RUclips should have a video’s like this pin’d as “Educationally Significant” so people know they’re about to learn something groundbreaking and significantly important to the advancement of mankind. Amazing that no one else has commented on this video.
As an Oncology and Hospice Nurse working with people who mostly have Stage IV cancer, and with many who have breast cancer, I have already met three patients on Alpelisib in the past 10 days. The information from this video is crucially important -- keto diet ideal if on this drug -- and explains it so well, I consider it one of the gems in RUclips. Just the title stinks. Thank you Dr. Cantley for your ceaseless curiosity and passion to solve puzzles that will truly transform our fight against cancer. And thank you to Jumpstart MD for providing content like this. I am providing this video link to every patient I speak with who is considering or prescribed Alpelisib (Piqray) -- all over the country. Unfortunately they tell me they were told nothing about need to consider reducing carbohydrate intake, much less about the keto diet option. I do not recommend a heavy animal product or saturated fat version - mostly plant based with some animal/fish. Lots of non-starchy veggies, nut butters, olive oil, oily cold-water fish and meat if they wish. Lots to learn but when a drug like this comes along and the cancer has become resistant to so much, makes sense to consider.
I was vegan for 5 years and I have a carcinoid tumor in my trachea and I switched to vegan to be able to make this tumor disappear but not was not working. I'm trying carnivor/keto know
Same here! Insulin, while necessary for life, is deadly when it's out of control. We (humans) were never meant to eat sugar or processed carbs. The evidence is overwhelming-- great lecture.
Around 33:30 you can see the issue. Basically, the entire body becomes resistant to insulin except cancer tumors, which are exquisitely sensitive to it. It's almost as if the biology is saying, if you keep getting more insulin resistant, I'll make new cells that aren't resistant. But cancers are really rogue cells that opportunistically take advantage of a good food supply and forced-feeding environment (chronically high glucose and insulin).
This struck so many cords with me... the women in my family have a history of ovarian cysts... is this because our body is being told to "grow" something... yes.. and eventually that leads to cancer.
Excellent talk. Oh hello Dr Robert Lustig! I knew his voice the minute he started asking his question. Goodness knows I've watched enough of his videos. :-)
I just stumbled on this... this is AMAZING. Now I feel like I have a much better handle on why sugar and high insulin does cause cancer. I only wish this could be broadcast on NBC or something. Thank you Dr. Atkins to alerting me to the dangers of carbs back in 2000 and though I just got hip to keto I have been low carb for the last 20 years due to him. Probably saved my life.
Very eye opening thought in the end about how we are like the bears. Become insulin resistant, fatten up, survive the winter. In today's constant plenty, how do we manage these natural primal instincts? I have much more empathy for the obese now.
@@abbynady Grossly elevated insulin levels is completely different from normal insulin and dangerous. People are taking the diabetic medication because their insulin is too high.
I took a fall one day and was taken to hospital. I'm keto, when I arrived my blood was checked, the glucose was low (of course) and the doctor ordered I drink a sugar drink. I was utterly disgusted. It really wasn't low enough to do me any harm.
IMHO it shows that no matter how we pat ourselves on the back, we still have a very primitive health care system and our bodies are a million times more complex than we even know. Until the medical system stops this "we are so great" attitude... we will never be open to good science.
@@holyhellal They did a biopsy to make sure she had the PI3K gene. They prescribed the drug last July, but she had to stop after only four days, as the side effects were too much for her. By then it was too late for chemo and she died in late October, thirty months after diagnosis.
I am thinking then from watching this talk that if they had done studies inducing type 1 diabetes and the effect on tumors. How this potentially help to suppress a cancer.
This video's title is misleading. It should be re-named "PI3K, Insulin Resistance, and Cancer". The word "Obesity" should be removed, because HELLO, Dr. Cantley specifically says that obese women (who carry their fat peripherally and NOT in the liver) are at a much lower risk of tumor growth than skinny women with insulin resistance. Any person going on a PI3K inhibitor to fight cancer--or just anyone who is fighting cancer--should watch this video as it provides important information about doing your best on what is an expensive drug with heavy-duty side effects. Just one of the many important points presented here: start a ketogenic diet at least once week before you start a PI3K inhibitor (like Piqray). There is a slide (about 36:53 mark) that shows just how much more effective the drug is on a ketogenic diet than by itself.
I started the keto diet proper today, and am now using c8 mct in my bulletproof coffee. It's inspiring that his brain is working overtime and yet he consumes no added sugars. We are pushed constantly to consume sucrose and products containing added sugars, but this man goes totally against the wave of "We need sugar" "Sugar is not toxic", and yet he receives an Honoria from Novo Nordisk. There is a conspiracy theory that Novo Nordisk wants people to become insulin resistant and works with sugar producers, and Big Food &Big Pharma, Dr Assem Malhotra from the UK claims this to be his opinion! I like Dr Cantley he appears to be sincere and does actual research, unlike many pseudoscientists who display no humility, and present a lack of conviction. I will now avoid added sugars until at least 2020, and see how my liver and overall metabolic health upgrades itself. Thanks Dr Cantley!
The implications of this information should be on billboards throughout the USA especially! It should be an "all hands on deck/code red" approach to eliminating excess insulin production, iow, carb intake. So the food pyramid is upside down. And I would wager that the timeline of the rises in both obesity and breast cancer coincide with the release of the new Government Guidelines in the US. Excess carbs causes cancer. Full stop. And existing body fat, laid down by insulin in response to excess carbs will NOT burn in the presence of carbohydrate. And that syndrome x fat becomes the new endocrine system and runs the show from then on.
Bottom line: avoid chronically high insulin levels to minimize risk of cancer. How? Low carb diet ideally free of fructose from a young age. And if you do get cancer this drug will work much better. Any questions?
55:00 the Mitochondria question has not been perceived at all.. out of his realm of expertise at it seems. till that moment it had been so interesting. I was so curious to hear how he would react to this question... No. No reaction... Healthy Mitochondria contol the Apoptose of cells... Uneffective mitochondria are unable to lead cancer cells to suicide.. of course I am not an expert but this question has not been understood and answered.. he said I am a chemist, a chemist and a chemist... Not a biologist..
Hi. What has been answered is that cancer is a mitochondrial condition. Lewis and Thompson are amazing contributors to the cancer biology field because they are helping to illuminate that cancer metabolism plays a key role in cancer progression and therapeutics that interfere with metabolic pathways are proving to be productive in cancer treatment. The disease has decent evidence to make the claim that cancer starts in the mitochondria. The organelle sustains chronic damage and eventually the accumulative damage done to its electron transport chain structures lead to an inability to perform its normal function ( energy creation and apoptosis). With a growing number of individual mitochondria sustaining this damage a crucial mass may be met which then leads to cancer. The aggressiveness of the cancer is tied to the level of normal respiration that still remains. Scientists have shown that under microscopy that the mitochondrial proteins and lipids are damaged to varying degrees. No cancer cell has completely normal mitochondria. All of them however have been shown to have structural damage which would strongly suggest that the function of those structures probably has also been impeded. Structure equals function. Lewis Cantley and others recognize the role cancer metabolism plays and indeed have targeted a major oncogenic pathway with pi3k inhibition. Pi3k is a major player in Cell Metabolism as well as with growth and proliferation. Pi3k inhibitors work better in a low insulin environment because insulin is one of its major inputs in terms of nutrient sensing and growth signaling. Take insulin away and you have a weekend signaling cascade.
I have to ask.... who the fck are the people in the audience of these talks? I ask this because the Government recommendations are not changing, my GP's are not up to speed on these ideas, neither are the dietitians or exercise physiologists. How can I know more about this stuff from watching RUclips than the professionals, who are still recommending dietary information that is still messing up peoples bodies?
![Seungmin "그렇게, 천천히, 우리(As we are)" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/kAzmhLHePqU/mqdefault.jpg)
RUclips should have a video’s like this pin’d as “Educationally Significant” so people know they’re about to learn something groundbreaking and significantly important to the advancement of mankind.
Amazing that no one else has commented on this video.
I see Dr Cantley as an unsung hero. This is a gift.
As an Oncology and Hospice Nurse working with people who mostly have Stage IV cancer, and with many who have breast cancer, I have already met three patients on Alpelisib in the past 10 days. The information from this video is crucially important -- keto diet ideal if on this drug -- and explains it so well, I consider it one of the gems in RUclips. Just the title stinks. Thank you Dr. Cantley for your ceaseless curiosity and passion to solve puzzles that will truly transform our fight against cancer. And thank you to Jumpstart MD for providing content like this. I am providing this video link to every patient I speak with who is considering or prescribed Alpelisib (Piqray) -- all over the country. Unfortunately they tell me they were told nothing about need to consider reducing carbohydrate intake, much less about the keto diet option. I do not recommend a heavy animal product or saturated fat version - mostly plant based with some animal/fish. Lots of non-starchy veggies, nut butters, olive oil, oily cold-water fish and meat if they wish. Lots to learn but when a drug like this comes along and the cancer has become resistant to so much, makes sense to consider.
Thanks Kristin! Why not "...a heavy animal product or saturated fat version"?
I was vegan for 5 years and I have a carcinoid tumor in my trachea and I switched to vegan to be able to make this tumor disappear but not was not working. I'm trying carnivor/keto know
This is the reason I measure my blood glucose (not diabetic) and eat keto to minimise insulin production.
me Too - keep insuin low keep the body insulin sensitive
Same here! Insulin, while necessary for life, is deadly when it's out of control. We (humans) were never meant to eat sugar or processed carbs. The evidence is overwhelming-- great lecture.
@@marcyeverest589 I'd add industrial seed oils to insulin-inducing food. AVOID!
Around 33:30 you can see the issue. Basically, the entire body becomes resistant to insulin except cancer tumors, which are exquisitely sensitive to it. It's almost as if the biology is saying, if you keep getting more insulin resistant, I'll make new cells that aren't resistant. But cancers are really rogue cells that opportunistically take advantage of a good food supply and forced-feeding environment (chronically high glucose and insulin).
This struck so many cords with me... the women in my family have a history of ovarian cysts... is this because our body is being told to "grow" something... yes.. and eventually that leads to cancer.
Excellent talk. Oh hello Dr Robert Lustig! I knew his voice the minute he started asking his question. Goodness knows I've watched enough of his videos. :-)
I just stumbled on this... this is AMAZING. Now I feel like I have a much better handle on why sugar and high insulin does cause cancer. I only wish this could be broadcast on NBC or something. Thank you Dr. Atkins to alerting me to the dangers of carbs back in 2000 and though I just got hip to keto I have been low carb for the last 20 years due to him. Probably saved my life.
Very eye opening thought in the end about how we are like the bears. Become insulin resistant, fatten up, survive the winter. In today's constant plenty, how do we manage these natural primal instincts? I have much more empathy for the obese now.
50:40 "A very sugary drink while you're getting chemotherapy. It's just crazy."
All hospitals did that.
Try 50:20
@@abbynady Grossly elevated insulin levels is completely different from normal insulin and dangerous. People are taking the diabetic medication because their insulin is too high.
I took a fall one day and was taken to hospital. I'm keto, when I arrived my blood was checked, the glucose was low (of course) and the doctor ordered I drink a sugar drink. I was utterly disgusted. It really wasn't low enough to do me any harm.
IMHO it shows that no matter how we pat ourselves on the back, we still have a very primitive health care system and our bodies are a million times more complex than we even know. Until the medical system stops this "we are so great" attitude... we will never be open to good science.
Thank you Lewis, great talk. More please!
My wife is on Letrozole and we are also doing HBOT on our own. I'm sending this video to her oncologist. STAT. :)
No way he's gonna watch it.
How did that go?
too arrogant to take advice
@@holyhellal They did a biopsy to make sure she had the PI3K gene. They prescribed the drug last July, but she had to stop after only four days, as the side effects were too much for her. By then it was too late for chemo and she died in late October, thirty months after diagnosis.
@@jselectronics8215 i am sorry for your loss ,,take care with all this covid problem
Finally, the Keto way of life is getting some notification.
I am thinking then from watching this talk that if they had done studies inducing type 1 diabetes and the effect on tumors. How this potentially help to suppress a cancer.
This video's title is misleading. It should be re-named "PI3K, Insulin Resistance, and Cancer". The word "Obesity" should be removed, because HELLO, Dr. Cantley specifically says that obese women (who carry their fat peripherally and NOT in the liver) are at a much lower risk of tumor growth than skinny women with insulin resistance. Any person going on a PI3K inhibitor to fight cancer--or just anyone who is fighting cancer--should watch this video as it provides important information about doing your best on what is an expensive drug with heavy-duty side effects. Just one of the many important points presented here: start a ketogenic diet at least once week before you start a PI3K inhibitor (like Piqray). There is a slide (about 36:53 mark) that shows just how much more effective the drug is on a ketogenic diet than by itself.
I started the keto diet proper today, and am now using c8 mct in my bulletproof coffee. It's inspiring that his brain is working overtime and yet he consumes no added sugars. We are pushed constantly to consume sucrose and products containing added sugars, but this man goes totally against the wave of "We need sugar" "Sugar is not toxic", and yet he receives an Honoria from Novo Nordisk. There is a conspiracy theory that Novo Nordisk wants people to become insulin resistant and works with sugar producers, and Big Food &Big Pharma, Dr Assem Malhotra from the UK claims this to be his opinion!
I like Dr Cantley he appears to be sincere and does actual research, unlike many pseudoscientists who display no humility, and present a lack of conviction. I will now avoid added sugars until at least 2020, and see how my liver and overall metabolic health upgrades itself.
Thanks Dr Cantley!
Well the Ketogenic diet worked for DR Boz's mother. She just reduced her carb intake to near Zero.
She passed away
COVID killed her, sadly;
ruclips.net/video/ACwhE5TMEqM/видео.html
Generally blood cancers don't respond excessively well to reducing sugar but they do respond to reducing inflammation..
The implications of this information should be on billboards throughout the USA especially! It should be an "all hands on deck/code red" approach to eliminating excess insulin production, iow, carb intake. So the food pyramid is upside down. And I would wager that the timeline of the rises in both obesity and breast cancer coincide with the release of the new Government Guidelines in the US.
Excess carbs causes cancer. Full stop. And existing body fat, laid down by insulin in response to excess carbs will NOT burn in the presence of carbohydrate. And that syndrome x fat becomes the new endocrine system and runs the show from then on.
Bottom line: avoid chronically high insulin levels to minimize risk of cancer. How? Low carb diet ideally free of fructose from a young age. And if you do get cancer this drug will work much better. Any questions?
Peter Cyr
Where’s the problem with fructose? It’s common in all no starchy vegetables, broccoli etc.
Low carb diets deliver significantly higher mortality risk. however.
AMAZING INFO WORTH KNOWING
3222222
Insulin Resistance in the body = Tremendous Tumor Advantage 25:40
55:00 the Mitochondria question has not been perceived at all.. out of his realm of expertise at it seems. till that moment it had been so interesting. I was so curious to hear how he would react to this question... No. No reaction... Healthy Mitochondria contol the Apoptose of cells... Uneffective mitochondria are unable to lead cancer cells to suicide.. of course I am not an expert but this question has not been understood and answered.. he said I am a chemist, a chemist and a chemist... Not a biologist..
Hi. What has been answered is that cancer is a mitochondrial condition.
Lewis and Thompson are amazing contributors to the cancer biology field because they are helping to illuminate that cancer metabolism plays a key role in cancer progression and therapeutics that interfere with metabolic pathways are proving to be productive in cancer treatment.
The disease has decent evidence to make the claim that cancer starts in the mitochondria. The organelle sustains chronic damage and eventually the accumulative damage done to its electron transport chain structures lead to an inability to perform its normal function ( energy creation and apoptosis). With a growing number of individual mitochondria sustaining this damage a crucial mass may be met which then leads to cancer. The aggressiveness of the cancer is tied to the level of normal respiration that still remains.
Scientists have shown that under microscopy that the mitochondrial proteins and lipids are damaged to varying degrees. No cancer cell has completely normal mitochondria. All of them however have been shown to have structural damage which would strongly suggest that the function of those structures probably has also been impeded. Structure equals function.
Lewis Cantley and others recognize the role cancer metabolism plays and indeed have targeted a major oncogenic pathway with pi3k inhibition. Pi3k is a major player in Cell Metabolism as well as with growth and proliferation. Pi3k inhibitors work better in a low insulin environment because insulin is one of its major inputs in terms of nutrient sensing and growth signaling. Take insulin away and you have a weekend signaling cascade.
Surprise, I never heard that fructose could be changed into glucose before😮
Why Pakistan has the highest diabetes rate?
WOW
I have to ask.... who the fck are the people in the audience of these talks?
I ask this because the Government recommendations are not changing, my GP's are not up to speed on these ideas, neither are the dietitians or exercise physiologists.
How can I know more about this stuff from watching RUclips than the professionals, who are still recommending dietary information that is still messing up peoples bodies?
Wow. Lustig looks insulin resistant. After all he does say he is not a "keto guy".
No, he isn't but never explains why. That can't be the problem.