[TALK 14] Analytical Ultracentrifugation - Stephen McLaughlin

Analytical Ultracentrifugation
Speaker: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK
2024 Introduction to Biophysical Techniques
The LMB Biophysics Facility houses a wide range of state-of-the-art and in-house built instruments that enable the molecular characterisation of macromolecular size, shape, mass, stability, binding affinity, dynamics and interaction kinetics.
The facility is primarily intended for hands-on research by students, postdocs, and group leaders, who prepare samples and make measurements. Biophysics supports users in advice on experimental techniques and results, training and in collaborative research.
In this video Stephen explains the physical principles that underlie analytical ultracentrifugation (AUC). He describes the different types of experiment, detection systems, sample requirements and how data is analysed to investigate the mass, shape and interactions of sedimenting particles. He gives examples of how AUC has been employed in a variety of projects at the LMB. In addition, he shows how recent methods have been applied to the analysis of glycoproteins and membrane proteins.
The Biophysics Facility is headed by Stephen McLaughlin, supported by Chris Johnson and Chris Batters.
Read more about the facility here: www2.mrc-lmb.c...
You can find more videos from the LMB 2024 Biophysics Techniques Lecture series here: • Biophysical Techniques...
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