Видео

the way i imagine it with higher cardiac output being a factor of slower emergence (at least for inhalational agent) is due to a much shorter transit time during which agent is able to exude from plasma into alveoli and breathe out by the patients. the opposite is true with induction.

3:45 this is beautiful, if replace Q(Flow) with Pressure divided by Resistance, you will get t = V x R / P, and V / P is compliance, so you will get t = compliance x resistance

2:49 the exponential decay is not a flip upside down, but the exponential(runaway ) function on the left if the y aixs, ie. flip horizontally

Great explanation thank you so much

appreciate, your video solved my confusion for the English reading of the time of blood-brain equilibration.

Serial brain biopsy had me burst into laughter 😁😁👌👌

1:35 An astute viewer pointed out that the values or description in table 2.1 must be incorrect. Plasma concentration of 127mcg/mL (= 127mg/L) is indeed ~60x the hypnotic concnetration of propofol, ~2mcg/mL. Clearly, it cannot be 2^8mcg/mL.

Thank you sir for your patiently and carefully explain, could you kindly tell me how we draw the isobologram by computer?

Thank you

Thank you. What's the source of the depicted answers ? They look good for revision.

A decrease in pH of 1 isn’t a 10 fold increase in H+? (excellent video by the way!!)

Thanx ❤

An astute viewer picked me up on an error. After some further digging: -Standard deviation of MAC is said to be 10%. If a normal distribution applies, then at 1.3 MAC 99.7% (not 95%) of the population will be immobile. -Be mindful that 10% is a ball-park figure; it turns out standard deviation of MAC varies between drugs, from as low as 2% to as high as 20%. -The main thing to appreciate is that the variability in the concentration required to produce immobility is quite low for the volatile anaesthetics in comparison with propofol. Thanks and happy studying -Stuart

love your use of satire :') thanks for the insightful discussions, Doctor!

the only useful thing i got from this video was the book the lecturer kept referencing to

ruclips.net/video/NKKKCnhJULk/видео.html Anesthetic considerations in traumatic brain injury

I'm not a medical professional but remember a very interesting time in my 20s working in a very busy OD in London...and maybe hadn't the courage or means to push on...you h have excellent delivery and clear love for the subject...jeez inhalation gases..effective but hard to measure ...a few puffs of ether would probably suffice less than 100 years ago..the PK/PD profiles of these drugs seem to be specific to a point....I guess there is a lot of presumption about these issues..Keep experimenting..

Whats's the formula to calculate concentration on site effect (biophase) having Cp, ke0 and t values?

Correction: ketamine's t1/2ke0 is 3.5 minutes, not 0.5 minutes (Source: Miller's Anesthesia)

I must be stupid coz im having a hard time here

0:22 N.B.: Vdc should be 0.3L/kg

Hey, great lecture. I use a lot of your resources and find them super helpful! I did have a quick question though - why does adding a depolarising muscle relaxant antagonise the effect of phase 2 and NDMR action?

Very nice , brief and helpful. Thanks

Thank you, this is so helpful! You explained it so well. Serial brain biopsy xD

Please keep the videos coming, contextual learning is really really useful and these are really well done

I am one of your biggest fans. Excelent presentation!

My general recommended reading list: ketaminenightmares.com/pex/other/recommended/recommended_reading.htm Primer for the primary exam: primarydailylo.files.wordpress.com/2018/03/a-primer-for-the-primary-fanzca-examination-1.pdf Steven Shafer - the biophase: web.stanford.edu/~sshafer/LECTURES.DIR/Notes/Biophase%20in%20Anesthesia.doc BJA education: academic.oup.com/bjaed/article/4/3/76/292148 academic.oup.com/bjaed/article/16/3/92/2897754 Textbooks: -Pharmacology for Anaesthesia and Intensive Care (Peck and Hill) -Pharmacology and Physiology for Anaesthesia (Hemmings and Egan) -Miller's Anaesthesia -Anesthetic pharmacology (Evers, Maze, Kharasch) -Gerry's Real World Guide to Pharmacokinetics and other things (Gerald Woerlee)

Thanks for your excellent videos!! they really helped a lot and I look forward to more of them. Could you also post links of the web resources here? It's kind of hard to get to the hyperlink in the video Cheers

Really good videos please do continue!!

I am relatively new to the specialty (pre-exams so critiques welcome) but think about this kind of thing loads, currently my practice has been to use ketamine for paradoxical emergence around the time you would probably be starting the des. Then switch off the sevo and start nitrous at low flows so that they equilibrate around 0.6MAC. cruise the end of the procedure post stimulating parts on nitrous low flows with whatever opiates and ket I've got on board.

many thanks!

You should make more videos. Very helpful

Great vid! Thank you

Anesthesiology resident here. Thanks a lot, really helpful!

Thank you. It is awesome.

Excellent presentation and clear concepts but voice is not clear in some parts of presentation, please rectify it, otherwise extraordinary class

*That kind of standard diving dress as it is pressurised and soft would not prevent the bends, as a hard suit (i.e a one person submarine) would.

Is the Va:FRC ratio a simplification of the whole machine time constant which takes into account the volume of the circuit (FRC+circuit volume) and all flows (Minute ventilation + fresh gas flow) or are those seperate concepts?

Thanks bro

Awesome, awesome content. Pls keep the content coming

The biophase article by Steven Shafer: web.stanford.edu/~sshafer/LECTURES.DIR/Notes/Biophase%20in%20Anesthesia.doc

Dear viewer, If you found this video helpful, I suggest you also watch this one on the subject of MAC (minimum alveolar concentration). ruclips.net/video/mfrPC2b6OxU/видео.html Kind regards, Stuart

This is an excellent explanation of Keo, thank you!