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I know it is possible to convert amide to nitrile by dehydration with thionyl chloride or phosphorus pentoxide. One recipe, for example, suggests heating acetamide with phosphoric anhydride. But in either case, we get an acidic by-product - hydrochloric acid + sulphur dioxide or phosphoric acid. I wondered why the resulting nitrile does not undergo hydrolysis? I concluded that the formation of -OH anion is essential for hydrolysis. In the reverse reaction, all water is either bound into phosphorus acid or broken down into HCl + SO2. It's true?
We don't typically talk about the mechanism of this reaction (it's quite complex), but I do think that a video on the reactions of the benzylic position is a good idea.
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Hi sir .i want to asked about What amide is the simplest amide ?
Formamide or acetamide?😊
Formamide, of course.
I know it is possible to convert amide to nitrile by dehydration with thionyl chloride or phosphorus pentoxide. One recipe, for example, suggests heating acetamide with phosphoric anhydride. But in either case, we get an acidic by-product - hydrochloric acid + sulphur dioxide or phosphoric acid. I wondered why the resulting nitrile does not undergo hydrolysis? I concluded that the formation of -OH anion is essential for hydrolysis. In the reverse reaction, all water is either bound into phosphorus acid or broken down into HCl + SO2. It's true?
Yes, in order to do the hydrolysis you need the said *"hydro"* aka water, so if you're using dehydrating reagents, then there will be no hydrolysis.
Hello 😊 Can you explain oxidaxion toluene to benzoic acid ?
We don't typically talk about the mechanism of this reaction (it's quite complex), but I do think that a video on the reactions of the benzylic position is a good idea.