HIV Replication 3D Medical Animation
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- Опубликовано: 17 окт 2024
- Excellent animation which explains the hiv replication very clearly by 3D animation .
Regards,
Dr.Rufus
The Audio note of this video :
Targeting HIV replication
The replication of HIV 1 is a multi-stage process.
Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs.
Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte.
Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4.
These receptors interact with protein-complexes, which are embedded in the viral envelope.
These complexes are composed of two glycoproteins:
an extracellular gp 120 and
a transmembrane gp 41
When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment.
It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120.
This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane.
Gp 41 then folds back on itself.
This draws the virus towards the cell and facilitates the fusion of their membranes.
The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes:
Integrase, Protease and Reverse Transcriptase.
Reverse Transcriptase begins the reverse transcription of viral RNA.
It has two catalytic domains:
The Ribonuclease-H active site
And the polymerase active site
Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA.
The polymerase then completes the remaining DNA-strand to form a DNA -- double helix.
Now Integrase goes into action.
It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends.
Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome.
The host cell genome now contains the genetic information of HIV.
Activation of the cell induces transcription of proviral DNA into messenger RNA.
The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised.
Some of them have to be processed by the viral protease.
Protease cleaves longer proteins into smaller core proteins.
This step is crucial to create an infectious virus.
Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid.
This immature particle leaves the cell acquiring a new envelope of host and viral proteins.
The virus matures and becomes ready to infect other cells.
HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression.
Drugs which interfere with the key steps of viral replication can stop this fatal process.
Entry into the host cell can be blocked by fusion inhibitors for example.
Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens.
The action of Integrase can be blocked.
Protease inhibitors are also part of standard antiretroviral therapy.
Each blocked step in viral replication is a step towards better control of HIV disease.
Script, Storyboard, Art Direction by: Frank Schauder, MD
Animation: MACKEVISION
Publicity:
Dr.Rufus Rajadurai.MD.,PG Dip DIAB (UK).,ICME (BOSTON).,D.DiaDENS.,
This feels like an apocalyptic movie and I wish more lecturers taught like this
NO LITERALLY!!! I’ve been watching this since elementary school and I absolutely love it because of that
It was posted 16yrs ago 😮😮
Having it feels apocalyptic 😒 thanks CIA
1:40 I need this vidéo in.french please
Man, I wish all lectures were explained visually and lucidly like this.
Say no more
@@AIejandro2025
I've been an HIV Prevention Specialist for the West Virginia Bureau for Public Health for over 15 years, and THAT has got to be one of the best, most fascinating illustrations of the HIV replication process. ASTONISHINGLY complicated, but still fascinating. Thanks for posting this.
Fabulous! Its equivalent to reading 10k words text. Thanks
Jawaid Khan
Not really, they didnt even talk about capsomere proteins
ONE OF THE BEST EXPLANATIONS ON EVERYTHING ON RUclips!!! THAT WAS REMARKABLE. HOW IS IT EVEN POSSIBLE THAT YOU DESCRIBED SO PERFECTLY THE WHOLE PROCESS.
I’m amazed by the level of detail uncovered medical science on this topic.
Some extra info:
The envelope proteins are formed by the cleavage of a larger protein called gp160
The capsid protein is called gp24 and the matrix of the virus is called p17
Great video btw!
First Aid?
how does 160 cleaves to 161 { 120+41] ?
The gene that forms the gp160 is the env gene. And R. I. P. Is formed via the Pol gene
@@ash-joanhabib3014 I know it doesn't make sense. You would think it would be gp161, but it's not. It's gp 160
The sound effects in this thing get me. Listen to this with good headphones on, it is one hell of an experience.
The "blocking noise" is the best part.
One of the best videos on RUclips. Fascinating!
Cool! I'm a visual learner, and my teacher recommended this animation. According to other comments, the spoken facts may not be entirely correct, but the visual aid is priceless.
the music is amazing in this. makes everything so epic
This is pure excellence! I work in HIV and this is the best explained video I’ve seen so far.
i dont'T believe you .. even indians are way to big to work IN a virus.
best video on HIV i've watched so far. thank you.
This vid is on my recommendation after 13 years, yes, it is 2020 😂🙄
San pedro laguna
This video posted 16yrs ago still has a lot of information that is helpful in my class today. I was wondering how much effort you could have put into making this video in 2007. Thank you:))
Its stuff like this that motivate me to remain abstinent.
OMG i'll save this video for reminds me this
And keep IT in your pants🤷🏾♂️
AMEN!!! (Or to, at least, wear a condom).
This micro-world is damn Fascinating !!
Yeah
except it's not micro.. but even smaller!
@@NitishKumar-qd6nt nano
ITS terrifying
thats one the best explanatory vids i've ever seen! awesome thanks!
!Wow! As a 7th grader this video was very helpful.. with some explanation on the side. This video is exactly as you described. Thanks!
WOW. this video totally helps me in understanding HIV replication and it's life cycle. Thanks a LOT!
Sending lots of loveee to you 💌 love your content, animation, everything ❤️❤️❤️
This has been really informative. I wish it would go further, like explain the potential side effects of each therapy, difficulties in universal treatment and total elimination of the virus, and why sometimes mixes of them are made.
What does a retro viral therapy do?
It kills the replicated virus inside and outside the cell, but cannot remove the source generating the replicated virus which is the modified human DNA
Very informative. I have a family member who is an AIDS patient. I certainly hope that they come up with a cure soon. It would seem with the new protien folding stuff they've been doing, that they're getting close. I just hope they're in time.
this is the best video ever in helping me study about HIV. Thank you so much
love the way it makes the essential replication enzymes sound so epic lol
So, I am assuming the two viral RNA strands at the end are created from the original RNA strand? Can reverse transcriptase do that? Also, since every new cell gets its own share of the 3 crucial enzymes, does it get new enzymes from the new proteins that are created?
This video is very useful! I'm studying HIV replication and enzyme inhibitors, so this video is perfect to better understand and revise this argument. Thank you so much 😊
after 17 years sooo nice you are majical . bac 2024 hhh vive dz
This is amazing! My Virology Prof showed my class this to help us better understand HIV replication and we were stunned and the deatils you put into this!
Only one concern: we were taught that reverse transcriptase is what actually works as the intergrase instead of one coming in with the virus.
I like the additional notes on where drugs are designed to target
Hope you all having a good day today?
3 things that will remain as an unsolvable mistery:
- 1969 Moonlanding
- area 51
- RUclips recommedations
Biology teacher showed this video to class today. It’s a great video.
excellent animation,every thing was jst so clear
How can they be so smart? It is like they know exactly what to do. Amazing
This is one of the best videos I have ever watched!!! It is extremely helpful!! Thank you so much!! #lifesaver
This is way easier to understand than reading text. Thank you!
use norton anti virus
aldore bryer I DIED 😂😂😂😂😂😂😂😂😂😂😂😂😂
Quick heal best
Lol
Lol
EXCELLENT VIDEO!
It's a five-minutes review of what I took hours to learn in the books. Excellent
Great video,good job!can you make another video animation about Paramixoviridae Or orthomixoviridae?
I learned this in more detail in molecular. Terrifying virus!
the most smart virus ever
A smart virus does not kill it's host.
If you want to see a smart virus, check Herpes viruses. Truly fascinating.
@@evangel18 many herpes viruses causes cancer which kills the host. Then again other herpes viruses are oncolytic viruses. So it's kinda hard to tell
@@evangel18 but to replicate the virus has to consume all the amino acids in a cell.
Does the same thing as the coronavirus 🤷🏾♂️
Corona:Hold my airdroplet
The replication of HIV is multistage process. Each step is crucial to successful replication....
Great video!
This vid is 10 days younger than me
Remember kids, don't let your affection get you an infection, put some protection on that erection.
***Now we know where the S protein on the Corona virus came from***
Furin cleavage. HIV Protein Insertions. Big-time trouble in little China.
That replicating DNA part is crazy
I feel dumb when I watch this
I agree with you that this video is educational with conveying to us the mechanisms and treatments against HIV. Some people are just ignorant of the facts. But then again to those non-biology students, they may have difficulty understanding the complex facts and mechanisms involved as this video are not made to be 'layman'
didn't understand a fucking word!!!
You know what, You are absolutely right. Prop to doctors and nurses, but bigger props to Biochemists and Cell Biologist.
Please help us and society by Supporting our Start-up
Medical Program on CRISPR.
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Excellent video! Thank you so much, I wouldn't understand this mechanism without you video. Great job!
And then we look at the stars to find aliens. This video deserves the medical oscar. 😅
Admit it! You got this video recommended by RUclips!
Most vital steps are shown..... attachment right back to maturation..very simple and straightforward animation------Recommended anytime!!
Man this video helped me understand this process, it taken all day for my genetics teacher to explain it!
I am too high for this. Who knew it was this detailed. Humans can really be amazing. 22 years this has been going on in my body. Dang this is a good edible.
Got a biochem exam tomorrow. This movie just saved my ass!
This is a fantastic and informative video on HIV. I am currently doing A levels in Biology and find the disease aspect of the course interesting. Thanks for posting this video!!
man awesome...no words to express..the work of animation is the classic part...thumbs uppppppppppppp
Bind blowing video its way too much better then the text on the books
thanks a lot for your comments and rating.have a great day
wow..have now got the knowledge and I believe I can explain t well in papers now...thank u
This is gonna help me for my test tomorrow thank you so much....
Wow. This is beautiful mechanism
they doing it wrong in school this video is better than the whole year at school
This is like saying that the smallest form of matter is a molecule. It is sooooooo simplified.
Perfect.bravo. the best video about HIV I have ever seen perfect animation . nothing hard to understand
Can a single cell be infected by multiple HIVs? If yes, do viral DNA integration happen at different sites or is it targeted? Thanks
Every night I pray to God that they may find a cure to this terrible disease,
thanks for the great video. Continue to share and it is the real sign of your professionalism.
Excellent animation- my professor linked to it because it helps so much to see it at a microscopic scale!
Beautiful video. Scary sound effects. Ready for those quiz questions now.
The animation was so informative of what actually goes on on a micro level.
This animation makes it easier to remember
i am so thankful...now i can finally understand how it works...preparing for exam -medic
Thank you very much! Clear, concise and shows a big picture of HIV entry and replication. Now delving into details will be much easier
what the word in 3:32 (this step is crucial **** ) , what word after Crucial ?spelling like Jobriate or what? can anyone help
"to create"
i heard it like jubriate .. strange i asked many people whom english their first language they did not recognize it
Did you ask them what it says or did you ask them if he is saying "jubriate?" I heard to create immediately, however the pronunciation is slightly slurred.
***** yes maybe .. there is no word like Jubriate .. thank you for comment
Hey man, it says "to create an infectious virus"
very good animation it is easy to understood, thanks for creating this
Best animation of Mechnism of HIV and drugs😍😍
Top class video explanation.
Thank you for the done work
the same reason both of my uncles who became hiv+ in 1984 aren't dead: they look after themselves and they are just lucky enough to have found the right medical combination.
in fact, One of my two uncles has never taken medication in 26 years as he seems to be one of the rare people who control HIV effectively on his own.
Breathtaking. Am impressed😮
Well explained!!! I have understood the whole process perfectly
you just saves my immunology test score thanx
to whoever created the vid.. thanks mucho!
I'm learning alot from this channel
Very good...CLEAR...MADE ME UNDERstaND IT FOR BIOLOGY A LEVEL!!
THANKYOU MAN
Thanks for the video! I'm in nursing school and trying to read how this process works looks likes gibberish. This video was GREAT! Thanks again!
it is one of best i have ever watched.
That sounds very interesting, how long into the future are we talking about here?
Amazing video.. I wounder why some people dislike it!!!
This is a great video! The link to it is broken, though. Is it available elsewhere?
When I look at videos like this and hear all that crazy terminology, I realized how dumb I'm. Great job doctors and nurses!
EVOLUTION!
The more you know, the more it makes sense.
This is why im taking biology in college
Wow. This is complex stuff but the video makes it much easier to comprehend. Thanks.
this is so fascinating...I feel so thrilled after watching this.
Why we need the coreceptor gp120 on our T-lymphocyte cells, just to get HIV or does it have any other purpose?