Filling Missing Residue in PDB Structure Using Modeller | Homology Modelling | Bioinformatics

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  • Опубликовано: 24 янв 2025

Комментарии • 41

  • @bioinfoxpert
    @bioinfoxpert  2 года назад +2

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    • @mohammaddabiri9506
      @mohammaddabiri9506 7 месяцев назад

      can you please put applied scripts for us here or tell us where we can get these essential scripts to repair the sequence?

  • @iceinmyshoes5827
    @iceinmyshoes5827 10 месяцев назад +2

    from where i can the script files?

    • @bioinfoxpert
      @bioinfoxpert  7 месяцев назад

      These scripts are available at Modeller website. We have customized the scripts and they are available in our course at Udemy Bioinformatics: Learn Docking and MD Simulation from Scratch.

    • @jewel6856
      @jewel6856 Месяц назад

      what are the name of scripts?
      How Can I find?

  • @ajyui847
    @ajyui847 Год назад +1

    Am wondering , cant the descovery stodio fix it all with clean geometry option ?!

    • @bioinfoxpert
      @bioinfoxpert  7 месяцев назад

      To some extent yes, but Modeller is considered gold standard so far.

  • @avonfonds2567
    @avonfonds2567 2 года назад +1

    My protein has missing atoms in some of the residues instead of whole residues can this fix that ?

  • @AltafAhmadShah
    @AltafAhmadShah 2 года назад +1

    hello sir, I have a query:- I have a protein PDB ID 4HJO. in it the residues are missing in the begining, in the midlle region and at the end how to make changes in the script 3 so as to execute it w ithout any error, please help as I am stuck with it ? thank you

    • @bioinfoxpert
      @bioinfoxpert  2 года назад

      Dear Altaf Ahmad Shah, many thanks for watching our videos. Please do not worry for the residues that are missing at the start and end. You just need to focus on the middle one. Hope it will help you out

    • @dennisag4936
      @dennisag4936 Год назад

      Dear Altaf, Im trying to do this tutorial but I cant find the cripts and the comment section is not helping. Could you please share the script files or tell me where can I get them? Is it on the Udemy course?

    • @kashafaltaf3462
      @kashafaltaf3462 Год назад

      @@dennisag4936 drop your mail here i will send the link. else you can find the scripts given in Modeller tutorial link site

  • @shanzaakhtar5481
    @shanzaakhtar5481 3 года назад

    Such a great teacher I have ever seen in my life...thank u soo much sir for teaching us in this way, such an outstanding way of teaching. May Allah always bless u 💟 appreciated 👏👏

  • @Mohamedshehata
    @Mohamedshehata 2 года назад +5

    First if you make a tutorial you should keep your scripts accessible and don't hide them. Second, all of these steps can be done automatically in chimera.

    • @hanstsahnang4533
      @hanstsahnang4533 2 года назад

      Hi sir Mohammed, that's true and one main problem with is that after inspection of the model structure you notice a change in the amino acid residues like they have been replaced by other amino acides.

    • @bioinfoxpert
      @bioinfoxpert  Год назад +1

      I agree and apologise for not providing scripts

    • @carolinesargent2998
      @carolinesargent2998 Год назад

      Hi! Do you have a tutorial for doing this automatically in chimera? Thanks!

    • @Mohamedshehata
      @Mohamedshehata Год назад

      @@carolinesargent2998 I will post this as soon as I have time

  • @MBUGodson
    @MBUGodson 7 месяцев назад +1

    what to do if plenty of molecules is missing in the middile of the sequence it self ?

    • @bioinfoxpert
      @bioinfoxpert  7 месяцев назад +1

      you can fix them all easily using described methodology in video

  • @bioinfoxpert
    @bioinfoxpert  3 года назад +1

    Please like share and subscribe to our channel

  • @rishabhkhare3180
    @rishabhkhare3180 2 года назад +1

    Do we have to use these same scripts for all proteins??

  • @cosmosco370
    @cosmosco370 2 года назад +1

    where to get these 3 script template files?

    • @bioinfoxpert
      @bioinfoxpert  2 года назад

      Please visit the Modeller website. You can find all scripts there.

    • @bibhuprasadrath59
      @bibhuprasadrath59 Год назад

      can you provide the direct links@@bioinfoxpert

  • @sulaimonridwan373
    @sulaimonridwan373 3 года назад +2

    Thanks for uploading this video. Can you please share python scripts 1, 2 and 3 used in this video?

    • @bioinfoxpert
      @bioinfoxpert  3 года назад +1

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    • @svetlanaacc283
      @svetlanaacc283 2 года назад

      salilab.org/modeller/wiki/Missing_residues

  • @sandaligamage1143
    @sandaligamage1143 3 года назад +1

    Can you please share python scripts 1, 2 and 3 used in this video?

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      @bioinfoxpert  2 года назад

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  • @sarthaktrivedisvnit9032
    @sarthaktrivedisvnit9032 2 года назад

    Nice explanation, how can we fill missing residues of a protein containing two or more chains ?

  • @anilbhattarai4807
    @anilbhattarai4807 3 года назад +1

    Simple and excellent

    • @bioinfoxpert
      @bioinfoxpert  3 года назад

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  • @pauloguerrero7618
    @pauloguerrero7618 Год назад +1

    need the scripts

  • @gokurauyga5552
    @gokurauyga5552 3 года назад +1

    Upload all the script files which is used in this video fast

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      @bioinfoxpert  2 года назад

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    @bioinfoxpert  3 года назад

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