Seeing Cell Division Like Never Before
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- Опубликовано: 14 сен 2022
- Using a combination of fluorescent microscopy and cutting-edge cryo-electron tomography, researchers in the labs of Luke Chao and Tom Bernhardt in the Blavatnik Institute at Harvard Medical School have provided never-before-seen views of double-membraned bacteria as they divide.
The work offers new insights into the division process and may aid in the fight against antibiotic resistance, since these drugs typically target bacteria as they divide, when the cell wall and membranes are weakest.
Led by postdoctoral research fellows Paula Navarro and Andrea Vettiger, the two groups made the discoveries possible by combining their expertise in bacterial cell division, bacterial genetics, and cutting-edge imaging.
Results were published Sept. 12 in Nature Microbiology.
Version that includes an audio-description: • Seeing Cell Division L...
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Website: hms.harvard.edu/
Not gonna lie, kinda happy that RUclips felt the need to recommend this to me so early. Fascinating video.
Truly amazing
Same
Yeah same. But I am not surprised that RUclips recommended me that.
Unlike the 10 year old vids… lol
Literally dude, this is the first video of the day for me.
The fact technology has gotten so sophisticated enough to render something as miniscule as the inner workings of cell division, in a 3D plane, is blowing my mind.
Yup! Although, the first imaging of DNA was made by Rosalind Franklin in 1952. (Was stolen by two male collegues)
@@tvre0 what does that have to do with his comment lol
And yet I can’t still can’t play minecraft with shaders on… 😢
@@bolson42 we have been able to observe insanely small objects for a while
@@Tester-sh1mn use more than 4 gigs of ram
Fascinating! Knowledge gleaned from further study of this could be very useful...
flappy duck ago
As an ex EM microscopist who did lots of cryo, I know what was involved and this is tricky stuff to get right, with a lot of good spec prep technique required, great work
Is it possible for a consumer to own an EM microscope? I would like to study aging outside of academic institutions so I can be more creative and exploratory.
@@SogMoseeit would be EXTREMELY expensive, not to mention how you acquire the materials you would need to study. What exactly do you mean by exploratory study of aging?
@@SogMosee you need money or good networking
I'm in AP Biology right now and found this video in my recommended. My bio teacher is always telling us that the information we're learning now could be completely different in the future, and it's fascinating to watch significant scientific developments happen as a complete biology noob. Awesome video! :D
It’s crazy bc I was in AP Bio 8 years ago, and always wonder what advancements have been made and what new concepts you are learning that we didn’t!
I got my B.S. in Biology 40 years ago, back when we still thought illnesses were caused by demons or an imbalance of bodily humors, lol...I'm ECSTATIC about how the biological sciences have progressed in the ensuing decades. We usually only had idealized artist's rendition of a cell in our textbooks or a blurry look through a microscope...these new technologies are Star Trek...!
That’s incredible
@@bluedreamyellowblack4745 I took ap bio as a senior in 1990. We learned about the miasma theory of illnesses.
Same I'm taking a test on mitosis and cell division tmr as well!
It's so interesting to see cells under microscope.
Yeah ! 🙂
No it isnt
@@matttzzz2 Then why are you here?
It's not actually under a microscope you can't really see anything it's all part of the plan look into it
@@matttzzz2 don't watch the video then
This is incredible! It's also weird how my brain associates black and white imaging and pixelated stuff with low quality, and yet this is focusing onto more detail than I could imagine! The fact that we can see the individual holes forming on cells is just amazing
Ah, consider old starpictures. Microscopes and telescopes progress almost equally. A single pixel can make a difference. One of the voyager crafts that was leaving waaaay the bloody hell out there caught a lucky shot at one of the oldest rocks we know about. Two frames, of one star being blotted out, or something bullspit like that, got us the data we needed to pull off a shot that boggles the mind with how tight the calculations needed to be, and how quickly they needed to be ready to get there in time. You know, one of those Two-Stone potatoes, but it's OOOOLD and still in pretty good shape cuz it's so far out there. I swear they're trying to one-up eachother now.
Most of the science imagery you see was captured in black and white and false-colored later.
i never thought about seeing three dimensional cell division, mind blowing
I can't wait to see this in our textbooks
will only take about 50 years lol
@中村奈々 why not? You don't like to learn?
@@burnburnfirefire learning is for nerds. I prefer fortnight 😎
@@matttzzz2 tf 😂
@@burnburnfirefire i hate having to learn anything biology related, everything is way too specific
*My problems Multiplying like:*
relatable
but with this multiplication comes division so you're also breaking up something if you're using that analogy
@@timelyseeker I hear the stupid "it's a joke" comments from a distance.
@@timelyseeker basically his 1 single problem itself has another 100 problem as the root cause of the main problem..
lmao 😭💀
Cell membranes are incredible and gets me so excited. I just think all things cell membranes, how ATP supports life and how mitochondria used to be bacteria that our bodies evolved to decide ‘I like you, I like what you could do for me, want to come inside?’ And the protein channels etc. it’s all just so fascinating and exciting.
Incorrect
@@Dad-lu1oi what is incorrect about that? ATP does support our metabolism/life, mitochondria likely was engulfed bacteria that developed an endosymbiotic relationship with early eukaryotes (hence mitochondria having their own DNA distinct from nuclear DNA that allows it a level of self-autonomy not present in other organelles) although I suspect the interaction was less asking for consent and more bigger cell “eating” the smaller cell
@@cahan557 There is no definable endosymbiotic relationship that can subsequently write the obligate genetics instructions (code) in the correct place, timing and in the required amount that is then left on it's own for creation, let alone duplication of a double-membraned bacteria. The code responsible for duplication is currently beyond our comprehension despite simplistic thinking it's "likely" a big cell eating a small cell which then figured out the obligate relationship and wrote DNA segment code out to perfectly execute duplication.
DNA code over huge expanses of time decreases in complexity by dropping genetic instructions, in other words, it degrades, not improves.
DNA code, mitochondrial and nuclear, is so far beyond our comprehension to recreate, let alone create from scratch, despite advances in mapping and successes/failures in DNA manipulation. We can finally map the DNA sequences but it's anybody's guess what all the combinations do or affect.
Science just isn't there yet, but we're working on it.
@@SpaceCadet4Jesus Still, you really can't discount how Republicans appropriated viral genes through horizontal gene transfer. How else would you explain their effect on the environment?
@@dangerfly Think Uncle Joe could use a viral gene pick-me-up? The Republicans might be happy to give it to him.
Wow this is amazing! Is this the actual speed of the division? I know microscopic life is usually the example of multiplying really fast, but this looks insane, the way it's so smooth is both beautiful and terrifying.
it depends on the bacteria and temperature. for example e coli takes 30 mins to reproduce
E coli divides every 18 to 20 minutes
@@alexschannel7514 the generation time is closer to 20 minutes in ideal conditions
@@juliee593 Jeebus Crust How horrifying
@@silverseth7 how so? Most strands of E. coli are harmless.
You have them in your gut and they help you digest. And those ideal conditions for a 20 minute generation time only really happen in labs, when scientists are purposefully trying to make bacteria reproduce as fast as possible. I've done it as a 2nd year undergrad student. It's not really dangerous or scary.
This is really weird but at the same time amazing because of the way it looks so seamless, I hope RUclips sends us more of these vids in our recommended videos. Keep up the good work scientists and thanks for a better future!
I’m just liking and replying so the algorithm knows I like this stuff lmao
Maybe in case the algorithm is in a good mood.
This is the creation of our lord praise to him😍
@@apollo1573 smart. doing the same rn
Agree, but I wish they would stop sending me CRAP VERTICAL stuff. I have repeatedly asked them to send nothing on my feed that is CRAP VERTICAL, but I still keep getting the trash that I routinely downvote and skip without watching. Together we can stop this vertical stuff ruining RUclips.
This is gonna be in our textbooks
In about 20 years
@@arnavpoddar 😂
@@arnavpoddar Agreed bro.
More like text holograms
@@snowpea98 so much more annoying than tactile data. The endless uses of paper and how integral it is to the act of human invention is gonna slap you in the face really hard in 20 years
Sculptors still sculpt in clay first before going to 3d model... cause things made strictly in 3d models are usually ugly as sin and even if they aren't then they still don't have the wow factor.
It is crucial to identify such phases via these sort of model organisms, because the diversity starts at very molecular level and how each molecule contributes to those post translational changes are significant in drug development...this is fascinating work to know that how actually things are happening at that minute scale just now! Amazing work. This paper is going to be a huge success
Awesome research! Glad that world have people interested in moving further the progress and allow all humanity have access to it.
Thanks for sharing!
This is amazing beyond words !
I had always seen cells in books but seeing them like this is astonishing
This is just awesome, main reason why I want to study microbiology.
The amazing thing is how these organism without sight, hearing, taste etc can separate into perfectly equal copies, you don't see a 30-70% split or any uneven split. Always a perfect 50-50 split.
The belief in a Creator starts from here.
Maybe because a less than perfect split would result in cells that aren't viable, cells that wouldn't do their work correctly etc, so cells evolved and ended up with this type of perfected split which allows them to do their job properly? I'm so fed up with people trying to justify anything they don't understand or find "amazing" with some unproven creator crap. Seriously. Everything that seems 'perfect' today may just be the result of many failures in the very distant past. Cells are one of the oldest things on this planet, I honestly don't find it weird at all that they eventually perfected themselves and reached the current level, in which they form pretty advanced organisms. By believing in gods, people just undermine the incredible progress of these amazing, fascinating little things. Because it's easier to say that some other life form came up with this "design". It's definitely easier than trying to understand how cells work and how they could have ended up forming the organisms we see today. But that's just for lazy and/or dumb people
@@dipteeshukla7 Only if you are naive.
@@dipteeshukla7 Then, who is the creator of creator?
@@avigamer7285 Things which are created have a creator, God always existed.
Did Microbiology at Commonwealth Pathology Labs back starting in the 1970s. Not in it now, but this is so cool. Like visiting old friends.
The exponential growth in knowledge and potential benefits is exciting, and needed, with the multi resistant horrors looming.
Studied biology major years ago, now I left but always fascinating to see news and discoveries in this field
Do you think they have regenerative medicine or substances that they’ve made?
Thank God this was recommended to me! I can now finish my world changing research!
youtube recommending me random bio videos is always my favorite part of the day
An actual good youtube recommendation. An extremely important, fascinating, informational and succinct youtube video that's not a short.
it curious that, after division, the cells produced from the same mother cell are still tight with each other when sliding on each other.
Iam in 11th grade and this was so fun to learn
Iam glad our generation has a lot of resources
It makes learning so enjoyablee
This is really insightful. Keep up the great work!
What a time to be alive! :) Incredible work!!
It really is fascinating learning about how life at the most basic level works.
Fascinating! This will be so helpful!
This one is really impressive, thanks yt for recommending
Life is so astonishingly complex, beautiful, and fascinating. Hats off to those whose work brings us these jaw dropping insights 🙏
It's so cool to see the whole process, I grew up thinking I would never get to see this.
This is simply amazing. Not just the dividing of the cells, but the fact that technology has advanced so far since the 20th century that we can now see cellular level things in clear and good detail.
*September 23rd, 2022*
I mean, we can see atoms in a pretty clear image for quite a while
Nah silly it’s the 21st century
That detailed cell wall image through the tomography blew my mind
The fact that this is possible to see is just mind blowing!!!
Absolutely amazing video!
Amazing that cell division is quicker than a blink of an eye yet humans could track them with millions of frames, plus even making a 3d version of the division.
Not sure where you're getting that impression. An article I found says "DNA replication of E. coli cells growing with doubling times of between 20 and 60 min takes about 40 min. After termination of DNA replication, the cell needs another 20 min to divide into two daughter cells."
@@darrentibbils9271 cells need 60 min to reproduce? 💀
i think you’re mistaken with the idea that cell division happens so quickly, it can take several minutes or even hours as darren says. nevertheless it’s fascinating that we can capture it in 3D :)
Cell division is not that fast, this is closer to real time than you might expect. DNA replication occurs a lot faster than we imagine it though.
What kind of uneducated stupid misinformation is this? An average bacteria divide about every 20 min. Unless your eye take 20 min to blink, it is not quicker than "a blink of an eye". Why are people liking your comment and why is your comment even existing in the first place when you clearly don't know what you're talking about?
SO MUCH IDIOTS SMH
How amazing being able to see this!
Fascinating and informative video. I'm so glad that RUclips recommended this video to me.
This is so fascinating!
I never really considered the “pull / push” microstructures that are part of cell division. I guess I always thought it just kind of, fell in half. Amazing!
Really? Didn't you play with soap bubbles when you were a kid and observe how they form and divide?
@@riproar11 did you observe their molecular structure back then?
Amazing views I never imagined I would live to see. Incredible detail!
thank you for making this kind of information free for all
This is a certified class 11th chapter 8 cell cycle and cell division bussin' practical moment. Truly a ncert moment
Ha bro sahi kaha
Kya tum dropper ho?
Textbook production companies be like : yes...it's time for action
Hell yeah my man popping off with that division
Mitosis’s is AMAZING, this looks so cool
i absolutely LOVE biology and studying cells under a microscope is one of my favorite things to do
and this video was just so damn interesting, I can't wait to be one of these people who make such unexpected things happen.
Amazing. Maybe hopefully we can utilize this to help understand cancer cells, utilizing crispr and maybe fighting back at it
"Cancer" is not a disease nor a single entity. It is a symptom of hundreds of diseases that will never be cured all at once.
@@mikemondano3624 it's just dna mutation so stfu
I'm in the 1st year of my Biology PhD program and it's nice to get video recommendations like these.
I was just thinking about how cool it would be to visualize dividing cells in real time, then I get recommended this video!
This feels like incredible news. For so long I hated the fact that we were essentially stuck playing catch-up with microscopic organisms. After all the hard work and effort we put in to prevent people from suffering and dying to diseases, bacteria just... _go around_ that? Hell nah. About time we take the fight to them.
Suffering and dying must always be a part of life though. It's only fair humans get it too. A world without diseases is far from the "heaven on earth" that most people think of. If no one got sick, there would be other problems. Humans are already in too high numbers, diseases serve a good purpose, that's just the objective truth.
You do know that anti-biotics also kill parts of you right? Good bacteria is part of you as well and that part dies when you take anti-biotics. Also chances are that better anti-biotics just result in evolution to an bacteria resistant to anti-biotic resistant anti-biotics... maybe one day we'll have perfect control over anti-biotics but for now it's just an arms race. Not to say we shouldn't develop these but this time we should absolutely require serious prescriptions to use them because god damn was the general public incredibly irresponsible with regular anti-biotics.
@@TheInfectous Between doctors over prescribing antibiotics to overuse in dairy and meat we created a worse problem than necessary.
By the time we find the cure for cancer, the bad bacteria resistant to antibiotics will be a bigger problem to deal with. With this breakthrough, there's hope that that worse-case scenario won't happen.
A most impressive video.
I'd love to know more about how they did this.
You can read their paper for free, it has a lot of details. The title is "Cell wall synthesis and remodelling dynamics determine division site architecture and cell shape in Escherichia coli", published in Nature Microbiology.
This was so fascinating to watch!
WOW! Bravo on that discovery! Quite significant! Keep them tools coming for all them scientists!!
this is the type of video thats gonna be recommended to everyone after 5 years
Wow, more stuff for kids in the future to learn
This is amazing. Technology has never been so advanced as it is these days. This is very informative. Thank you for recommending it.
Technological advancements are opening up a whole new world of exploration and knowledge. What an exciting time to be alive.
I'm so very glad that smart people are out there doing this kind of work. You keep saving the world, I'll make sure your networks stay up and running. 🙂
It takes a village :)
JESUS LOVES YOU PLS REPENT OF LUKEWARMNESS AND SIN AND EMBRACE CHRIST HE IS THE ONLY WAY TRUTH AND THE LIFE. YOUR MY OUR DAY OF JUDGEMENT MIGHT COME AT ANY MOMENT REPENT. ETERNITY IS FAR TO LONG TO GET IT WRONG.
Biology student here, thank you for maintaining our internet connections, we wouldn't get anything done without you
Also I'm glad we can have more diversity and allow women in these spaces, we can get a lot done and more research
It’s incredible just how much we’ve advanced, I can’t wait to see what the future holds!
Learn to enjoy life in the present and don't hold your breath that the future is going to be some incredibly advanced place. Cars and furniture styles change. Modern architecture makes an area seem sterile. Before mobile devices and social media grew, one would observe that not much has really changed. Social media and mobile devices have done great damage to where I have observed someone have a tantrum because their Facebook post didn't receive enough likes.
@@riproar11 what is to say I can’t enjoy the present _and_ be excited for the future?
The fact of the matter is that we’ve advanced so quickly over the past couple of decades and our advancement is getting faster and faster, so I’m excited to see what the future holds.
Social media has its flaws, but overall, it’s been great for humanity and is very important.
@@xXmlgamingXx355 When I was a kid my parents bought me lots of books that discussed space travel and the future. At the time, the books made me not appreciate the present and even resent it. I remember many of the illustrations and now see them are being quite silly with the way they imagined the clothing people would wear and moving sidewalks. That's the last thing people would need in a world with rising obesity. 62 Million in China. Other than city skylines, automobile styling and medical techniques, everything else will look about the same in 2042. Sadly, there will be those who cannot appreciate their reality and will become addicts of virtual reality.
There is no real future for humans. They will soon be gone. But what happens after would be great to see.
Fantastic work
The Microverse is one insane space! Fascinating learning and fun facts.
this is a really bad idea. i wish i could see a group of cells
Funny to think that a billion of these are dividing inside me at this moment 😁👍
Most impressive. Awesome information. Let's hope researchers can take advantage of the new insights to create ever better cures.
This is overwhelmingly amazing in so many aspects. Science is so damn crazy
Why does this feel like a murder case being briefed? 😂❤️
This is just a high resolution imaging of what´s happening while division occur. The protein content and sequential events already kind of "known". This is a great research by the way but the reason why this is not in the children textbook is that it is really complicated to understand how this is happening without have an idea about genetics and biochemistry :)
Not "that" complicated but indeed too complicated for kids.
I am just thankful that such information is still free and available. I am not in a medical field, though I wish I had at least considered it more when in my previous years. But I develop digital solutions. And I know I will find a ise for it in the future. Take the logic of it and not the process, and it can be applied anywhere. Great bit of research and a great video 👏
Great recommendation, see you all again after few years
As a PhD candidate, i did not expect this to filled with comments 😂
Me neither 😂
Algorithm. But im happy I got this in my reccomended even whrn I only do follow dumb meme and reaction channels. I like biology a lot, got into it more when I took advenced biology for 3 years. But I study ee engineering 🤠
I’m no med student, but this was just really cool to see. Thank you
Incredible that this is happening thousands of times per minute in our bodies all day every day!
I just started learning about this in my bio class!!! We were looking at the phases of mitosis and I was wondering, “can we use a microscope to actively watch cell division happen?” And this video popped up in my recommend!
Damn, this is crazy.
Why is this music so intense 🤣
This Is Fascinating! I'm Glad That RUclips Recommended This To Me :0
Better than most other videos I have ever watched.
awesome
I love you jesus
How is this a verified account
Would it hurt cells made up our body as well, since all cells plasma membrane have this phospholipid bilayer?
You could specify for E. coli's outermost layer specifically (and avoid human cells) by biochemically targeting its NAM-NAG crosslinkages. These NAM-NAG crosslinkages are present only in the type of bacteria that E. coli is so adding specificity for that trait would allow you to avoid human cells during administration of your drug. Granted, targeting this crosslink would hit other friendly colonies of bacteria that inhabit the various other microbiomes in our body that share this crosslinkage trait, but we may just have to accept that as collateral damage in order to fight off a more deadly infection. 🤷♂
@@Waeweas so does it mean that the outer membrane of E. coli is the reason why our immune system could not detect and kill these bacteria?
@@Waeweas Microbiologist has entered the chat.
@@Cryptofearia i am the storm that is approaching
@@Waeweas you may avoid human cell but what about our gut microbiome ,,,, what a shame that most research centers still don't invest more in investigations of bacteriophage therapy
Can't wait for this to get recommended to me again in 7 years
Amazing how we can see what controls the push and pull of cell division! I never would have thought to research that but here we are! :D
As a biotech major this is sick as fuck
Awesome
*puts chlorine in it
This video is a gem.
This is fascinating!
its so amazing to see cells duplicating so fast in just seconds.
and also terrifying
That's some 10 to 20 times sped up footage
What do you mean in just seconds? It takes above 20 minutes. It's sped up.
@@Izanagioomikami Oh i thought it wasnt sped up
@@hyp3r764 Nope, sorry to disappoint. But 20 min is still fast compared to human cells that takes one day on average.
Ok that's probably maybe pretty cool I guess possibly perhaps yeah I suppose 🤯
Imagine youself one of the Wright Brothers an hour before that first flight. What's it really like to fly, now medecine has flown in this respect. I'm sure this is a dummied down version of what all the boffins concluded but separate labs must verify things before spouting off on the new possibilities. Or else they can scare away funding. Not always easy predicting the future even when you see it for your very eyes.
Good jop to all researchers and support staff involved.
More people need to see this
We have a pretty cool rock, huh? Lots of cool things on this rock. But lots of not cool things. Let's get a new rock.
Martian Belle
cringe
Mars looks like a pretty good rock to me. Still gotta find out more about it though
millenial comment
dont know what is more impressive:
the way it all just works in Nature,
or the fact they discovered this with their telescopes and other fancy pancy stuff
Great images, but I really would have loved to hear more about these "push" and "pull" mutants.
RUclips, these kinds of informational vids are what I want my algorithm to focus on 🎉 INCREDIBLE!!!
I feel so special watching something that will be in biology textbooks in a few years haha
Damn , God buff the bacteria
Cell membranes are amazing. This was very cool. Thanks!
Great. Thanks for sharing