How This Poisonous Plant Became Medicine (Belladonna) | Patrick Kelly
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- Опубликовано: 2 июн 2021
- Of all the poisons of the world, belladonna is one of the most beautifully badass. What started as a feared plant ended up becoming medicine, and then THAT medicine became a lifesaving antidote for certain forms of poisoning. In this video, we’ll break down the story of belladonna and atropine.
Check out BioZone’s video here: • belladonna: a tale of ...
☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️
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"Quickly! Inject Atropine!" Was shouted in an old military training film teaching about chemical weapon attacks. Organophosphate nerve agents are no joke, but its quite ironic that their antidote is an equally horrific, albeit natural poison. Fight fire with fire i guess?
Fun fact: The half-brother of the North Korean leader, carries vials of atropine sulfate in his hand carry, until he was assasinated in Malaysia using a nerve agent called VX. This was so ironic.
What is equally scary the largest stockpiles of Organophosphates are not in military arsenals but on farms. Many farmers accidentally poison themselves.
From poison arrows to balanced anesthesia - tubocurarine is another drug with an interesting history that is worthy of a video.
I grew up on a farm. I was really allergic to grain dust - the dust produced when harvesting and handling things like oats, wheat, sorghum, etc. Not a good thing for a farm kid. At the time, there was an OTC capsule called Contac. One of the ingredients was "belladonna extract". Nevertheless, the Contac of that era minimized the grain dust effect for me. For years, taking Contac was just part of the harvesting season. Then someone changed the formula, eliminating "belladonna extract". I found an alternative and eventually "grew out" of my grain dust allergies.
Alternative medicine gets a pretty bad rap. I’ve actually found natural stuff to be way more helpful than the stuff I got with a prescription. Not sure if this sounds like something I wanna take though now lol
This is an important part of treatment of pesticide poisoning, particularly organophosphate insecticides like Malathion, as well as nerve agents like VX and sarin (they have the same chemical structure with organophosphates - phosphines).
This is what I came to say. Atropine was the go to drug for a long time but in recent years, Scopolamine has become that drug and both are from the same family
Well most nerve agents are organophosphates
Dude this has been my favorite plant for about 7 years now, and I’ve been doing as much research as possible. I just wanted to say thank you so much, listening to people talk about this plant brings me so much joy.
Hey I'm just finding out about this now. Can you tell me how much a first-time user would take? What drug would you compare it to?
did you watch the vid at all? this is pure poison and wont give u a good time. it'll only mess you up.@@nicholashamilton4197
@@nicholashamilton4197comparable to diphenhydramine, scopolamine, a deliriant.Not at all comparable to lsd or ketamine. As someone who tried all aforememtioned substances, stay the fuck away from deliriants especially solanaceae containing tropane alkaloids.
@@nicholashamilton4197excuse me…?
What do you use it for
In the 60s I used the cold medicine that had bella donna as an ingredient. Loved how it made me feel and often too a double dosage.
In the 60s there was a product that was reputed to aid in asthma and UR congestion...It was in the form of a Belladonna cigarette sold at pharmacies...you can't make this up. I don't remember the brand name, but several of us tried it out, expecting some psychoactive properties...we were disappointed. We did get dilated pupils, dry mouth and one of us (who actually had asthma) claimed some relief.
Makes you wonder why it's banned
Dude your actually really good at this! Keep up the good work
Thanks a ton!
@@PatKellyTeaches Except for what you said about Homeopathy totally not true. It works great on high sudden onset fever person hot red and throbbing headaches etc.Thats why they still sell it in Homeopathic pellets. If it didnt work why would they sell so much of it? Other than that loved this video
Beautiful flower. I sell the cousin, the bittersweet nightshade.
I appreciate your thoughtful videos on antibiotics, belladonna, and digitalis. As a 3rd year medical student, I had to memorize these terms without understanding their origins or significance. after watching your videos, I learned the historical context behind these concepts. Thank you for creating such phenomenal content. I look forward to watching more of your antibiotic series!
What other modern day pharmaceuticals do you want to hear about? I've been thinking about making a video about foxglove (which eventually became digitalis).
I'd love to hear about Foxglove for sure. Do you think you'd be interested in trying to break down all the history of Willow Bark, Salicilin and how it eventually lead to the synthesis of Salicylic Acid?
@@Clockworkbio Salicylates are pretty ancient drugs. That could be interesting.
The origins of Protamine.
I like the salicylates / willow bark story. I wrote something similar for SciShow a few years ago and I think I could do a reprise of that script with some new twist on it
Lachesis, anacardium orientale, stramonim, henbane
Having written a research paper on hyoscyamine, i love this video. Fun fact: atropine is actually a racemic mixture of both hyoscyamine enantiomers (meaning, molecules with identical formulas and structures, but with the slightest difference in orientation in space, leading to a biological difference. 'Racemic' means its a equal mixture of both enantiomers.)
In plant form, it exists as only the L/levo enantiomer, but when its extracted/synthesized, half of the molecules switch to the D/dextro enantiomer to increase stability. Only the L- enantiomer is biologically active in the way described in the video, and is way more active in general, so in doses of atropine, only the L enantiomer effects are really present since it overrides the effects of the D enantiomer. The exception is when very low doses are given systemically, as a low dose causes a transient decrease in heart rate from the D enantiomer before the L enantiomer kicks in and increases the heart rate.
Since it can have an effect locally, (as mentioned with it being used to dilate pupils to make the eyes look bigger) the ocular effects of it is sometimes known colloquially as 'cornpickers eye' as corn pickers' equipment would grind up datura stratimonum weeds in corn fields, producing a dust that got into their eyes and dilated their pupils!
This is an amazing video! From the narration to the graphics, it's a visual delight!
Lovely video, I am doing research on Belladonna for my Ethnobotany class and this is a great resource to start with! Thank you do much man!
I’m allergic to this one! Lol learned the hard way when I got scopolamine patches to try to control my CVS 😭 love your content! I’m an rx tech who wants to go back to school to be a pharmacist and this content really scratches my interest!
Just found this channel. And I just want you to know that you're doing a great job and you should definitely have more subscribers
Agree 100%!
7:48 captions: [Patrick gets flustered and makes it look handsome]-- I love this little hidden gem LOL! Great content, too! PS, nerding out makes you look very handsome, Patrick.
This channel is going to blow up. Excellent stuff.
Underrated. You deserve more views and likes!
I dig the creepy music at the beginning. Random Fact: I learned about atropine from watching Nic Cage in Con Air. Thanks for another great video.
Clotho who spindle the thread of life, Lachesis who determines the mechanism of death and Atropa who cuts the thread of life the three sisters who are daughters of Zeus and Hera. The three Fates are also sisters of the nine Muses because the nine Muses are also daughters of Zeus and Hera. Mount Olympus and the Olympians.
The three Fates.
I never knew about this plant, thanks for giving us knowledge.
:)
So nice of you, glad you liked it :)
The h**k 1.3 subs with this quality content? I'd say you should have more subs than this.
Not a lot of people talks about the botanical. So thank you so much!
Thanks for the kind words.
@@PatKellyTeaches I just looked up you main channel and found your anatomy course. It took me quite a while on memorizing the names and some of their functions but when I watched your musculoskeletal of the head and how you explained the anatomy and anatomy names clearly, I smacked my forehead. I was luck to find it early tho because even tho I know most of the major muscles in the body and some of their functions, the playlist will help me to understand them even better😆.
Really grateful for all the resources you provide 🙏🥰🥰
Great video! Just one little thing, the deadly nightshade is not native to northern Africa, it has been introduced to Northern Africa in the past;
I remember first hearing about Belladonna in Agatha Christie’s ‘A Caribbean Mystery’. In the story a young woman’s night cream is spiked with Belladonna and she loses time and wanders in a delirious state….The amount of Belladonna wasn’t to kill her it was to put her in this mental state and to convince her that she was descending into madness… We use Atropine injection in Cardiac Arrest Kits, Atropine Eye Drops
When I was in the Army, we had to learn how to give ourselves injections if we were exposed to biochemical agents. And as you, know one of the injections was atropine. That was in the 80s so I have no idea if it is still a thing but I remembered it and because of my curious nature I looked it up on the internet many years later. 😂
How long belladonna takes to fully grown mine just start to germinate
Love your channel, keep them coming. One small comment. Something is reflecting into your pupils making themlook slit like cat eyes or snake eyes.
subtitles at 7:45 [Patrick gets flustered and makes it look handsome] I agree 🤪..
I looked this up after watching practical magic.
In our NBC defense kit we had an Atropine surette that was to be used as a self injected antidote for nerve gas exposure.
Oh hell yes. Super jazzed to see Biozone doing collabs now!
Animation showcase here is off the charts. Really loved the timing and momentum of that stroke turning into an EKG readout.
Me too. I pitched April on this idea and we had a video done in less than a month I think!
And thanks for the kindness -- I feel like transitions between images are my next big animation challenge
@@PatKellyTeaches Animations look great to me, but I know what you mean. I feel the same with my work in photography. There's always something to improve.
I have to watch with subtitles, turn on the sub titles and watch from 7:44 and have a giggle.
Wow! 😍😍😍
Got rid of my fever 🤕
I likely accidentally ate one nightshade berry few years ago, while eating forest-gathered blueberries by handfuls. It was like a 2 days long, severe coffee overdose with overwhelming thirst.
سعيدة وممتنة لتوَفُر ترجمة عربية في هذا المقطع😩
So like, what’s the recommended dose? 😂
It sounds interesting. I'm 46 years old and just learning about this. Can somebody that has taken this tell me what it feels like? I think a place over by my house has it and I want to hear from somebody other than what's in the video about what it feels like
so almost everyone that died from this, was from meeting dead people and being so scared they jumped or took their own organs out. so what makes this deadly is not the CSN response witch takes quite a bit, but the effect on the mind.
@John Dalton wow, after ten months, this is what you have to say?
Belladona is one of the few things that helps my cluster headaches if I catch them soon enough. I wouldn’t call homeopathy as pseudoscience.
Right some call it that, then when Western medicine doesn't work, then they are all open to homeopathy. Natural healing has worked for my family in heart conditions, autoimmune conditions, migraines, concussions, arthritis, liver damage, and GI issues. Compared to the tons of prescriptions, the doctors were prescribing.
It's a shame Doctors are not taught how to treat a patient as a whole, not just put a bandaid on the symptoms.
Also the Medical Professionals should be taught how to start with natural options and then work your way up to pharmaceuticals if needed.
Doctors give pharmaceuticals out and the pharmaceuticals cause more problems and only treat the symptoms of the underlying problem on the other hand, they cause side effects, which damages other things in the body and cause more damage to other areas. Therefore, they can write you a prescription for those two and the cycle goes on and people go around with a suitcase of medicine that don’t know no better it’s all a money game will be on doctors and lawyers. The Bible says.
Clinical trials for drug approval use a placebo (or an older, proven effective treatment) group because for many illnesses a placebo will result in improvement. People tend to gloss over the fact that placebos work (even when the recipient is told that they're taking a placebo), and should be seriously considered as treatment (of course if there's a more effective treatment, that should usually be preferred).
Homeopathy is psuedoscience. If it's homeopathy the drug is usually indistinguishable from a placebo (a 30X preparation contains 0.00000000000000000000000000001% of the original ingredient, and there's no evidence for believing in the water/solvent acquiring special properties from that). It will often work as well as a placebo, and if that's effective, I have no complaints (provided the homeopath advises their patients to seek modern medical care where appropriate and charges fair rates for their services).
If it contains substantial amounts of an active ingredient (like a 1X preparation, which is 10%-higher than many pharmaceutical drugs) it's probably just calling itself homeopathic. Many pharmacy aisles here in the US contain such "homeopathic" products.
Recently I purchased some 1% topical diclofenac ("Voltaren"-it's an NSAID, with similar effects to oral ibuprofen, naproxen, or diclofenac, but with less systemic side effects and stronger local effects), and it was placed near some topical 1X (10%) arnica montana ("Arnicare", the plant is also called wolfsbane). Wolfsbane works, it contains compounds with similar effects to diclofenac and topically is comparable (similar enough to have a hard time comparing them with the studies available, due to differences in dose and conditions of patients). It also contains a lot of compounds that probably make it a bad idea to take orally, doesn't have as much safety testing as a regulated drug like diclofenac, doesn't have the same quality control regulations that regulated drugs have, and costs less than topical diclofenac.
I tell people that topical diclofenac is a more regulated drug, and that topical arnica montana is a cheaper medication. Both are drugs (don't take either without medical consultation if you're on blood thinners), and both have reasons for someone to prefer one over the other. I prefer to buy the pharmaceutical because I dislike Arnicare's use of the "homeopathic" label on a drug and trust the FDA to ensure that my diclofenac contains roughly 1% diclofenac with good safety testing on the final product.
@@iperalta7777
Modern medicine is excellent (doubled life expectancy), but has issues. Definitely consider alternatives, but be extremely cautious of charlatans when you do so.
Many pharmaceuticals started as natural chemicals and were purified or improved to create pharmaceuticals. Natural drugs can and should be compared to modern pharmaceuticals, but they should be examined with the same standards for safety and efficacy (just because it's natural doesn't mean it won't kill, have severe side effects, or give you cancer).
Doctors are taught to treat their patients, and generally want their patients to get better. Unfortunately we are incapable of doing that in all cases, so we do what we can. Doctors usually "put a bandaid on symptoms" when they don't have a good cure, which is generally the best way to handle that situation.
Insurance companies love it when medical care is cheaper, I assure you they'd be lobbying hard if cheap alternative medicine could save them from paying for expensive treatments and drugs.
It's great to have a medical care provider who shows compassion and recommends less commonly provided treatments when modern medicine is unsuccessful. There are definitely things to learn from alternative medicine, but it has massive issues too.
Thankyou!!!
Is bella donna good for psychosis or schizoaffective disorder?
friend of mine went to the psych ward after smoking Datura seeds, family of the Bella Donna plant I believe
Edit: I believe he was doing it for the scopolamine, as replacement for cocaine
From the time I was 16, I took Donnatal for Irritable Bowel Syndrome for 10 years. Then switched over to Bentyl.
Weird how all of the nightshades are poisonous save for potatoes which are a yummy food lol.
Tomatoes, ground cherries, peppers and gooseberries are nightshades
Wow help with cancer
Would touching cause harm?
It is in the same family as tomatoes, potatoes, peppers, and eggplants.
If this is so poisonous why did my doctor prescribed this I am scared
Have you heard of the tattoo ink that changes color based on blood sugar? They sound amazing! How would it even work?
I have not heard of this, no! I might have to investigate
Has anyone had success using this to treat seizures? I'm trying to go all natural.
The only thing that might help thats “natural” might be lavender chamomile or passion flower that work similar to benzodiazepines and have similar side effects (addiction, depression)
Atropine works only for a very specific type of seizures
Dose makes the poison...
Is hydrophobia rabies?
yeah
Who came here from DECA
I don't know too much about homeopathic medicine, but I think you're really misunderstanding something about it.
The concept, in general, is about using a small dose of something that would otherwise cause the symptoms you're trying to get rid of.
This stimulates your body to fight your body's reaction to the toxin(s), which helps relieve symptoms of whatever it is that particular medicine was for.
It is real medicine. It's just such a small dose, and meant to stimulate your system, that people don't understand it.
Do people still use belladonna to dilate their eyes to this day?
I'm not sure if it's still a thing, but I advise against it!
@@PatKellyTeaches Maybe not in that way, but when I was a kid (in the '60s) with an eye problem (born with a squint), before every visit to the opthalmologist, I had to have Atropine ointment put in my eyes to dilate the pupils for easier examination - it wasn't very nice, as it was in a waxy base which had to melt..!
Opthologists do.
Homeopathy is pseudoscience? Should make another detailed video on that.
Yes but he has to have someone show him how to use it. If you dont know how to use it , it will not work for you. There is a science and a definite method. People that take it randomly usually dont have any results.
You are arrogant about what you think you know. There is much more to the story. Pay attention
I'm happy to listen. What specifically do you think should've been included in the video?
Hey what can you tell me about this stuff? Have you taken it?
@@PatKellyTeaches The fact that in Homeopathy Belladona works wonders in Homeopathic form and it has been proven again and again. Its a polycrest in Homeopathy meaning its one of the medicines that is most used and proven. Its good for many things. Please dont make the mistake of just repeating what you hear. Homeopathy is one of the fastest growing natural medicines in the world. I belong to a group that has grown to so much in the last 3 years because people are looking for things that work without side effects. Its far from a placebo
Your content is good. But have you done research and tested homeopathy yourself to make an informed decision about its effectiveness?
No he has not or he woudnt say that