Physiology of Cortisol : Endocrine Physiology USMLE Step 1

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash
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Physiology of Cortisol : Endocrine Physiology USMLE Step 1
Cortisol is a steroid hormone produced by the adrenal cortex in response to the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary gland. Cortisol plays a critical role in regulating metabolism and immune response, and its release is tightly regulated by a complex feedback system.
The physiological effects of cortisol are primarily mediated through its binding to specific intracellular receptors, which are expressed in nearly every tissue in the body. Once bound to its receptor, cortisol modulates gene expression and cellular signaling pathways, leading to a wide range of effects on the body.
One of the primary functions of cortisol is to increase glucose availability in the body by promoting gluconeogenesis (the conversion of non-carbohydrate sources into glucose) and glycogenolysis (the breakdown of glycogen into glucose). Cortisol also stimulates lipolysis (the breakdown of fats) and inhibits glucose uptake by peripheral tissues, further increasing the availability of glucose in the bloodstream.
In addition to its metabolic effects, cortisol is also a potent immunosuppressive agent, inhibiting the proliferation and function of immune cells such as T cells and B cells. This anti-inflammatory effect of cortisol is important in the body's response to stress and infection.
Cortisol levels in the body are regulated by a negative feedback system involving the hypothalamus, pituitary gland, and adrenal cortex. When cortisol levels rise, the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to release ACTH. ACTH then stimulates the adrenal cortex to produce and release cortisol. When cortisol levels are high enough, they inhibit the release of CRH and ACTH, effectively shutting down the HPA (hypothalamic-pituitary-adrenal) axis.
Abnormal cortisol levels can have a significant impact on the body, leading to conditions such as Cushing's syndrome (excess cortisol production) or Addison's disease (insufficient cortisol production). These conditions can result in a wide range of symptoms, including metabolic disturbances, immune dysfunction, and psychiatric disorders.
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[@rutvikrana512]

Feeling regret not watching this video early almost missed coushing patient. Was post manopausal but early onset manopause with DM, hirsutism and newly diagnosed HTN. done S.testosterone normal, referred to gynaecologist. Just missed the diagnosis after excluding adenal and malignancy. this didn't come to mind.

[@alanwaterman1328]

Great explanations of cushings syndrome and disease.

[@devikrishna248]

Thank you so much sir 😊

[@doctorbhanuprakash]

Most welcome

[@mashooqamanzoor601]

We are very thankful to you sir!❣️❣️❣️

[@doctorbhanuprakash]

Tysm

[@torchlight3662]

Well explained
Dr V.Ahmed.

[@lokeshnainiyappan2267]

Thank you for writte and explaining that will be more understanding

[@doctorbhanuprakash]

Glad it was helpful!.

[@tharun976]

This is only one channel super teaching 😊

[@doctorbhanuprakash]

Thank you so much 🙂

[@i.mancuso738]

Thank you. 🙏 Please add an explanation on psychological symptoms on Cushing. Also there are adrenal adenomas causing Cushing.

[@tacobell5827]

Cortisol - centripetal obesity , hyperglycemia , osteoporosis, anti inflammatory , high bp , peptic ulcer , infertility , inc neutrophils , dec eosinophils, muscle wasting, buffalo hump , moon facies , abd striae , easy bruisability, hyperpigmentation, hirsutism

[@nasmaandirahim8199]

Excellent lecture

[@vishnumohanan2296]

Thank you sir

[@doctorbhanuprakash]

Welcome.

[@alamkhan6375]

Can a person who ks having stress of daily life can't have all these illnesses in minor intensity like central obesity osteoporosis etc...?

[@omarfaruk1274]

Can anyone tell me what devices he use to take this type of class?

[@vikyaths6277]

iPad and Apple Pencil

[@shankhan6586]

Zbardast❤

[@doctorbhanuprakash]

Thanks 🤗

[@saeedrkhan1372]

What about lymphocyte:..??.

[@amolkelkar7231]

Nice information and video

[@doctorbhanuprakash]

Thanks

[@tharun976]

Sir make a video on lymphatic system please please 🙏

[@doctorbhanuprakash]

As soon as possible

[@sandilimahale3676]

Very thankful to you sir 🎉

[@doctorbhanuprakash]

So nice of you