Bioprinting and Pig Chimeras: The Possible Future of Organ Transplants
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- Опубликовано: 22 янв 2019
- From bioprinting to growing organs in non-human animals, doctors and scientists are looking at different ways to make organ transplants a less challenging procedure.
Hosted by: Stefan Chin
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Image Sources:
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I'm a biologist in Maine who works with Induced Pluripotent Stem cells. SciShow did a really good job with this episode and explained some complex ideas in an easily digestible way
Research faster - I'm getting old lol.
Here in Aachen we're getting a stem cell factory and I'm SO exited, even though I don't usually work with human cells... 😅
@@gregorymalchuk272 conceptually? Yes, it's within the realm of possibility.
However, not many people (if any) are sinking money into figuring out how to do it
@@gregorymalchuk272 as for the politics in you fight, it might help you to know that we can do amazing things with induced pluripotent stem cells that we can make from living adults. Many people assume that all stem cell research is done on murdered babies, but in reality it is most often done from IPSC's or tissue from an umbilical cord that was litterally going to be thrown in a dumpster otherwise.
Change how the politics talk and think about the subject, and you will get funding. End the false narrative created by polititions that scientists murder babies for stem cells and you will open new doors for the world
Bioprinted Pig Chimeras sound like lvl 60 monsters in some mmo
Chiradori im dedd its soo true. *stares at xenoblade chronicles x*
@Prince Derpedro I had a B O N E R
As the recipient of a porcine pulmonary valve, I'm very happy that this technology exists.
Could you do an episode on the Platypus? A venomous mammal that lays eggs and can detect electrical currents, what’s not cool about them!
Platypuses are creatures straight out of science fiction. They’re fascinating.
Wicked Wildlife there’s a crazy conspiracy theory that platypus and a few other animals I can’t recall but including the panda”bear” are from another planet or evolved differently cuz of a comet or something like that lol pretty crazy but they are weird af lol idk bout the sincerity but it is fun to think ab.
@@JW-wp3yh there are "otherworldly" creatures in every corner of the planet. That's part of what is so beautiful about life on Earth. I imagine if people are sincere about the whole alien life thing, it's a different manifestation of an idea of a higher power.
The platypus is nature's way of saying "You'll never understand my possibilities."
Hanif Huzairi they are interesting, butbmany of those traits are common in amphibians.
So its less surprising how it evolved than that it happened to survive so long in a transitional form.
When you think about it, transplanting organs is a real modern medical miracle. Although we, humans, have been doing it for a long time, there are still a lot of risks! Thanks to all of the awesome people who donate organs both dead and alive!
You're welcome.
How can they be both death and alive?
As a long time dialysis patient , this video made me even more scared of a kidney transplant. Option #1 stay on dialysis until I have no quality of life. Option #2 Get a deceased donor transplant, hope it works, destroy my immune system completely with immunosuppressants and hope everyday for no rejection and no other serious disease. Option #3 stop dialysis and call hospice
Dean Vass it sure is scary, but transplants might make your life longer and increase your quality of life (more energy and free time than with dialysis) they usually work really well especially if the kidney is from a live donor!
Never missed a dose, 5+ years going. Kidney transplant 7-10-13... Been a challenge, take care of yourselves please.
You too
TMP912, You're a social media - posting, deep thinking, articulate, and well mannered medical miracle. Congratulations on 5 years of fortitude and success with your new kidney. My donor status is listed right on my ID, and I don't understand why more people don't want to possibly save lives with what they can't carry with them when they go...
@@midori8703 Anyone selling a brand of religion or culture that requires one to not be missing any bits, is harming humankind as a whole. That is a petty and pathetic god, who can't accept a soul that contributed to saving the lives of others with their organs. I'd bet that if a son or daughter, husband or wife needed a liver, heart or kidney, many "anti-donor" people would change their tune. Hopefully we get to the point that we can produce new ones, and then there won't be anything to worry about at all :D
@@Gun4Freedom I have medical reasons my organs are pretty worthless but you never know maybe they can use the scaffolding like the video lol.
Frankly without a ton of surgeries as a kid I'd likely need transplants too.
stay positive, take care of yourself, and don't forget them immunosuppressants. I had my transplant (kidney) in 97, so almost on 23 years with not one single rejection ( yes you can withstand multiple minor rejections before fully rejecting an organ so long as it is caught on time, so don't miss that bloodwork) Good luck and I wish you the best and good health : )
Another amazing video, SciShow! My mom had a double lung replacement done on her in 2004, and I can tell you from experience just how complicated organ transplants can be. From the different medications, to the surgery itself, it is almost as hard on the FAMILIES of recipients as it is on the recipient themselves! I continue to be amazed at just how far the science of organ transplants has come, yet I know that we still have a long way to go!
How about putting her own Stemcells on top of forign cells. So as forign cells are regected her own Stemcells while take their place
@@vanparker9344 Unfortunately, any type of Stem Cell surgery or even research into that type of treatment was definitely not available when Mom had her surgery.
You literally just summed up my major! I’m a bioengineering major hoping to concentrate in cell and tissue engineering :) loved watching this
Very cool. My transplant doctor has additional hours spent researching pig to human liver transplants. Martin Hertl is so bright and warm.
Just get a blood transfusion from Daddy Hank, and you'll be healthy and swoll for life.
We will drink the blood as it falls. Like peasants and dead kings
Thank you daddy!
I have a felling Muscle Hank is really Hank in disguise. Hank is that you???
"Organs are highly specialized and have organized tissues..."
Organs are organized...
Bahdum-TISH!
Ha, I noticed that too ^_^
Just three years after Stefan said that it's a "long ways away," we now have had the first successful pig heart xenotransplants
I'm eating dog and petting my burrito while watching SciShow
Um switch that
"Eating hundreds of babies and kissing hundreds of chicken dinners"
Parent’s friends: hey What new class are you taking this semester?
Me: scishow
The timing of this video is quite fitting. Tomorrow will be my one-year kidney anniversary. One of my amazing and kind older sisters donated her kidney to me. I hope and pray that I never forget to take my medications. I find the occasional nightmare in which I forget to take my medications quite motivating.
It feels strange that all of this happened a year ago. I have been able to do so many things because of her gift.
Ghost in the shell 2nd season looked at this. in fact it was sooo common pigs with modified genes were held in a facility and if they weren’t wanted by the original owner then they would be sold off.
Well otherwise they are mostly slaughters so...
People! Give the videos some love! The likes have been low lately, I never want SciShow to stop!
As someone who is currently actively looking for a kidney donor, it's very cool to know that there are some new technologies on the horizon for people who will be in this situation years from now!
Really big help thanks for making this epic video☺️
❤ Stem cell research should have been FAR more advanced than it is now, and 3D (bio-)printing is one of the most underused techs in modern science.
🐖 As for xeno and chimera: it's worth keeping on hand, if feasible. I personally think human-to-human is the way to go.
Hopefully, stem cells & 3D printing will make even worries about blood transplants💉 a thing of the past. This is especially needed for bone marrow donations.
Thank u for the subtitles!!!
Thank you that was informative. Good show.
Thanks scishow I never knew so much about organ transplants
I'm glad he didn't forget to be awesome!
Fantastic T-Shirt!
(Also awesome video, but I needed to comment on the t-shirt. :D)
A big thanks to all donors, especially to the parents who donate their child's. You parents gave 2 extra years with my son.
we need to be able to grow organs using the patient's own tissue. This would solve all the issues relating to donating organs.
Donating an organ like a kidney is also not without its long-tern risks for the donor either. It puts a significant strain on the remaining kidney which can cause serious issues later down the line
Yay, printing organs is so cool. I like it.
My father-in-law received a liver transplant. He had cancer in his bile duct. He's 10+years in with his new liver from a young man who had been in a car accident not far from the Mayo Hospital in Denver where Dad was receiving treatment.
The young man who had passed, saved/changed the life of 6 other people not included my father-in-law. Amazing young man.
love this guy
Hey friends, I have just uploaded a video of using math formula to make a beating heart graph, check it out, its pretty neat. (: (:
If you like it subscribe for more in the future. (:
I like this one alot!😁
Incredible. My transplant doctor is additionally involved in research with pigs and livers
Sweet shirt buddy!
The ultimate chimera!!! The pig mask army is at it again.
Porky!
It's... MAN BEAR PIG
1st person thats 2nd
It’s a creature that’s half man, half bear, and half pig.
you're really active today Justin Y, this is i think the 7th time today i've seen you and im not trying to....
The Recommended Page
I don’t think you get the joke. It’s a quote from South Park.
Half man, half bear, half Justin Y.
i went to back to this video after the successful transplant that happened last week
Come to this video from the latest news about kidney transplant from pig, that is likely related to this topic.
Interesting explanation.. Thanks
GOD DANG IT DID NOBODY WATCH FULL METAL ALCHEMIST NO STAHP PLEASE
SoulLight i kno thats what i was thinking to myself.... the only ep i ever watched as my start of the series. When i went to watch it again... guess what ep aired.
Next video will be about a girl who received dog's organs.
@@gibranhenriquedesouza2843 Big brother Edward.
I was no joke eating a burrito and petting my dog while watching this. If only I’d have received an organ transplant at one point and I’d be wondering if I was being called out.
And today, October 21st 2021, I read we've done it- tested in the US.
Nice vid
LOL, Alistair Reynolds called it :D In one of his books there is a charahcter who is an anthropomorphic pig, his people came from this very concept of "Let's make pigs organ donors"
Hopefully, this research will improve over time to the point were it can
be a lot easier for people who need a we organs and such.
As someone whos gonna need new kidneys in a few years this is super exciting.
Can u guys made a video on fibrodysplasia ossificans progressiva ( It's a rare disease where your muscles behind to turn to bone and you eventually become immobile) because I think it's really interesting.
I applaud your great research, pretty much everything you said was on point. I work at the university of bayreuth on this precise topic. Just one thing, the word "bioprinting" has kinda been replaced by the word "biofabrication", a more general term for the process at hand. Still great work, you guys.
@@gregorymalchuk272 no clue, lad. Only working on livers right now. But I'd assume no, as that is the answer to pretty much everything in this area;)
Good video, but 2 things. 1. In the transplant community, chimera also refers to patients that have been able to stop their immunosuppressive medications completely. 2. You left out one of the difficulties that scientists have been having with bioprinting, that they are having problems getting to stop replicating, leading to the organ becoming cancerous. This is particularly true for liver cells due to their regenerative nature.
Using pigs to grow organs was in a Ghost in the Shell comic several years ago and it made me wonder if we would ever go the same route.
What are the ethical issues within making chimeras?
Can you please do a video on the current state of research into antibody-mediated rejection?
how putting your own stemcells on top of forign cells instead of removing cells already there so as forign cells are regected
8:45 Big Brother Ed, is that You?
Stem cells and chimeras is pretty 'old news'. I have heard about it already 10 years ago. There were also some interesting experiments going on...
could you use CRISPR to reduce the likelihood of rejection?
like when you copy a new file to a program, delete the old one and rename the new same as before?
A question for an Episode ( why do we appreciate Bass so much in Music??)
Question that hopefully you'll be able to answer someday... What are some scientific proven ways to lower high cholesterol? I've heard that the whey protein and the very popular metimucil claim to help, but I'm finding it difficult to find solid evidence to back up those claims. Thanks for your excellent videos, DFTBA.
1:07 no organ doners 1:23 dying organ 2:01 rejection
1:23 dying organ 2:01 rejection
3:52 tissue engineering
Anybody here read oryx and crake from Margaret Atwood? This video gave me chills down the spine. No spoilers please I'm only halfway through the book.
Hediyeh B That book is the first thing that came to mind!
this is how most body horror B-movies start
Ooh, xenotransplatation. Sweet, I love the new word!
Bio printing seems like the long term solution, they have been talking about it for years. I'd love to see this become a reality.
Just recently 2 experiments of pig kidney transplant has been tested on brain dead humans and acute rejection was not found, also recently a pig heart gave a extra 3 months of life to a patient and while he died, it is not sure if the heart was the issue as he suffered from amyloidosis and caused severed medical conditions
Can you please explain chimeras in further detail?
Could you do a video on the guy who inproved organ transplants and made a two headed dog
I love seeing these advancements in tissue engineering but its unnerving not knowing what the future will hold for me. I don't know if I'll make it that long or not. I'll we can do is hope I suppose.
reminds me of "The Island".
Those pigs in OBSERVER the game :O oh god
Getting bad Fullmetal Alchemist vibes...
edward...
Ikr? The word chimera hit me bad ...
@@ThatWarioGiant do you want to play with me?
GOD DAMN IT
yeah... except it pig instead of dog.
Do not make an FMA reference
Do not make an FMA reference
Do not make an FMA reference...
Must resist urge.
I got myself a bull's value implanted into my heart last June. ✌️😃
0:25 Missed your chance to use the Droste effect
Pig-Human hybrids sound like a great way to produce Orcs.
Who gives a video like this a thumbs-down? Like, what don't you like? Did you not expect it to be about science stuff?
I can imagine it might be due to the ethics of animal experiments/organ harvesting. We are the machines in The Matrix from some animals point of view.
If they can 3-D print living tissue, would it be the 1st step to a Star Trek style transporter?
Can you explain the science/validity behind using human clones to harvest organs, like in the movie “never let me go”.?
WOOOOOH! BACON HEARTS!
Got here at view 665. I think this is gonna go well
Were the pig-human chimeras and the pig who carried them genetically modified to remove porcine endogenous retrovirus?
Have a wonderful day🤪😃
I think scientists should focus on bioprinting, IMO that has the most chance of success out of all of these ideas and unlike the others it is able to mass produce organs.
OMG, scientists are working on Man-bear-pig!
Also, you left out the growing of cartilage for ears and noses that is done on the backs of mice.
I have kidney transplant so i know this already
hello, I love your content but would it be possible that your videos have French subtitles please? Thank you
Very cool! But more importantly, is ANYONE working on 3D printed bacon? Because I gave up eating pork (because pigs seem too smart to eat) and I miss bacon SO MUCH.
www.amazon.com/Bacon-Salt-Original-Ounce-Pack/dp/B00CNVJMXK?th=1 :D
Ed...ward...
GOD NO STOOOOP
Growing a new organ would be perfect. No chance of rejection, don't need immunosuppression.
Dart Mada depends on why you need the transplant in the first place. Many people require transplants due to diseases with genetic or even unknown causes. They would not be able to revive an exact replica and still need to take immunosuppressive medications.
@@vsilverisisv at the moment but as the technology becomes more advanced....
And in the year 2022... it became reality
Why don’t you make a video on the alternative theories about the Universe on RUclips this would be interesting and good for the RUclips community!!!
an we integrate specialised cells into stem cells?
I remember one episode on Ghost in the Shell Stand Alone Complex where there were companies that used gene splicing to harvest organs on pigs. Guess it's not so science fiction now... But scishow! *Drumroll*
I was thinking that too. Love ghost in the shell.
Wow, all of these sound like sci-fi.
Oh, How I desperarely want this figured out today.. It gets really exhausting and painful just trying to get by one more day for me, Now that it's been about 8 years since my kidneys gave up..
Oh yeah yeah
If scientists are looking for an expert in the field of rejection, I am your guy.
This was literally an episode of Ghost in the Shell SAC.
Best way to get stem cells for this would be to alter the person's gametes to become the opposite sexes gametes then "combine" them with the original material and create a very close replica of the person. Problem us that it would have certain mutations and might be different enough to cause a minor rejection but if we can perfect it or use clones it would be fine.
Edward? Sorry i couldn't resist.
So we can have organ farms with pigs stuffed full of kidneys livers and such. Have each blood type represented and you can even sell the pork after harvesting the human organs.
*Dr. Marcoh has entered the chat
Well, when my aunt was a kid she was diagnosed with diabetes type 1, and she used to have to use pig insulin
Why all this gives me such strong sci-fi vibes?
Greideren science fiction is no fiction until science can achieve it.
We're getting there
I have a stupid question. If human bodies reject organs from other humans, why doesn't my body reject the three pieces of metal that was inserted into my hip when it was broken?
Jokes aside, it seems bio-printing is the future or similar process. Wouldn't it be easier to just try figure out how to manipulate the immune system to accept an organ rather than to reject it? It really can't be that hard people just aren't looking in the right area. Things always tend to be a lot easier than one would think