I swear I heard you introduce yourself as Captain Toke-off.🤣 I need to go to bed. EDIT: Woah!!! That video and explanation was AMAZING!!! Thank you for going step-by-step and making each phase, process and purpose crystal clear. You are my new best friend lol. Thank you, Captain Toke-off!💗
Excellent presentation about LDL...I have a question about unused LDL ....does HDL capture those and send them back to the liver....also, a question about LDL readings in blood tests....does the LDL reading represent LDL on its way to feed the cell, or does it read the unused LDL floating in the blood stream, or both?
There’s different fates for ldl particles. Absorption by the liver, cell uptake or uptake by macrophages which produce foam cells and which are atherogenic.
Your first point, sort of. Hdl particles are responsible for the reverse cholesterol transport pathway. Excess cholesterol within tissues are dumped on hdl particles which are taken up by the liver for excretion
Thanks for the lecture. My interest is in knowing why in diabetes glucose associates with heamoglobin .. My feeling is that the brain requires glucose and in a state of brain inflammation..the lactate shuttle requires Hb1ac... Is it a similar mechanism to this lecture on LDL Are there any papers as to the biochemistry And metabolism of glycated hemoglobin....when insulin becomes insensitive..to transport of sugar does the body rely on transport of sugar via association with HB protein...
@ Thank u for the info again... I am trying to see why diabetes is preceded by a period of low sugar levels. Is the low sugar levels a result of the body adapting to aerobic glycolysis set off by brain inflammation. So my hunch was that maybe the body requires the assiciation of glucose with Hb...as a result of a change in metabolism pathway in the body I am trying to see whether it is the brain inflammation and change in its metabolism that causes the onset of diabetes.. One interesting paper i was researching ..was about curry leaves .and i have experience of the use of curry leaves to reduce blood sugar after food intake ... Google : Linking Inflammation to the Brain-Liver Axis And Google : Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from Murraya koenigii (Rutaceae) Leaves How does curry leaf have such a quick response.. Doed the sugar get dissaciated with the heamoglobin ..and allow the the uptake by insulin..is the hyperinsulinemia in diabetes patient caused by association of sugar with the HB... Somewhere there is a chronic inflammatory signal due to high fructose diet... ..causing an aerobic glycolysis pathway to feed the innate immune system triggered by chronic inflammation... Or does the chicken come before the egg.. Thanks again ..i have subscribed to ur lectures..
![Cardiac Pharmacology [Part 2] | Anti-thrombotics & Anti-coagulants](http://i.ytimg.com/vi/eYJckemPJ7o/mqdefault.jpg)
![Cardiac Pharmacology [Part 2] | Anti-thrombotics & Anti-coagulants](/img/tr.png)
I swear I heard you introduce yourself as Captain Toke-off.🤣 I need to go to bed. EDIT: Woah!!! That video and explanation was AMAZING!!! Thank you for going step-by-step and making each phase, process and purpose crystal clear. You are my new best friend lol. Thank you, Captain Toke-off!💗
Excellent presentation about LDL...I have a question about unused LDL ....does HDL capture those and send them back to the liver....also, a question about LDL readings in blood tests....does the LDL reading represent LDL on its way to feed the cell, or does it read the unused LDL floating in the blood stream, or both?
There’s different fates for ldl particles. Absorption by the liver, cell uptake or uptake by macrophages which produce foam cells and which are atherogenic.
Your first point, sort of. Hdl particles are responsible for the reverse cholesterol transport pathway. Excess cholesterol within tissues are dumped on hdl particles which are taken up by the liver for excretion
Thanks for the lecture. My interest is in knowing why in diabetes glucose associates with heamoglobin ..
My feeling is that the brain requires glucose and in a state of brain inflammation..the lactate shuttle requires Hb1ac...
Is it a similar mechanism to this lecture on LDL Are there any papers as to the biochemistry And metabolism of glycated hemoglobin....when insulin becomes insensitive..to transport of sugar does the body rely on transport of sugar via association with HB protein...
@
Thank u for the info again...
I am trying to see why diabetes is preceded by a period of low sugar levels. Is the low sugar levels a result of the body adapting to aerobic glycolysis set off by brain inflammation.
So my hunch was that maybe the body requires the assiciation of glucose with Hb...as a result of a change in metabolism pathway in the body
I am trying to see whether it is the brain inflammation and change in its metabolism that causes the onset of diabetes..
One interesting paper i was researching ..was about curry leaves .and i have experience of the use of curry leaves to reduce blood sugar after food intake ...
Google : Linking Inflammation to the Brain-Liver Axis
And
Google : Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from Murraya koenigii (Rutaceae) Leaves
How does curry leaf have such a quick response..
Doed the sugar get dissaciated with the heamoglobin ..and allow the the uptake by insulin..is the hyperinsulinemia in diabetes patient caused by association of sugar with the HB...
Somewhere there is a chronic inflammatory signal due to high fructose diet...
..causing an aerobic glycolysis pathway to feed the innate immune system triggered by chronic inflammation...
Or does the chicken come before the egg..
Thanks again ..i have subscribed to ur lectures..