Thanks. I’m a 50yo male with 2 copies of APOE4. No obvious related symptoms but I’ve been incoporating wellness lifestyle modifications for years already. Low-ish carb, high protein, TRE (18/6), whole foods, wide spectrum plant, tons of fish, monounsaturated fats…lots of movement / walking and heavy resistance training 2x / week + periodic IR sauna and emphasis on 8hours+ / night sleep. Planning to get a cognitive baseline soon with the support of a knowledgeable care team. This video pretty much summarizes what I’ve learned going down the rabbit hole of preventative lifestyle for APOE4 carriers. Still…it feels like we have much to learn.
You might want to consider picking up a copy of Dr Dale Bredesen's first book (The End of Alzheimer's) from the book store or your local library. imho, he's the world's top clinical expert, an MD PhD, he integrates his research on the molecular mechanisms behind Alzheimer's with his very successful treatment protocol. There are several subcategories of causal mechanisms that he clearly explains. Should be fairly easy to adopt prevention strategies once you understand these categories. He explains how APOE evolved in hominins from variants with higher inflammation drivers to protect them from infection in their transition from tree dwellers to grasslands where injuries and predator attacks were a higher risk. The APOE inflammatory forms have been becoming less common in homo sapiens in our evolution over the past several hundred thousand years. fwiw, I'm a medical neuroscientist and did Alzheimer's research for several years. I think Bredesen is spot on. Great idea for everyone to manage inflammation and support their mitochondria and this is especially true for someone with 2 copies of APOE4.
@@phreedomphile I have the book 🤓 Dr. Bredesen is one of my primary sources for all things related to cognitive decline and the reason I’m scheduling a cognitive baseline and blood tests to hopefully get ahead of the game. Many thanks for your supportive words.
Thank you for all of your information Mike. I did my best to try to understand everything you were saying about APOE4. I still feel an incredible amount of frustration on this topic. My mother-in-law passed away of Alzheimer's in May of 2020. She was not overweight. She went to a "physical" twice a year and all of her labs were always perfect. She never smoked. She never drank. No diabetes. She had a low BMI. She always got a good night sleep. Mother to one child. Worked full-time outside the home most of her life. Neurologist did brain scans and said her brain was in good shape for her age (which was in the 80s). They checked her vitamin B12 and it was normal. Two of her sisters also died of Alzheimer's. So even though she was otherwise healthy and even though her brain scans were looking good, her memory deteriorated and she got to the point where all of that typical Alzheimer's behaviors came out. She would not understand where she was or when she was or who she was with. This would create great amounts of panic as you can imagine. Thete was a study that was conducted using Catholic priests and nuns. Those with symptoms had normal brains and those with messed up brains had no symptoms. I think we still have a lot to learn.
I am on the ApoE4 diet which is a low carb diet that is also low in saturated fat and I have extremely poor compliance with it. My diet made up of lean meats, olive oil, avocados, vegetables, and a fish oil supplement. I also cannot eat egg yolks because I am hyperabsorber of dietary cholesterol.
Mike, Please take a deep dive on Phopholipids and Sulforaphane, Those two products have helped me immensely. I have autoimmune UC. This put a cap on the bleeding. Not just that, but my mental clarity is through the roof, and right now I have NO hemoglobin (4). This stuff needs to be looked at deeper
Sorry to hear about your Dad, but don't give up hope. There are many causes for dementia, and some are controllable and even reversible, depending on how much damage has already been done. This is one example where this doctor explains how giving the brain ketones can make a huge difference. ruclips.net/video/cE2cuaMZiN8/видео.html I've also read about vitamin deficiency (I think it was B17, but can't find the study, sorry) where just spraying this on the tongue brought people 'back'. So do everything you can to ensure he is eating the right foods, just in case. Good luck.
Dig in, and fight like hell for him!!! January begins year 11 of us chaperoning my mother through Alzheimer's. She's spent nearly 10 full years in nutritional ketosis. We prioritized endogenous ketone production, protein, physical activity (functional movement), and plenty of family interaction. Get him as metabolically healthy as possible, and keep him active. Mike here is a great resource. So too is Dr Georgia Ede, Dr Ken Berry, Dr James DiNicolantonio, Liz Wolfe, Gary Taubes, Nina Teicholz, Shawn Stevenson, and pretty much anyone else Mike references. Dementia organizations and groups are very siloed off. They tend to be loud echo Chambers, that refuse to allow any outside ideas from entering. The advice we were given in the early 80's for how to care for my grandfather, was the same advice we got in 2000 for how to help my father, and that I got in 2011 on how to care for my mother. It's going be a hard fight, but you can absolutely do this. I promise, it is absolutely worth it.
@@sportysbusiness B17 is Laetrile. The most effective, least costly way to take B17 is by eating 2-3 apricot kernels daily or every other day. UofM Ann Arbor MI nutritional oncologist recommended. I found them at health food store in 1-lb (16 oz) bag. They look like small size almonds, taste like almond extract. The cost was $12, enough apricot kernels for about 1-2 years, Rainbow Acres LA CA 90066. Don’t overeat bc they may be toxic at higher doses. Nutritionist said it’s better to eat raw apricot kernels than take supplements. We also eat 2-3 raw Brazil nuts almost every day to obtain natural selenium from food source. Again, do not overeat bc at higher doses you develop selenosis…
TY Mike - again and again - even with medical and physiological jargon you make it pretty clear. Gonna act like we (husband and I) have at least 1 APOE (we have one parent w/ Alzheimer's and one w/ Dementia). IF (& compressed eating window), Omega 3 supps, and fresh fish.
Loving the content! Im a health sciences student and cannot thank Mike enough for facilitating basic-content learning as well expanding on increasingly-pressing topics one oughtta know if he intends to become a nutrition expert 😉
Chylomicrons never become LDL. The saturated fat you eat gets packaged into Chylomicrons, which are then dumped into your lymphatic system and your circulation via the superior vena cava. However, the sugar that you eat goes to the liver through your portal system and under the influence of insulin gets converted to saturated fat (mainly palmitic acid) gets packaged into VLDL and then LDL. For this reason, it is the sugar (not the saturated fat) you eat that is the culprit. The saturated fat that you eat never becomes VLDL or LDL. However, when you eat saturated fat, there are fewer LDL receptors in the liver to take up the LDL; therefore, sometimes you see a bump in LDL.
How do you find your genotype? My grandmother died of Alzheimer’s. It fairly common among the women on her side of the family. Before she lost her mind she told me often that her mom and grandmother both went crazy before dying and that she expected for her to die the same way. I have always been very conscious about my health and want to be prepared for any potential risks I may have to experience later in life.
Check the aluminum products they use. Aluminum is a top contributing factor for Alzheimer's. (Deodorant, pots, foil etc...) Reduce the aluminum content and reduce your risk of Alzheimer's as you get older.
I found mine when a family member gave me a 23 and Me test kit for Christmas. I was shocked and fearful when I first found out I carry 2 APOE4 alleles, but when I researched things and learned how much lifestyle can mitigate the risk I simply took control. Now I just live my life and go days at a time without even thinking about it. Some people don't want to know their genetic risk factors and it was hard getting the news, but I am so happy I know about it so I can take steps to help protect me. Dr. Bredeson's book is good, but if someone tried to implement every one of his protocols it's all you would spend your day doing and it would cost a fortune in supplements. I like Mike's distillation of what is most important. I can handle it.
great talk. I would rather tell people to stop using refined oils such as olive, and others to bring down the W6/omega3 ratio than encouraging them to eat more fat. This sounds more sensible to me. I liked your reminder of testing APOB /A ratio. Exercise seems to define a lot of things and it also predisposes to musculoeskelettal infjuries. Sauna is a good alternative. We don't know the long term effects of increasing fats to treat things. It may fix one thing and in the long run hurt biomembranes and heakth
My mom has dementia. She has been low fat forever because that’s what the doctors told her to do to this day she still thinks that she needs to drink skim milk and I tried to explain to her that that is not what is good for you. She’s getting a little better since her husband passed away last year and she pretty much just it’s what she wants. She is very tiny not overweight at all but I’m afraid she’s going to go into Alzheimer’s
I asked my doctor about a ApoB to ApoA1 test today. We practically had a fight about it. She finally conceded. And then I looked at the lab order after my appointment.... calculated LDL.
Great info. No intention at this point in getting tested. I really don’t want that info, which could be very scary, in my brain. Instead, I will continue living in a manner that optimizes my health in all ways I know and searching for even more great info like this. I’ve been IF/healthy Keto since May and really focusing on my microbiome. Heard the nose/sinuses has a microbiome that has an influence on Alzheimer’s. That’s my next research!
According to cardiologists the worst food in terms of LDL cholesterol is “1. Red meat. Yes, that includes burgers, ribs, steak and pork chops. · 2. Anything fried · 3. Processed meat · 4. Baked goods.”
@HighIntensityHealth -any opinion on C15:0, which is the first new essential fatty acid discovered in 90 years? “C15:0 is an odd-chain saturated fatty acid present in trace levels in whole fat dairy products & some plants and fish. FA15™ is a pure powder form of C15:0 - the only ingredient in Fatty15” supplements. I’m using the supplements but would be interested in your opinion of C15:0 & it’s relevance (if any) to expression of APOE4.
Great talk! I have 2 copies ApoE4, MCT oil can be helpful, on low carb high dose omega 3 5000 mg a day, lifetime athlete, good brain blood low key no alcohol processed food or sugar. Also I am clinical RD and kinesiology Phd studies- nun study Is very interesting have a look
Thanks!! I’ll be getting blood work for first time in nearly 4 yrs next month, also the first time since becoming a senior citizen. Will ask my doc to add such testing or order one. Do you or anyone think supplements are needed, so-called “fish oils” at least, if one eats wild fish daily??
This was hard for me to follow due to Christmas cookie cognitive impairment but explained so much of my Dad's dying with dementia and my hbp issues. My internist has me on Vasepa which is Rx levels of fish oil and it has really helped.
Thanks, I am good I had my tests done and I'm not predisposed for Alzheimers, dementia,or any cancers. I would like your opinion on medical marijuana for alzheimers. I have friends that give their elders medical cannabis honey for their dementia and they told me it helps with the anxiety and calms them down. I hope it is truly helping them.
My father had Lewey Body Disease with dementia. My mother gave him CBD oil without THC to ease his evening anxiety. Be careful. THC is known to exacerbate negative behaviors with some dementia such as LBD.
Be EXTREMELY careful about getting this testing done. If your doctor adds the results to your records, insurance companies (health and life) can and will deny you coverage.
Insurance broker here, affordable care act removes the ability to be declined for coverage due to existing health conditions in the United States. That's why health insurance is so expensive, that and government subsidization
I just tried to open my last two panels to see if they checked Mine. Apparently the state of Oregon and California require 7 days for a doctor to be allowed to discuss your results. I cant even see my own labs. That is crazy egotistical.
I'm APOE 3/3 but my Mom suffered with vascular dementia for well over 15 years of her life, ending up with mixed dementia, so I have concerns for myself. I'm wondering if my asthma, which started in my late 40s would put me at risk for vascular dementia myself?
Thank you for the incredible video! Curious if you could discuss the relationship between high copper and low zinc contributing to Alzheimer’s. Are these individual markers something people should check yearly to make sure they’re balanced?
To make matters more complicated person can be both copper toxic and copper deficient at the same time. Possibly the need for coofactor or toxic form but not enough bioavailable form or maybe some unknown mutation.
You want to look at aluminum being the cause of Alzheimer's. Aluminum is the cause or mediator of all the biomarkers which have been identified for Alzheimer's. Dennis N Crouse has just written a ground breaking book in this regard. Here is a link to the introduction. The good news is drinking silica rich mineral water removes aluminum. (There are many waters high in silica - Fiji, Volvic and Acilis ). prevent-alzheimers-autism-stroke.blogspot.com/2022/03/finding-cause-and-potential-cures-for.html
I have questions about the suggestion to increase fish intake. I have Hashimoto's disease and have read that mercury can aggrivate thyroid problems (and bad for the brain), so I am hesitant to eat more fish. Like you, Mike, I am also E3/E4. So obviously we should consume the "SMASH" fish that are lower in mercury (salmon, mackrel, anchovies, sardines, herring), but how much and how often? Is one time per week enough? or is 2-3 times per week better for E4s? What about shell fish?
The bad from fish oils is that they get rancid quite fast, cooling them in the refrigerator reduce the oxidation that make those oils rancid but maybe is not good enough to keep the oil fresh
I have bought mollers bottled with lemon scent, it was good in taste at the beginning but I had to threw it to the bin because of the taste. On the second bottle I did store it in the fridge and taste lasted longer ( bad taste is a sign of rancidity)
@@ConanFC I bought Carlson cod liver oil and it does have a lemon taste to it. It's not bad at all to be honest. Just a matter of having a teaspoon of it everyday.
I have not tested for apoe status. Can that be done thru standard medical blood tests? This topic is related to glucose metabolism of the brain and that is also related to mental illness. I would like to hear more on those connections.
And what about healthinsurance? Can we test without it going on a medical record somewhere? There is dementia in our family. Part of me doesn't want to know. I think I would stress and not enjoy the remainder of my life.
As part of a healthy diet for individuals who have at least one copy of APOE4, what are your thoughts of not only eating a lower carb diet and increasing Omega-3 fats, would it also be beneficial to lower saturated fats and increase monounsaturated and poly unsaturated fats? For example, maybe buying leaner cuts of meat and adding in monounsaturated fats such as EVOO AND Avocado oil to this to drive up the fats. This would allow you to live a low carb/ high fat diet, without getting so many of the saturated fats, which seem to be an issue with APOE4 individuals regarding how their body uses those saturated fats. To me this would make sense to decrease the oxidation of some of the bad small particle LDL. any thoughts?
Hi there! Anything in the pipeline about the topic Ozone Therapy and/or Ozone water? I’m curious as to how this could assist with gut health and other things. Thank you :-)
As a 3/4 with two demented parents I have read a lot about this. I like Dr Dale Bredesen’s work but am not convinced by his minimal meat recommendations and pro ( some inflammatory) vegetables. I am sceptical of Dr Gundry and his obsession with olive oil and know he is also anti meat. I like Dr Paul Saladino’s podcasts which contain very detailed biochemical explanations of everything. I’m sure he has done at least 2 podcasts with Dr Tommy Wood where they discuss this ( more in the most recent one). Paul’s podcasts with Peter ( Dobromylsky ?spelling!!)from hyperlipid are excellent and very in depth. Also his conversations with Dr Malcolm Kendrick are enlightening on the real causes of heart disease. I have also been a long time listener of Peter Attia’s podcast but in the last couple of years I have begun to doubt the integrity of some of his guests ( in many fields). His most recent podcast on dementia was with a female Dr who ran a dementia prevention program ( I think) and she couldn’t answer or even speak to many different points which I have heard extensively discussed elsewhere so I dismissed her. He also did a podcast early on with ? Isaacson who again didn’t seem to be interested on being informed on some topics relating to dementia. He has done many podcasts with people deep in the lipid hypothesis and again I think they are too far down their own speciality to see the bigger picture and it would be career suicide for them to start seeing what I see ( sound like any ‘covid specialists’ you know?!).
You certainly have been doing a lot of research/reading. Have you looked at the writings of Dennis N Crouse? He has written 4 books and has a you tube channel. His information is evidenced based. His mother in law is 3/4 and has late onset Alzheimer's. He has spent the last 10 years reading the scientific literature to find ways to help her and he achieved his goal. He has been compelled to write these books as what he learned shocked him as well as brought him hope. You can not prevent a disease or treat a disease until you know the cause. Research has reached a tipping point and aluminum is the cause of Alzheimer's and the good news is drinking silica rich mineral water removes aluminum. In his most recent book he presents data on aluminum being a cause or a mediator of all the biomarkers of Alzheimer's . Here is a link to the introduction of the book which discusses why APOE 4 increased your risk of Alzheimer's. I am Dennis' wife. I am 3/4. prevent-alzheimers-autism-stroke.blogspot.com/2022/03/finding-cause-and-potential-cures-for.html
The camera work is not that nice... especially the swing movement... quite disturbing... and someone was in the back....hard to pay attention... seeing someone's photo is also distracting.... The studio setup needs to be worked I think... it is not good to lose good content from the studio environment, etc. (basic things first). ☺
Hi everyone :) I need help -- I took a gene test awhile back - does this mean anything to anyone? APOE-rs7412 - labelled as Homozygous "CC" & APOE-rs429358 - Wildtype "TT". I cant tell if this is ApoE4?
I believe you are doing a disservice by not acknowledging that the healthy fats APOE4 carriers need (DHA in particular) can be obtained from plant based sources such as flaxseed, chia seed, and and algae-based supplements. Fish is fine if people all willing to accept the risk of heavy metals and industrial runoff, but it is not necessary; omega-3 IS necessary. I have other issues with this video as well, but this is the big one.
Hi Mike, great video (as usual)...I too have 1 copy of the APOE4 allele...this is my "go to" video to re-watch just to re-ground myself with great info and strategies for living the best lifestyle to avoid some of the risks associated with APOE4. Thanks!
Yes... and no. Look at Nigeria. One of the highest concentrations of APOE4 people in the world, and one of the lowest rates of Alzheimer's. That being said, as they adopt a more western style diet, with high levels of carbohydrates, seed oils, and preservatives... and low in animal based proteins, fats, and less sugars... this will unfortunately change.
@@toneyniko99 Thanks for posting the information on Nigeria. This information is so important especially for people with APOE 4. For those not familiar with the Nigerian study here is an evidenced based write up. You will also learn that the drinking water in Nigeria is high in silica. The form of silica in the water is effective at removing aluminum from the body. Research has reached a tipping point and aluminum is the cause of Alzheimer's. prevent-alzheimers-autism-stroke.blogspot.com/2018/10/apoe-e4-gene-nigeria.html
Cholesterol is good. Both hdl and ldl have use. But you need to have it in a well balanced ratio. Goes with the saying too much of anything is bad. Heated Oil and processed sugar is a deadly combo which clogs blood vessels and contributor to poor blood circulation.
Same here, and I'm scared beyond belief. I have always had high cholesterol too and eat a low fat, no fried foods no eggs, etc. Now I know it's high because of my Apoe4. I'm still not taking statins. Good luck
That doesn’t explain why women have dementia more than men. If Osteoporosis is low then it’s a risk of breast cancer and dementia. My mother didn’t take HRT. Then later in her life she had breast cancer and dementia. Now she’s in a nursing home. But I don’t know why there are a few men in the home.
All the spouses are probably dead, men die earlier than women. I don't know the gender difference in prevalence and trends, will need to look into that!
@@Highintensityhealth the husbands visit their wives in the home. Also there is a restriction of glucose to their brain. I heard ketones can get to the brain, so I gave my mother MCT oil and she improved. . A lot calmer and could speak whole sentences. Until her doctor stopped it. Because she didn’t know what that oil is and doesn’t want to know.
Very low fat (10-12% calories) and whole plant based diet. Not low or high carb and not processed. The key term is WHOLE PLANT based diet. Statins normalize risk of cardiovascular disease in APOE4 to APOE3. Lp (a) also needs to be considered along with Muslim style fasting one month a year and twice a week
Thanks. I’m a 50yo male with 2 copies of APOE4. No obvious related symptoms but I’ve been incoporating wellness lifestyle modifications for years already. Low-ish carb, high protein, TRE (18/6), whole foods, wide spectrum plant, tons of fish, monounsaturated fats…lots of movement / walking and heavy resistance training 2x / week + periodic IR sauna and emphasis on 8hours+ / night sleep. Planning to get a cognitive baseline soon with the support of a knowledgeable care team.
This video pretty much summarizes what I’ve learned going down the rabbit hole of preventative lifestyle for APOE4 carriers. Still…it feels like we have much to learn.
You might want to consider picking up a copy of Dr Dale Bredesen's first book (The End of Alzheimer's) from the book store or your local library. imho, he's the world's top clinical expert, an MD PhD, he integrates his research on the molecular mechanisms behind Alzheimer's with his very successful treatment protocol. There are several subcategories of causal mechanisms that he clearly explains. Should be fairly easy to adopt prevention strategies once you understand these categories. He explains how APOE evolved in hominins from variants with higher inflammation drivers to protect them from infection in their transition from tree dwellers to grasslands where injuries and predator attacks were a higher risk. The APOE inflammatory forms have been becoming less common in homo sapiens in our evolution over the past several hundred thousand years. fwiw, I'm a medical neuroscientist and did Alzheimer's research for several years. I think Bredesen is spot on. Great idea for everyone to manage inflammation and support their mitochondria and this is especially true for someone with 2 copies of APOE4.
@@phreedomphile I have the book 🤓 Dr. Bredesen is one of my primary sources for all things related to cognitive decline and the reason I’m scheduling a cognitive baseline and blood tests to hopefully get ahead of the game. Many thanks for your supportive words.
@@phreedomphile That's a read for me. Thank you!
You're not avoiding Saturated Fats?
Thank you for all of your information Mike. I did my best to try to understand everything you were saying about APOE4. I still feel an incredible amount of frustration on this topic. My mother-in-law passed away of Alzheimer's in May of 2020. She was not overweight. She went to a "physical" twice a year and all of her labs were always perfect. She never smoked. She never drank. No diabetes. She had a low BMI. She always got a good night sleep. Mother to one child. Worked full-time outside the home most of her life. Neurologist did brain scans and said her brain was in good shape for her age (which was in the 80s). They checked her vitamin B12 and it was normal. Two of her sisters also died of Alzheimer's. So even though she was otherwise healthy and even though her brain scans were looking good, her memory deteriorated and she got to the point where all of that typical Alzheimer's behaviors came out. She would not understand where she was or when she was or who she was with. This would create great amounts of panic as you can imagine. Thete was a study that was conducted using Catholic priests and nuns. Those with symptoms had normal brains and those with messed up brains had no symptoms. I think we still have a lot to learn.
I am on the ApoE4 diet which is a low carb diet that is also low in saturated fat and I have extremely poor compliance with it.
My diet made up of lean meats, olive oil, avocados, vegetables, and a fish oil supplement.
I also cannot eat egg yolks because I am hyperabsorber of dietary cholesterol.
Really appreciate this channel and recommend it all the time 👍
Mike, Please take a deep dive on Phopholipids and Sulforaphane, Those two products have helped me immensely. I have autoimmune UC. This put a cap on the bleeding. Not just that, but my mental clarity is through the roof, and right now I have NO hemoglobin (4). This stuff needs to be looked at deeper
What phospholipid do you take? I have APOE4 and am trying to figure out the best form to take. Thanks!
This is great next level content. I have no idea what my APOE is but I’ve been trying to live like I have one or two 4’s anyway so all good. Thanks 👍
That sounds like a great plan!
Love the attitude, Rod!
Great work.
My dad got diagnosed with frontal temporal dimentia. He going downhill very fast since diagnosis with no treatment 😥😥
Sorry to hear about your Dad, but don't give up hope. There are many causes for dementia, and some are controllable and even reversible, depending on how much damage has already been done. This is one example where this doctor explains how giving the brain ketones can make a huge difference. ruclips.net/video/cE2cuaMZiN8/видео.html
I've also read about vitamin deficiency (I think it was B17, but can't find the study, sorry) where just spraying this on the tongue brought people 'back'. So do everything you can to ensure he is eating the right foods, just in case. Good luck.
Dig in, and fight like hell for him!!! January begins year 11 of us chaperoning my mother through Alzheimer's. She's spent nearly 10 full years in nutritional ketosis. We prioritized endogenous ketone production, protein, physical activity (functional movement), and plenty of family interaction. Get him as metabolically healthy as possible, and keep him active. Mike here is a great resource. So too is Dr Georgia Ede, Dr Ken Berry, Dr James DiNicolantonio, Liz Wolfe, Gary Taubes, Nina Teicholz, Shawn Stevenson, and pretty much anyone else Mike references.
Dementia organizations and groups are very siloed off. They tend to be loud echo Chambers, that refuse to allow any outside ideas from entering. The advice we were given in the early 80's for how to care for my grandfather, was the same advice we got in 2000 for how to help my father, and that I got in 2011 on how to care for my mother. It's going be a hard fight, but you can absolutely do this. I promise, it is absolutely worth it.
@@sportysbusiness
B17 is Laetrile. The most effective, least costly way to take B17 is by eating 2-3 apricot kernels daily or every other day. UofM Ann Arbor MI nutritional oncologist recommended. I found them at health food store in 1-lb (16 oz) bag. They look like small size almonds, taste like almond extract. The cost was $12, enough apricot kernels for about 1-2 years, Rainbow Acres LA CA 90066. Don’t overeat bc they may be toxic at higher doses. Nutritionist said it’s better to eat raw apricot kernels than take supplements. We also eat 2-3 raw Brazil nuts almost every day to obtain natural selenium from food source. Again, do not overeat bc at higher doses you develop selenosis…
TY Mike - again and again - even with medical and physiological jargon you make it pretty clear. Gonna act like we (husband and I) have at least 1 APOE (we have one parent w/ Alzheimer's and one w/ Dementia). IF (& compressed eating window), Omega 3 supps, and fresh fish.
Loving the content! Im a health sciences student and cannot thank Mike enough for facilitating basic-content learning as well expanding on increasingly-pressing topics one oughtta know if he intends to become a nutrition expert 😉
Chylomicrons never become LDL. The saturated fat you eat gets packaged into Chylomicrons, which are then dumped into your lymphatic system and your circulation via the superior vena cava. However, the sugar that you eat goes to the liver through your portal system and under the influence of insulin gets converted to saturated fat (mainly palmitic acid) gets packaged into VLDL and then LDL. For this reason, it is the sugar (not the saturated fat) you eat that is the culprit. The saturated fat that you eat never becomes VLDL or LDL. However, when you eat saturated fat, there are fewer LDL receptors in the liver to take up the LDL; therefore, sometimes you see a bump in LDL.
Mike- Are you referring clients to Strategene for testing/ APOE status or using another test?
How do you find your genotype? My grandmother died of Alzheimer’s. It fairly common among the women on her side of the family. Before she lost her mind she told me often that her mom and grandmother both went crazy before dying and that she expected for her to die the same way. I have always been very conscious about my health and want to be prepared for any potential risks I may have to experience later in life.
Many labs offer it! It's cheap too, Quest and Lab Corp come to mind.
@@Highintensityhealth that is great news!
Check the aluminum products they use. Aluminum is a top contributing factor for Alzheimer's.
(Deodorant, pots, foil etc...)
Reduce the aluminum content and reduce your risk of Alzheimer's as you get older.
@@1todobless you need to cite the studies you talking like you KNOW what causes it
I found mine when a family member gave me a 23 and Me test kit for Christmas. I was shocked and fearful when I first found out I carry 2 APOE4 alleles, but when I researched things and learned how much lifestyle can mitigate the risk I simply took control. Now I just live my life and go days at a time without even thinking about it. Some people don't want to know their genetic risk factors and it was hard getting the news, but I am so happy I know about it so I can take steps to help protect me. Dr. Bredeson's book is good, but if someone tried to implement every one of his protocols it's all you would spend your day doing and it would cost a fortune in supplements. I like Mike's distillation of what is most important. I can handle it.
great talk. I would rather tell people to stop using refined oils such as olive, and others to bring down the W6/omega3 ratio than encouraging them to eat more fat. This sounds more sensible to me. I liked your reminder of testing APOB /A ratio. Exercise seems to define a lot of things and it also predisposes to musculoeskelettal infjuries. Sauna is a good alternative. We don't know the long term effects of increasing fats to treat things. It may fix one thing and in the long run hurt biomembranes and heakth
My mom has dementia. She has been low fat forever because that’s what the doctors told her to do to this day she still thinks that she needs to drink skim milk and I tried to explain to her that that is not what is good for you. She’s getting a little better since her husband passed away last year and she pretty much just it’s what she wants. She is very tiny not overweight at all but I’m afraid she’s going to go into Alzheimer’s
I asked my doctor about a ApoB to ApoA1 test today. We practically had a fight about it. She finally conceded. And then I looked at the lab order after my appointment.... calculated LDL.
So do you know your ratio yet?
Interesting that there was no mention of histidine intake and the suppression of APOE.
Great topic. Thank you!
Great info. No intention at this point in getting tested. I really don’t want that info, which could be very scary, in my brain. Instead, I will continue living in a manner that optimizes my health in all ways I know and searching for even more great info like this. I’ve been IF/healthy Keto since May and really focusing on my microbiome. Heard the nose/sinuses has a microbiome that has an influence on Alzheimer’s. That’s my next research!
Thanks for this video! A. is in my family history so I always want to learn more
According to cardiologists the worst food in terms of LDL cholesterol is “1. Red meat. Yes, that includes burgers, ribs, steak and pork chops. · 2. Anything fried · 3. Processed meat · 4. Baked goods.”
Great video! Thank you so much.
Would love to see long sleeve t-shirts.
Thanks for all the content on this channel so helpful.
@HighIntensityHealth -any opinion on C15:0, which is the first new essential fatty acid discovered in 90 years?
“C15:0 is an odd-chain saturated fatty acid present in trace levels in whole fat dairy products & some plants and fish. FA15™ is a pure powder form of C15:0 - the only ingredient in Fatty15” supplements.
I’m using the supplements but would be interested in your opinion of C15:0 & it’s relevance (if any) to expression of APOE4.
Great talk! I have 2 copies ApoE4, MCT oil can be helpful, on low carb high dose omega 3 5000 mg a day, lifetime athlete, good brain blood low key no alcohol processed food or sugar. Also I am clinical RD and kinesiology Phd studies- nun study
Is very interesting have a look
I lost my grandmother to this disease. I absolutely despise.
Same, it's a terrible disease.
Thanks!! I’ll be getting blood work for first time in nearly 4 yrs next month, also the first time since becoming a senior citizen. Will ask my doc to add such testing or order one. Do you or anyone think supplements are needed, so-called “fish oils” at least, if one eats wild fish daily??
Good call on getting tested! There's loads of options out there, customers report great feedback with this 3rd party tested blend: bit.ly/32GSaW3
@@Highintensityhealth So, a yes?!? (supplementing in addition to fish)
Thank you mike taking notes this is good information 👍🏽
I need to get this test done both my grandparents on my moms side had this. I don't want it I do everything to stop it.
This was hard for me to follow due to Christmas cookie cognitive impairment but explained so much of my Dad's dying with dementia and my hbp issues. My internist has me on Vasepa which is Rx levels of fish oil and it has really helped.
Christmas Cookie Cognitive Impairment 😂 OMG. Hope you find the best way that suits you both.
Thanks, I am good I had my tests done and I'm not predisposed for Alzheimers, dementia,or any cancers. I would like your opinion on medical marijuana for alzheimers. I have friends that give their elders medical cannabis honey for their dementia and they told me it helps with the anxiety and calms them down. I hope it is truly helping them.
I heard that as well... Sometimes the weed can be used for good things and I'm a believer these are one of those situations
My father had Lewey Body Disease with dementia. My mother gave him CBD oil without THC to ease his evening anxiety. Be careful. THC is known to exacerbate negative behaviors with some dementia such as LBD.
Thank you!!!
Be EXTREMELY careful about getting this testing done. If your doctor adds the results to your records, insurance companies (health and life) can and will deny you coverage.
Insurance broker here, affordable care act removes the ability to be declined for coverage due to existing health conditions in the United States. That's why health insurance is so expensive, that and government subsidization
Insurance companies do not know how to comprehend this data yet. But could use it against patients in future.
Good info, thanks
Like always, great content!
Do you have an updated video on APoe?
It says test is sold out. Are you still offering this?
Fantastic show 💞….as usual 🙌
I just tried to open my last two panels to see if they checked Mine. Apparently the state of Oregon and California require 7 days for a doctor to be allowed to discuss your results. I cant even see my own labs. That is crazy egotistical.
Always good. Thank you.
I'm APOE 3/3 but my Mom suffered with vascular dementia for well over 15 years of her life, ending up with mixed dementia, so I have concerns for myself. I'm wondering if my asthma, which started in my late 40s would put me at risk for vascular dementia myself?
Can you give a hypothetical dosing protocol for rapamycin?
I'm apoe3/4 eating a
Whole food animal based diet with carbs like vegetables and sweet potato, white rice... What are peoples thoughts? Thoughts Mike?
thank you.
Thoughts on apoe 3 diet recommendations? I don’t think I react well to low fat.
Thank you for the incredible video! Curious if you could discuss the relationship between high copper and low zinc contributing to Alzheimer’s. Are these individual markers something people should check yearly to make sure they’re balanced?
To make matters more complicated person can be both copper toxic and copper deficient at the same time. Possibly the need for coofactor or toxic form but not enough bioavailable form or maybe some unknown mutation.
You want to look at aluminum being the cause of Alzheimer's. Aluminum is the cause or mediator of all the biomarkers which have been identified for Alzheimer's. Dennis N Crouse has just written a ground breaking book in this regard. Here is a link to the introduction. The good news is drinking silica rich mineral water removes aluminum. (There are many waters high in silica - Fiji, Volvic and Acilis ). prevent-alzheimers-autism-stroke.blogspot.com/2022/03/finding-cause-and-potential-cures-for.html
I have questions about the suggestion to increase fish intake. I have Hashimoto's disease and have read that mercury can aggrivate thyroid problems (and bad for the brain), so I am hesitant to eat more fish. Like you, Mike, I am also E3/E4. So obviously we should consume the "SMASH" fish that are lower in mercury (salmon, mackrel, anchovies, sardines, herring), but how much and how often? Is one time per week enough? or is 2-3 times per week better for E4s? What about shell fish?
What are thoughts on supplements of fish oil vs algae omega 3 supplements?
Could be handy fir those with fish allergy.
Another great video
Hi Mike, how do I contact you regarding translation of the genetic test I have and my APOE results please ?
Here you go! Thanks courses.highintensityhealth.com/store?tag=consults
The bad from fish oils is that they get rancid quite fast, cooling them in the refrigerator reduce the oxidation that make those oils rancid but maybe is not good enough to keep the oil fresh
It depends on how it was processed and encapsulated.
@@Highintensityhealth well, when is bottled I don't think that you can do much about it, on pills do you know any brand that have a good quality?
Thoughts on taking cod liver oil that is refrigerated?
I have bought mollers bottled with lemon scent, it was good in taste at the beginning but I had to threw it to the bin because of the taste. On the second bottle I did store it in the fridge and taste lasted longer ( bad taste is a sign of rancidity)
@@ConanFC I bought Carlson cod liver oil and it does have a lemon taste to it. It's not bad at all to be honest. Just a matter of having a teaspoon of it everyday.
This helps!
I have not tested for apoe status. Can that be done thru standard medical blood tests? This topic is related to glucose metabolism of the brain and that is also related to mental illness. I would like to hear more on those connections.
Life Extension offers this test but it's 100 bucks and insurance doesn't cover it
great stuff!
Why not just do low carb and low SF, and high MUFA and Omega 3.
Good stuff
So one would want excellent capillary function to help with distribution of APOEs
Wow! Mike. Great info. I'd want to increase my life insurance before getting this test.
And what about healthinsurance? Can we test without it going on a medical record somewhere? There is dementia in our family. Part of me doesn't want to know. I think I would stress and not enjoy the remainder of my life.
As part of a healthy diet for individuals who have at least one copy of APOE4, what are your thoughts of not only eating a lower carb diet and increasing Omega-3 fats, would it also be beneficial to lower saturated fats and increase monounsaturated and poly unsaturated fats? For example, maybe buying leaner cuts of meat and adding in monounsaturated fats such as EVOO AND Avocado oil to this to drive up the fats. This would allow you to live a low carb/ high fat diet, without getting so many of the saturated fats, which seem to be an issue with APOE4 individuals regarding how their body uses those saturated fats. To me this would make sense to decrease the oxidation of some of the bad small particle LDL. any thoughts?
Hi there! Anything in the pipeline about the topic Ozone Therapy and/or Ozone water? I’m curious as to how this could assist with gut health and other things. Thank you :-)
Ozone is not good for you. It rips electrons from important molecules in your body and this potentially leads to inflammation and cancer.
As a 3/4 with two demented parents I have read a lot about this. I like Dr Dale Bredesen’s work but am not convinced by his minimal meat recommendations and pro ( some inflammatory) vegetables. I am sceptical of Dr Gundry and his obsession with olive oil and know he is also anti meat. I like Dr Paul Saladino’s podcasts which contain very detailed biochemical explanations of everything. I’m sure he has done at least 2 podcasts with Dr Tommy Wood where they discuss this ( more in the most recent one). Paul’s podcasts with Peter ( Dobromylsky ?spelling!!)from hyperlipid are excellent and very in depth. Also his conversations with Dr Malcolm Kendrick are enlightening on the real causes of heart disease. I have also been a long time listener of Peter Attia’s podcast but in the last couple of years I have begun to doubt the integrity of some of his guests ( in many fields). His most recent podcast on dementia was with a female Dr who ran a dementia prevention program ( I think) and she couldn’t answer or even speak to many different points which I have heard extensively discussed elsewhere so I dismissed her. He also did a podcast early on with ? Isaacson who again didn’t seem to be interested on being informed on some topics relating to dementia. He has done many podcasts with people deep in the lipid hypothesis and again I think they are too far down their own speciality to see the bigger picture and it would be career suicide for them to start seeing what I see ( sound like any ‘covid specialists’ you know?!).
I’m a 2/3. My dad has dementia. I suspect he Carrie’s a 4. I got the 2 from my mom.
You certainly have been doing a lot of research/reading. Have you looked at the writings of Dennis N Crouse? He has written 4 books and has a you tube channel. His information is evidenced based. His mother in law is 3/4 and has late onset Alzheimer's. He has spent the last 10 years reading the scientific literature to find ways to help her and he achieved his goal. He has been compelled to write these books as what he learned shocked him as well as brought him hope. You can not prevent a disease or treat a disease until you know the cause. Research has reached a tipping point and aluminum is the cause of Alzheimer's and the good news is drinking silica rich mineral water removes aluminum. In his most recent book he presents data on aluminum being a cause or a mediator of all the biomarkers of Alzheimer's . Here is a link to the introduction of the book which discusses why APOE 4 increased your risk of Alzheimer's. I am Dennis' wife. I am 3/4. prevent-alzheimers-autism-stroke.blogspot.com/2022/03/finding-cause-and-potential-cures-for.html
A ton of Information - but not easy to digest for laymen! 👍❗
What about those of us whose fish allergy is slightly less serious than others’ peanut allergy?
Have you tried fish oil? It's just the oil, shouldn't have proteins (that cause anaphylaxis).
The camera work is not that nice... especially the swing movement... quite disturbing... and someone was in the back....hard to pay attention... seeing someone's photo is also distracting.... The studio setup needs to be worked I think... it is not good to lose good content from the studio environment, etc. (basic things first). ☺
Hi everyone :) I need help -- I took a gene test awhile back - does this mean anything to anyone? APOE-rs7412 - labelled as Homozygous "CC" & APOE-rs429358 - Wildtype "TT". I cant tell if this is ApoE4?
You're apoe3/3. Just look into snpedia apoe index.
Where do I get this test?
23 and me genetic testing.
@@chrismyers9951 wondering if Ancestry DNA has it. I already have that one. I’ll do some research. Thank you.
I believe you are doing a disservice by not acknowledging that the healthy fats APOE4 carriers need (DHA in particular) can be obtained from plant based sources such as flaxseed, chia seed, and and algae-based supplements. Fish is fine if people all willing to accept the risk of heavy metals and industrial runoff, but it is not necessary; omega-3 IS necessary. I have other issues with this video as well, but this is the big one.
Hi Mike, great video (as usual)...I too have 1 copy of the APOE4 allele...this is my "go to" video to re-watch just to re-ground myself with great info and strategies for living the best lifestyle to avoid some of the risks associated with APOE4. Thanks!
PLEASE SLOW DOWN.
Does APOE Status show dementia predisposition?
Yes... and no. Look at Nigeria. One of the highest concentrations of APOE4 people in the world, and one of the lowest rates of Alzheimer's. That being said, as they adopt a more western style diet, with high levels of carbohydrates, seed oils, and preservatives... and low in animal based proteins, fats, and less sugars... this will unfortunately change.
@@toneyniko99 Thanks for posting the information on Nigeria. This information is so important especially for people with APOE 4. For those not familiar with the Nigerian study here is an evidenced based write up. You will also learn that the drinking water in Nigeria is high in silica. The form of silica in the water is effective at removing aluminum from the body. Research has reached a tipping point and aluminum is the cause of Alzheimer's. prevent-alzheimers-autism-stroke.blogspot.com/2018/10/apoe-e4-gene-nigeria.html
The brain 🧠 is half cholesterol
Cholesterol is good. Both hdl and ldl have use. But you need to have it in a well balanced ratio. Goes with the saying too much of anything is bad.
Heated Oil and processed sugar is a deadly combo which clogs blood vessels and contributor to poor blood circulation.
@@1todobless Seed oils are worse than sugar and vaccines
My 23andMe says I have two APOE4 genes and I feel like I’ve been sentenced to death at 30 :(
Same here, and I'm scared beyond belief. I have always had high cholesterol too and eat a low fat, no fried foods no eggs, etc. Now I know it's high because of my Apoe4. I'm still not taking statins. Good luck
U talk sooo fast a little hard to keep up with and the jargon, but ty. 😉
I'm apoe3/3
👍👍🙏
That doesn’t explain why women have dementia more than men. If Osteoporosis is low then it’s a risk of breast cancer and dementia. My mother didn’t take HRT. Then later in her life she had breast cancer and dementia. Now she’s in a nursing home. But I don’t know why there are a few men in the home.
All the spouses are probably dead, men die earlier than women. I don't know the gender difference in prevalence and trends, will need to look into that!
Dementia related to low estrogen.
@@Highintensityhealth the husbands visit their wives in the home. Also there is a restriction of glucose to their brain. I heard ketones can get to the brain, so I gave my mother MCT oil and she improved. . A lot calmer and could speak whole sentences. Until her doctor stopped it. Because she didn’t know what that oil is and doesn’t want to know.
@@KevinAmatt , I feel for you. How awful that the doctor interfered with a working strategy. What dose of oil were you giving your mother, please?
This guy sounds really smart, but it’s all an illusion. Really bad advice in this video.
Very low fat (10-12% calories) and whole plant based diet. Not low or high carb and not processed. The key term is WHOLE PLANT based diet.
Statins normalize risk of cardiovascular disease in APOE4 to APOE3.
Lp (a) also needs to be considered along with Muslim style fasting one month a year and twice a week
Statins are a neurotoxin. Plant based diets are inevitably high carb, if that low in fat/oil
Thank you!!!