Human Fertilization | Zygote | Blastocyst | Embryology

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  • Опубликовано: 22 июл 2024
  • #HumanFertilization #Fertilisation #Zygote #embryology
    Human Fertilization | Zygote | Blastocyst | Embryology
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    ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
    Fertilisation or fertilization, also known as generative fertilisation, syngamy and impregnation, is the fusion of gametes to give rise to a new individual organism or offspring and initiate its development. Processes such as insemination or pollination which happen before the fusion of gametes are also sometimes informally called fertilization. The cycle of fertilisation and development of new individuals is called sexual reproduction. During double fertilisation in angiosperms the haploid male gamete combines with two haploid polar nuclei to form a triploid primary endosperm nucleus by the process of vegetative fertilisation.
    In vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the womb, in vitro.
    After the sperm enters the cytoplasm of the oocyte (also called ovocyte), the tail and the outer coating of the sperm disintegrate and the cortical reaction takes place, preventing other sperm from fertilizing the same egg. The oocyte now undergoes its second meiotic division producing the haploid ovum and releasing a polar body. The sperm nucleus then fuses with the ovum, enabling fusion of their genetic material.
    When the sperm enters the vitelline space, receptors on the sperm head called Izumo1 bind to Juno on the oocyte membrane. Once it’s bound, 2 blocks to polyspermy then occur. After approximately 40 minutes, the other Juno receptors on the oocyte are lost from the membrane, causing it to no longer be fusogenic. Additionally, the cortical reaction will happen which is caused by ovastacin binding and cleaving ZP2 receptors on the zona pellucida. These two blocks of polyspermy are what prevent the zygote from having too much DNA.
    Human Fertilization - Zygote - Blastocyte - Embryology
    (0:00-6:58)
    Defining Fertilization; Zygote & Embryo.
    Fallopian Tube/Uterine Tube anatomy; seat of fertilization.
    (7:00-15:12)
    Transportation of Ovum & Sperm; in detail.
    Role of Luteinizing Hormone(LH) & Follicle Stimulating Hormone(FSH).
    Corona Radiata & role of Fimbriae in transport of Ovum into Fallopian Tube.
    Differentiating b/w Primary, Secondary & Definitive Ovum; fate of Secondary Ovum in absence of fertilization.
    (15:13-24:03)
    Slow movement of sperm through vagina; Semen & Ejaculate.
    Role of Vesiculase enzyme; vaginal environment & sperm motility.
    Energy source for sperm's movement.
    (24:05-31:44)
    Fast movement of sperm through the cervix & rest of the Fallopian Tube;
    Role of Prostaglandins, chemo attractants & cilia of fallopian tube.
    (31:46-37:08)
    Importance of Capacitation Reaction for the motility & later fertilization of the sperm inside the Fallopian Tube; "Conditioning" of the sperm inside the female reproductive tract.
    Only Capacitated sperms are able to cross Corona Radiata.
    (37:10-50:20)
    Explanation of Acrosomal Reaction; fusion of sperm with oocyte.
    Cortical reaction in the ovum leading to Zona reaction; inactivation of specie-specific receptor & impermeability to any remaining sperms.
    (50:21-57:52)
    Fusion of genetic materials; ovum undergoing 2nd meiotic division; Formation of Definitive Ovum.
    (57:54-1:00:06)
    Recap:
    1-Cortical & Zona reaction.
    2-Completion of 2nd meiotic division; formation of definitive ovum.
    3-Metabolic activation of Ovum; fate of fertilized & unfertilized ovum.
    ---------------------------------------------------------------------------------------------------------------------------
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  • @smallscalefarmingasabusine2132
    @smallscalefarmingasabusine2132 4 года назад +230

    Am a final year medical student ( MBChB) from Africa, Zambia. Throughout my entire medical journey, if l cant watch a recording on any topic from you Doctor, then l cant fully understand that topic. You are simply a Blessing to millions of medical students out there. May God continue to bless you.

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      Thank you so much for the legendary compliment! ❤️

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      Eei Akosua nie🤓

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      Am watching from Sierra leone 🇸🇱

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    How do i thank this great man.... I have no words.. Just pray for you to live a very long and healthy life sir❤️

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    Even I am a microbiologist but addicted of your channel 😂 may god keep you happy and bless your family.

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    I am not a medical student but your classes are easy to learn sir.. First I searched through youtube about the placenta formation & found your video. You are amazing sir.

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      Are you in college now?

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    I am from India doing medical and Dr. Najeeb was really fun to learn with....

  • @ciyabenoy
    @ciyabenoy 10 месяцев назад

    sir , I'm a medical student and my obgyn classes just started and the basics we had to learn ourselves. I wanted to recap fertilization and gametogenesis and reading the books was just getting me confused more and more and I had so many doubts , I was scrolling mindlessly on youtube an was on the verge of tears, thats when I found ur video and decided to give it a try.
    earlier I couldn't even concentrate on long youtube videos but ddamn , I'm talking to you at the 1:13:20 min mark. I'm so happy I came across the video. your jokes about capacitation and the mighty sperm made me laugh and wipe my tears. I finally understood this. thank you so much for this, please never stop making videos if you can... you help many students across the world smile. thank you DOCTOR!!!!

  • @josephbenjamin3142
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    For me, I lack words to describe how much you have helped me through your teachings. I will wait patiently to see this teachings compiled in form of TEXTBOOK 📚. God bless you sir, BENJAMIN from NIGERIA 🇳🇬.

    • @DoctorNajeeb
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      Blessed to have such great students. Stay blessed 💖

  • @Jsp916
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    Greatest teacher ever born on this planet

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    Sir I am nursing student ....sir the way taught are best....u r world's best....thanku sir

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      That’s so nice of you. Students like you keep me going. More power to you. ❤️🔥

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    Dear Sir ,I am a nurse by profession .Thanks a lot for clearing all my doubts .

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    Ever best lecture from awesome professor ..i am watching lectures again for my fcps part ist

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    Sir you're my ideal ,, your teaching method is incredible ,, thank you sir for teaching us , your student Anamika ..

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    its my 1st year in medicine and i am so lucky to found your videos.... its making me very easy to learn the concepts.... thanks to you SIR u r a saviour.....

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    Dr najeeb you the best teacher in world, thanks so much sir, God bless you and your family sir.

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    Your videos are really helping sir..u r making topics much much easier and also remembering.. Thank yu so much sir.. expecting more and more videos from you

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    Sir with huge respect.. You made my life easy. What a lecture, I enjoyed through out the class. Most importantly I learned lot of things. Thank you sooo much🙏🙏
    From India.

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +2

      You are most welcome❤️

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      @@DoctorNajeeb sir thank you .u are really a good teacher 🙂.which subject u are specialized in (md/ms)sir?

  • @elinaparkkonen517
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    Dear dr. Najeeb, your enthusiasm makes the human heart smile🙏💗. Best wishes from Finland ❄☃️ . Thank YOU❣

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    the best teacher for MBBS....❤❤

  • @ImranKhan-hm4ki
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    When i watch u lecture then i go to classess there i ask many questions from teachers and the concept is always cleared there is no words to praise u.

    • @DoctorNajeeb
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      Glad you appreciated my hard work. Stay blessed 💖

  • @benstev9790
    @benstev9790 Год назад +2

    Watching from Nigeria
    You're the light of medical and clinical medicine

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      Glad to hear that. Keep supporting ❤️

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    I spent 1:13:37 minutes of time is very Amazon and fabulous time tq so much najeeb sir😍😍

  • @ayabanani6895
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    Subhanallah. I am always amazed by the creation of Allah by learning the mechanism of these processes. May he bless you

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      Thanks for your appreciation and support.

  • @jammusharaf6849
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    Sir your way of teaching is outclass
    U are doing great job .may Allah bless you long life with health ❤️

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    You r my real hero made each and every concept crystal clear

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    Iam a civil engineering student but I love watching your videos in my free time

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    Awesome now I have cleared all my doubts about the topic😀 thankyou for that sir

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    I am fsc 2nd year student wow wow you cleared my concept thankss sir

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    Everytime when I searched a lecture for on any particular topic, 1st I searched your video on that particular topic
    You're just amazing. Thanks to Almighty Allah he blessed us with such a legendary teacher ☺️.

    • @DoctorNajeeb
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  • @ajayagenhotri8510
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    Sir,, you're the one.... I wanna say,, you're gift of God to us.... And happy birthday in advance sir thank you for coming in this world.. I wish you'll reply me..

    • @DoctorNajeeb
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      Thanks dear ❤️❤️❤️

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    Dr.najeeb is a ever best teacher

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    I'm a nursing student and im watching ur lectures since four years .your videos teach me a lot . Im very thankful to God and at the same time u for giving me a strength to do best .......May God give u more and more success ....ameen
    Thank u sooooo much for every word i learnt from u .....💫
    Legend

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      Jazakallah Khairan! ❤️😊

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    Dr Najeeb is a real genious

  • @omerfarooqspesalai2166
    @omerfarooqspesalai2166 2 года назад +5

    my allah blessing you long life with health❤

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +2

      Thank you for all the love and support❤️ Stay blessed ❤️

  • @creativestar8696
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    Sir, I am from Bangladesh!!! I wanna say one thing that it really helps me😃

  • @fahimurrehman5428
    @fahimurrehman5428 2 года назад +2

    Sir i have no words how to express my words that how much i likes you.
    Even every medical students likes you and love you🥰🥰🥰❤❤❤

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Thank you so much for all the love and support. Stay blessed❤️

    • @fahimurrehman5428
      @fahimurrehman5428 2 года назад

      @@DoctorNajeeb always welcom ❤❤❤❤

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    thank you so much for this amazing video!

  • @medinaallen5847
    @medinaallen5847 3 года назад +20

    I love this man, so funny, makes learning so much fun and interesting. Such a great teacher. I have learnt much. Thanks Dr 💞💞

  • @anonymous_girl692
    @anonymous_girl692 3 года назад +2

    Oml thankyou so much Sir ! You are Great I have really understood everything like literally It's so Good MashaAllah may Allah succeed you more ❤️

  • @dncmi1436
    @dncmi1436 4 года назад +37

    I'm in class 12th...and i understood everything....thank u sir

  • @namankanungo3314
    @namankanungo3314 Месяц назад

    namaste sir 🙏🙏🙏 badia lecture tha . very conceptual . aab koi doubt nahi😇😇😇

  • @hassanlolhassle8872
    @hassanlolhassle8872 8 месяцев назад

    U r the most amazing doctor that i have ever seen..

    • @DoctorNajeeb
      @DoctorNajeeb  8 месяцев назад

      Glad to hear that❤️ Keep supporting ❤️

  • @shraddhasamal1790
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    sir your lectures are so helpful and well explained....how much i say it will be short to describe your exceptional way of teaching...THANKS SIR

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Glad to hear that❤️ Keep supporting❤️

  • @mrxd4926
    @mrxd4926 Год назад +1

    Your lecture are proving saviour for me🖤.

  • @petlasanyasinaidu1784
    @petlasanyasinaidu1784 3 года назад +1

    Sir I have ever seen this type of teaching... great explanation sir...u r the world's finest lecturer...sir...

    • @DoctorNajeeb
      @DoctorNajeeb  3 года назад +1

      Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always. We wish you success and happiness in every walk of life and good luck in your future endeavors. Regards, Dr. Najeeb Team

    • @petlasanyasinaidu1784
      @petlasanyasinaidu1784 3 года назад +1

      @@DoctorNajeeb thank you sir

  • @rathodnehal2869
    @rathodnehal2869 3 года назад +10

    great teacher i ever seen 🙏tq so much sir for making these excellent video 🙏 thanks a lot 🙏🙏🙏

  • @armyluv1164
    @armyluv1164 2 года назад +1

    Having a test tommow so lucky I get to watch this thank you very much sir🙏

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      Kindly visit our video library and view all the available lectures using the link below members.drnajeeblectures.com/#!/video-library

  • @augustorvz3543
    @augustorvz3543 3 года назад +3

    Top doctor. Top professor. 👍👍

  • @mornobells2375
    @mornobells2375 Год назад +2

    Allah kamyab kry apko sir g❤❤❤ blessing truly

    • @DoctorNajeeb
      @DoctorNajeeb  Год назад

      Thank you for your kind words❤️ Stay blessed ❤️

  • @homosapienssapiens4848
    @homosapienssapiens4848 Год назад +2

    The lesson that I learnt from this video is to become a gold medalist 🏅

  • @flowerlily5838
    @flowerlily5838 3 года назад +2

    God of medical.thank you so much our God of Medical.

  • @hanidave1905
    @hanidave1905 3 года назад +2

    *sir it was the best video I had ever seen thanks sir* 🙏🙏🤗

  • @shaukiyashayrivivekkumar1102
    @shaukiyashayrivivekkumar1102 4 года назад +3

    Sir Maine aapke kai lecture padhe hai aap aisa padhate hai ki koi bhi smjh jaye
    You crystal clear concept 💛💛💛🤩🤩

  • @queenie5416
    @queenie5416 Год назад +2

    41:29 he spoke Urdu 😅
    Btw best teacher ❤ most useful 1:13:17 of my life

  • @meghasganiger5031
    @meghasganiger5031 3 года назад +1

    Your videos a boon to medicos sir thank you 🌛

  • @AbdulWahab-ti5uf
    @AbdulWahab-ti5uf 4 года назад +8

    Who is the editor of this.
    Whoever it is he/she is doing a good job

    • @DoctorNajeeb
      @DoctorNajeeb  3 года назад

      Glad to know that. 👍 Keep sharing your feedback. ❤️

  • @insiaqamar5022
    @insiaqamar5022 2 года назад +2

    Watching from your homeland 🇵🇰thank you so much you make my embryology so easy .. ❤️❤️❤️

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      My pleasure 😊 Happy learning ❤️

  • @preritmalhotra1432
    @preritmalhotra1432 3 года назад +1

    superb explanation great approch keep it up

  • @OradiErick-pn2ef
    @OradiErick-pn2ef Год назад +1

    You make me understand the concept. Thank you Doctor

  • @dreamifymedicos3352
    @dreamifymedicos3352 4 года назад +3

    Wow fabulous sir
    i am mbbs student in india
    I want to become a new dr najeeb

  • @simranrajput4703
    @simranrajput4703 3 года назад +3

    Huge respect 🙏🏻

  • @pingpongGS
    @pingpongGS 4 года назад +2

    You are the best sir.......

  • @sigma12964
    @sigma12964 2 года назад +3

    Doctor your lecture is also useful for my NEET preparation.
    Thank u doctor sahab..

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      You are welcome dear❤️ Keep supporting ❤️

  • @jafarusman5641
    @jafarusman5641 2 года назад +2

    Thank u so much Dr. Najeeb, u made it very easy 🙏

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Thanks for liking. Stay blessed ❤️

  • @sunitarokaaryal4672
    @sunitarokaaryal4672 3 года назад +1

    Igot great help. Thank you Sir

  • @user-wm3mg6vq5v
    @user-wm3mg6vq5v 4 месяца назад

    thankyou so much sir for making this complicated topic easy for us.May Allah give you all the happines you want.💖❤❤❤💖💖💖

    • @DoctorNajeeb
      @DoctorNajeeb  4 месяца назад +1

      Ameen. Thank you for supporting

  • @sahistasheikh5184
    @sahistasheikh5184 3 года назад +2

    Sir it's a humble request that u will attach the notes PDF with video sir i want this lecture's pdf

  • @imranhaider4246
    @imranhaider4246 2 года назад +2

    Sir i am from pakitan.i am watching your lecture v.amazing way to convey complicated lecture into easy

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Glad to hear that❤️Keep watching stay blessed ❤

    • @imranhaider4246
      @imranhaider4246 2 года назад +1

      Sure sir 😊 Ameen

  • @rustamshaheen9265
    @rustamshaheen9265 3 года назад +2

    You are not only a great teacher you are always a Dr.......
    Thank you sir...
    Ma sirf app k he lacture dakhta hu.....

  • @abebawtesfa3074
    @abebawtesfa3074 3 года назад +21

    A man created for medicine

  • @varsha8109
    @varsha8109 2 года назад +2

    I m watching uh from India

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      Thank you for your love and support! Stay tuned. ❤️

  • @tofiqueahmedsoomro5225
    @tofiqueahmedsoomro5225 2 года назад +2

    Thanks sir ....I am enjoying your lectures from Pakistan

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      You are welcome❤️ Keep supporting❤️

  • @DrTayyabaIqbal
    @DrTayyabaIqbal Год назад +1

    How an amazing teacher you're sir. May Allah Keep you happy an blessedd Aamen.wish i had taken these lectures at Start of the med term wouldn't have suffered now.🤧🤧🤧❤️❤️❤️❤️🇵🇰

  • @khanazhar3385
    @khanazhar3385 2 года назад +6

    Sir as I have said this many times no one can teach like u .U r outstanding ❤️

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +2

      Thanks a ton Keep supporting.❤️❤️❤️

  • @muhammadalsheyab7236
    @muhammadalsheyab7236 4 года назад +2

    awesome professor keep up

  • @wajhulabbasi2050
    @wajhulabbasi2050 4 года назад +8

    I like your way of teaching.

  • @sardarm.s2317
    @sardarm.s2317 4 года назад +4

    Exquisite !! What a class professor!

  • @shibaghosh1817
    @shibaghosh1817 3 года назад +1

    You are my mentor,

  • @nidalnidal1745
    @nidalnidal1745 3 года назад +2

    Thank you dr !

  • @javeriaakhlaq2511
    @javeriaakhlaq2511 2 года назад +1

    What a nice, precise, and I must say an easy lecture. Thanks a lot.

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      Glad it was helpful! ❤️

    • @eswarisivanandam3091
      @eswarisivanandam3091 2 года назад +1

      Thank you
      You should be born again to give lectures for my grandchildren!

  • @khushboojaiswal4604
    @khushboojaiswal4604 4 года назад +2

    thank you sir☺☺

  • @violakangogo78
    @violakangogo78 2 года назад +1

    Watching from Kenya,you are the best Sir.

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Wow, Thanks! Stay blessed and keep watching❤️

  • @faisaleshagmakenfaisal2529
    @faisaleshagmakenfaisal2529 2 года назад +1

    Thank you very much I am watch your videos avry day and become very good in embryology 💞💞💞I am from Sudan 💕💕

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Glad you loved it. Stay tuned ❤️

  • @jeevathusharaMBBS1217
    @jeevathusharaMBBS1217 2 года назад +3

    Your lectures are very clear sir....thank you sir....from srilanka

  • @hritikbhattacharya9796
    @hritikbhattacharya9796 4 года назад +1

    A good lecture sir

  • @Pradeepyadav-jj1ih
    @Pradeepyadav-jj1ih 2 года назад +1

    Sir your video is helpful and supportive medical student

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Thank you for your love and support! ❤️

  • @akhtarmunir6712
    @akhtarmunir6712 2 года назад +1

    Very impressive. I am impressed. Thank you sir.

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Thank you for your appreciation! ❤️.

  • @osamaahmad6371
    @osamaahmad6371 3 года назад +3

    Thank you Sir

  • @vibesinternational8625
    @vibesinternational8625 2 года назад +1

    Siiiiirrrrrr............how it feels being the best in your kind
    💓💓💓

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      It feels amazing when students like yourself appreciate hard work! Stay motivated and stay blessed. ❤

  • @ihsanjuma3599
    @ihsanjuma3599 2 года назад +1

    Special Respect from Afghanistan you are the real one thank you sir.

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад

      Thank you so much for your love and support! ❤️❤️❤️

  • @bossminto4961
    @bossminto4961 2 года назад +1

    Thank you so much sir
    Really study with fun
    I was enjoying when you said all windows closed after entering of one man 😆😆😆

    • @DoctorNajeeb
      @DoctorNajeeb  2 года назад +1

      So nice of you. Happy learning ❤❤❤