Female breast pathology

This is a brief video on neoplastic and nonneoplastic diseases of the breast in females (excluding gynecomastia)
I created this presentation with Google Slides.
Image were created or taken from Wikimedia Commons
I created this video with the RUclips Video Editor.
ADDITIONAL TAGS:
Breast pathology
Neoplastic and nonneoplastic diseases of the breast in females
Fibroadenoma
Phyllodes tumor
Fat necrosis
Acute mastitis
Periductal mastitis
Mammary duct ectasia
Fibrocystic changes
Intraductal papilloma
Ductal carcinoma in situ
Paget disease
Invasive ductal carcinoma
Lobular neoplasia
Invasive lobular carcinoma
Benign conditions
Malignant conditions
Def: Noncancerous breast tumor consisting of stromal and epithelial tissues
Epi: women in 20s to 30s, most common benign neoplasm
Clinical: painless, firm, rubbery, mobile lump
might enlarge based on menstrual cycle (estrogen-sensitive)
Gross: solid, lobulated, tan/pink, firm, no necrosis, no hemorrhage; well-circumscribed
US: solid, round, homogenous mass; well-circumscribed
Histo: gland structures with stromal and ductal proliferation, no cytologic atypia
Phyllodes tumor
AKA cystosarcoma phyllodes, cystosarcoma phylloides and phylloides tumor
Def: Masses arising from stromal cells surrounding ducts of the breast
Fibrous neoplasia pushes out tissue→ gross and histologic changes
Epi: older (40+ and postmenopausal), African American, rare tumor
Clinical: large mass, bulky, mobile, firm as a “wooden log†-- twice as large as the other breast
Gross: blue veins on skin surrounding tumor, well-circumscribed
Histo: fibrous gland and tissues with intermittent cystic spaces, epithelial leaf-lined structure; cytologic atypia and mitotic figures are rare
Spread: might recurs after excision, 5-10 percent undergo malignant transformation
Treatment: excise surgically (wide local excision or mastectomy)
Fat necrosis
AKA fatty lumps
Def: normal fat cells of the breast become round lumps through necrosis
Caused by trauma, radiation, or surgery involving breast
Epi: women post trauma, radiation, or surgery
Clinical: painful, induration with irregular contours, retraction of skin
Mammogram: eggshell calcification (results from saponification)
Gross: necrotic fat tissue → must biopsy to rule out cancer; induration
Histo: necrotic fat with calcifications, giant cells, granulation tissue, lipid-laden macrophages
Spread: no malignant potential
Although confused with cancer bc of calcification, induration, skin retraction, irregular contours
Treatment: not necessary
Fibroadenoma
Phyllodes tumor
Fat necrosis
Acute mastitis
Periductal mastitis
Mammary duct ectasia
Fibrocystic changes
Intraductal papilloma
Ductal carcinoma in situ
Paget disease
Invasive ductal carcinoma
Lobular neoplasia
Invasive lobular carcinoma
Fibroadenoma
Phyllodes tumor
Fat necrosis
Acute mastitis
Periductal mastitis
Mammary duct ectasia
Fibrocystic changes
Intraductal papilloma
Ductal carcinoma in situ
Paget disease
Invasive ductal carcinoma
Lobular neoplasia
Invasive lobular carcinoma
Histo: necrotic fat with calcifications, giant cells, granulation tissue, lipid-laden macrophages
Acute mastitis
Def: bacterial infection of the breast
Typically caused by skin organisms Staph aureus (or Strep), when breastfeeding → stress on skin allows bacteria to enter breast
Epi: breastfeeding women
Clinical: purulent discharge from breast; warm, erythematous breast; engorgement; loss of nipple integrity
Spread: no malignant potential
dicloxacillin for beta-lactamase-producing organisms such as S aureus) and drainage
Periductal mastitis
Def: inflammation of breast tissue beneath the nipple
Epi: smokers
AKA duct ectasia of breast or plasma cell mastitis
Def: lactiferous duct becomes blocked or clogged
Inflammation of the duct leads to duct dilation → debris piles up and goes into nipple → discharge
Epi: postmenopausal, multiparous women; rare
Clinical: green/brown nipple discharge
Mammogram: typical rod-like calcifications
Histo: chronic inflammation, plasma cells
Fibrocystic changes
AKA fibrocystic breasts or fibrocystic breast disease or fibrocystic breast condition (FBC)

[@schinreddy]

Great summary of the highlights from Pathoma and First Aid!

[@ifyude2977]

Great summary! These videos have been helping me so much. Just as a correction: I believe fat necrosis of the breast is actually painless. Thanks!

[@hssu9076]

You are amazing. I just received an ultrasound result and I'm awaiting biopsy. Of course these lectures are not meant to replace doctors but this video definitely helped giving some insights. Thank you.

[@irinacortez5618]

hi! just want to clarify, according to Robbins fat necrosis presents as a PAINLESS palpable mass :) great lecture by the way!

[@tomex73able]

when i see you have a video about a topic i study i get more excited than hyperpolarized cell

[@imrankibria7400]

Absolutely amazing video, thank you so much! I've always found this a tricky subject to stick in my head but your descriptions were spot on and so helpful, cheers.

[@sashak6798]

Eaxctly the video I looking for; thank you!

[@openbrainsecrets5690]

Very good video, clear cut explanation of Breast Carcinoma

[@akanksha786]

superb explanation!!

[@amitsavran]

Thanks alot, for such a brief explanation. I have always found this topic very hard bcoz I never finished this whole breast pathology in one go ......I get bored actually.
This is my first time to finish in 21:20 mins ...

[@solomonmpalanyi7226]

Excellent job! Keep it up

[@yuliaantonenkovolkovamd552]

If there is a minimal risk of malignancy with intraductal papillomas, why the treatment is duct excision???

[@fitsumbelayneh4559]

Such a nice video, Thanks!!

[@notsofiltered.3222]

Thank you most simple and comprehensive

[@farihinirin2077]

thank you so much!!! your videos helps a lot!!!

[@josefalagicere399]

A thousand thank yous
for this amazing video.

[@karanmaurya7102]

Sir Great video, but i think you have missed only granulomatous mastitis ?

[@orangzaib618]

Medullary good prognosis

[@martinsmith6534]

Very educative video. Thanks

[@danae7022]

This saves my time
.thank you.

[@gabrielatsalamandris9704]

incredible video thank you

[@hawsawis1]

Thank you for good information

[@hinagary9829]

Fantastic lecture

[@johnytaku5025]

God bless u sir love of thank 4 share such vedio

[@yashvendrasingh234]

thanks for the great lecture sir..

[@miranuar784]

Thank you!

[@MrPrinceW1]

medullary carcinoma has a good prognosis

[@aliriyadh643]

Thnx alot great video

[@karataych0p]

This was solid. Except around 4:10 when you mentioned that Phyllodes tumor has "blue veins" structures visible around the nipple. Would that be seen in gross pathology with heavily pigmented skin? Seems odd/exclusionary, since the neoplasm is MCC in African American pts.
Anyways, thanks! Love how succinct this is.

[@sarap7879]

thank you!

[@deepdoshi7113]

Very helpful.. thnx alot

[@sashaveselkova9639]

Thank you so much!!

[@natashagull2935]

Mistakes ..
Phylloids tumors :have increased mitotic figures
Fat necrosis :are painless

[@evergreensongs8730]

thank u so much

[@samirnacer9206]

Lecture notes?

[@snehaldongare4633]

Where may I get this slides available???

[@mahmoudshahat2264]

waaaaaw u are prince
really thank u

[@sniyut1037]

Superb

[@missataris]

Thank you!!!@

[@siegmac3267]

Phyllodes dont mets right? But occasionally recur?

[@aafrinyusuf5741]

Malignant Phyllodes metastasize to lungs and bone

[@maricelam8376]

I need a second opinion on my ultrasound ,mammogram can u help me ?

[@poddus]

excellent video, thanks! just one question, did you record this on an alien spaceship? 😂