This is the best video about mechanism I ever watched. I take my hat off, now I understand everything. Thank you for this verry informational videolesson!
I’ve been searching it from my notes and textbooks but still I was confused !! This video just cleared the concept like hair extracted from butter , you know !!
Can anyone please explain if it block Na*/K* atpase pump than how contration of K* is restored after each cardiac cycle back to normal, as K* was leaving the cell during phase 1 to 3.
In the presence of digoxin,Na ion conc is Higher inside.Shouldn’t Na go outside in exchange of Ca ion coming inside via NCX rather NCX become completely disable?
Na concentration gets higher compared to before Digoxin inhibits the Na/K-ATPase. Not higer than extracellular (in average dose of Digoxin). So the driving force for Natrium to get IN the cell gets lower. Thats why the NCX "throttles down" > less Calcium is eliminated via the NXC > more Calcium accumlate in cell > Ca ATPase of SR undertake Calcium-elimination > More Ca in SR in the case Natrium-concentration gets higher than extracellular NXC will transport Na and Ca reversed > so thats what you meant
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
Why do cell use sodium calcium exchanger pump because due to depolarization already there is much sodium inside the cell so why do cell increases sodium level?
In the absence of digoxin, the concentration of Na inside the cell is low compare to outside the cell, but when digoxin acts, it blocked Na/K pump which inhibit transfer of Na to the outside as well as K to the inside. Therefore the amount of Na inside the cell will consequently be higher which will prevents the cell from getting rid of Ca which leads to increase in Ca conc. in the cell and its subsequent storage in the endoplasmic reticulum. So now when action potential transfers one Ca ion into the cell through L tupe calcium channel the calcium ion will trigger massive release of more calcium which could produce much powerful contraction.
Why is your Na/Ca exchanger in opposite direction? Pretty sure the MOA is the increased Na in the cell from digoxin causes increased activity of the Na/Ca to pump the Na out of the cell, which brings more Ca into the cell. It doesn't stop the Na/Ca from working...
In another video that i have watched,increasing sodium activates sodium calcium channel that leads to increasing calcium intracelluler,which one is legit?
more clear than this? impossible! Thank you so much for making it easy to visualize!
This is the best video about mechanism I ever watched. I take my hat off, now I understand everything.
Thank you for this verry informational videolesson!
Simple and clear - thank you !
yeah 😊
Best explanation ever! Thank you so much for this, it is the first time I properly understand the mechanism. Thank you, thank you, thank you!!!
I’ve been searching it from my notes and textbooks but still I was confused !!
This video just cleared the concept like hair extracted from butter , you know !!
Wow ,,
Never could understand this better.
this is the best video out there for this!
Thank you for the video. I'm learning for my medicine-examen and never understood this mechanism completely til now. Hospital I'm coming :-)
Best video of digoxin out of all i have seen so far .. V well explained! Thanks.
great video. Thank you
Wow I lost hope understanding this until I saw your video Thanks 🥺🥺
short and easy to revise. Thank u ☺️
The best video on this. Thank you 😩
Thanks for making it easier for us👍💛
Bro! Hours of research in a few minutes! Gr8 & Thanks
have to say a very useful video. helped my understanding a lot thanks.
Precise and to the point.. thanks for this short review
OMG Thank you. This is so simple to understand.
Thank you. This will be the last vid on my playlist as I go in for my Viva..
Same😃
Thank you so much ! that was very useful and simple, god bless you
You made it so simple to understand!! Thank you
You r great teacher!..Thank you for high yield video
Thanks for that pretty video 🙏🏻
Thank you. You explained it clearly.
Thanks a lot, complex made easy to understand, doing a great job!!
Great Explanation, Thank You!
Perfectly explained. Nice
U just made my day😍
amazing video, thank you
Utterly clear...thank you!!
Very clear explanation... thanks soo much..
Very helpful. Thank you !
Amazingly explained 👍
Thanks a lot
Simplified and to the point
Thank you very much
This was much needed
Thanks for the explanation.
Well explained and concise. Thank you
Alhamdulillah
thanks team work
Absolutely accurate, thx for this
Thank you for the video. Very helpful!
God bless you🙏🏻
Very nice explain
Thank you
Excellent video!!!!
simple & useful thank you
Beautiful 🤩
Amazing
Very helpful, thank you very much
Excellent explanation! Thank you so so so much
thank you sir
Thanks dear
Thanks a ton 👌🏻
Ok Boomer 😂😂
🗿good video
V well explained
Best best supper best video.
Thanks
Thanku
Very nice explained
So the muscle relaxes when Ca is exchanged for Na , how is it able to relax when the exchanger is blocked?
Simple to understand. Thanks.. can u also explain digoxin toxicity
U helped me so much. Thanks:)
Wonderful!
Thank u
Well explained 👍🏻
However, what would happen to potassium? and what are the side effects if a person is already taking a diuretic that is non-spearing potassium?
Great❤
Can anyone please explain if it block Na*/K* atpase pump than how contration of K* is restored after each cardiac cycle back to normal, as K* was leaving the cell during phase 1 to 3.
To the point & very useful! Thank you & please work on your visuals. Do it like osmosis. You've got great content don't let trivial things ruin that.
Venkatesh Sawant the visuals are good enough bruh
Thanks man
Thank you.
Helpful!💫
Great
In the presence of digoxin,Na ion conc is Higher inside.Shouldn’t Na go outside in exchange of Ca ion coming inside via NCX rather NCX become completely disable?
Na concentration gets higher compared to before Digoxin inhibits the Na/K-ATPase. Not higer than extracellular (in average dose of Digoxin). So the driving force for Natrium to get IN the cell gets lower. Thats why the NCX "throttles down" > less Calcium is eliminated via the NXC > more Calcium accumlate in cell > Ca ATPase of SR undertake Calcium-elimination > More Ca in SR
in the case Natrium-concentration gets higher than extracellular NXC will transport Na and Ca reversed > so thats what you meant
@@515silas thanks,,, its enough to understand 💓
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
@@mrrock3162 is it possible that both Na & Ca concentration is higher inside,,,but Ca is going outside via NCX and Na is influxed??
thank you
Thanks a lot
Amazing! Thx
understande it totally
thnks
Why can't people explain it like this? Man, life would be so much easier. Thanks.
Why do cell use sodium calcium exchanger pump because due to depolarization already there is much sodium inside the cell so why do cell increases sodium level?
Glad to see pharm D
I dobt understand. To begin with isnt there more Na outside the cell and mre K inside the cell??
In the absence of digoxin, the concentration of Na inside the cell is low compare to outside the cell, but when digoxin acts, it blocked Na/K pump which inhibit transfer of Na to the outside as well as K to the inside. Therefore the amount of Na inside the cell will consequently be higher which will prevents the cell from getting rid of Ca which leads to increase in Ca conc. in the cell and its subsequent storage in the endoplasmic reticulum. So now when action potential transfers one Ca ion into the cell through L tupe calcium channel the calcium ion will trigger massive release of more calcium which could produce much powerful contraction.
THANKS Buddy🤓
Good
Thank youuuuuuu so much
What becomes the resting membrane potential of this cell then if it has such a high Na+ content?
Why is your Na/Ca exchanger in opposite direction? Pretty sure the MOA is the increased Na in the cell from digoxin causes increased activity of the Na/Ca to pump the Na out of the cell, which brings more Ca into the cell. It doesn't stop the Na/Ca from working...
In another video that i have watched,increasing sodium activates sodium calcium channel that leads to increasing calcium intracelluler,which one is legit?
The mechanism you are talking about is of cardiac action potential.
This one is different. It is effect of Digitalis on cardiac myocyte.
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Anyone can get it.
Please lecture at my uni haha
👾💛
👍
I'm pretty sure that the NCLX allows 2 Na+ ions in (not 3) in exchange for 1 Ca ion
Shit!!
Thank you
Thanks
Thank u
Thank you
Thank you