There wasn’t a ton of *space* in between all the great explanations to make that *needle* joke, but I’m glad a Washington guy like yourself was able to make room for it
People that skipped vid one shorted themselves. This is exactly what I've been searching out for 8 years. I wish YT had suggested this channel long ago. It took Dr Huberman's tip who also should have been suggest to me on his 1st vid.
Great work! I am going to share this with the students at my institution. You explained everything in far greater depth than I ever could and with better visuals!
Hello from Italy! Starting to watch your older stuff after seeing you around at all the top podcasts. Everything is so well explained. This is a wonderful resource. One correction. While his paper was in German, Morpurgo was Italian. He was a professor at the Università di Siena.
My brain is exhausted, but awesome video!!! I’m a little confused with what proteins are growing if contractile fibers are not growing. I’ll have to rewatch
When watching other RUclipsrs video: I watched 3 min out of 10 But for Andy's video, I can't skip a beat. Love from India man, the way you explain is brilliant🔥
Thank you for providing complex scientific knowledge on muscle physiology in a more graphical, illustrated, and simplified way. One comment and question: Satellite cells are stem cells so that they can become new muscle fibers (adding new cells, aka hyperplasia), so that it appears that, to some extend, under damage or injury of muscle fibers there is hyperplasia (a place we do not want to get under optimal progressive loads), so that an hypothesis could be that hyperplasia of muscle fibers is restricted as a mechanism of tissue repair from significant damage or injury. However, is valid to distinguish between new muscle fibers from satellite cells versus mitosis of actual muscle fibers. ;-)
First of all thank you for this amazing video, amazing content and always for free. What impressed me most about all of this, is to finally know the truth about hyperplasia, fiber splitting etc. and then also to see it in a different point of view, that is the myofibular way. That's whats impressed me most, going through all levels from macroscopic to ultrastructural and trying to see whats is happening there and to know from where does hypertrophy come. I'm looking forward to jumping to the other videos thanks Andy :))
Holy smokes, this was a brilliant video! Just recently found your channel via my friend who shared this video, at the first glimpse your channel's content looks great! As an enthusiastic exercise physiology science reader and coach there was a lot new things and studies I learned through this and above them all, new info about muscle fiber hyperplasia, real thing or not. I've always used term muscle hypertrophy a lot, but haven't really known all the things it holds inside. So this really widened my view and next I'll head to those referenced studies and your other videos. Thank you!!
Phenominal. Absolutely incredible the detail and extent of explanation in this video. Loved it, especially the discussion on the sources and levels that actually cause the increase in muscle growth!
this serious does not have enough views for the amount of important information it delivers. so many younbg guys training who should watch this. ill recommend these to everyone interested in bodybuilding
Andy, your videos are incredible, I’ve been learning so much from you! I wish it was a live class so I could ask the millions of questions and thoughts I had! Here goes one: If heavy load hypertrophies myofibrils, resulting in the increase of their diameter and potentially more contractile, which would technically result in greater strength, how come some people are really strong but not big in size at all? The opposite may be explained by the sarcoplasmic hypertrophy but what about the opposite? Purely neurological adaptations? Thanks and looking forward to videos # 2 and 3!!!!!
Amazing series. Thank you for this. Do you have a series on the stages 1 - 5 for speed/power training. What is the stimuli, proteins, end adaptation etc. Does speed training add fibers/convert to type 2?
I love these videos. Thanks for sharing your knowledge and the science of exercise with us. I was going to volunteer to come in for a muscle biopsy until I saw you got your needle from Seattle. I don't have nearly large enough muscles for that. You could likely fit my entire body in the Space that that Needle occupies. :)
Great video! Would be great if you could link to the various resources in the description, plus links to part 2 and part 3. Would just make it easier. I also found a typo in one slide "Sarcoplasmic" is misspelled at 28:55. Loved seeing the actual biopsy of muscle fibers - that's just so cool! More of that stuff please!
Love this video! Quick question: If the length of a muscle is finite (i.e. insertion and origin are set) then how can the sarcomeres lengthen? If a 10 cm long myofibril contains 10 sarcomeres, each sarcomere would be approx. 1 cm long. If we theoretically grew a new sarcomere wouldn't that then shorten the length of every other subsequent sarcomere?
Joke laughter coefficient is negatively correlated to the duration of the pandemic. Otherwise, the information provided is phenomenal. Thanks for breaking this down so dummies like me can learn this stuff.
Wow after watching your Huberman 6 part series. I thought you were some super serious science dude. But hearing you crack jokes and have fun with your explanations is a welcome surprise haha
Hi Dr. Galpin and anyone else reading, a point of confusion around 29:15 . The slides say 10% of proteins are for contraction, but then also say 70% are actin and myosin. Aren’t actin and myosin contractile proteins? Also, if 10% of proteins are for contraction and 40% are for metabolism, what is taking up the rest of the 50%? Thank you for reading
men iloveyour content. but i suggest maybe u change ur title. make it cache so people in fitness industry will get in this channel easily but overall your so so so great man, thankyou for sharing such incridble information
Excellent! Do you or your colleagues have videos on ligaments and tendons? I'm a layman of 66 years old and have nerve damage from trama attempting to understand the best approach to physical improvement of muscle, nerve, ligament and tendons health and performance. Thank you very much. Leo
Regarding tendon/ligaments, check out Ben Patrick, the Knees Over Toes Guy - ruclips.net/user/TheKneesovertoesguy His method incorporates training the stretched muscle under load, so although he's not particularly muscular, he is extremely strong. I believe this is why certain martial arts styles, (tied in with technique), can aid a smaller person to deal effectively with a bigger opponent. Sorry I cannot help with the nerve issue.
Wow 🤩 this is just awesome. Thanks for all your incredibly insightful videos. I recommend you to all my learners, hopefully you will start getting a strong Scottish following :)
Great presentation, thanks for that. One question: Fiber-splitting sounds a lot like mitosis; is known what happens to the nucleii of the cell? Are all copied/the DNA-content of each replicated? Are they spread between both cells and further nucleii formed thereafter?
It's not that it's low, it's just not really clear. I love his videos, but I have to focus so hard to hear him properly, especially when a video is this long.
@@4lifescape1 Part of it is mic. Part is low-volume-emphasis, or conclusion, vocal style. Like in music when a bridge ascends, followed by resolving it when returning to the chorus. Brits do it a lot.
Love your videos and content, but you really need to update your audio quality. When you were on Dr Huberman's podcast it is 100x easier to listen and understand you...
Why this increase in strength without adding muscle volume could not be a neuromuscular adaptation. That way you would not feel obligated to give some merit to the very unstable sarcoplasmic hypertrophy narrative? or am I too wrong XD
You asked for 3 things I learnt ... Interesting fact 1: there are people in the world who are prepared to give their knowledge for free. Interesting fact 2. There are people who are very grateful for this knowledge Interesting fact 3. Fact 1 plus fast 2 = a better world. Your contribution is very much appreciated. Came to this via Huberman interview. Thank you both for the inspiration. Thank you.
What an impressively thorough and mechanistic description this video is!
RUclips algorithms suck eggs I have never been suggested these videos. Thanks for pointing these videos out.
Mr. Huberman is watching Dr. Galpin? How cool is that!
Andrew, my brother. Your videos are the best.. Thanks for recommending us to this channel.
OK THIS IS ENOUGH FOR ME NOW I’M SUBSCRIBING
Real gratitude for tipping me to Dr Galpin. I suspect you know Dr Bill Hare and wish I could ask you.
Criminally underrated channel
Love your long form videos. I'm and exercise phys grad student and I listen to your videos on repeat while I'm riding the indoor trainer.
There wasn’t a ton of *space* in between all the great explanations to make that *needle* joke, but I’m glad a Washington guy like yourself was able to make room for it
An 81 minute, "55 minute" tutorial, maybe there is some good in the universe? 🙌🏼
People that skipped vid one shorted themselves. This is exactly what I've been searching out for 8 years.
I wish YT had suggested this channel long ago. It took Dr Huberman's tip who also should have been suggest to me on his 1st vid.
Same here. I had to search specifically for this video. I learn best from Dr. Galpin over the other RUclips muscle influencers.
He’s back!
Your channel should have millions of subscribers
Great work! I am going to share this with the students at my institution. You explained everything in far greater depth than I ever could and with better visuals!
Hello from Italy! Starting to watch your older stuff after seeing you around at all the top podcasts.
Everything is so well explained. This is a wonderful resource.
One correction. While his paper was in German, Morpurgo was Italian. He was a professor at the Università di Siena.
Andrew Huberman and Costello brought me here. Thank you,Dr. Galpin, for your work.
My brain is exhausted, but awesome video!!! I’m a little confused with what proteins are growing if contractile fibers are not growing. I’ll have to rewatch
Thank you very much, Dr. Andy Galpin, for sharing this valuable knowledge.
Thank you from the bottom of my heart for taking the time to make such well done educational videos Andy.
When watching other RUclipsrs video: I watched 3 min out of 10
But for Andy's video, I can't skip a beat. Love from India man, the way you explain is brilliant🔥
Thank you for providing complex scientific knowledge on muscle physiology in a more graphical, illustrated, and simplified way. One comment and question: Satellite cells are stem cells so that they can become new muscle fibers (adding new cells, aka hyperplasia), so that it appears that, to some extend, under damage or injury of muscle fibers there is hyperplasia (a place we do not want to get under optimal progressive loads), so that an hypothesis could be that hyperplasia of muscle fibers is restricted as a mechanism of tissue repair from significant damage or injury. However, is valid to distinguish between new muscle fibers from satellite cells versus mitosis of actual muscle fibers. ;-)
First of all thank you for this amazing video, amazing content and always for free.
What impressed me most about all of this, is to finally know the truth about hyperplasia, fiber splitting etc. and then also to see it in a different point of view, that is the myofibular way. That's whats impressed me most, going through all levels from macroscopic to ultrastructural and trying to see whats is happening there and to know from where does hypertrophy come. I'm looking forward to jumping to the other videos thanks Andy :))
Omgggg seeing the actual fibers outside the body was so cool!!!!
Holy smokes, this was a brilliant video! Just recently found your channel via my friend who shared this video, at the first glimpse your channel's content looks great! As an enthusiastic exercise physiology science reader and coach there was a lot new things and studies I learned through this and above them all, new info about muscle fiber hyperplasia, real thing or not. I've always used term muscle hypertrophy a lot, but haven't really known all the things it holds inside. So this really widened my view and next I'll head to those referenced studies and your other videos. Thank you!!
This is so helpful!
Thank you so much for sharing knowledge! 😊
Svaka čast majstore, world needs more people like Andy
Phenominal. Absolutely incredible the detail and extent of explanation in this video. Loved it, especially the discussion on the sources and levels that actually cause the increase in muscle growth!
this serious does not have enough views for the amount of important information it delivers. so many younbg guys training who should watch this. ill recommend these to everyone interested in bodybuilding
Amazing stuff, looking forward to the rest of the series, thanks Andy
Andy, your videos are incredible, I’ve been learning so much from you! I wish it was a live class so I could ask the millions of questions and thoughts I had!
Here goes one: If heavy load hypertrophies myofibrils, resulting in the increase of their diameter and potentially more contractile, which would technically result in greater strength, how come some people are really strong but not big in size at all? The opposite may be explained by the sarcoplasmic hypertrophy but what about the opposite? Purely neurological adaptations? Thanks and looking forward to videos # 2 and 3!!!!!
Unreal. This is phenomenal!
Thanks Doc! Really looking forward to the rest of this series and the updates to come!
Andy you are amazing M8. Thanks for sharing such great information.
Amazing series. Thank you for this. Do you have a series on the stages 1 - 5 for speed/power training. What is the stimuli, proteins, end adaptation etc. Does speed training add fibers/convert to type 2?
Great talk thanks Dr Galpin. I'm onto the next one 🥇
Huge load of information. Thank you Andy!
I love these videos. Thanks for sharing your knowledge and the science of exercise with us. I was going to volunteer to come in for a muscle biopsy until I saw you got your needle from Seattle. I don't have nearly large enough muscles for that. You could likely fit my entire body in the Space that that Needle occupies. :)
Great video! Would be great if you could link to the various resources in the description, plus links to part 2 and part 3. Would just make it easier. I also found a typo in one slide "Sarcoplasmic" is misspelled at 28:55. Loved seeing the actual biopsy of muscle fibers - that's just so cool! More of that stuff please!
Thanks doc..❤️
Love this video! Quick question: If the length of a muscle is finite (i.e. insertion and origin are set) then how can the sarcomeres lengthen? If a 10 cm long myofibril contains 10 sarcomeres, each sarcomere would be approx. 1 cm long. If we theoretically grew a new sarcomere wouldn't that then shorten the length of every other subsequent sarcomere?
Joke laughter coefficient is negatively correlated to the duration of the pandemic. Otherwise, the information provided is phenomenal. Thanks for breaking this down so dummies like me can learn this stuff.
What are your thoughts of the phase of "microtears", is there a better 5min way of saying how muscle grows for client education?
Was it because you used the Seatle Space needle as if it were a needle? in the bicep around 13:40?
Wow after watching your Huberman 6 part series. I thought you were some super serious science dude.
But hearing you crack jokes and have fun with your explanations is a welcome surprise haha
Dr. Andy Galpin said it, so I hope im right lol.I saw the seattle space needle for the graphic of the muscle biopsy. I get points!
I can only imagine how amazing it must be to be in one of your lectures.
This was awesome! Maybe next level would be learning science from the coolest animation documentaries! Mil gracias doctor!!
Why why WHY does this channel only have 55k subscribers??? Madness!
Thank you for this video. Well explained.
Hi Dr. Galpin and anyone else reading, a point of confusion around 29:15 . The slides say 10% of proteins are for contraction, but then also say 70% are actin and myosin. Aren’t actin and myosin contractile proteins?
Also, if 10% of proteins are for contraction and 40% are for metabolism, what is taking up the rest of the 50%?
Thank you for reading
men iloveyour content. but i suggest maybe u change ur title. make it cache so people in fitness industry will get in this channel easily but overall your so so so great man, thankyou for sharing such incridble information
I never comment but this is amazing!
Such a hidden gem that should be the largest gem in the entire world
Amazing to watch something like this for free.
No BS Exercise Science. I love it!
7:30 so, hypertrophy training improves bone density more than strength training??
Great information. Thank you Andy! :)
Thank you. I love your videos. Keep em comin please
At 12:46, is there a special article that you’re referring to?
How could we compare muscle growth on bones and vegetal growth from soil?
hight quality content .thanks dr.
@Andy Galpin
😂 the space needle
1:04:50 oh please get into it, i would love to hear that!
So much information,
Superb video...
make a seperate video on Body types and appropriate training protocol, Ectomorph bone density, how to increase after 30's
hello sir Andy, any new research on theories?
Thank you for making these videos.
"Dr. Andy, aren't you splitting hairs here?"
"No, actually muscle fibers"
Appreciate your efforts. Love the science.
Do you need to feel Delayed onset muscle soreness or DOMS for the muscle to grow? That Is one of my big concerns 🤔😫🤷♂️
How do satellite cells relate in all of these?
Excellent! Do you or your colleagues have videos on ligaments and tendons? I'm a layman of 66 years old and have nerve damage from trama attempting to understand the best approach to physical improvement of muscle, nerve, ligament and tendons health and performance. Thank you very much.
Leo
Regarding tendon/ligaments, check out Ben Patrick, the Knees Over Toes Guy -
ruclips.net/user/TheKneesovertoesguy
His method incorporates training the stretched muscle under load, so although he's not particularly muscular, he is extremely strong. I believe this is why certain martial arts styles, (tied in with technique), can aid a smaller person to deal effectively with a bigger opponent.
Sorry I cannot help with the nerve issue.
great video defornately one i need to watch more than once, any books or textbooks anyone would recomend for learning more ?
Thank You so much information!!!
In conjunction with the proteome we need to consider the Glycome. Glycan Age are doing assessments on biological age.
55:35 What's the name of the study from 1981?
Greetings from France.
The home of the great Serge Nubret!
Wow 🤩 this is just awesome. Thanks for all your incredibly insightful videos. I recommend you to all my learners, hopefully you will start getting a strong Scottish following :)
Tremendous content!
space needle in Seattle?
Great presentation, thanks for that.
One question: Fiber-splitting sounds a lot like mitosis; is known what happens to the nucleii of the cell? Are all copied/the DNA-content of each replicated? Are they spread between both cells and further nucleii formed thereafter?
Part 2?
@andygalpin when are you uploading part 3 😂
Great content! Could I use parts of your lecture for a video? i'll give you credits
Great video! Is it just me or is the audio a little low ?
It's not that it's low, it's just not really clear. I love his videos, but I have to focus so hard to hear him properly, especially when a video is this long.
@@4lifescape1 Personally experienced zero issues.
@@4lifescape1 Part of it is mic. Part is low-volume-emphasis, or conclusion, vocal style.
Like in music when a bridge ascends, followed by resolving it when returning to the chorus. Brits do it a lot.
Space Needle....I get it! LOL!
Born in Seattle, I liked it when it showed up.
Well, thank you sir, really really thank you very much!!
Never have I clicked so fast
Same
My only question is.... which 6 assholes gave this a thumbsdown? Thank you, Dr Galpin!!
Love your videos and content, but you really need to update your audio quality. When you were on Dr Huberman's podcast it is 100x easier to listen and understand you...
for anyone interested in seeing the results of sarcoplasmic hypertrophy, go look at Coach Patrick Tuor's athletes on IG.
Why this increase in strength without adding muscle volume could not be a neuromuscular adaptation. That way you would not feel obligated to give some merit to the very unstable sarcoplasmic hypertrophy narrative? or am I too wrong XD
How can the body be 40% muscle, 50% water and 10% other if the muscle itself is largely composed of water?
Lol Space Needle
thanks bo$$
I went to my Master's to study muscle physiology and I ended up studying brain physiology 😅😅
Space Needle
Space needle har har :) Also appreciating the joke about 900 views!
Space Needle I got it 😃
You asked for 3 things I learnt ...
Interesting fact 1: there are people in the world who are prepared to give their knowledge for free.
Interesting fact 2. There are people who are very grateful for this knowledge
Interesting fact 3. Fact 1 plus fast 2 = a better world. Your contribution is very much appreciated.
Came to this via Huberman interview. Thank you both for the inspiration.
Thank you.
leaving a timestamp for later 25:23
SPACE NEEDLE
Chet Holmgren better be watching this.
It’s never 55 minutes but I will let it slide
Hope you got Over that case of gainz that was affecting your voice 😂