Human Endocannabinoid System
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- Опубликовано: 16 июл 2024
- Human Endocannabinoid System
Professor DeBacco
Different Types of Cannabinoids
Different types of cannabinoids include Side Chain, Varinoid, Orcinoid, and Bibenzyl/Alkaloid.
These are produced not only by cannabis, but also by species of liverwort, rhododendron, cylindrocarpon fungi, and amorfrutin species.
Cannabinoids are defined generally as a specific species of terpenoid molecule that has the potential to interact with the endocannabinoid system (ECS).
Do Not Forget About Terpenes
There are also some terpenes that interact with the endocannabinoid system…
One established example of this is the effect of beta-caryophyllene, which has been identified as a CB2 agonist, acting as an analgesic as well as a suppressor of neuroinflammation, making it a candidate for the treatment of MS (Ceccarelli 2020, Alberti 2017).
Cannabinoids are Inside You…
Your own body contains a system of endogenous receptors and ligands which work to regulate a vast number of cellular functions, in tissues throughout your body.
Cannabinoids actually play a vital role in maintaining homeostasis in your body. At least two of these cannabinoids are produced by your own body. They are called:
Anadamide: Endogenous analog of THC
2-Arachinoglycerol: Endogenous analog of CBD
CB1 and CB2 Receptors Target
Cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), determine the behavioral effects of cannabis when consumed, as well as the effects of your body’s own cannabis chemicals, 2-AG and anandamide.
Cannabinoid Receptor 1 (CB1)
CB1 receptors are expressed most densely in the central nervous system and are largely responsible for mediating the effects of cannabinoid binding in the brain.
Endocannabinoids released by a depolarized neuron bind to CB1 receptors on pre-synaptic glutamatergic and GABAergic neurons, resulting in a respective decrease in either glutamate or GABA release.
The strong presynaptic localization of CB1 receptors and their inhibition of voltage-dependent calcium channels and adenylyl cyclase suggest that a primary function of CB1 receptors might be to inhibit neurotransmitter release
Cannabinoid Receptor 2 (CB2)
CB2 receptors are primarily found on immune cells, particularly cells of macrophage lineage.
These receptors only indirectly affect neuronal function
modulating CB2 signaling could be promising for the treatment of various inflammatory conditions.
Link to Lecture Slides: drive.google.com/file/d/1bEti...
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This channel is the absolute best there is on you tube, possibly the whole internet as well. I want to thank you for taking the time to make this for everyone. Keep up the good work!
Thank you so much for the very positive and uplifting comment! Hopefully others agree and share the channel!
Excelente investigación
Gracias por el aporte y tu talento al entendimiento de los demas. He podido comprender mejor como funciona tanto el cb1 en nuestro sistema corporal y thc mas nivel cognitivism y como la misteriosa planta 🌿 permite ser tanto antagonista y agonista en su efecto por lo cual su adiccion es mayor conductual que neuroquimica y lo loco que solo actualmente de acuerdo al farmacólogo tally de la universidad se conoce que solo la phytocannabis o cañamo generan esos endogenos que mucha veces de forma patológica no generemos y esta sagrada planta desde 1660 en china su primer registro , bueno ya me fui largo, dios bendiga tu vida y la de nosotros 💙💙
Gracias por tu comentario detallado y positivo. Es bueno saber que la información fue útil para usted.
Fantastically insightful. Thank you !
Always happy to provide useful content.
This is really helpful into to the cannabinoid system. Much appreciated.
Glad to hear you liked it.
in the end this subject will be a core topic in every educational system in the world...hope that end comes soon..very important topic which is constantly growing in research and application...the body is all we have and the more natural the better...what i like most is how it helps to control the hormonal system as a gate keeper...even without this scientific knowledge the intuition knows it helps and is important...just not too much at any time...also read the comments forget the trolls-are they posting or sharing-it about getting the info out not bashing they who share important and specific info
ps may be a good idea to periodically update with new findings..such a topic probably more and deeper finds worth sharing=manythxs4CARING
Yes, more research is needed in this area.
Thank you, I have been looking for those kind of info. Good work!
Glad to help.
Thanks for your videos!
Thanks for learning about the human endocannabinoid system.
Amazing info! Thank you Prof. 🙏
You are welcome!
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@DeBaccoUniversity at time 5:53 do terpene profiles impact which direction when you say …bind on presynaptic neurons resulting in a respective decrease in “either” glutamate or GABA, do u mean just respective to what site they bind too or do you also mean an influx of the analogue or NT is directed specifically to a higher affinity of glutamate vs GABA sites?
When the endocannabinoids bind this results in the decrease in the availability of glutamate and GABA sites. So, since there is a limited number of binding sites when one component increases the other must decrease. Hope this helps clarify.
Great information, but they really need to get someone who can pronounce the words correctly
Please be more specific so corrections can be made.
@@DeBaccoUniversity beta "cary off eilene" not beta "chlorophallamine"/"anne al gee sick" not "al oh jest ick". He also says b-caryophyllene is an antagonist of the CB2, but the text on screen says it is an agonist. I'm available for consulting if you need.
And this was less than 2 minutes in. I couldn't finish the video.
I think this is just a single guy sharing his love, knowledge, and wisdom for cannibis with the world dude, not an actual university. Some people simply like doing things because they wish others to share in their happiness.
@@bd7254 Sounds like YOU have some issues to work out. You can't even be appreciative of the sincere time and effort as well as the mass of knowledge this gentleman puts into his videos. Go back to your videos that spam you with "don't forget to like and subscribe" over and over again.