Hi Sir Please make video on Dissolution performance verification using USP Prednisone tablet..I have gone through certificate but not able to understand
Just check is it 5% of your balance capacity? If answer is yes then you have selected this weight based on the European Pharmacopeia. As per EP to carry out Repeatability test, weight should be in lower end and should not more than 5% of balance capacity.
Ok but my question is to find SD u have to do repeatability. So while performing repeatability how many gm weight should I use? If i have 220gm balance..than how will I know what weight should i use for repeatability to get SD. Please do reply. Thanks
Sir as per accuracy formula, if observed weight will get higher value than certified value then calculation results get in minus value, how we can write final results (limit is NMT 0.10 %)
Hello sir, Hope you are doing well. Let me know that a statement given in accuracy parameter that ' the test weight's max. Permissible error (mpe), or alternatively it's calibration uncertainty shall be NMT one third of applied test limit of the accuracy limit. Plz explain .
Sir, if i perform repeatability parameter as per monthly calibration then there may be possibility of changes in SD every time. In this case how we can find out smallest net weight of balance ?
Smallest net weight need to change based on your monthly Repeatability test calibration. But ideally you will see there will not be much change in smallest net weight because most of the time your SD will be less that 0.41 d
Ok sir. i have a 5 digit semi micro balance with range of 1 mg to 200 gm. As per USP chapter we can calculate smallest net weight by using formula 2000 x 0.41d i.e. 2000 x 0.41 x 0.00001 = 8.2 mg. Then can i weight below 8.2 mg for any HPLC analysis. Most of the times we have very less quantity of CRS or Impurity standard so In this case, can we weight below 8.2 mg for HPLC or other analysis preparation?
Please explaine, In repeatability there is one note that is 'The test weight must be within the balances capacity, but the weight need not be calibrated.'
Hello sir, Hope you are doing well. Sir let me explain below; Repeatability formula = 2000 x SD / Smallest net weight Repeatability= 2000 x SD x 100 / smallest net weight Which one is correct and how ?
![LAVROV's interview with Tucker CARLSON 😁 [Parody]](/img/1.gif)
This was just what I needed to fill the gap in my knowledge. Thanks a lot!
Glad it helped!
Superb so good like this video 💯👍🙏🙏
Thank you! Cheers!
Good information sir 👍
Thanks Ramakrishna G
thank you for summarizing this information!!
Glad it was helpful!
......
😅@@PharmaPill😮😮😮😮😮😮
Thank you informative
Glad it was helpful!
Please do one video on reviewed oos guideline
Is d value & least count is same ?
Yes both are same
Thank you for this video
glad it was helpful
❤❤❤❤
Thank you!!
Hi Sir Please make video on Dissolution performance verification using USP Prednisone tablet..I have gone through certificate but not able to understand
Hello sir
LOD ko tripliket me kaise lete and calculation please
Why we are selecting 5 gm weight for repeatability test on analytical Balance? Plz tell me about this sir.🙏
Just check is it 5% of your balance capacity? If answer is yes then you have selected this weight based on the European Pharmacopeia. As per EP to carry out Repeatability test, weight should be in lower end and should not more than 5% of balance capacity.
Thank you very much sir
Most welcome
For rough top pan balance for monthly verification is only accuracy enough or we need to perform repeatability also..
As per European pharmacopeia Repeatability and Sensitivity.
As per USP All 5 parameters required.
How to find minimum load of balance?
2000xSD is the formula
Ok but my question is to find SD u have to do repeatability. So while performing repeatability how many gm weight should I use? If i have 220gm balance..than how will I know what weight should i use for repeatability to get SD. Please do reply. Thanks
Sir, For accuracy test only weight shall be use for calibration or all weights shall be use for calibration?
Only one test weight is taken for accuracy test. Generally between 5 to 100 % of balance capacity weight is taken.
Sir as per accuracy formula, if observed weight will get higher value than certified value then calculation results get in minus value, how we can write final results (limit is NMT 0.10 %)
Hello sir,
Hope you are doing well.
Let me know that a statement given in accuracy parameter that ' the test weight's max. Permissible error (mpe), or alternatively it's calibration uncertainty shall be NMT one third of applied test limit of the accuracy limit. Plz explain .
What is certificate value
Sir, if i perform repeatability parameter as per monthly calibration then there may be possibility of changes in SD every time. In this case how we can find out smallest net weight of balance ?
Smallest net weight need to change based on your monthly Repeatability test calibration. But ideally you will see there will not be much change in smallest net weight because most of the time your SD will be less that 0.41 d
Ok sir.
i have a 5 digit semi micro balance with range of 1 mg to 200 gm. As per USP chapter we can calculate smallest net weight by using formula 2000 x 0.41d i.e. 2000 x 0.41 x 0.00001 = 8.2 mg.
Then can i weight below 8.2 mg for any HPLC analysis.
Most of the times we have very less quantity of CRS or Impurity standard so In this case, can we weight below 8.2 mg for HPLC or other analysis preparation?
@@ajitjadhav607 excellent Question. Don’t use for weighing below 8.2 mg. You should use ultra micro balance or micro balance.
@@PharmaPill sir it means ye 8.2 least count hai
How to calculate least count of weighing balance. Plz explain
@@PharmaPill sir it means ye least count h ??
Sir. Why 2000 we are using .. why not use for 1000 could you please explain to us
1:19 good
Sir as per the formula if I perform, the answer is always 0.10
For suppose
(2xsdx100)/2000xsd=0.10
Am right or wrong
Yes exactly...always it's 0.1% then what is the right formula
Why 2000 , why not 1000 sir
Please explaine, In repeatability there is one note that is 'The test weight must be within the balances capacity, but the weight need not be calibrated.'
Test weight must be within in operating range not balance capacity…
Hello sir, Hope you are doing well.
Sir let me explain below;
Repeatability formula = 2000 x SD / Smallest net weight
Repeatability= 2000 x SD x 100 / smallest net weight
Which one is correct and how ?
Sir what is the difference between smallest net weight and minimum operating weight ??