Vera Gorbunova | Mechanisms of longevity Lessons from Long-Lived Mammals
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- Опубликовано: 31 июл 2024
- Seminar summary: foresight.org/summary/vera-go...
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Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital
Vera Gorbunova | Mechanisms of longevity Lessons from Long-Lived Mammals
Vera Gorbunova is an endowed Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals.Dr. Gorbunova pioneered comparative biology approach to study aging and identified rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability. More recently the focus of her research has been on the longest-lived rodent species the naked mole rats and the blind mole rat.
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30:45 which brown algae activate SIRT-6❓ You said only 1/3 of them do it😳 which ones?
I definitely wanna take it😁 edit: GOT IT👍🏻 Fucoidan!!! YOU CAN BUY THAT SUPPLEMENT EVERYWHERE
I just love this woman, she is outstanding 🫶🏼
The whole Centenarian SIRT6 thing, you need to read between the lines thing. If you actually read the study carefully, there are several red flags. First, they base the theory that those Centenarians live that long brcause they have these two SNVs(single nucleotide variants). If you look at it, they assumed that these two nucleotide changes are responsible for their longevity due to statistical probability only. The Centenarians had a 2 X higher rate of having those two mutations compared to control, but the problem is that even in the Centenarians the two mutations were rare with only 1% of the Centenarians having them. While it's "statistically" significant that the rate of these two mutations is twice higher in the Centenarians than in the controls, I think that what is more important here is the absolute rate of occurrence of these two mutations, which is very, very low even in the Centenarians. Disfferences in statistical occurrence of a trait are only relevant if the traits are relatively abundant. For instance, you can say that the "G" allele of SNP rs2802292 correlates with longevity because about a third of all people are homoozygotes for it, and they live longer by 5-10 years compared to people that are heterozygotes for the allele, or homozygotes for the alternative allele "T". But you can only say that because a lot of people have all 3 versions of the SNP, so the statistical trneds have value because the higher longevity of people that are homozygotes for the "G" allele cannot be explained by the presence of other genes since the only thing that they have in common that can explain their higher longevity is being homozygotes for the "G" allele of rs2802292 . But when it comes to the Centenarian SIRT6, only 1% of the Centenarians have it, so how can you explain the longevity of the other 99% of Centenarians that don't have it.
Another problem with "Centenarian SIRT6": the two SNVs are intronic, and one of them is a missense variant. They are both located at non-coding areas of the SIRT6 genes. They cannot possibly have an effect on the catalytic activity of the gene. They can control the protein level expression, but the problem is that gorbunova claims that the Centenarian SIRT6 has a greater auto-ribosylation activity compared to acetylation activity. But that can only be determined by nucleotide sequences located at the coding area of the gene. Introns are too removed from the catalytic sites of the gene to be active.
This is an important presentation. Hope to hear the result of your study.
I was wondering have you looked into the Glycocalyx Structure that sits above the Endothelial cells? As I understand it, if you repair the Glycocalyx then you might not have a problem with the Endothelial cells and no need for DNA repair. Just a thought from one Dr to another.
It would be interesting to see Hyaluronic Acid supplementation VS transgenic modification for increased Hyaluronic Acid production... How well does Hyaluronic Acid supplementation work?
How can one activate ALL the Sirtuins: SIRT 1, 2, 3, 4, 5 & 6 ?
I wonder if you could do a parabiosis study between an ordinary rat and a naked mole rat, to see if the longevity factors are circulating in the naked mole rat blood? That would take the research beyond just speculating about the role of hyaluronic acid.
Good luck Vera & team, I'm hoping you make some major breakthroughs soon!
❤❤❤ In conected and cybertortured in Sweden, probably för life-science and AI.
"Gilgamesh, you have travelled many miles to come here. Perhaps you think that your journey has been useless. You see no chance of conquering death. But I will let you into a secret. There is a plant that grows under the sea. It has a thorn like a rose that will prick your hand if you grab hold of it, but if you succeed in taking it, this plant will restore your youth and strength."
And round and round we go. Still no CURE for AGING. Why don't you start selling your sir T6 if you have "several companies"?
Look at the Sirt6 activator by Do Not Age. Dr Gorbanova's lab does quality testing on the product before it's released for sale.
Verrry Intermeresting.....