At @2:30 I say we will focus on Anadamide today. Initially I had read significantly more papers and wanted to discuss the role of endocannabinoids in depression, anxiety, and stress. However, after writing and recording the sections on cellular mechanisms. I realized to adequately discuss what I wanted to, the video would be significantly longer. Since my schedule has been giving me less time to work on videos I removed that section. This line is a missed remnant from the original scope of the script.
@@gahfwa3541 Another place with a decent amount of GABA production is the hippocampus. Our memory center. There are very few concrete papers on THC and it's effects on the hippocampus. But one theory is that the GABA in the hippocampus is there to suppress neuronal 'noise' so only important and strong memories stick around. When you have chronic THC exposure the hippocampus becomes more noisy and it's harder to identify and consolidate memories. However, there wasn't any concrete proof/experiments I could find proving this one way or the other.
Why is this video not getting recommended to people? Does RUclips discourage potentially problematic topics despite the content having purely educational value?
Ha! The real reasons were: I've had much less free time. I had to read a lot more than usual as biological processes are not as concrete as other fields of science. So papers are sometimes not super straightforward. Also I just didn't seem to enjoy animating this one as much as others.
Visual inconsistency, am I right! That's why I chose to look for Drew Berry/WEHI animation videos for biology lessons. The Protein Data Bank channel is there, too.
Biology has to be some of the craziest, most time consuming complicated stuff to research. I literally can't even imagine how you even begin to approach researching something like a complex interconnected chain of reactions and biological processes. With physics I can at least understand the big picture of "better telescope to see things further away" or "faster accelerator to see smaller particles" but I can't even imagine how they would've researched this and isolated the biological system enough to understand it.
Puzzles are done starting from the edges and then connecting distinct looking pieces together until it all slowly starts to look like something. I imagine biology is the same with each of the thousands of pieces being the life work of a team of scientists.
This is why people become so hyperspecialized in biology. In my major (biochemistry), I see faculty seemingly devote their lives to understanding just one protein or one pathway. It makes me question if I'll ever have enough obsession to make it in this field.
It's actually really similar to physics and somewhat intuitive. If they want to research a protein, they take the mRNA that codes for said protein, inject it into bacterial cells who are then forced to mass produce said protein, then they pop the cell, and empty all it's contents onto a very small copper lattice. Under the microscope they will select those proteins/complexes that they think are the right ones, and then an algorithm analyses all the different angled images of the selected proteins and generates a 3D rendering of the supposed protein/protein complex. Finally, biochemists know the mRNA code, so they know which amino acids they should find in the 3D model, so they start guessing where which amino acids go. It's exactly like solving a 3D puzzle actually
I got more questions than I started with😭 What happens when THC is saturated in the receptors? Do the receptors become somewhat resistant or it’s something else entirely? Why do some people have tolerances more than others? Adversely, why do some people always get high every single time every day after many years without fail? What does weight and height have to do with it? What’s its or does it have an interaction with our adipose tissue? Why do some people have bad trips but others have great times smoking the same spliff? Why is it that some people, including myself, lack the ability to digest and feel the effects of THC in all formats, purity, and different time? Why does smoking and working out or working out and then smoking work so well together???? or is that a lie we all collectively believe or want to believe at least? What are the effects of the other phytocannabinoids in the human body in greater detail? What are the effects of the phytocannabinoids in the human body at different concentrations and with different consumption methods? Are there any benefits to them? if yes, what and how? Although it’s nearly impossible to OD on weed, what would be the negative effects (beyond lacing) of phytoc’s over the period of one’s life? With that same question in mind, how does this interact with one’s physical activity levels and cardiovascular and vagus health? Why does weed in all its glory work so well with people with ADHD and other neurological conditions that self medicate with it? How exactly do cannabinoids help people with conditions like ASL? Or completely unrelated conditions like anxiety and depression but also not helpful at the same time for people with schizophrenic symptoms? Last one might be unrelated but idk and a stretch. I got ALLLL the questions, i hope i can finally get answers for some of these questions. Outside my realm of answering but within my grasp of inquiry. And I wouldn’t even know how to test it. Can’t even ask my friends cuz I want science!! There’s so many more questions but the best answer is without it ✨✨✨
generally, too much of a ligand will downregulate the production of the corresponding receptors. Receptors are just proteins, and are continuously produced. The rate of production will decrease. Some people have a higher tolerance because they are fat/tall -> more of the drug gets absorbed in other places besides where its intended effects are. (Increased volume of distribution for the same amount of drug necessarily means there is a lower concentration of the drug in any given place) Others have taken the drug for too long, and their receptor production have been downregulated. The concept that you should dive into that addresses most of your questions is pharmacokinetics.
@@randombreg-kv5pj thank you for replying bro/brodette. I’m already familiar with it but it would make for an amazing video if he went into further details as for a part 2. I’m sure there’s points i didn’t even mention that should be added in there too but it’s not really necessary. If someone really wants more info, google is right theree
A bit sad: 16 years ago I was assigned a talk in biochemistry class at university about this exact topic and it seems only very little new knowledge has been discovered since then :(
I love this channel because you actually read the papers of the field and go into some detail about the physical/biological processes behind the topic you're exploring! Never stop doing that!
What an outstanding video! It goes beyond the surface level "summary" and explains the details involved, without oversimplifying or condescending. The GPCR activation cascade in particular was nice to see. It would be great in a future video to look at the feedback loop from GPCR activation via beta-arrestin that results in tolerance and dependence.
I’m so sad that this video is very likely gonna get less views than your typical stuff due to delving into biology instead of physics! This is just as good as (if not better than, for such a great explanation you give here!) everything else you make! A seriously great video, I learnt so much! Never knew that there were endocannibinoids, let alone the slightest bit about all the neuro-stuff! I’m glad you touched on the lack/presence of CB1 receptors on dopamine, I was wondering why the GABA producers were getting suppressed but not the dopamine producers! I find it interesting how when they removed the CB1 receptors on dopamine the effects of cannabis lessened, I would’ve assumed removing the inhibitor’s receptors would’ve made the dopamine production/effect skyrocket, not the inverse! Maybe I misinterpreted things though, haha. Genuinely mind boggling how complex biology is when you get real deep into it like this, it’s awesome to get a guided tour into a tiny part of it! Thanks for the video, I’m sure there was a *lot* of research put into this, especially since it isn’t your usual affair! (Unless medical stuff was your “day job” prior to making physics RUclips videos, haha; even in that case though, I’m sure a lot of research went into it regardless!)
"I would’ve assumed removing the inhibitor’s receptors would’ve made the dopamine production/effect skyrocket, not the inverse! Maybe I misinterpreted things though, haha." You did not misinterpret things! Yes it is very strange. It is important to note that these experiments though are for mice and not humans. So things are likely not perfectly comparable. But still, it doesn't make straight forward sense right?
Further question, why does THC make some people "trip" like they took a smaller dose of Acid? This is a rare but recognized phenomenon that happens to only certain people. Some people experience it only after using another psychedelic like Psilocybin, or LSD. For others causing a trip is the only thing THC does for them. Why does this happen in some people but not all people? What interaction causes a psychedelic experience when THC is involved?
I happen to be one of these people, and I think it comes down to me being moderately schizophrenic. My first time doing THC was only a few months ago, but it was an incredible experience I will never forget... it was the only time I had an out of body experience and some aspects of it mimiced the times I've had psychotic breaks. I haven't had any out if body experiences since the first time, but the hallucinations continue (mostly visual, audio, and tactile) and it is quite a fun experience. I would want to try a small dose of a "real psychedelic" at some point, though they say that may not be a smart idea in my case.
interesting i would like to see a sample of these type of people so i could speculate based on their traits before dinging into the difference in function taking places in their bodies on ingestion
Psychedelic effects and mode of action are even less well understood than cannabinoids, though it was my, perhaps outdated, understanding and experience that THC (perhaps along with an entourage of other phytocannabinoids) is simply weakly psychedelic and people may be more or less susceptible to those effects as they are to many other drugs.
@@Pickelhaube808 I am also one of these people, but I do not have schizophrenia. This has always happened to me on THC and nothing else. This is why it's such a fascinating question for me. What is the common link, if any, between people who use THC and their experiences differing from the expected outcome.
this video caught me off guard i knew this guy was really smart and could animate well but i didn't know he would figure out something in a completely different scientific field than the other vids I've watched on this Channel. This vid was a very good explanation, i intently watched the entire thing.
This video has helped me alot in understanding why quitting weed has been so helpful for me. I was wondering if you could maybe do a video on nicotine? Your videos explain things very well while also being easy to understand, due in part bc of the amazing graphics. It's incredible how immediately addictive nicotine is and even though I feel that process is fairly well understood (I think?) I would love to see your take on it. Thank you
I saw in a comment you said you were applying machine learning to climate science. I was wondering if it's possible to use a protein folding model (like alpha fold) to engineer an enzyme that would capture and store co2?
THC binds to specific receptors that make it harder for those neurons to fire. This means some inhibitory processes in the brain are stopped allowing other processes to function at higher capacity.
And it is good to remember that THC has other pharmacological actions then binding to CB receptors, such as inhibition of Acetylcholinesterase what "create more" acetylocholine (simplified). Also you have difrent phytocannaboids with difrient effects and above all of that you have difrient active compouds in cannabis such as essential oils (for example Linalool, with has pharmacological action as NMDA antagonist and GABA positive modulator). So brain is compleks and the plant is complex.
As a computer scientist, these kinds of videos only make me feel more and more like the brain is a type of computer running on code written in proteins that are assembled to atom blobs
This level of research and content for free feels illegal to someone who pirates stuff, Do you have any pateron or something of that sort? Would be happy to pay whatever I can.
Dude, Im on yt for a while now, I saw quite a few things. Nothing competes with this, the animation, the detailed research, this is something else... congratulation you are going to be huge ! I predicted the rise of channels before like Captain Disillusion, 3blue1 brown, or Veritasium and many others, back when they had a few 1000 subs. You are firmly on that track !
My major was quantum physics. I got to measure end states to model the intermediate interactions.. This organic, biological systems are way more difficult. Math-wise, quantum is easy....
Are you comfortable saying if you've been high a substantial number of times? Because as someone who has, this explanation is wholly unsatisfying. The dopamine angle seems sus, because there really isn't any euphoria or feeling of contentness with THC. Unless you're saying the reward pathways are learning to select for the novelty of a THC high over time, because it's novel in the same way as anything that gives us a dopamine hit, then I don't get it... And what I was really interested to know is, what causes the actual feeling of being high, which is so unique from other drugs? Is it the slowing-down of synaptic firing, that you touched on? Does it have something to do with GABA mediation? What mechanism is actually being induced when those receptors are activated? What evolutionary function did that serve? These are the types of answers I was hoping for.
Thc doesnt do anything for me except help me get some really good sleep. Makes me tired and dumb. I wouldnt personally describe that as a “high” since no elevated feeling or mood is associated. But im aware this is probably just me and how screwy my brain is.
8:52 I'm gonna be a total Dunning Kruger here and come with a theory, I personally think the difference in cb1 receptor counts between the two papers could be due to the plasticity of the brain, in combination with either natural resistance or built up resistance. Would this make sense? I have absolutely no idea really, that's why I started with the Dunning Kruger approach. Brains are naturally random in nature, because they're built from experiences that are random in nature, a bit of tweaking in vito by the brain itself isn't unheard of.
I don't know any more than you, but I would assume the papers had a sample group large and diverse enough to account for variance in receptor spread between individuals.
@@yayaya4345 That's a fair assessment, the information we were given didn't lean in any particular direction so we're left with theories. My theory only works if both studies were done correctly, and that's not necessarily true so my theory is on wonky ground. The problem is that if both studies had that diverse sample group they would have eliminated the extremes and those extremes could be random in nature, leading to a difference in the properties of sample groups. I only see it as a possible point of failure, but it's impossible to say that definitely was responsible for the differences.
there is so much going on. i feel if it is broken into parts like this the bigger picture understanding of what is going on will be hard to grasp. i feel it will be easier to to top down approach like a tree. or a van-diagram set theory big picture first then effects of the high group into factors that cause those effects. any who good stuff ill need to watch this a few times
I have a criticism, but it's hard to put together. I don't know how, but sometimes, it is only at the end of a sentence that I understand what you wanted to say and until there, I can't connect what I'm hearing with what I'm seeing. for example 0:26 the new scene is there, I need a moment to process what I can newly see but you instantly start to talk. And you don't start with what I see, you start with "the endocanabinoid system", which doesn't refer to the thing on screen so it doesn't help explain what I see... In this case me reading "endocanabinoid system" (not a common word to read) does not line up with you saying it, making it harder to follow. And the moment you say what I see - "synaptic communication" - is when the scene changes away, resulting in a "wait, what? let me rewind" moment. To be clear, it's not really hard to follow because of the topic... I know neuro science basics, but the way you phrase things interacting with what's on screen is sometimes sub optimal. I hope you get what I'm trying to say...
compare that to 0:35 "these are released" - you see particles being released a second later you say "synapse" - the word appears on screen a second later this is perfect to follow!
At @2:30 I say we will focus on Anadamide today.
Initially I had read significantly more papers and wanted to discuss the role of endocannabinoids in depression, anxiety, and stress. However, after writing and recording the sections on cellular mechanisms. I realized to adequately discuss what I wanted to, the video would be significantly longer. Since my schedule has been giving me less time to work on videos I removed that section.
This line is a missed remnant from the original scope of the script.
ahh makes senses
What are some other types of neurons that are primarily regulated by GABA? And do they also fire more frequently when CB1 is bound by cannabinoids?
@@gahfwa3541 Another place with a decent amount of GABA production is the hippocampus. Our memory center. There are very few concrete papers on THC and it's effects on the hippocampus. But one theory is that the GABA in the hippocampus is there to suppress neuronal 'noise' so only important and strong memories stick around. When you have chronic THC exposure the hippocampus becomes more noisy and it's harder to identify and consolidate memories. However, there wasn't any concrete proof/experiments I could find proving this one way or the other.
Why is this video not getting recommended to people? Does RUclips discourage potentially problematic topics despite the content having purely educational value?
So this is why bro hasn't uploaded in a while
Lmao
😵💫
Ha!
The real reasons were:
I've had much less free time.
I had to read a lot more than usual as biological processes are not as concrete as other fields of science. So papers are sometimes not super straightforward.
Also I just didn't seem to enjoy animating this one as much as others.
@@ButWhySci despite my "Lmao" I think you did a great job on the video. Thank you for doing your research!
@@ButWhyScianimations are 👌
My cells are filled with ribbons, blobs and little acronyms.
Epic biology moment
Biblically accurate cellular biology.
It's surprisingly unhorrifying. 😃
Visual inconsistency, am I right! That's why I chose to look for Drew Berry/WEHI animation videos for biology lessons. The Protein Data Bank channel is there, too.
Fantastic much detail in short accessible video.
Dafuq happened to my comment? I had one here previously.
i got stoned and watched this and i thought i could feel the shift from tonic firing to phasic firing in my brain.
Hahahaggahaha
Biology has to be some of the craziest, most time consuming complicated stuff to research. I literally can't even imagine how you even begin to approach researching something like a complex interconnected chain of reactions and biological processes. With physics I can at least understand the big picture of "better telescope to see things further away" or "faster accelerator to see smaller particles" but I can't even imagine how they would've researched this and isolated the biological system enough to understand it.
"better imaging to see things in more details" "better chemical imaging to understand the landscape in which these reactions operate"
Puzzles are done starting from the edges and then connecting distinct looking pieces together until it all slowly starts to look like something. I imagine biology is the same with each of the thousands of pieces being the life work of a team of scientists.
This is why people become so hyperspecialized in biology. In my major (biochemistry), I see faculty seemingly devote their lives to understanding just one protein or one pathway. It makes me question if I'll ever have enough obsession to make it in this field.
W
It's actually really similar to physics and somewhat intuitive. If they want to research a protein, they take the mRNA that codes for said protein, inject it into bacterial cells who are then forced to mass produce said protein, then they pop the cell, and empty all it's contents onto a very small copper lattice. Under the microscope they will select those proteins/complexes that they think are the right ones, and then an algorithm analyses all the different angled images of the selected proteins and generates a 3D rendering of the supposed protein/protein complex. Finally, biochemists know the mRNA code, so they know which amino acids they should find in the 3D model, so they start guessing where which amino acids go. It's exactly like solving a 3D puzzle actually
You have the most comprehensive graphics , the best I've ever seen.
This one of my favorite channels for information. You go into way more detail than anyone else and i love it.
I got more questions than I started with😭 What happens when THC is saturated in the receptors? Do the receptors become somewhat resistant or it’s something else entirely? Why do some people have tolerances more than others? Adversely, why do some people always get high every single time every day after many years without fail? What does weight and height have to do with it? What’s its or does it have an interaction with our adipose tissue? Why do some people have bad trips but others have great times smoking the same spliff? Why is it that some people, including myself, lack the ability to digest and feel the effects of THC in all formats, purity, and different time? Why does smoking and working out or working out and then smoking work so well together???? or is that a lie we all collectively believe or want to believe at least? What are the effects of the other phytocannabinoids in the human body in greater detail? What are the effects of the phytocannabinoids in the human body at different concentrations and with different consumption methods? Are there any benefits to them? if yes, what and how? Although it’s nearly impossible to OD on weed, what would be the negative effects (beyond lacing) of phytoc’s over the period of one’s life? With that same question in mind, how does this interact with one’s physical activity levels and cardiovascular and vagus health? Why does weed in all its glory work so well with people with ADHD and other neurological conditions that self medicate with it? How exactly do cannabinoids help people with conditions like ASL? Or completely unrelated conditions like anxiety and depression but also not helpful at the same time for people with schizophrenic symptoms?
Last one might be unrelated but idk and a stretch. I got ALLLL the questions, i hope i can finally get answers for some of these questions. Outside my realm of answering but within my grasp of inquiry. And I wouldn’t even know how to test it. Can’t even ask my friends cuz I want science!! There’s so many more questions but the best answer is without it ✨✨✨
generally, too much of a ligand will downregulate the production of the corresponding receptors. Receptors are just proteins, and are continuously produced. The rate of production will decrease. Some people have a higher tolerance because they are fat/tall -> more of the drug gets absorbed in other places besides where its intended effects are. (Increased volume of distribution for the same amount of drug necessarily means there is a lower concentration of the drug in any given place)
Others have taken the drug for too long, and their receptor production have been downregulated.
The concept that you should dive into that addresses most of your questions is pharmacokinetics.
@@randombreg-kv5pj thank you for replying bro/brodette. I’m already familiar with it but it would make for an amazing video if he went into further details as for a part 2. I’m sure there’s points i didn’t even mention that should be added in there too but it’s not really necessary. If someone really wants more info, google is right theree
A bit sad: 16 years ago I was assigned a talk in biochemistry class at university about this exact topic and it seems only very little new knowledge has been discovered since then :(
It could just mean that we figured it out. Weed might not be that deep.
@@mrlilhannathat’s unlikely given the complexity of the metabolic pathway. Source: I study biochemistry
These attention to detail and accuracy of the animations and explanations are top notch!
I love this level of detail on the mechanism of action. Keep it up man!
I love this channel because you actually read the papers of the field and go into some detail about the physical/biological processes behind the topic you're exploring! Never stop doing that!
What an outstanding video! It goes beyond the surface level "summary" and explains the details involved, without oversimplifying or condescending. The GPCR activation cascade in particular was nice to see. It would be great in a future video to look at the feedback loop from GPCR activation via beta-arrestin that results in tolerance and dependence.
I’m so sad that this video is very likely gonna get less views than your typical stuff due to delving into biology instead of physics! This is just as good as (if not better than, for such a great explanation you give here!) everything else you make!
A seriously great video, I learnt so much! Never knew that there were endocannibinoids, let alone the slightest bit about all the neuro-stuff!
I’m glad you touched on the lack/presence of CB1 receptors on dopamine, I was wondering why the GABA producers were getting suppressed but not the dopamine producers! I find it interesting how when they removed the CB1 receptors on dopamine the effects of cannabis lessened, I would’ve assumed removing the inhibitor’s receptors would’ve made the dopamine production/effect skyrocket, not the inverse! Maybe I misinterpreted things though, haha.
Genuinely mind boggling how complex biology is when you get real deep into it like this, it’s awesome to get a guided tour into a tiny part of it! Thanks for the video, I’m sure there was a *lot* of research put into this, especially since it isn’t your usual affair! (Unless medical stuff was your “day job” prior to making physics RUclips videos, haha; even in that case though, I’m sure a lot of research went into it regardless!)
"I would’ve assumed removing the inhibitor’s receptors would’ve made the dopamine production/effect skyrocket, not the inverse! Maybe I misinterpreted things though, haha."
You did not misinterpret things! Yes it is very strange. It is important to note that these experiments though are for mice and not humans. So things are likely not perfectly comparable. But still, it doesn't make straight forward sense right?
Not the video I was expecting, but still really cool information! Great stuff.
Criminally underrated channel
watching while high really hits differently....also, finally, a video that explains the questions I have in good detail.
best video I've seen expalinign this mechanisms with detail.
Further question, why does THC make some people "trip" like they took a smaller dose of Acid? This is a rare but recognized phenomenon that happens to only certain people. Some people experience it only after using another psychedelic like Psilocybin, or LSD. For others causing a trip is the only thing THC does for them. Why does this happen in some people but not all people?
What interaction causes a psychedelic experience when THC is involved?
I happen to be one of these people, and I think it comes down to me being moderately schizophrenic. My first time doing THC was only a few months ago, but it was an incredible experience I will never forget... it was the only time I had an out of body experience and some aspects of it mimiced the times I've had psychotic breaks. I haven't had any out if body experiences since the first time, but the hallucinations continue (mostly visual, audio, and tactile) and it is quite a fun experience. I would want to try a small dose of a "real psychedelic" at some point, though they say that may not be a smart idea in my case.
interesting i would like to see a sample of these type of people so i could speculate based on their traits before dinging into the difference in function taking places in their bodies on ingestion
Psychedelic effects and mode of action are even less well understood than cannabinoids, though it was my, perhaps outdated, understanding and experience that THC (perhaps along with an entourage of other phytocannabinoids) is simply weakly psychedelic and people may be more or less susceptible to those effects as they are to many other drugs.
@@Pickelhaube808 I am also one of these people, but I do not have schizophrenia.
This has always happened to me on THC and nothing else. This is why it's such a fascinating question for me. What is the common link, if any, between people who use THC and their experiences differing from the expected outcome.
*L i g h t W e i g h t s*
A week to early for Weed Day on April 20th
Also weed is now legal in Germany
Great explanation. It is very complicated.
this video caught me off guard i knew this guy was really smart and could animate well but i didn't know he would figure out something in a completely different scientific field than the other vids I've watched on this Channel. This vid was a very good explanation, i intently watched the entire thing.
Because it's some good shit
This is the only valid answer 😂
This video is slept on
This video has helped me alot in understanding why quitting weed has been so helpful for me. I was wondering if you could maybe do a video on nicotine? Your videos explain things very well while also being easy to understand, due in part bc of the amazing graphics. It's incredible how immediately addictive nicotine is and even though I feel that process is fairly well understood (I think?) I would love to see your take on it. Thank you
Yes a new video! And yes cannabis!!!! ❤
This is awesome! I could totally get down with an ongoing cannabinoid series. Cannabigerol is a very interesting one.
I saw in a comment you said you were applying machine learning to climate science. I was wondering if it's possible to use a protein folding model (like alpha fold) to engineer an enzyme that would capture and store co2?
Literally been waiting this video to drop 😮
Great graphics and explanations. However, I'd have liked a high level conclusion statement that answers the videos title. (I'm synapse lacking.)
THC binds to specific receptors that make it harder for those neurons to fire. This means some inhibitory processes in the brain are stopped allowing other processes to function at higher capacity.
This is why I'm subscribed to this channel
It’s amazing biological systems have homeostasis with these thousands of complex ongoing interactions.
And it is good to remember that THC has other pharmacological actions then binding to CB receptors, such as inhibition of Acetylcholinesterase what "create more" acetylocholine (simplified). Also you have difrent phytocannaboids with difrient effects and above all of that you have difrient active compouds in cannabis such as essential oils (for example Linalool, with has pharmacological action as NMDA antagonist and GABA positive modulator).
So brain is compleks and the plant is complex.
Awesome content, please keep it up!
You mean "keep it high".
In future, could you create a similar video to describe (on a molecular level) on how addiction occur in humans? It would be quite helpful. Thanks.
As a computer scientist, these kinds of videos only make me feel more and more like the brain is a type of computer running on code written in proteins that are assembled to atom blobs
Welcome back ✌
great explaination however "I know no more that I did before but now I know all that I need!
Great video. Very thorough.
So... why do we get high?
Sad that youtube doesn't recommend certain topics no matter what, even though so much effort went into this video😢
Thank you for mentioning anandamide
This level of research and content for free feels illegal to someone who pirates stuff, Do you have any pateron or something of that sort? Would be happy to pay whatever I can.
Great explanation
Nice video very interesting
Babe wake up ButWhy uploaded
Did this video get age restricted or something? I would have really liked to see it when it came out but it wasn't recommended to me.
Great video!
I think it has something g to do with the receptors growing. First times you use TCH you don't get high.
RUclips subscribed me to this channel out of nowhere, thanks I guess?
Good video ❤
You can't leave us with "recently deceased people" and not tell us about that research...
Part 2 please!
My question is can a person have a not reaction to stimulants like caffeine or cannabis to act
Like a non stimulant and the contrary too
love your videos
Amazing 🔥
"Now it should be clear that..."
Me: Ah, yes, of course, absolutely understood all of that 👌
zooted right now learning some cool info i might not remember
ok now give us the video files
At 3:45 it says GCPR
Dude, Im on yt for a while now, I saw quite a few things. Nothing competes with this, the animation, the detailed research, this is something else... congratulation you are going to be huge ! I predicted the rise of channels before like Captain Disillusion, 3blue1 brown, or Veritasium and many others, back when they had a few 1000 subs. You are firmly on that track !
Doesn't have the "killer instinct" of a narcissist like V.
My major was quantum physics. I got to measure end states to model the intermediate interactions..
This organic, biological systems are way more difficult. Math-wise, quantum is easy....
Biochemestry is soo cool
Terrific video! Watching lit asf lol
Are you comfortable saying if you've been high a substantial number of times? Because as someone who has, this explanation is wholly unsatisfying. The dopamine angle seems sus, because there really isn't any euphoria or feeling of contentness with THC. Unless you're saying the reward pathways are learning to select for the novelty of a THC high over time, because it's novel in the same way as anything that gives us a dopamine hit, then I don't get it...
And what I was really interested to know is, what causes the actual feeling of being high, which is so unique from other drugs? Is it the slowing-down of synaptic firing, that you touched on? Does it have something to do with GABA mediation? What mechanism is actually being induced when those receptors are activated? What evolutionary function did that serve?
These are the types of answers I was hoping for.
I have enjoyed many of your videos, but I prefer your physics based content.
Be me. Be high. Watch this
At 4:45 i realized i was to high to watch this video. 😂
the lil' animated guys are high
I still don't know why they get us "high"
😍
Algorithm really smothered this.
Yeah
I’m wayyyy to high to understand this but the graphics are cool
Thc doesnt do anything for me except help me get some really good sleep. Makes me tired and dumb. I wouldnt personally describe that as a “high” since no elevated feeling or mood is associated. But im aware this is probably just me and how screwy my brain is.
Gonna watch this while high
Wtf is a cananabanoid? Bro im way to high for this cool ass video💔
6:57 ow💔
cause smoke flies up as it lighter than air 💥💥💯💨
*blinks*
... wait what
You're speaking to the wrong person...
I Delta Tested this 30 years
2:10
You missed CB3 Receptors
I know why but I'm watching this video to celebrate
Us?
magic, got it.
He Just waited Till it's legal in German to smoke it
❤❤
This goes very low level without much context. I got lost very quickly.
8:52 I'm gonna be a total Dunning Kruger here and come with a theory, I personally think the difference in cb1 receptor counts between the two papers could be due to the plasticity of the brain, in combination with either natural resistance or built up resistance.
Would this make sense? I have absolutely no idea really, that's why I started with the Dunning Kruger approach.
Brains are naturally random in nature, because they're built from experiences that are random in nature, a bit of tweaking in vito by the brain itself isn't unheard of.
I don't know any more than you, but I would assume the papers had a sample group large and diverse enough to account for variance in receptor spread between individuals.
@@yayaya4345 That's a fair assessment, the information we were given didn't lean in any particular direction so we're left with theories.
My theory only works if both studies were done correctly, and that's not necessarily true so my theory is on wonky ground.
The problem is that if both studies had that diverse sample group they would have eliminated the extremes and those extremes could be random in nature, leading to a difference in the properties of sample groups.
I only see it as a possible point of failure, but it's impossible to say that definitely was responsible for the differences.
Hell yeah
damnm it ecplsine alot
there is so much going on. i feel if it is broken into parts like this the bigger picture understanding of what is going on will be hard to grasp. i feel it will be easier to to top down approach like a tree. or a van-diagram set theory big picture first then effects of the high group into factors that cause those effects. any who good stuff ill need to watch this a few times
I have a criticism, but it's hard to put together.
I don't know how, but sometimes, it is only at the end of a sentence that I understand what you wanted to say and until there, I can't connect what I'm hearing with what I'm seeing.
for example 0:26
the new scene is there, I need a moment to process what I can newly see but you instantly start to talk.
And you don't start with what I see, you start with "the endocanabinoid system", which doesn't refer to the thing on screen so it doesn't help explain what I see...
In this case me reading "endocanabinoid system" (not a common word to read) does not line up with you saying it, making it harder to follow.
And the moment you say what I see - "synaptic communication" - is when the scene changes away, resulting in a "wait, what? let me rewind" moment.
To be clear, it's not really hard to follow because of the topic... I know neuro science basics, but the way you phrase things interacting with what's on screen is sometimes sub optimal.
I hope you get what I'm trying to say...
compare that to 0:35
"these are released" - you see particles being released a second later
you say "synapse" - the word appears on screen a second later
this is perfect to follow!
i love weed can you do more on the other molecules please
👀ツ
tsu
Video was hidden from my feed prolly bc of drugs
i do love me some good cannabis
the way you say endocannabinoid makes me laugh
Weed ruined my ECS. I have no motivation or appetiete
All I can say is, Huh!
weed
This guy could be completely lying rn and no one would know😂