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New Science of Muscle Hypertrophy - Part 1, Physiology: 55 Min Phys

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  • Опубликовано: 22 ноя 2020
  • For all of you muscle nerds out there, I cover the latest science on:
    1. How much muscle grows
    2. Is the growth uniform across the muscle?
    3. Show you ACTUAL elite athlete muscle fibers
    4. Sliding filament theory
    5. Myofiber lengthening
    6. Myofiber splitting & hyperplasia
    7. Myofiber growth
    8. Bodybuilder vs. powerlifter muscle growth
    9. Sarcoplasmic hypertrophy
    10. Include a special challenge.....
    In Part 2 of this 3 Part series, I'll cover "What & How To Cause Muscle Hypertrophy".
    ◾ I'd appreciate support on patreon: / andygalpin
    ◾ More information at: www.andygalpin....
    ◾ Instagram: @drandygalpin
    ◾ Twitter: @drandygalpin

Комментарии • 135

  • @hubermanlab
    @hubermanlab 3 года назад +434

    What an impressively thorough and mechanistic description this video is!

    • @asifsays9849
      @asifsays9849 3 года назад +33

      RUclips algorithms suck eggs I have never been suggested these videos. Thanks for pointing these videos out.

    • @kristiyan2073
      @kristiyan2073 3 года назад +14

      Mr. Huberman is watching Dr. Galpin? How cool is that!

    • @ss_GOAT
      @ss_GOAT 3 года назад +4

      Andrew, my brother. Your videos are the best.. Thanks for recommending us to this channel.

    • @blazayblazay8888
      @blazayblazay8888 3 года назад +4

      OK THIS IS ENOUGH FOR ME NOW I’M SUBSCRIBING

    • @billytheweasel
      @billytheweasel 3 года назад +3

      Real gratitude for tipping me to Dr Galpin. I suspect you know Dr Bill Hare and wish I could ask you.

  • @Canonall
    @Canonall 3 года назад +7

    Criminally underrated channel

  • @PrimeMatt
    @PrimeMatt 3 года назад +39

    An 81 minute, "55 minute" tutorial, maybe there is some good in the universe? 🙌🏼

  • @mattreinecke4399
    @mattreinecke4399 Месяц назад +1

    Hello from Italy! Starting to watch your older stuff after seeing you around at all the top podcasts.
    Everything is so well explained. This is a wonderful resource.
    One correction. While his paper was in German, Morpurgo was Italian. He was a professor at the Università di Siena.

  • @Lane_Narrows
    @Lane_Narrows 8 месяцев назад +2

    Love your long form videos. I'm and exercise phys grad student and I listen to your videos on repeat while I'm riding the indoor trainer.

  • @mrbournemouth1
    @mrbournemouth1 3 года назад +11

    He’s back!

  • @adamcatto3109
    @adamcatto3109 3 года назад +3

    There wasn’t a ton of *space* in between all the great explanations to make that *needle* joke, but I’m glad a Washington guy like yourself was able to make room for it

  • @ryanfollweiler691
    @ryanfollweiler691 3 года назад +12

    My brain is exhausted, but awesome video!!! I’m a little confused with what proteins are growing if contractile fibers are not growing. I’ll have to rewatch

  • @billytheweasel
    @billytheweasel 3 года назад +3

    People that skipped vid one shorted themselves. This is exactly what I've been searching out for 8 years.
    I wish YT had suggested this channel long ago. It took Dr Huberman's tip who also should have been suggest to me on his 1st vid.

    • @a_woman_who_loves_to_lift
      @a_woman_who_loves_to_lift 5 месяцев назад

      Same here. I had to search specifically for this video. I learn best from Dr. Galpin over the other RUclips muscle influencers.

  • @Masleus
    @Masleus 3 года назад +3

    Andrew Huberman and Costello brought me here. Thank you,Dr. Galpin, for your work.

  • @justinmabe3077
    @justinmabe3077 3 года назад +3

    Great work! I am going to share this with the students at my institution. You explained everything in far greater depth than I ever could and with better visuals!

  • @marketissupreme229
    @marketissupreme229 3 года назад +7

    When watching other RUclipsrs video: I watched 3 min out of 10
    But for Andy's video, I can't skip a beat. Love from India man, the way you explain is brilliant🔥

  • @coachpaul-vedicfitness
    @coachpaul-vedicfitness 3 года назад +5

    Thank you from the bottom of my heart for taking the time to make such well done educational videos Andy.

  • @edmundomiranda2259
    @edmundomiranda2259 7 месяцев назад +1

    Thank you for providing complex scientific knowledge on muscle physiology in a more graphical, illustrated, and simplified way. One comment and question: Satellite cells are stem cells so that they can become new muscle fibers (adding new cells, aka hyperplasia), so that it appears that, to some extend, under damage or injury of muscle fibers there is hyperplasia (a place we do not want to get under optimal progressive loads), so that an hypothesis could be that hyperplasia of muscle fibers is restricted as a mechanism of tissue repair from significant damage or injury. However, is valid to distinguish between new muscle fibers from satellite cells versus mitosis of actual muscle fibers. ;-)

  • @philippjochem6308
    @philippjochem6308 Год назад +2

    Thank you very much, Dr. Andy Galpin, for sharing this valuable knowledge.

  • @bluntforcetanya
    @bluntforcetanya 3 года назад +3

    Omgggg seeing the actual fibers outside the body was so cool!!!!

  • @pickyvanilla
    @pickyvanilla 11 месяцев назад +2

    This is so helpful!
    Thank you so much for sharing knowledge! 😊

  • @Persepolis8564
    @Persepolis8564 7 месяцев назад +1

    Your channel should have millions of subscribers

  • @KarenWinna
    @KarenWinna 3 года назад +6

    Andy, your videos are incredible, I’ve been learning so much from you! I wish it was a live class so I could ask the millions of questions and thoughts I had!
    Here goes one: If heavy load hypertrophies myofibrils, resulting in the increase of their diameter and potentially more contractile, which would technically result in greater strength, how come some people are really strong but not big in size at all? The opposite may be explained by the sarcoplasmic hypertrophy but what about the opposite? Purely neurological adaptations? Thanks and looking forward to videos # 2 and 3!!!!!

  • @2299fabio
    @2299fabio 3 года назад +1

    First of all thank you for this amazing video, amazing content and always for free.
    What impressed me most about all of this, is to finally know the truth about hyperplasia, fiber splitting etc. and then also to see it in a different point of view, that is the myofibular way. That's whats impressed me most, going through all levels from macroscopic to ultrastructural and trying to see whats is happening there and to know from where does hypertrophy come. I'm looking forward to jumping to the other videos thanks Andy :))

  • @ekiboi5746
    @ekiboi5746 3 года назад +2

    Holy smokes, this was a brilliant video! Just recently found your channel via my friend who shared this video, at the first glimpse your channel's content looks great! As an enthusiastic exercise physiology science reader and coach there was a lot new things and studies I learned through this and above them all, new info about muscle fiber hyperplasia, real thing or not. I've always used term muscle hypertrophy a lot, but haven't really known all the things it holds inside. So this really widened my view and next I'll head to those referenced studies and your other videos. Thank you!!

  • @SnakeC666
    @SnakeC666 3 года назад +10

    Huge load of information. Thank you Andy!

  • @capthtz
    @capthtz 3 года назад +10

    Joke laughter coefficient is negatively correlated to the duration of the pandemic. Otherwise, the information provided is phenomenal. Thanks for breaking this down so dummies like me can learn this stuff.

  • @fullaffectfitness5070
    @fullaffectfitness5070 3 года назад +1

    Phenominal. Absolutely incredible the detail and extent of explanation in this video. Loved it, especially the discussion on the sources and levels that actually cause the increase in muscle growth!

  • @JustinSnyder-tb1dg
    @JustinSnyder-tb1dg 6 месяцев назад

    I love these videos. Thanks for sharing your knowledge and the science of exercise with us. I was going to volunteer to come in for a muscle biopsy until I saw you got your needle from Seattle. I don't have nearly large enough muscles for that. You could likely fit my entire body in the Space that that Needle occupies. :)

  • @christianpombo7761
    @christianpombo7761 3 года назад +2

    men iloveyour content. but i suggest maybe u change ur title. make it cache so people in fitness industry will get in this channel easily but overall your so so so great man, thankyou for sharing such incridble information

  • @jnolife-2ndSite
    @jnolife-2ndSite Год назад

    this serious does not have enough views for the amount of important information it delivers. so many younbg guys training who should watch this. ill recommend these to everyone interested in bodybuilding

  • @daliborpetkovic8606
    @daliborpetkovic8606 9 месяцев назад

    Svaka čast majstore, world needs more people like Andy

  • @jeremybeyer4268
    @jeremybeyer4268 3 года назад +2

    Unreal. This is phenomenal!

  • @eminems99
    @eminems99 3 года назад +2

    Andy you are amazing M8. Thanks for sharing such great information.

  • @RedApple-jv4sx
    @RedApple-jv4sx 2 месяца назад

    Such a hidden gem that should be the largest gem in the entire world

  • @InfinityHardware77
    @InfinityHardware77 3 года назад +1

    Amazing stuff, looking forward to the rest of the series, thanks Andy

  • @Denny_7782
    @Denny_7782 3 года назад

    Dr. Andy Galpin said it, so I hope im right lol.I saw the seattle space needle for the graphic of the muscle biopsy. I get points!

  • @healthyyou9887
    @healthyyou9887 3 года назад +3

    Thanks doc..❤️

  • @in8guru
    @in8guru 5 месяцев назад

    Great talk thanks Dr Galpin. I'm onto the next one 🥇

  • @MarcJMusic
    @MarcJMusic Год назад

    Why why WHY does this channel only have 55k subscribers??? Madness!

  • @nathancarter6311
    @nathancarter6311 9 месяцев назад

    Wow after watching your Huberman 6 part series. I thought you were some super serious science dude.
    But hearing you crack jokes and have fun with your explanations is a welcome surprise haha

  • @bortbenxley6880
    @bortbenxley6880 3 года назад

    Thanks Doc! Really looking forward to the rest of this series and the updates to come!

  • @patrickdeininger5725
    @patrickdeininger5725 3 года назад +1

    Thank you for this video. Well explained.

  • @maryannmadulid9408
    @maryannmadulid9408 Год назад

    I can only imagine how amazing it must be to be in one of your lectures.

  • @YIO777
    @YIO777 Год назад

    @Andy Galpin
    😂 the space needle

  • @aljosastropnik3314
    @aljosastropnik3314 3 года назад +1

    I never comment but this is amazing!

  • @neutron1251
    @neutron1251 3 года назад +3

    Greetings from France.

    • @billytheweasel
      @billytheweasel 3 года назад +1

      The home of the great Serge Nubret!

  • @pilarfernandezmartin7553
    @pilarfernandezmartin7553 3 года назад

    This was awesome! Maybe next level would be learning science from the coolest animation documentaries! Mil gracias doctor!!

  • @benjaminschnepf7362
    @benjaminschnepf7362 3 года назад +2

    Amazing to watch something like this for free.

  • @pchiethegreat1
    @pchiethegreat1 3 года назад

    No BS Exercise Science. I love it!

  • @mahdihabib8667
    @mahdihabib8667 3 года назад +1

    hight quality content .thanks dr.

  • @jeffreyseifer7729
    @jeffreyseifer7729 Год назад

    Great video! Would be great if you could link to the various resources in the description, plus links to part 2 and part 3. Would just make it easier. I also found a typo in one slide "Sarcoplasmic" is misspelled at 28:55. Loved seeing the actual biopsy of muscle fibers - that's just so cool! More of that stuff please!

  • @johnfrancis_kennedy
    @johnfrancis_kennedy 10 месяцев назад

    Great information. Thank you Andy! :)

  • @taylorholko7628
    @taylorholko7628 Год назад +1

    Love this video! Quick question: If the length of a muscle is finite (i.e. insertion and origin are set) then how can the sarcomeres lengthen? If a 10 cm long myofibril contains 10 sarcomeres, each sarcomere would be approx. 1 cm long. If we theoretically grew a new sarcomere wouldn't that then shorten the length of every other subsequent sarcomere?

  • @ilililililili563
    @ilililililili563 Год назад

    1:04:50 oh please get into it, i would love to hear that!

  • @peterbyers1033
    @peterbyers1033 3 года назад +1

    My only question is.... which 6 assholes gave this a thumbsdown? Thank you, Dr Galpin!!

  • @rajanikabeywickrama2426
    @rajanikabeywickrama2426 2 года назад

    So much information,
    Superb video...

  • @ati8153
    @ati8153 3 года назад

    Thank you. I love your videos. Keep em comin please

  • @oliverlopez9072
    @oliverlopez9072 3 года назад +1

    What are your thoughts of the phase of "microtears", is there a better 5min way of saying how muscle grows for client education?

  • @alanmorton5303
    @alanmorton5303 3 года назад +2

    Wow 🤩 this is just awesome. Thanks for all your incredibly insightful videos. I recommend you to all my learners, hopefully you will start getting a strong Scottish following :)

  • @NikhilBhat-cc2fm
    @NikhilBhat-cc2fm Год назад

    make a seperate video on Body types and appropriate training protocol, Ectomorph bone density, how to increase after 30's

  • @Denny_7782
    @Denny_7782 3 года назад

    Thank you for making these videos.

  • @vhughes13abs
    @vhughes13abs 2 года назад

    Appreciate your efforts. Love the science.

  • @user-ud7le2zl6s
    @user-ud7le2zl6s 8 месяцев назад

    How could we compare muscle growth on bones and vegetal growth from soil?

  • @bigbodymeech
    @bigbodymeech 11 месяцев назад

    thank you

  • @jeannedp9010
    @jeannedp9010 3 года назад +3

    Space Needle....I get it! LOL!

    • @billytheweasel
      @billytheweasel 3 года назад

      Born in Seattle, I liked it when it showed up.

  • @wdadwawdadawdwdwa4133
    @wdadwawdadawdwdwa4133 3 года назад +1

    "Dr. Andy, aren't you splitting hairs here?"
    "No, actually muscle fibers"

  • @brianfiori4610
    @brianfiori4610 2 года назад +2

    Space Needle

  • @maryannmadulid9408
    @maryannmadulid9408 Год назад

    Thank You so much information!!!

  • @anthonylawrence5842
    @anthonylawrence5842 3 года назад

    In conjunction with the proteome we need to consider the Glycome. Glycan Age are doing assessments on biological age.

  • @wyvern132
    @wyvern132 3 года назад +3

    Hi Dr. Galpin and anyone else reading, a point of confusion around 29:15 . The slides say 10% of proteins are for contraction, but then also say 70% are actin and myosin. Aren’t actin and myosin contractile proteins?
    Also, if 10% of proteins are for contraction and 40% are for metabolism, what is taking up the rest of the 50%?
    Thank you for reading

  • @corneliusparkin2401
    @corneliusparkin2401 Год назад

    Tremendous content!

  • @ferchemac180
    @ferchemac180 7 месяцев назад

    hello sir Andy, any new research on theories?

  • @benjaminbrown854
    @benjaminbrown854 Год назад

    Was it because you used the Seatle Space needle as if it were a needle? in the bicep around 13:40?

  • @nalcon1
    @nalcon1 3 года назад

    Excellent! Do you or your colleagues have videos on ligaments and tendons? I'm a layman of 66 years old and have nerve damage from trama attempting to understand the best approach to physical improvement of muscle, nerve, ligament and tendons health and performance. Thank you very much.
    Leo

    • @wetrupload9375
      @wetrupload9375 2 года назад

      Regarding tendon/ligaments, check out Ben Patrick, the Knees Over Toes Guy -
      ruclips.net/user/TheKneesovertoesguy
      His method incorporates training the stretched muscle under load, so although he's not particularly muscular, he is extremely strong. I believe this is why certain martial arts styles, (tied in with technique), can aid a smaller person to deal effectively with a bigger opponent.
      Sorry I cannot help with the nerve issue.

  • @kaisiddiqui2017
    @kaisiddiqui2017 3 года назад +3

    Lol Space Needle

  • @ttouittou
    @ttouittou 3 года назад +2

    Part 2?

  • @deanvargas3921
    @deanvargas3921 Год назад

    space needle in Seattle?

  • @johannbraun5480
    @johannbraun5480 3 года назад

    Well, thank you sir, really really thank you very much!!

  • @AndJusTIceForRob
    @AndJusTIceForRob Год назад

    7:30 so, hypertrophy training improves bone density more than strength training??

  • @patrickkelly885
    @patrickkelly885 3 года назад

    great video defornately one i need to watch more than once, any books or textbooks anyone would recomend for learning more ?

  • @Mindsetsandreps
    @Mindsetsandreps 3 года назад +4

    Never have I clicked so fast

  • @Luxumbra69
    @Luxumbra69 Год назад

    Love your videos and content, but you really need to update your audio quality. When you were on Dr Huberman's podcast it is 100x easier to listen and understand you...

  • @goodbuy7556
    @goodbuy7556 Год назад

    Why this increase in strength without adding muscle volume could not be a neuromuscular adaptation. That way you would not feel obligated to give some merit to the very unstable sarcoplasmic hypertrophy narrative? or am I too wrong XD

  • @SchmittsPeter
    @SchmittsPeter Год назад

    Great presentation, thanks for that.
    One question: Fiber-splitting sounds a lot like mitosis; is known what happens to the nucleii of the cell? Are all copied/the DNA-content of each replicated? Are they spread between both cells and further nucleii formed thereafter?

  • @DomFrancis88
    @DomFrancis88 3 года назад +2

    Great video! Is it just me or is the audio a little low ?

    • @4lifescape1
      @4lifescape1 3 года назад +2

      It's not that it's low, it's just not really clear. I love his videos, but I have to focus so hard to hear him properly, especially when a video is this long.

    • @fullaffectfitness5070
      @fullaffectfitness5070 3 года назад +1

      @@4lifescape1 Personally experienced zero issues.

    • @billytheweasel
      @billytheweasel 3 года назад

      @@4lifescape1 Part of it is mic. Part is low-volume-emphasis, or conclusion, vocal style.
      Like in music when a bridge ascends, followed by resolving it when returning to the chorus. Brits do it a lot.

  • @dh6072
    @dh6072 3 года назад +1

    thanks bo$$

  • @andrewstankus3507
    @andrewstankus3507 3 года назад +1

    How can the body be 40% muscle, 50% water and 10% other if the muscle itself is largely composed of water?

  • @fishisnotfishfish2267
    @fishisnotfishfish2267 3 года назад

    Do you need to feel Delayed onset muscle soreness or DOMS for the muscle to grow? That Is one of my big concerns 🤔😫🤷‍♂️

  • @britchie7224
    @britchie7224 2 года назад

    You asked for 3 things I learnt ...
    Interesting fact 1: there are people in the world who are prepared to give their knowledge for free.
    Interesting fact 2. There are people who are very grateful for this knowledge
    Interesting fact 3. Fact 1 plus fast 2 = a better world. Your contribution is very much appreciated.
    Came to this via Huberman interview. Thank you both for the inspiration.
    Thank you.

  • @modernwarriors7288
    @modernwarriors7288 3 года назад

    Great content! Could I use parts of your lecture for a video? i'll give you credits

  • @blazayblazay8888
    @blazayblazay8888 3 года назад +1

    SPACE NEEDLE

  • @georgekozma7530
    @georgekozma7530 3 года назад

    @andygalpin when are you uploading part 3 😂

  • @Jazzipurr
    @Jazzipurr 3 года назад

    At 12:46, is there a special article that you’re referring to?

  • @sorenlindberg8816
    @sorenlindberg8816 3 года назад

    for anyone interested in seeing the results of sarcoplasmic hypertrophy, go look at Coach Patrick Tuor's athletes on IG.

  • @CoachKolton
    @CoachKolton 3 года назад

    How do satellite cells relate in all of these?

  • @kevinwieninger8608
    @kevinwieninger8608 3 года назад

    55:35 What's the name of the study from 1981?

  • @timrizzo3941
    @timrizzo3941 10 месяцев назад

    Space needle har har :) Also appreciating the joke about 900 views!

  • @marcelocoip7275
    @marcelocoip7275 Год назад

    Space Needle I got it 😃

  • @rodrigovsbastos
    @rodrigovsbastos 3 года назад

    Top

  • @iamdivyansh
    @iamdivyansh 3 года назад

    leaving a timestamp for later 25:23

  • @mrtopramen
    @mrtopramen 3 года назад

    I recognize those fibers, those are obviously from Thor.

  • @maozeduck6164
    @maozeduck6164 3 года назад

    I went to my Master's to study muscle physiology and I ended up studying brain physiology 😅😅

  • @zvonimirbrekalo1291
    @zvonimirbrekalo1291 2 года назад

    Chet Holmgren better be watching this.