Could a Perfume Ingredient Save ER Patients?
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- Опубликовано: 17 авг 2023
- Sometimes, major injury causes blood loss that results in improper clotting, or coagulopathy. Some researchers think a compound used in perfume to create jasmine fragrances could help save these patients.
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The other time you get DIC (Disseminated Intravascular Coagulation) is when a woman has an extremely difficult delivery in L&D. That was when I would get doctors frantic on the phone to me in the lab, asking for results.
Counterintuitively, the typical correct treatment is to give the patient a lot of heparin - which makes them bleed even more but prevents the clotting - and then start a stream of transfused blood to keep the patient alive.
If you can break the DIC cycle of coagulation, get the body to normalize, then you can discontinue the heparin - and eventual the transfusions.
😲 Y'all are good people, thank you.
This just came up in my MLS classes. It was one reason I'm watching this this morning... The other is that I'm a science nerd!
I am a med tech, as you no doubt guessed. I worked at the bench - graveyards - for 17 years before switching to medical software development.
As a Hemophiliac... I find this interesting...
...and I appreciate reminding the world that Hemophilia is a thing that exists...
...(and that medication to treat it -in the USA- is absurdly expensive and needs to be regulated to affordability)
I was diagnosed with Thrombophilia 5 years ago when I landed in the ER with a huge blood clot in my lungs, when they checked all of my main arteries I was riddled with clots through out my body. The worst part is they have no idea what caused it in the first place, something in my body changed and it changed so slowly it was never picked up until I collapsed on the way to a medical appointment. Since then I have to have blood thinners everyday for the rest of my life. That in itself now causes the issue of slow clotting when I get cuts and scrapes. I use the spray on Band-Aid it’s like a glue it works fast but my skin does not react to it as I’d does to bandaids because of the latex on them, I have latex free bandaids now but they don’t stay on for very long so are a waste of time and money 😼
Simply carry around some bacon and a stapler at all times
@@The_KingDogewait why bacon? 😅
I am glad to have medical issue in this day and age. Epilepsy alone woulda seen me dead by now without modern medicine, and likely woulda died from my thyroid it was so bad at one point.
Hopefully they push this breakthrough and you can get the help you need!! :)))
@mandiblackwell4668 in case you get hungry from having to staple bacon to your leg you can eat some.
While DMM is an important precursor for the synthesis of jasmonates including the well-known and widely used Hedione, it in itself is not used as a perfumery ingredient.
A similar compound, DEM (the ethyl ester) does have a scent, but is more often utilised in fruity rather than jasmine accords.
Thrombophilia can also cause fertility problems! A blood clot forms next to the baby in the womb outside the placenta and it can endanger the baby's life. It's considered a high risk pregnancy so make sure you get tested for this disorder if you're trying to get pregnant! It's hard but not impossible! And your baby can still come out strong and healthy! You just gotta be extra careful to keep them safe in there.
I have antiphospholipid syndrome, a form of thrombophilia. Its incidence is said to be over 5 percent of the population, often without knowing it.
@Julika7, I have it too and had between5 &7 ministrokes before my Rheumatologist found it. All I have to take is one baby aspirin daily...and lo and behold! No more mini-strokes. What do you take for it?
Marvellous break through!" This is why we should leave the brainy ones in charge 😊
There will need to be strong, unbiased testing to reveal who is actually brainy and who is just good at using leverage
You have no idea how much this comment saved my sanity. Thank you.
Compassionate power always involves consent.
Otherwise it's crazy for everyone lol.
Hey. That's a philadelphus species (mockorange) flower.
Jasmines don't have showy stamens out in the open like that, and usually have more than 4 petals. They're tubes with petals to sit on for nectar-suckers.
Collecting and wearing perfumes is one of my biggest hobbies, and I just happen to be wearing a fragrance with a jasmine note in it as I'm watching this (Hermes Le Jardin de Monsieur Li), really caught me by surprise :D This is so neat!!
Hi Reid!
Who knew survival could smell so good!
So blood clotting is like security?
There is only too much of it and too little of it - and both cases are not mutually exclusive.
Nice analogy
Another thing our bodies use as a sort of security is vasoconstriction in the form of vascular spasms, in which major blood vessels will permanently close in the event of extreme injury. This is useful to not die in the moment but once in the ER it becomes a major problem as it can lead to the loss of limbs or organs which could have otherwise been saved
I have an autoimmune disease called 'antiphospholipid antibody syndrome'. Despite being a baccalaureate RN, I had never done my homework on my condition. Thanks to your biochemical flow charts. I now have a handle on it and a starting place for further reading.
coagulopathy is the funniest sounding word I've heard today, thank you
"The scent of Jasmin flowers could signal hope for people with severe bleeding." Yay, a new way for me to die in the hospital due to allergies!
....you do realise it's just replicating the smell right
@@YanramichYou do realize people can be allergic to more than just flowers, right? It's the same thing used in the perfume - that is what I'm allergic to.
@@burnyizlandK, goner boy.
@@curlyhairdudeify Well aren't you pleasant. I'm a woman, BTW.
Same thing I was thinking...I am allergic to the chemicals they use to make perfumes. Sigh.
I want a new drug, one that won't make me sick
One that won't make me crash my car
Or make me feel three-feet thick
I want a new duck
One that won't try to bite
One that won't chew a hole in my socks
One that won't quack all night
This does do a good job of painting how the human perception of "bad" easily and readily obscures the things that are actually bad.
Yeah, it'd be really nice if the things that help us treat and cure ailments that were death sentences 100 years ago didn't also have uncomfortable side effects.
But the choice isn't life-saving drug with vs. without uncomfortable side effects. It's life-saving drug with uncomfortable side effects vs. assured and an all-but guaranteed, horrifically slow death (eg: TB, smallpox, bubonic, curable cancers, etc., etc., etc.)
They're allowed to wish they had a better medication that didn't make them feel terrible. It is their perception of bad because they live with these symptoms daily... Try to have some compassion.@@FlyingDwarfman
I somehow had the impression. that glycocalyx was unique to bacteria
It looks like epithelial cells are a bit unique in having this, but it is usually more known in bacteria, I hadn't known it was in skin cells and I studied mircobiology and medicine so it is a bit obscure. Hope this cleared things up for you, too!
I'm a molecular biology undergrad and just did Metabolism last term. This video feels like all the words hitting me all at once.
I love learning from this show.
Ointment and perfume rejoice the heart:so doth the sweetness of a man's friend by hearty counsel ❤-Proverbs 27:9⭐
This information is interesting to know! I'll keep it in mind!
perfect video and consistent uploads good job sci show(thanks for the likes people)
"He needs more blankets and less blankets!"
There is hope. Thank you.
Succinate: A vampire vaccination
A vaccine *for* vampires, or a vaccine *against* vampires?
5:05 idk if "there are many other factors" was a joke, but i laughed
Gotta love unexpectedly great things💝
You sound like Teller from Pen and Teller! Dude! Identical 👌🏻
No way! I can't believe it!
Krebs Cycle actually being relevant!
So glad it's not ambergris!
🤢🤢🤢
Yeah I clicked and watched just to see if it was animal or plant, kinda disappointed it wasn't ambergris or beaver butt wax.
Learning the term thrombophelia makes the name of the famil in Knives Out kindda funny
Freinds told us a long time ago that too much ROS leads to a bad thing......
Pretty sure dimethyl malonate isn't actually used in perfumes much per se - but is used in the synthesis of methyl dihydrojasmonate which these days in very nearly every fragrance.
Lolwut
That's what exactly said in the video
Did you comment before watching?
Does the glycocalyx coating also prevent bacteria from sticking to vessels?
I sent this to The Perfume Guy!
I was hoping for precious ambergris but still cool
The different natural and man made chemicals used in fragrances do weird things in fragrances. Like some chemicals that come from flowers used in low concentrations extend the performance of fragrances. I wear fragrances every day even when I don't go out. I have a very small collection of only twelve fragrances.
I love fragrances too❤❤❤
I have a lot tho. I have a perfume room 😂😂
Would you be willing to share a few favorites?
same here, this is my hobby
Perfumes are all made from synthesized scents. None of it's real anymore. Every perfume I've smelled for the past 40 years has smelled like a straight up chemical. Like a kerosene or gasoline wave. I've had to avoid going in public because so many people, mostly women, wear all manner of perfumes and it all mixes together in the air and makes a nasty, toxic mess and I can't breath.
So thanks.
@@src3360oooh, wish you were my neighbor! I don’t have the room for a room but I do wonder about insurance. They stopped making the majority of my horded favorites so it’s not like I can ‘just’ buy more.
Anything is possible ❤
I wonder if that could also help prevent heart attacks and cholesterol clotting.
We evolved to clot quick and then we discovered aspirin, heparin, coumadin!😂
I love how all of those were originally derived from plants and animals, we have so many meds to thank nowadays for both!
@@mandiblackwell4668
I love modern chemistry!!
@@src3360 same! I also love pharmacology and love to study it. I recently got a large book that has scholarly publications and trial info for a huge variety of herbs, very cool read.
It is probably the same ingredient in perfume that triggers my asthma. Good thing I'd already be in the hospital.
I was really hoping it was ambergris-related. 😂
I’ve been fighting blood clots for years it’s no fun I’ve been told twice that I’m lucky to be alive the last time my doctor walked in and said I should have bought a lottery ticket with the luck I have lol god has a plan for me I guess I just pray i figure out what
Hmm, if ROS can affect the mitochondria, could this tie in with the new study suggesting that CFS/ME is tied to a mitochondrial disorder?
Hey, would you mind sharing the title and authors of that study?
Ive yet met or at least heard of girls having haemophilia signs and symptoms
Which ia apparently distinct from anemia, thrombocytopenia
that succinates 😂
So the trouble comes when Oxygen is supplied and the engine cycle in the cell that provides energy clears the backlog of succinate? So we introduce a chemical that prevents that part of the engine's cycle - didn't we just throw a wrench into all the cells and stop their engine? Cell death?
My favorite perfume ingredient is alcohol
I'm totally not an expert on any of this but isn't Jasmin also being used in herbal medicine? If so it's kindoff funny and backwards in a way that perfume, a consumer good, is rooted in this discovery instead of finding something directly from nature in the first place. Even more so if you consider next to no one know anything about herbal medicine but a lot of us have used or encountered perfume.
Flower remedy woo advocacy in 3....2....1...
And Creationists maintain that humans were created to be perfect!
LOLz. Listening to his voice not talking about space stuff it confuses me!! LOLZ
Cool that you use a picture of an ambulance and nurse from the uk's nhs
Reid tan as hell
⚡️ POWERHOUSE OF THE CELL ⚡️
I am so allergic to perfume. Jasmine is a bad one for me, where I can sometimes tolerate organic lavender, in very small amounts for very brief periods of time, like a few seconds. Cedar and pina are also tolerable in the same way. But jasmine and patchouli, etc, are horrible and cause instant throat swelling. Also baby powder and E.V.E.R.Y. scented laundry product on the market. Gag! Public scenting should be illegal. Why should I and many others have to wear gas masks to go out!?
I am the same way. For me it's all the synthetic stuff. People be going out smelling like they used 75 cents of that 25 cents a gallon perfume. SOO strong.
Conversely, I love natural scents. I grow rosemary and lavender in the garden. Lilies in the spring are a bit strong, but the wind wafts it around and dilutes it, so I like that also. Kale and tomato leaves smell good to me. Sage and cantaloupe. Also, Fleabane is considered by most to be a weed, but the scent is super sweet. The light scent of my Abelia bush. I can tolerate some of the essential oils but tend to stick to male scents like cedar and pine with a touch of orange and nutmeg. I do love patchouli still. The trick with patchouli is to go very, very light. Like the very tippy tip of one of those skinny toothpicks and then layer lighter scent on top. I have smelled a couple of men's colognes that use patchouli as a base note, but it is very light with some kind of citrus as a top note.
I got some stuff in the mail the other day from Barefut oils and so far those smell fine.
There are a lot of scents that I like. It's the chemical smell I can't take.
Same here I brake out in hives if it gets on my skin, I have to wash the clothes twice once with the laundry detergent and then without, I stopped using fabric softener decades ago when it stopped the towels from doing their job of soaking up water, and made the clothes feel slimy when you got sweaty. It also made clothes water phobic so washing them was a pain in the butt.
Now I throw the towels into the dryer and that makes them nice and soft and fluffy but also removes any dust caught up in the fibers once they have dried out in the washing line. Because they are dry they only need 10-15 in the dryer for airing out it’s enough to fluff them up and remove dust partials.
I love light perfumes but stopped using them because I read how some people are allergic. I've read your comments and just wanted you to know that some people care
@@ladytech52 you are a good citizen and I thank you. I read an article once about scent sensitivity wherein a woman who was a receptionist at a doctors office had a bad respiratory reaction to someones perfume or maybe several someones and she ended up in the emergency room.
immediate migraine. i had to check out of a hotel because they doused the room in febreeze
so, in very bold words, chugging jasmine perfume could help me not get bad coagulation after injury?
Or maybe just wearing it? Couldn't blame someone for trying.
Nah, has to get into the bloodstream, just make sure to inject a lot of it, I think scent chemicals usually aren’t super concentrated.
@@slepp449you could get surprised just how efficient aerosol drug distribution to human systemic organs are. Its alot better than oral/eating (no gastric juice trying to destroy it, no Liver trying to filter & deactivate its compound). Straight from lungs to heart to all part of your body. The deactivation happens later after it goes around, no first step filtration or metabolism. Its basically the 2nd best way to administer drugs behind injection. 3rd is rectal (anus) and bucal (under your tongue).
how do they injure the rodents?
Wynaut?
How many human bones exist on earth right now?
Pikmin spicy spray
4:39
hehehe, succinate
Maybe
schience
Poor rats 😞
So y'all have resorted to clickbait....nice
1:20 "Injury was the leading cause of death in people ages 1 to 44 in the US in 2019" - I wonder if gun control would be more effective in preventing these deaths than a new anti-coagulopathy medicine?
I believe prevention is better than cure
I’m pretty sure injury from gunshots are actually counted separately from other injuries
@@darkstarr984 Yes, you are right, I found the study: "Unintentional injuries include opioid overdoses (unintentional poisoning), motor vehicle crashes, and unintentional falls." - and account for 80.2k deaths in 2020 among individuals ages 1 to 44. Homicides would add another 18.8k to this number.
Here comes another 100000 videos of aroma therapy to cure Cancer. Thanks..
Because rats and humans are just so similar. We share over 90% of DNA with bananas too. Let's experiement on bananas because we're so much the same. Experimenting on animals provides faulty data and is no more accurate than flipping a coin.
Rats also have blood, bones, brains, bowels and butts, as do humans. Bananas do not. Yes, there are major problems with animal testing and the data we get from it. However, you can make this point on scientific grounds, rather than making anti-scientific false equivalence arguments.
@@hughcaldwell1034 Yes well that's a fair point you make. As the accuracey of data from animal experiments is unreliable, I was saying that a banana could be just as accurate. I think in time most experiments on animals will be seen as something outdated like phrenology.
@@CatGirl-xq9pj Yeah, I get what you were saying, but a good point made badly can harm more than help. Your original comment, by focusing only on percentage of shared genes and nothing else, makes it seem like you know nothing of genetics, biology, or animal experimentation, which makes people more likely to dismiss your claims out of hand.
@@hughcaldwell1034 l guess sarcasm doesn't translate very well to text or having in-depth scientific arguments to RUclips comments. Even tho you consider my point to be made badly, you still got my point.
@@CatGirl-xq9pj I understood the sarcasm. And your point was clear; I suppose I should've said "supported badly" rather than "made badly".
"Injury was the leading cause of death"... you don't say? in other news, water is still wet and the sun is still shining as of ~8min ago.
first?
Would you make a video about ~How to Use A Sextant~ (...and other historical devices from the Age of Exploration and thereabout.)
And try to make it simple enough for an 8-12 year old to understand.
the average under 30 human wears so much perfume already that am pretty sure it could help "patients" in a fken morgue rise from death itself