Type IV Hypersensitivity

[@kipling1957]

This only part of the story. There is another type IV hypersensitivity subtype that does not involve T-helper cells (CD4+), MHC-II or professional APCs such as dendritic cells or macrophages. Instead this pathway utilizes MHC-I on tissue cells that have absorbed a hapten and present the antigen directly to CD8+ cytotoxic T-cells. The cytotoxic T cells are activated and release cytokines, performs and granzymes to kill the cell directly. This is sometimes called direct T-cell mediated cytotoxicity.

[@KalEl9280]

came for this

[@uzma__noor__official3625]

U said this subtype does not involve t cell so why is it called t cell mediated cytotoxicity?

[@kipling1957]

@@uzma__noor__official3625 I said it does not include Helper T cells, but it does involve a direct attack by cytotoxic T cells-different versions of T cell.

[@uzma__noor__official3625]

@@kipling1957 oh ok🙂

[@Dr.vishal_makwana]

I think direct t cell mediated cytotoxicity happens after the first exposure of antigen ! 🤔

[@laibazahidlaibazahid1300]

very well explained Sir
Finally found the right video after searching a lot

[@poppins5907]

Thank you soo much doctor, your way of explaining makes us feel the subject light,your use of colours, and your writing is really helpful.
Thank you sir

[@hussainbiology]

First of all thank you so much for appreciation and this really boosts my confidence....
Secondly i ain't a doctor .....i am student like you...
😊😊😊😊

[@godlessheathen6425]

@@hussainbiology well are you doctor now?

[@MsSimsima22]

Thank you soo much for your effort
Ireaalllly needed to understand it ..
☘🌸 جزاك الله عنا خير الجزاء

[@hussainbiology]

Thanks for appreciation...Glad to know that it helps.

[@inimitableleader6062]

شكرا أستاذ كثيرا على المجهود ونتمنى لو كانت الترجمة بالعربية لمساعدتنا أكثر 😊

[@hussainbiology]

Thanks for appreciation , brother...InshaAllah in near future i will try to add subtitles in Arabic

[@bblastos]

excellent ! I'll be BACK :)

[@hussainbiology]

Thanks bro,,,,

[@vishaldey6828]

You gave some wrong information to us, at 2:45-2 :50 u said haptens are bound to antigen and formed a immunogenic particle, but hapters are also antigens but unable to induce immune response, so they are abtigens but not immunogenic. To be immunogenic they bound to carrier protein present in affected tissues and formed conjugate protein, which acts as a immunogenic particle, and engulfed by tissue macrophages or dendritic cell... So foreign particle due to small size they act as hapten.

[@pritamprasad9317]

You need to google it

[@kaustavghosh6500]

simple and best...thank u so much

[@hussainbiology]

Glad to hear that it helps.....Thanks Kaustav for feedback

[@kaustavghosh6500]

i will be back again♥

[@hussainbiology]

thanks bro.....really appreciable

[@FahadAli-xw4hh]

Thanks sir
Great efforts....🥰😇

[@hussainbiology]

thanks for appreciation

[@Asquare369]

Very nice❤

[@Potnoodle123]

thankyou sm so usefull!!!!!

[@hussainbiology]

You're welcome!!

[@sadafshakeel4627]

**There is a correction:**
5:12 pr jo aapne " activated macrophage secretes" btaya hai wo sb activated macrophage nhi TH1 secrete kryega
TH1 secretes: IFN gamma, TNF beta, IL-2,3,8.
Effects of macrophage activation:
Increase class II MHC Molecules
Increase TNF receptors
Increase oxygen radicals
Increase nitric oxide
Please correct this part, so tht students Exms m Sahi likh kr aye.

[@hussainbiology]

InshaAllah.. Mai na is pe naye video banawunga (, updated and animated )... where i will rectify all errors

[@hussainbiology]

thanks for ur feedback...✌️

[@sadafshakeel4627]

Good to see that you accept your mistake.
Btw, you videos r awesome nd easy to understand.
May Allah give u more success.

[@hussainbiology]

@@sadafshakeel4627 that is what makes learning dynamic and authentic.....
InshaAllah i will make new video abt it pretty soon

[@satishdarlz7655]

Neat diagrams and presentation sir very easy to understand

[@hussainbiology]

that is how Biology is easily understood.... :)

[@anna4164]

Thank you.

[@hussainbiology]

welcome Na Ya

[@misbahhussain1021]

What is hapten here

[@missbee1330]

Thanks

[@hussainbiology]

Glad to hear that..........it helps

[@evamadaan4933]

Isn't adjuvants increase the immnunogenicity of antigens

[@hussainbiology]

Increase Immunogenicity towards antigens....I might not have discussed this in my video since this is too old video✌️

[@evamadaan4933]

@@hussainbiology yes I have started your videos from the very start

[@hussainbiology]

@@evamadaan4933 Pretty good then...But old videos are less informative

[@riya7408]

❤❤❤

[@cosmictickle5168]

i know that this is an old video. I see a lot of people in the comments with vast knowledge. I believe that I have this condition with a hypersensitivity to some chemical. I have documented exposures to TCE, PCE, benzene, and vinyl chloride. I cannot find anyone with the knowledge or tools to diagnose me. I am in Alabama, but will travel and pay for someone with expertise

[@shaikh3667]

Thanku Sir...

[@hussainbiology]

Glad to know that it helps,,,,,,,,,thank you bro

[@shaikh3667]

Sir...You are doing great work...On monday their is my exams and i m worried about this topic...But You explained it very well....May ALLAH bless you...Thanku So Much Sir....!

[@hussainbiology]

I am really happy that my work is getting appreciated and InshaAllah i hope many others will be benefited from these Lectures.....and i thank you for ur Support and love....

[@Noor-979]

👍

[@tanu6464]

😊😊😊😊😊😊😊

[@manjunathgoudanh3485]

Waste

[@sunaibarazaq06]

Thank you.

[@hussainbiology]

😊Most welcome