Gilteritinib, venetoclax, low-dose cytarabine, and actinomycin D in FLT3-mutated AML

Andrius Žučenka, MD, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania, discusses a retrospective single-center analysis of patients with relapsed/refractory (R/R) FLT3-mutated acute myeloid leukemia (AML) treated with gilteritinib, venetoclax, low-dose cytarabine, and actinomycin D as first salvage therapy. The study reported a 100% overall response rate (ORR) and an 88% complete remission (CR) plus complete remission with partial hematologic recovery (CRp) rate. Over two-thirds of patients were bridged to allogeneic stem cell transplantation (alloSCT), resulting in a median overall survival (OS) of 32 months. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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