Hey, great lecture. I use a lot of your resources and find them super helpful! I did have a quick question though - why does adding a depolarising muscle relaxant antagonise the effect of phase 2 and NDMR action?
Hi Josh, Sorry for the slow reply. Here is my take: -In phase 1 block due to suxamethonium, addition of more sux will augment blockade or cause phase 2 block (i.e. what I wrote in the video was a mistake) -The presence of rocuronium will impair the action of suxamethonium due to receptor occupancy -I don't know what the presence of suxamethonium means for the action of rocuronium. I've looked it up just now and I can't find a reference. However, I would anticipate antagonism owing to a) their opposite mechanisms of causing paralysis b) their competition for binding sites I hope that makes sense. Please let me know if you have evidence to the contrary. I'm hoping to touch up this video in a few months' time. Stuart
Anesthesiology resident here.
Thanks a lot, really helpful!
Really good videos please do continue!!
You should make more videos. Very helpful
Thanks. I'm hoping to make more of them once I finish the final exam.
@@ketaminenightmares403 good luck in your exams
Hey, great lecture. I use a lot of your resources and find them super helpful!
I did have a quick question though - why does adding a depolarising muscle relaxant antagonise the effect of phase 2 and NDMR action?
Hi Josh,
Sorry for the slow reply.
Here is my take:
-In phase 1 block due to suxamethonium, addition of more sux will augment blockade or cause phase 2 block (i.e. what I wrote in the video was a mistake)
-The presence of rocuronium will impair the action of suxamethonium due to receptor occupancy
-I don't know what the presence of suxamethonium means for the action of rocuronium. I've looked it up just now and I can't find a reference. However, I would anticipate antagonism owing to a) their opposite mechanisms of causing paralysis b) their competition for binding sites
I hope that makes sense. Please let me know if you have evidence to the contrary.
I'm hoping to touch up this video in a few months' time.
Stuart
Great explanation thank you so much