If the NH2 is protonated first like it mentions in the annotation at 8:13 then at what following step would you have an irreversible reaction? Because then you end up with NH3 instead of NH2 floating around to deprotonate the remaining OH group
How is it possible that leaving group of NH3 is not protoneted by excess of strong acid? Why not H2O is taking the proton from molecule after leaving the NH3 group?
In case of base catalysed rexn... hydroxide ion is better leaving group than amide ion so shouldn't hydroxide ion leave?
When do we specifically need to do acidic hydrolysis or how can we distinguish that either we should opt acidic hydrolysis or basic hydrolysis
If the NH2 is protonated first like it mentions in the annotation at 8:13 then at what following step would you have an irreversible reaction? Because then you end up with NH3 instead of NH2 floating around to deprotonate the remaining OH group
Can you use water as the base to take the proton in the acid hydrolysis?
How is it possible that leaving group of NH3 is not protoneted by excess of strong acid? Why not H2O is taking the proton from molecule after leaving the NH3 group?
nvm, thanks for the videos too God bless you
hello sir....please tell me that when NaNH2 react with isobutane then which product will be obtain
Acid catalysts reform in these reactions ?
Is the addition of H2O to base reaction necessary?
which condition is preferred?
acidic or basic?
acidic one
Why acid base reaction is not preferred here in basic hydrolysis?
Thank you❤❤❤
thanks. very helpful
am I missing where the H3O+ is regenerated or is it not a true catalysis
+KessaWitdaFro yea check 2:37 that's where the acid is generated
+Sk Khan Oh I totally missed that. Thank you!
where did the NH3 functioning as base come from
Oh, God! Why doesn't sodium ion from sodium hydroxide react with a carboxylic acid ion? It would make no sense to protonate it at that rate.
I don't get it. Why does NH2 leave? NH2 is a very bad leaving group...? Why do we have to make here an exception?
that's why you heat it, and you add proton to make it a good leaving group.plus, amides are more reactive than carboxylic acids
@@des6309 but in the basic medium NH2- ion leaves first and then accepts a proton from carboxylate group .the yield must be too low??
@@des6309 No, they are not. amides are the least reactive in the carboxylic acid hierarchy of +3 oxidation states
so complicated...
buzzing like bees plz try to speak clearly