helpful for non foot ball fans like few of us; I watch England foot ball so "No.18 is the referee who don't you out of the foot ball court during the game because no body can give him red card unless a LADA taxi come and give them lift! so number 18, refree BooooM, can afford LADA taxi "
You know for the visualization of Chediak-Higashi it also works if you make him a The White Knight Chediak-Higashi since it also causes partial albinism.
As an added bonus, Wiskott *ALL*-DRINK syndrome shows it affects both T and B cell lines (IgG) therefore causing the pt to get all infections (viral, bacterial and fungal). Great video, as always.
Thanks for the mnemonics! I have one for LAD that helped me remember - "LADs must be 18 to Integrate" LAD - Leukocyte Adhesion Deficiency Must be 18 - CD18 Integrate - CD18 is an "integrin" that is necessary for migration
"fungus went up your ass? throw some hydrogen peroxide at it" ---I don't think I've ever laughed that hard and not to mention I will never forget the enzyme again. ty ur videos are AMAZING.
Hey! Took step 1 today i get home and see this. I got 2 questions on CGD, one Bruton's and leukocyte adhesion which was baby who umbilicus doesn't fall off. Quick tip: study PARASITES!!!! who said they were low yield. Btw great videos guys... keep it up
No joke just finished this video and on a random UWorld block, first question is on CGD. Had to pause the block to laugh for a good 2 minutes. Great video!
A in WATER could also stand for "actin" because the WAS gene mutation leads to leukocytes/platelets being unable to reorganize their actin cytoskeleton --> ineffective APC function. Also thinking of it as Wisxott rather than Wiskott as it is X-linked recessive!
Correct me if Im wrong, as for the CGD The nitro blue test Positive = patient have super oxide therefore patient is free from the disease Negative = patient has the disease as the nitroblue remains blue! I think you may have confused us on the positive and negative. Patient has CGD if the test is NEGATIVE not as mentioned in ur video. Do check wiki or correct me if I'm wrong
Not quite! NBT is a colorless dye by itself. He clarifies this in the errata (pinned as the top comment). DirtyUSMLE wrote that the NBT is backwards as per the vid! Here's how it should be: Normal (positive) = turns from clear to BLUE (neutrophils can turn the dye blue because NADPH oxidase is present). In Chronic Granulomatous disease, it's Abnormal (Negative) = No color (indicates that there's No NADPH oxidase). No color = No NADPH Oxidase present Hope this helps!
Hi, your videos are amazing + life saver!! For future video topics, could you possibly do them on these: 1) antibiotics overview = when to use which + high yield side effects 2) cardiovascular drugs 3) Dermatology stuff (eg papules/macules etc...) = relevant for step 1 4) GI patho
Actually, in CGD the Nitroblue tetrazolium, if it’s positive meaning it turn blue the patient doesn’t have the disease. In the other hand, if it’s negative don’t turn blue the patient will have the disease. So in exam if they say the test is negative it means they have the disease.
This content and your amazing efforts to make everyone understand this ...are grreatttt ....thank you for teaching such helpful and important information
LAD is a disease with no migration, at age 18 you supose yo migrate from house (CD18), so you stay in home like a baby more time that supose (late umbilicak cord separation). Like if thist helps you
I just came across your post. My prayers are with you. May The Almighty place him among the highest ranks in Paradise and may you and your family be blessed with the strength to bear this loss and emerge from it stronger.
Does the hydrogen peroxide come from the infective organism in catalase negative infections? In CGD they can’t make it themselves right? Awesome video thank you!
I’m finding the pathophysiology of the infection process difficult to understand, like when does Th17 come into effect and how does it lead to Th1 or Th2? I think a lot of text books and stuff teach each part of immunology like T and B cell separate, then antibodies, then complements etc. but nothing tries to explain the whole process as a whole. I’ve gone through First Aid and General Principles Immunology section and I still don’t understand how everything is co-ordinated…
@@DirtyMedicine Thanks a lot for ur reply ! You could include the Cells that are defective ( eg B ,T or Both) , the organisms that cause infections in these , like some have viruses / fungi and other bacteria ! Just more details in an easy way. This is wonderful ,but just found it a bit concise. Thanks a ton & loads of love for ur vids :)
Leukocyte adhesion deficiency can be triggered by vaccine or infection disease such Varicella, Ebv or Citomegalovirus? Can, in the case of chronic illness such celiac disease, someone has a normal neutrophil count while having eosinophilia ? ( Cd 56 marker highly oresent in my gut flora with no cd18/19.. Thanks
Yaniv Hadi I read on wikipedia that it has “lymphoma-like syndrome, in which defective white blood cells divide uncontrollably and invade many of the body's organs. The accelerated phase is associated with fever, episodes of abnormal bleeding, overwhelming infections, and organ failure” but the histiocytosis part eludes me
Errata:
The NBT test is backwards.
15:45 I spelled Peyton wrong. My bad, Peyton!
DirtyUSMLE videos on dermatology cases plz
PLEASE ACCEPT MY DEEPEST THANKS ❤❤🙏🙏🙏
Thank goodness for the note, trying to figure out the NBT was some serious Stroop-effect shit.
I remember CD18 by thinking you're supposed to move out when you turn 18. There's a deficiency, and the neutrophils can't "move out" into the tissues.
Charla King also, you’re no longer a LAD at 18
helpful for non foot ball fans like few of us; I watch England foot ball so "No.18 is the referee who don't you out of the foot ball court during the game because no body can give him red card unless a LADA taxi come and give them lift! so number 18, refree BooooM, can afford LADA taxi "
I like that - parents "cut the cord" when their kid turns 18.
So good
I like to think you need to be 18 to get a sticker for voting and you need CD18 for leukocytes to STICK
You know for the visualization of Chediak-Higashi it also works if you make him a The White Knight Chediak-Higashi since it also causes partial albinism.
love it
Or the O could have been for oculocutaneous albinism, while the P would have been for phagolysosome
He's fighting White Walkers
A ched who is a white knight
Racial…I love it ☠️
As an added bonus, Wiskott *ALL*-DRINK syndrome shows it affects both T and B cell lines (IgG) therefore causing the pt to get all infections (viral, bacterial and fungal).
Great video, as always.
I love it! Thank you so much.
I also use the " A and E" in the WATER mnemonic to remember that there is increased IgA and IgE in Wiskott
Thanks for the mnemonics!
I have one for LAD that helped me remember - "LADs must be 18 to Integrate"
LAD - Leukocyte Adhesion Deficiency
Must be 18 - CD18
Integrate - CD18 is an "integrin" that is necessary for migration
the comments section is ALMOST as good as your videos. Bless your heart Dirty
"fungus went up your ass? throw some hydrogen peroxide at it" ---I don't think I've ever laughed that hard and not to mention I will never forget the enzyme again. ty ur videos are AMAZING.
Me too! I’m still cracking up 😂
Just a regular Tuesday for me...
Hey! Took step 1 today i get home and see this. I got 2 questions on CGD, one Bruton's and leukocyte adhesion which was baby who umbilicus doesn't fall off. Quick tip: study PARASITES!!!! who said they were low yield. Btw great videos guys... keep it up
wow congrats.what other HY systems
How was GIT?
Hello
Did you get usmle 1&2 passed?
No joke just finished this video and on a random UWorld block, first question is on CGD. Had to pause the block to laugh for a good 2 minutes. Great video!
YAY!! I requested this one a little while back. Thank you, thank you, thank you!!
A in WATER could also stand for "actin" because the WAS gene mutation leads to leukocytes/platelets being unable to reorganize their actin cytoskeleton --> ineffective APC function. Also thinking of it as Wisxott rather than Wiskott as it is X-linked recessive!
Wiskott for wisky ..drinking "Ethyl Alcohol "= increase in IgE and IgA
works in the wAtEr mnemonic too. But water is less fun...
@@bretw4754 nice
idk who you are or how you have the time to make these videos but you are my HERO
can you make a video about the upper/lower extremity nerve stuff?
Correct me if Im wrong, as for the CGD
The nitro blue test
Positive = patient have super oxide therefore patient is free from the disease
Negative = patient has the disease as the nitroblue remains blue!
I think you may have confused us on the positive and negative. Patient has CGD if the test is NEGATIVE not as mentioned in ur video. Do check wiki or correct me if I'm wrong
Not quite! NBT is a colorless dye by itself. He clarifies this in the errata (pinned as the top comment). DirtyUSMLE wrote that the NBT is backwards as per the vid!
Here's how it should be:
Normal (positive) = turns from clear to BLUE (neutrophils can turn the dye blue because NADPH oxidase is present).
In Chronic Granulomatous disease, it's Abnormal (Negative) = No color (indicates that there's No NADPH oxidase). No color = No NADPH Oxidase present
Hope this helps!
Hi, your videos are amazing + life saver!!
For future video topics, could you possibly do them on these:
1) antibiotics overview = when to use which + high yield side effects
2) cardiovascular drugs
3) Dermatology stuff (eg papules/macules etc...) = relevant for step 1
4) GI patho
Actually, in CGD the Nitroblue tetrazolium, if it’s positive meaning it turn blue the patient doesn’t have the disease. In the other hand, if it’s negative don’t turn blue the patient will have the disease.
So in exam if they say the test is negative it means they have the disease.
Yes , you are correct
correct. Negative NTB test means the person is lacking NADPH oxidase
Yes you are correct.. I hope he makes correction as I observed it immediately.
I seriously love this channel
You are so clever in how to be adhesive with informations you learn.
Your videos are way better than sketchy path
sketchy path is ass and it is way too damn long so I agree 100%
I used "Leukocyte EIGHTEESHIN deficiency". Thanks for the banger as always
CD18 can be remembered as "I ate $hit because I couldn't stop" where "I ate" = 18 and "couldn't stop" refers to adhesion issues
I love you in and out. Thank you so much for your work.
extremely helpful mneumonics! Please make more of these videos for diseases.
Amazing explanation!!! My goodness sooooo glad I found you guys 🙏🏽🙌🏼
I've loved your videos for years. Huge fan. Will be sure to donate later today!
Thanks Sir....
Please videos on Musculo nerve injuries & All Formula videos of book & Imp Graphs video Thanks
Thank you for this. So glad i found it
Thanks so much doctor,,, ur videos are the videos I needed to make A's... Good bless u abundantly
This content and your amazing efforts to make everyone understand this ...are grreatttt ....thank you for teaching such helpful and important information
he shot the Menke, *WASP*, and G6P... got your XLR song stuck in my head haha
Amazing mnemonics! Great work
I keep watching and rewatching these 😍
LAD is a disease with no migration, at age 18 you supose yo migrate from house (CD18), so you stay in home like a baby more time that supose (late umbilicak cord separation). Like if thist helps you
Thanks because I won't remember that football player LOL
thank u so much , ur videos are really helpful , can u consider to make avideo for embryologic derivatives , thanks
nermeen kolta yessss
Why did you remove your line weaver plot video? I liked it and it was really helpful
Great video as are all your other ones! For the CGD mnemonic, what about naDph oxidase deficiency?
My Son died from CGD in 99 at 6 1/2 years old.
I just came across your post. My prayers are with you. May The Almighty place him among the highest ranks in Paradise and may you and your family be blessed with the strength to bear this loss and emerge from it stronger.
vitamins vitamins vitamins please please please
thank you a lot!!!!!!!
Thanks a ton😄
You are amazing.
A video on inheritance patterns calculations pls
i just got 5 question about it in my last NBME
thanks
sir please make a pdf or slides of your video so make easy to revise in last time of exam
Never thought Podrick from GOT would teach me immunology
Its helpful. Thanks !
YOu inspire me! I wanna be like you!!
You may think of bruno fernandes no 18 for Leukocyte Adhesion Deficiency ☺️☺️☺️
Great tutorial!
Thank you so much Sir 🙏
Could NOT have had better timing! *clutch*
thank you! so helpful :)
for step2 i am seeing Dihydrorhodamine Test being asked for CGD!! just wanted to share
Thank you so much:)
This is amazing!
Thank you!
Does the hydrogen peroxide come from the infective organism in catalase negative infections? In CGD they can’t make it themselves right? Awesome video thank you!
Yes this is correct. Our immune systems hijack the native Hydrogen Peroxide in the virulent organism
Thanks!
Thank you
Very helpful
I’m finding the pathophysiology of the infection process difficult to understand, like when does Th17 come into effect and how does it lead to Th1 or Th2? I think a lot of text books and stuff teach each part of immunology like T and B cell separate, then antibodies, then complements etc. but nothing tries to explain the whole process as a whole. I’ve gone through First Aid and General Principles Immunology section and I still don’t understand how everything is co-ordinated…
Very clear
Vitamins please I beg of you
Rachel Slack pllesssseeee
Love ur work ! But this could have been more detailed and better . Many points are missing out....
What would you have liked to be included that wasn't? Remember that my primary audience is medical students
@@DirtyMedicine Thanks a lot for ur reply ! You could include the Cells that are defective ( eg B ,T or Both) , the organisms that cause infections in these , like some have viruses / fungi and other bacteria ! Just more details in an easy way. This is wonderful ,but just found it a bit concise. Thanks a ton & loads of love for ur vids :)
Awesome!
Electrolytes, nutrition, and vitamins
can you make a video on electrolyte imbalance? please pplease please
If you can't remember Peyton Manning - CD18 because your umbilical cord is so late falling off that you're 18 years old by the time it does
Hello.do u have a video about step 2 ck preparation?or could u give some advice regarding preparation.thank u.
Correct me if im wrng, but wasnt the purported dysfunction of microtubules proven as incorrect through further research?
you are amazing
LAD could also cause due to lack of LFA-1 in C3bi receptor.??
Leukocyte adhesion deficiency can be triggered by vaccine or infection disease such Varicella, Ebv or Citomegalovirus?
Can, in the case of chronic illness such celiac disease, someone has a normal neutrophil count while having eosinophilia ? ( Cd 56 marker highly oresent in my gut flora with no cd18/19.. Thanks
you have both lymphhistioCYTOSIS and panCYTOPENIA? :O
Yaniv Hadi I read on wikipedia that it has “lymphoma-like syndrome, in which defective white blood cells divide uncontrollably and invade many of the body's organs. The accelerated phase is associated with fever, episodes of abnormal bleeding, overwhelming infections, and organ failure” but the histiocytosis part eludes me
Hey dirty whr r u mo updates no recent uploads why dear mentor
OK, so now I know some awesome mnemonics, but if somebody asks me how any of the syndromes works, I still can't explain.
Awsm
Nice
Hope that I can pass the exam
Geniussss
awsome
Virat Kohli - Indian cricketer also has 18 number
I love you❤
yessssssss!
duro
Guys - donate if you can. I donated $25. Let’s all chip in - student loans or not.
Hey what happened to your ovarian tumor video? I had that bookmarked to watch FML
still live. not sure what youre talking about my friend
"fungus goes up your ass" hahahahahaha
👍👍👍
i love you
love from pakistan
boss
Ohhh dirty Reall Brilliant (Rb) lol lol thanks
o7