How do clustered circulating tumor cells initiate metastasis?

Circulating tumor cell clusters may break off from a solid cancerous tissue and lead to metastatic dissemination. The Aceto Lab at ETH Zurich (www.theacetolab.com) investigates the biology and vulnerabilities of these clusters, aiming to identify novel therapeutic opportunities.
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Additional Information
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mhs.biol.ethz....
Aceto et al., Cell 2014 (pubmed.ncbi.nl...)
Gkountela et al., Cell 2019 (pubmed.ncbi.nl...)
Szczerba et al., Nature 2019 (pubmed.ncbi.nl...)
Donato et al, Cell Rep 2020 (pubmed.ncbi.nl...)
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[@AdrianRodriguez-km2jf]

It is extremely interesting how cancer cells have the ability to cause metastasis, the way they do it is really a very complicated process but to summarize it invasion from the extracellular matrix where the expression of adhesion molecules is lost, they produce enzymes to degrade and adopt the capacity for movement and finally vascular dissemination is given by anatomical site, cellular tropism and evasion of tumor latency to grow in the new colonized site

[@ragini8447]

Really interesting