Type 3 Hypersensitivity Made Easy - Immunology
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- Опубликовано: 27 авг 2024
- Type III hypersensitivity occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes. Such reactions may progress to immune complex diseases.
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Type 1 Reaction : • Hypersensitivity Type ...
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These immune complexes insert themselves into small blood vessels, joints, and glomeruli, causing symptoms. Unlike the free variant, a small immune complex bound to sites of deposition (like blood vessel walls) are far more capable of interacting with complement; these medium-sized complexes, formed in the slight excess of antigen, are viewed as being highly pathogenic
Such depositions in tissues often induce an inflammatory response, and can cause damage wherever they precipitate. The cause of damage is as a result of the action of cleaved complement anaphylotoxins C3a and C5a, which, respectively, mediate the induction of granule release from mast cells (from which histamine can cause urticaria), and recruitment of inflammatory cells into the tissue (mainly those with lysosomal action, leading to tissue damage through frustrated phagocytosis by PMNs and macrophages)
The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunological memory of the precipitating antigen. Typically, clinical features emerge a week following initial antigen challenge, when the deposited immune complexes can precipitate an inflammatory response. Because of the nature of the antibody aggregation, tissues that are associated with blood filtration at considerable osmotic and hydrostatic gradient (e.g. sites of urinary and synovial fluid formation, kidney glomeruli and joint tissues respectively) bear the brunt of the damage. Hence, vasculitis, glomerulonephritis and arthritis are commonly associated conditions as a result of type III hypersensitivity responses.
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First I went through books and found this topic difficult then I watch this video and complete all 4 videos of types of hypersensitivity now I want to say these are the best best explanations ever. Thank you so much 🥰
Hypersensitivity reaction
I just love this, I have tomorrow my finals in microbiology and I've struggling for couple of hours now to understand the principles. Thanks a lot for making it so much easier
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Wonderful ! For an undergraduate student or a family physician, the knowledge about hypersensitivity is perfect and useful.
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Can you please explain why poststreptococcal glomerulonephritis is type 3 hypersensitivy and not type 2, as you said antigen which are bound to cell surface are mediated by type 2 hypersensitivity. Here the same situation in poststreptococcal glomerulonephritis but why type 3 mediated???.....Kindly please explain🙏🙏🙏🙏🙏🙏🙏
I have thé some question
Poststrepto in thé RAA id type 2 because thé is thé some ag in thé bactérie bd thé cells if thé body
But why glomérulonéphrite id type 3?
@perrytheplatypus9053wish I read this reply before messing up the assessment test I had today.
The acute glomerulonephritis explanation is wrong in this video other than that a very great video
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Have you made a video on Autoimmunity yet?
Can you make a video about food intolerance? Is it real? Are food intolerance tests accurate?
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Where is type 2 ???
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Sir will you please make the vedio on T cell maturation
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What heppend s to the antitoxin- antibody complex when infusing animal serum into human body?
(Is it anti body or whole complex)
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what type of hypersensitivity does Cipro cause? I got rashes from it?
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Is it possible to get the transcript of this video?
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Please edit your immunology playlist and remove unnecessary videos from it.
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