IVF with donor eggs with PGS/PGD. Is it worth it?

What is PGD/PGS genetic testing? Is it safe? Does it pose any risk to the embryo and the future development of the baby? How exactly is it performed? Which patients should have it and which patients do not need it? These and other questions were addressed by dr Rueda, the Director of the Genetics Unit at Hospital UR Vistahermosa in Spain during EggDonationFriends 8th webinar organized on 13th March 2018. The webinar attracted fertility patients who are considering IVF with own eggs and want to make sure they select treatment which gives them the highest success rate for a healthy baby.
What is it and how does it work?
This type of genetic testing is performed on an embryo before it is transferred to the recipient’s womb. The goal of such testing is to single out the healthiest of them. Thanks to such testing embryologists can choose embryo(s) that do not carry any genetic flaws. A healthy embryo will be more likely to implant correctly in the uterus and make a healthy baby. How does it work? The embryologist needs to acquire information about the gene makeup of the embryo cells. How do they do it? An embryo biopsy is performed on a frozen embryo - the embryologist removes about 3-8 cells from the blastocyst and has them tested in the lab.
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Success rates present just one way of looking at PGS success. Another way is by evaluating birth defects and genetic disorders. For example, PGS results in lower cases of Down’s Syndrome than without it. For women and couples with a higher risk of passing on genetic abnormalities, this information can be very useful and reassuring. Because embryos are so fragile, the process used for PGS matters a great deal. Damaged embryos may not implant, or could ultimately result in irreparable harm leading to miscarriage and IVF failure. Several situations pose a certain risk to PGS: Embryo damage. If the biopsy is performed too early, or incorrectly, the embryo could suffer trauma that wouldn’t necessarily be easily identified. Errors in screening. Embryologists must know exactly what they are doing when it comes to PGS. Any errors in biopsy or handling could result in a failed transfer or implantation. Mosaic embryos. An embryo is said to be mosaic if there are 2 (or more) different chromosomal patterns in the cells. Women who have had a lot of experiences with miscarriages benefit from PGS/PGD, as well, for the reasons mentioned above. Chromosomal abnormalities can cause miscarriage, and when there is no other obvious cause for repeat miscarriages. PGS can provide some much-needed answers and improve IVF success rates. Like in my case with my husband in Bio tex.