect has never been proven for anticholinergic drugs and cognitive decline. There are correlations. It is just as likely that people who have symptoms of cognitive decline, happen to use benadryl often. People with early dementia have insomnia so it makes sense that they would use things like benadryl to sleep.
Excellent video. I knew of this study a while ago, brought it up to dr. Who was familiar. Too soon to recommend using it! Also in the study on humans, they were receiving above recommended dose? I live in San Jose, may look at the study you mentioned. Is that the phase 3 study i hope? Or something else?
The phase III trial is the "Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) study" which you can find here: clinicaltrials.gov/ct2/show/NCT02521311 The contact information is near the bottom. The dose they are using is 12mg (4mg 3x/day) clemastine for 7 days followed by 8mg clemastine (4mg 2x/day) until 3 months. This is a relatively dose which could be sedating for many people when taking during the day.
@@DrBrandonBeaber
Thank you sir. Indeed i understand now. Very sedative effects.
Great video and thanks. I'd really like to be able to walk normally (after a few blocks) again and run because after about 100 meters my legs just lose coordination and I can't lift them. I can't run because of drop foot. Do you know of any way to cure this? I'm trying a lot of different things but have to wait and see if they have any effect. Thanks a lot. 😎✌
Excited to hear this. Now what's the cost? Is my ins gonna approve this. Can I even take this is this an injection or a pill.
It's a very inexpensive pill. The availability may be limited because it's not generally used in modern times, but I can't speak for insurance companies.
@@DrBrandonBeabercan you treat for ALS please please help 😢😢😢😢
My neuroimmunologist and MS specialist at UCI filled me in that clemastine is a bit of a dirty substance, has toxic effects and really only showed a reduction in latency for the VEP test in the studies. I decided to pass on it until they clean it up. He has published recent research on N-acetylglucosamine for remylination, fair warning, it will make you gassy! I volunteered to try it at 12 grams a day and have since been advised to sip that throughout the day instead of 3 big doses of 4 grams each. It doesn't affect A1c either. "NAG" not regular glucosamine.
I assume you are talking about Dr. Demetriou or Dr. Sy and their research. No doubt the clinical evidence for clemastine is limited.
Thank you for making this video I have Multiple Sclerosis so see that resurrection has been done with this issue is the best thing to finding out a cure against this Multiple Sclerosis sickness. ( like a piece to this puzzle that needs to be found )Thank you
@Dr. Brandon Beaber - Could you please comment or make a video on Clemastine vs. Metformin vs. Alpha-Lipoic Acid?
And thank you for all these great videos!
Is there a specific study doing this comparison?
@@DrBrandonBeaber When I saw your list of the most effective MS drugs, I thought something similar could be done for the remyelination. I've found only this, but I don't feel qualified enough to comment on that -
www.researchgate.net/publication/346858325_Systematic_approach_to_selecting_licensed_drugs_for_repurposing_in_the_treatment_of_progressive_multiple_sclerosis
@@jacekchwedenczak5894 Right now, there would be no way to create an evidence-based list of potential remyelinating therapies.
@@DrBrandonBeaber Thank you for your reply! I hope the research will progress over time.
@@jacekchwedenczak5894 It certainly will, but I can't predict the exact pace and direction.
I enjoyed this video and found the research intriguing! I participated in the CombiRx Phase Iii trial circa 2005-2012. Wo hi of you be able to review the results of this study please? I did receive both treatments in the study and feel that the course of my disease was dramatically slowed because of early and aggressive treatment. I understand that DMTs are very expensive and no insurance company probably would not cover two therapies. However, I wasn’t able to find the results of this study. Thank you!
The Combi-Rx study did not show any benefit of combining the two medications (copaxone and avonex). Copaxone was slightly superior in efficacy to avonex. I am actually going to do a video shortly looking at head-to-head trials which you may be interested in. This is the full publication of the combi Rx study if you would like to take a look: www.ncbi.nlm.nih.gov/pubmed/23424159
They have tested people with MS and gotten remyelinaton. The myelin has grown back thinner that it orginally was. Would this be because of scar tissue on the nerve being a issue?
Clemastine! Wow so exciting!
The whole question is not how to restore myelin, but how to remove the connective tissue (plaque) in the place where the myelin used to be. Whenever I read that scientists have learned to restore myelin, I understand that this is a scam for the dull. They don't understand what MS is. And why can’t myelin be restored where the plaque was.
Mind blown...
Hi,
Is it possible to know how the current experiment is going on in humans, as well as a possible date for the end of the experiment?
Also, regarding the experiment, in case it has positive results, would the treatment be valid for all types of Multiple Sclerosis or only those that suffer from Acute Optic Neuritis?
Thank you very much, it was a very interesting video.
Kind regards.
I don't know how the ReCOVER trial is going. Generally speaking, the results are not released until it is completed or for a planned interim analysis. In theory, the beneficial effects would be in general for multiple sclerosis and not just for acute optic neuritis. They chose to study optic neuritis because there are a lot of good paraclinical markers of optic nerve function (visual evoked potentials, ocular computed tomography). You can take a look at the ReCOVER trial on the USCF website here: greenlab.ucsf.edu/recover-trial You could also try contacting the coordinator Tracy Tran by email (listed on the website)
Interesting. Dr. are you aware of any MS Neurologists, who have or are currently, prescribing Clemastine as an off label use to treat MS? I ask because this theory has been around for a few years although the studies had not been done to support it until now.
Yes. I have prescribed it myself, though I can't say I actually advocate clemastine at this time. I would like to see better evidence.
Would this be prescribed in addition to your DMT? It’s exciting to hear and I’ve heard this about a few of the newer DMTs. Personally, I wouldn’t want to drop one for the other. Thanks for your great videos! 🤗❤️❤️
Hello doctor
I recently heard that intake of alpha-lipolic acid (300-600mg daily) can reconstruct the damaged nerve. Do you have any information regarding this? What about the side effects associated?
ALA is sometimes used for neuropathic pain (there is some evidence in diabetic neuropathy), but I am not aware of any good evidence in regrowing nerve tissue.
@@DrBrandonBeaber ok.. thanks a lot for the reply 😊
Does this mean that all drugs that block the M1 muscarinic receptor would work in the same way in regards to remyelination, at least in theory?
Hope! Thank you for sharing this information.
:)
@@DrBrandonBeabercan you treat ALS my wife has ALS please please 😢😢😢😢
Thankyou Dr Beaber for this information. You mentioned that it may help those with optic neuritis but would it help at all with mobility issues? Thanks again for your time.
It is possible that it could help with mobility in MS, but we don't have specific evidence of this yet.
@@DrBrandonBeaber it seems that there are two parts of the phase 2 in which the trial was conducted...one is REBUILD trial which assesses remyelination in general and measures Visual Evoked Potential as primary outcome measure and measures Myelin Water Volume, Magnetization Transfer Ratios, tolerability and EDSS score as secondary outcome measures...
The other part of the trial is ReCOVER which is for acute optic neuritis...
Regards.
@@aditya50499 You are right. I also mention the ReCOVER trial at the end of the video
@@DrBrandonBeaber sir, as you mentioned in one of your comments that it is unlikely to get an FDA approval for MS as it is an already approved drug, then how can we know if the drug Is really effective in humans and at what dose (so that we could start taking it off label)?
@@aditya50499 We would have to wait for the results of the ReCOVER trial to see if it is actually effective in humans.
Aaaaaaaand that’s the last you’ll hear of _that_
Thanks for the amazing information! The only problem is I am from Europe and Clemastine itself doesn't seem to be so readily accessible (also, I wonder that if it is proven to be effective, it will be taken off the market and then re-sold as an expensive MS drugh). Towards the end you mention that what's key is the muscaranate antagonist function. I wonder if I can fnd a list of available muscaranate antagonist drugs marketed in Europe...
You may be right about the marketing strategy, but clemastine is generic, so there should be multiple formulations available. Often, a pharmaceutical company will market a specific unusual dose or extended release formulation and then pretend the drug is brand new. You can look at the wikipedia article for muscarinic antagonists, but taking a drug just because it is in the same class as a drug which isn't even proven in humans with MS is somewhat dubious: en.wikipedia.org/wiki/Muscarinic_antagonist#:~:text=A%20muscarinic%20receptor%20antagonist%20(MRA,of%20the%20muscarinic%20acetylcholine%20receptor.&text=Besides%20responding%20to%20their%20primary,a%20variety%20of%20other%20molecules.
Didn’t they stop selling this over the counter awhile back?
It is possible to buy it in Spain, Lithuania and Turkey.
My mom died last month . Symptoms shows it was MS . Unfortunately doctors can't diagnose the disease .
I am so sorry for your loss 😔
did she take the covid vax? We are seeing uptick in MS after vax , here in NZ.
Sir will it be helpful for corticospinal axonal degeneration in dorsal spinal cord
Very interesting.
Thank you.
You're welcome. I plan to do more videos on emerging agents for remyelination in the future.
Dr. Brandon Beaber please do!
Hi Dr Brandon. I suffer from a disease called AMN. It is a rare genetic nerve disorder. At present, there are 0 treatment options, and breakdowns of myelin are the big issue. Do you think this treatment might be a possibility for this disease?
Can you do a video of Lemtra VS HSCT comparing treatment and long-term risks? I have been curious about which is better but haven't found much information comparing the two.
You may appreciate these videos: 1) ruclips.net/video/0rvT_DuAJ3Y/видео.html 2) ruclips.net/video/jNgoxJTgQJc/видео.html
@@DrBrandonBeaber thank you, I will check them out right now :)
see "lemtrada vs hsct ms news today"
no contest...get hsct save your life.
Can you make a video about how to talk to your neurologist about getting on these medications? I tried to get on the one for neurogenic bladder, and even mentioned it by name, but she prescribed me something else and I'm frustrated.
I have neurogenic bladder…what med are you wanting to take?
Wtf? Are you telling me that I just have to buy some hay fever tablets, that may be old-fashioned but are still available, and there might be some re-myelination? ... I wonder what they'll say if I buy this in January. Not that I care.
When will it be FDA approved? Have it gone through clinical trials?
Boohoo crying I pray this works .. I want to feel normal
Thanks, very informative
:)
Interesting..
Can you do a video about mirtazapine and JC Virus?
Maybe is something with Histamine receptors going on..
There should be more collaboration and study's done with ms. It seems like there are many people willing to sign waivers for experimental treatments and other countrys that have proven treatments which are like a fairy tail in other places. I've heard many of these remil stories from accredited people in the medical field about the same subject of remilination. This is where the trail runs dry. It goes into clinical trials purgatory.
What treatment do other countries have?
@@pattischmitz2680 there's a few I've heard about when the covid vaccine was being experimented with. Then of course stem cells but that's a serious procedure and price that may take several times to work and no one knows if any lasting effects come from it. There are others I forget, TBI.
Greetings from India 🇮🇳, My brother is diagnosed with MS, Can we provide him with Tavegyl tablet, It's available in India. Please advice, I am glad to share his medical reports for your opinion. Thanks in advance.
Sorry, I can't give your brother personalized medical advice. Clemastine is currently unproven, but some people do take it. It can be sedating and cause other side effects sometimes.
@@DrBrandonBeaber Thanks Doctor, Appreciate your swift response.
Give him some Lion's mane supplements from US. Preferably RealMushrooms brand.
Are the trials still going on ? I live in northern cal
Yes. They are still ongoing
And what about covid19 vaccine and MS?
It seems like this is very promising! I want to know what your opinion is on how close we can find a cure to MS. I'm not expecting it to be soon by any chance. Promising data like Clemastine didn't just occur overnight. As always, I'm very thankful for your videos as an MS patient myself.
I may do a video speculating on the possibility of a cure for multiple sclerosis. It is a little bit of a complicated topic because it depends exactly what is meant by "cure."
They have been working on this for almost 30 yrs! But lately scientists guided to assist humanity with autoimmune condition… between 5 to 10 yrs… I just can’t!
Can you cover Sobetirome? Why is it not FDA approved yet after positive animal and human trials for remyelination?
I am familiar with the animal studies, but I don't believe I have seen trials in humans with MS. Do you have a citation?
The pharma will give hell but we humanity must stand up for their right for better medicine medicine…
Any updates on this please ?
I hope to god we find a cure soon I think we will it’s all about demyelination
Wow! How does this video's topic possibly relate to BDNF and IGF-1 proteins which I understand are instrumental in remyelinization?
I need help like yesterday.
what can help with remyelination to the point of moving a body, such as wheelchair bound and moving arms and legs?
Hi Doc do you see this being effective for myelin repair across all nerves or more just vision? I have vertical nystagmus from MS hoping this will prove to be an effective treatment post clinical trials.
I hope it could be effective throughout the nervous system, but who knows.
@@DrBrandonBeaber Do you have any updates on the Clemastine metformin trials?
@@ajpello2003 Unfortunately, I do not
Plis mayor información. Gracias
I'm having neuropathy like feelings in my feet and in the last couple months its moved up my legs and in my hands and arms ...it could be ms? Im losimg my mind dealing with this what can i do ?
What about aspirin? I think I heard it has remyelination possibilities. I have found while taking aspirin to combat headache from nystagmus that I walk significantly better...still bad but much better from adding aspirin to everything else I take (not relating to demyelination of course) . I’d be interested in you doing a similar aspirin use in MS!
Off the top of my head, I haven't seen any articles on aspirin having remyelinating potential.
Dr. Brandon Beaber Tsau et al. Bcm medicine (2015) 13:153 but doesn’t directly address my walking improvement. Could be that as a pain inhibitors that opens up some amount of neural plasticity? Thoughts? Additionally I exhibit noticeable walking improvement immediately after Ocrevus treatment, my suspicion is the solumedrol? It doesn’t last. Could low grade inflammation be a component to my daily walking difficulty that is lowered with various anti inflammatory agents ? This strays from the remyelination but I’m equally interested in both because intimately I just want to walk straight again or at least keep walking!
Love your work on RUclips you are help the suffering searchers!
A d vitamin kúra segített már valakinek polineuropatiaban ? Nekem fluorokinolon okozta polineuropatiam van.
Would this be similarly helpful for NMOSD and MOG?
Thank you Mr. Brandon for the amazing explanation! I will start. to use "Betaferon" on next weeks and do you think that it's gonna be a trouble to use both "Betaferon" and "Tavegly" together?
Also, there's an only "1mg tablet" is available for sale in my country but in text, you mentioned appx. 5mg a day.. Do you have any recommendation about dosing?
Best Regards and thanks again!
Eren Bey selamlar, siz basladiniz mi tavegyl kullanmaya
Hayir oyle kafama gore baslamak cok yanlis bu klinik calismalarin hepsinin dozu, kullanim araligi gibi detaylar var. İlaclarinizi duzgun kullanin, pozitif dusunun ve mutlaka doktorunuza da danisarak fonksiyonel tip ile ilgilenin, paleo diyeti yapiyorum ben tum problemler geride kaldi :) sevgiler
#SharingisCaring #WeHaveMS. When do you think this will get realized and acceptable for adding to our meds?
🙏🏼🙏🏼🙏🏼I pray to God for this to happen! In Jesus Christ's Name! Amen!🙏🏼🙏🏼🙏🏼
Clemastine is not available in Puerto Rico :(
Has anyone researched clearing the debris from the demyelination? Or researhed the effects of that debris on OPCs ability to mature?
Hello doctor. Spinal cord lesions located centrally at C1 and T9 of size 10mm and 6mm respectively. How serious demyelination it is?
Sorry. I can't give you any direct medical advice here. I would suggest you review the films with your own provider.
@@DrBrandonBeaber ok doctor... thanks a lot for the reply :)
How long will this continue? we want remeissation treatment
Thank you so much for your videos. Can you please make an update video. I noticed in a comment that you have prescribed clemastine before. I would like to talk to my neurologist about replacing my sleep aid with it. How much should I use?
I can't give you personal advice, but these are doses which have been used previously. The dose used in the RECOVER trial was very high and would likely be sedating (12mg (4mg 3x/day) clemastine for 7 days followed by 8mg clemastine (4mg 2x/day)). For the ReBUILD trial, the dose is 5·36 mg orally twice daily. I think a practical approach is to take a lower dose only at night until there is real evidence.
@@DrBrandonBeaber Thank you for the reply. I know you can't give personal advice. I was just curious how you prescribed it. How many mg at bedtime do you think it's a good dose?
Do you have a video on Metformin? I read that it actually showed improvement on MRI. I wonder if it will be safe for those with normal blood sugars to use for MS in the future.
Good video
Thanks
So I’m just seeing this…and is clemastine still available? Looks like they took it off the market because it works?
It is available, and I have several patients who take it. There is still no definitive evidence in actual humans with MS.
Great Presentation Dr. Could Clemastine work with Guillen Barré Syndrome ? Tks
Possibly. the peripheral nervous system is myelinated by schwann cells rather than oligodendrocytes, so this research doesn't really apply, but the underlying muscarinic receptor target may be the same. In general, the peripheral nervous system has greater potential for remyelination.
@@DrBrandonBeaber Thank your very much..
I'm 21 years old I don't want to be disabled😭😭
❤️🙏🏼❤️
Is there any studies that connect Central Pontine Myelinosis with protocols being used/researched fir MS? My son got this in 2014 in connection with treatment from a hospital for very low sodium by raising it too fast. Is there a chance that this protocol could be helpful?
I am not aware of any specific research on clemastine for central pontine myelinolysis.
Considering my track record with pharmaceutical solutions, I think I will wait for a Google fiber upgrade.😜
Doctor Beaber, I have been digging into the histamine and MS connection a little deeper. Seems like the data is mixed and lacking at this point. Many of the drugs shown to promote Remyelination appear to be antagonist against Muscarinic Receptors. So an anti-histamine such as clemastine seems highly probable to be effective. Do you know if they studied diphenhydramine as a possible remyelinating agent? It is non-specific to the M receptors and has known access to the CNS. Also it is widely available over the counter and very cheap.
I am having trouble finding a list of medications they screened, but they used a 1,000-compound library screen, so I'm sure some antihistamine agents were screened. I'm not sure if diphenhydramine was included.
@@DrBrandonBeaber That was my thoughts as well, I will try to dig and find the entire list, even if it means scraping through the entire publication haha. Thanks for your response, I watch every video, and love your content. The MS world is so incredibly thankful for you!
@@charlespatton7402 Thanks Charles. That really means a lot to me. Let me know if you have any video suggestions. I would like to do more videos like this in the future, and I am going to interview Professor Dwight Bergles about his work with OPC soon
Ursolic acid will remylienate nerves.
Exciting research
Too bad about the news that came out a few weeks ago , it made MS worse 😢
That was funded by NIH and not peer-reviewed…….
Hey doc what's your opinion about nvg-291 and MD biotin 003 what do u think ll would live to see this kind of treatment In this lifetime
I have a specific video on biotin: ruclips.net/video/CS6CWPBHKGM/видео.html I don't think there is any clinical data on NVG-291. It is still in phase 1 trials, so it is years away, but certainly we would see it in our lifetime (easily within 5-10 years) if it is effective.
I need this asap
Is it only for optic neuritis?
Where do you practice Dr. Beaber? I am in the San Francisco Bay Area and am with Kaiser.
In Los Angeles.
Dr. Brandon Beaber thank you for replying. I thought maybe you are at UCSF.
What are the side effects of this medication? And how is it administered? I imagining it’s a little pill that makes your tired and prevents allergies like Benadryl. If so that sounds worth a try to take before bed every night. Unless their are further side effects or precautions on long term use?
This is a pill, and most people take it at night because it can be sedating. It is an old antihistamine just like Benadryl, so it has similar side effects. It has been reported that long term use of benadryl for insomnia may actually be linked to dementia, but I don't think Tavist is generally speaking likely to cause serious side effects.
Thank you for the response. Has this become a readily accepted treatment by most doctors or is still pretty unknown and controversial to prescribe?
@@ballzvlogz4601 Personally I’m taking it for my allergies.
"A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination"
it is stronger and two in one relieves inflammation and activates opc. even potentially for secondarily progressive.
Presumably, this type of treatment could be used in conjunction with disease modifying therapy.
@@DrBrandonBeaber that's very exciting!
When will myelin repair treatment be released?would you answer please
I honestly don't know.
@@DrBrandonBeaber Will it take 10 years?We don't want to be disabled
@@ramazan9857 I unfortunately could only speculate about this. hopefully not 10 years.
@@DrBrandonBeaber there is no hope😓
do you think that this can be applied to spinal cord injury pathologies ?
I suspect this would only be potentially helpful for demyelinating diseases.
Hey Doc is Tavist (clemastine) the same as clemastine fumurate?
Yes. They are the same as far as I know
Hello! Greetings from Iraq! I only have one question. Generally speaking, would Zeposia help a patient who is 57, female, with psoriasis and JC Virus? And please, if you don't know the answer to that, could you please connect me with someone who can?
Thanks in advance 😊
Sorry. I can't give direct medical advice here. PML would be a [very low probability] risk with ozanimod given our experience with Gilenya
@@DrBrandonBeaber ok, could you please provide me with your email address so I can send you her medical history, please?
Wonder if this could help with diabetic Amyotrophy ?
Possibly but there is no specific evidence to my knowledge.