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David Sinclair: Reverse Aging & Extend Your Lifespan

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  • Опубликовано: 8 сен 2021
  • David Sinclair (biologist, Professor of Genetics at Harvard Medical School, and author of Lifespan: Why We Age and Why We Don’t Have To) discusses ways we can extend our lifespan and the work he’s doing to slow and reverse aging brain cells. He details the best lifestyle changes and emerging technologies available now to prevent most diseases until our 80’s, increase longevity, and even reverse the effects of aging. David opens up about his mental health struggles stemming from his own insecurities and frustrations with the planet, how his mother’s passing changed his outlook on life, and the dream he had that influenced his research and became a turning point in his career. After debating about intermittent fasting, Mayim and David examine the thread between solving problems in medicine, economics, and sociology, the effects of stress on the aging process, and mental health components tied to the aging brain. Mayim considers the amount of resources needed if humans lived longer, and the impact western culture’s attitude about aging might have on an increased lifespan.
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Комментарии • 768

  • @karengregory46
    @karengregory46 Год назад +10

    Mayim is a realist , I love her empathy in this world . She is so not a snob . So so many women can relate to her . I wish she was my best friend!!!! Jonathan is so calm and good for her . Perfect partnership!!! And I’ve watched just about every podcast and even some twice .

  • @xman933
    @xman933 2 года назад +66

    Mayim you’re living in the past. A lot of bad stuff has happened in the past. Some of my ancestors were brought to the new world as slaves, some were brought as indentured laborers. I lost my dad in my first year at university, my mom in my last. I lost a 21 year old son tragically but I’m excited about the future. Why? It’s a choice. I choose not to live in the past, to let the past dictate my future.
    I’m excited by Dr Sinclair’s research. I’m doing things he’s talked about. I’m in better health at age 70 than I’ve been in more than 40 years. I’m looking forward to all the great things that I’m going to do in the future and that will take place in the future.
    I respect your emotions and empathize with the pain you feel but ultimately, for all of us, it comes down to the choice we make about how we deal with the past and how we look to the future. I hope you choose a bright future because someone as talented and accomplished as you has a lot to offer to the rest of humanity

    • @msnewmind328
      @msnewmind328 2 года назад +4

      Exactly

    • @ImAbbyNormal
      @ImAbbyNormal 2 года назад +1

      Epigenetics is real. Things like the holocaust physically change generations. Sometimes we need to look at the past for answers of the present.

    • @johannesgaede1139
      @johannesgaede1139 2 года назад +3

      X Man, your are exactly right ... I am also a scientist, 75 years old and experienced very very bad things during my life but I am exited about what Dr Sinclair and others are doing in this area ... I take almost everything David is taking and I feel good about it ... I have a lovely daughter and like very much what I am doing ... and of course I am exited living today ... also still play basket ball ... not as good as Steph Curry (: ...

    • @xman933
      @xman933 2 года назад

      @@johannesgaede1139 Johannes, keep up the good work. Live long and prosper 🖖🏽

  • @vernss3092
    @vernss3092 2 года назад +84

    Intermittent fasting has been a game changer for me. I am on a 20/4 cycle. I never feel hungry since I have one or two healthy meals each day. And my calorie intake is appropriate. My type 2 diabetes has gone away, I dropped a lot of excess fat and generally feel great. I will stress that I make sure I get enough calories in my meal so I am not starving my body. I am camp David on this one.

    • @JamesQHolden
      @JamesQHolden 2 года назад +1

      What are your meals and how many times and hours you fast?

    • @JamesQHolden
      @JamesQHolden 2 года назад +1

      @@freddykruger3320 what are your meals even you eat? Do you drink water ever day though and if so how much

    • @mishdude
      @mishdude 2 года назад +1

      This is a great video about intermittent fasting made by a cardiologist. ruclips.net/video/RuOvn4UqznU/видео.html
      I also got rid of my diabetes with 1 meal a day, eaten during a 1-2 hour period. It helped me lose 95+ lbs as well (not quite at 100 yet). I love this way of eating and was so surprised by Mayim's reaction to it. She should have done her homework on that.

    • @JamesQHolden
      @JamesQHolden 2 года назад

      @@mishdude whats your diet and exercise like? low carb?

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад

      Do you drink a bottle of wine each night too?

  • @joes6336
    @joes6336 2 года назад +133

    I got to see mayim in a way that makes me love her even more . She has a heart as big as the USA . I wish more people would be more like her and stop and think about what other people are going through and try to help rather than trying to hurt them more or take what little they have away . PAY IT FORWARD AS MUCH AS POSSIBLE . THANK YOU Mayim and Johnathan great job .

    • @m_brokenleg
      @m_brokenleg 2 года назад +3

      Absolutelly, Joe! 👏🏻👏🏻👏🏻👏🏻

    • @elizabethherrington7086
      @elizabethherrington7086 2 года назад +1

      such a kind, sensitive heart

    • @MrCoconutcat
      @MrCoconutcat 2 года назад

      That would be the only reason why I would want to live longer taking those anti-aging pills from David Sinclair is to help others and to pay things generously and lovingly forward

    • @MrCoconutcat
      @MrCoconutcat 2 года назад

      I was homeless in my hometown of San Diego for 15 years & I would only want to live longer with David's medicine to get my health & years back to make money to give money away to poor & middle class people to financially help them

    • @derekjetter4039
      @derekjetter4039 2 года назад +3

      ask her about palestinians and their home

  • @xenosonic
    @xenosonic 2 года назад +97

    After watching this, I am more than worried about Mayim. Many of the arguments she has for not living longer, could really be arguments for not living at all and that is ringing alarm bells for me!

    • @xman933
      @xman933 2 года назад +8

      There’re some worrying parallels with Robin Williams here. Brilliant, talented, outgoing but with some hidden demons. Hope I’m wrong 😑

    • @madtalks4507
      @madtalks4507 2 года назад +5

      I hope since she can let it all out,, she will be fine. Hope this is a therapy in disguise for her to let it all loose.

    • @Pakistan-Icecream
      @Pakistan-Icecream 2 года назад +2

      Mayim is saying that older people should make room for younger people. The rich should give their money to the poor.

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад +15

      She has compassion for people and that goes much further than the narcissism of David Sinclair. We need more Mayims in this world.

    • @Pakistan-Icecream
      @Pakistan-Icecream 2 года назад +3

      @@rosevanderreijden3216 I entirely agree with you.

  • @sugarbabylove1000
    @sugarbabylove1000 2 года назад +44

    You are right Mayim. There's little point in extending life if we don't address the social issues so that it's a longer quality life for ALL and not just the wealthy.
    Mayim. You have a beautiful heart. Never change. ♥️

    • @maryhiggins6783
      @maryhiggins6783 2 года назад +3

      Absolutely

    • @marykuhn337
      @marykuhn337 2 года назад +2

      Exactly

    • @kanidedas
      @kanidedas 2 года назад

      Yes, and that can be achieved through giving back to people their freedom, not trough more State intervention. But USA is taking the wrong path in the last decades therefore it will be impoverished.

    • @versuch8239
      @versuch8239 2 года назад +1

      It's not an either or question. I would think extending healthy life has a huge point, if I don't have to watch Grandma forgetting everyone she ever loved, sitting in a chair all day, not being able to do anything.
      Maybe cry for all those people in the retirement homes too, who have to rely extremely on other people to be able to live and give them a chance to live the life they actually want again?

    • @Danuxsy
      @Danuxsy 2 года назад +1

      So let me refute your silly argument, by extending lifespan and healthspan we are directly improving the human condition, we would have more time and experience in solving complex problems, imagine if Isaac Newton or Richard Feynman was still alive today, what contributions would they be able to muster up in our modern era? Extending lifespan would benefit our entire civilization and solving social issues can be done at the same time, it isn't one or the other.
      H+

  • @jonzerr
    @jonzerr 2 года назад +6

    Mayim is grounded in the reality of the human experience. How she has this in the aftermath of childhood stardom is both absolutely confusing and admirable. She has been able to see the world through her grandparents eyes and this helps her tune into a variety of harsh human experience. We will all live forever … through the memories and results of the love we gave while we were here. Some have more years than others, but this reminds us to live each day with passion and honest compassion.

  • @chribjslaha
    @chribjslaha 2 года назад +37

    David is such a humble person. Such an inspiration

    • @freckles2773
      @freckles2773 Год назад

      Mayim is so emotional about living longer and the human experience. I bet she lives to be over 100 but would like to see everyone else die so they don’t have to go through the pain of living. It is an interesting thing to project your feelings on the whole world.

  • @marjake3147
    @marjake3147 2 года назад +32

    Mayim is a perfect example of some people who are what I refer to as hyper intelligent and for some reason lack emotional maturity. Her Grandparents suffered and lived their life to the best of their ability. She seems to have missed the point of their lives; do what you can with what you have, move on- move forward and using the experiences of the previous generations make better choices, live a better life, and teach your children to do this also. There is no point, purpose, or reason to dwell on the past except to learn from it and not repeat their mistakes and not make yourself an emotional wreck. I would also add that what David Sinclair is doing is a great benefit to those who are disadvantaged. Think about this; you're not going to live longer if you aren't in good health. He is simultaneously trying to end suffering and by doing so is enabling us to live longer happier lives. I am amazed that this man has just said that he has a cure for blindness, and no one seems to understand how that will improve the quality of life for millions of people, and yet it's glossed over like "so what". Many many people are unhappy because they chose to be so. Not all, but many. Prof. Sinclair said it himself. He was a depressed and suicidal young man, witnessed his own Mothers' death, and he made a CHOICE to be optimistic and make the best life he could. He is an inspiration on many levels-

    • @JaniceAJanice
      @JaniceAJanice 2 года назад +1

      Well put in every way. Thank you for your keen observations

    • @stevebaig9564
      @stevebaig9564 2 года назад +1

      Isn’t she doing just that? Living a better life than the previous generations in her family?
      The inner turmoil is something that is not something that privilege takes away.

    • @jlg3315
      @jlg3315 Год назад

      she never fails to remind me why i do not like or respect her. and he never fails to do the opposite. she is what i call a well educated idiot.

    • @SCORP1ONF1RE
      @SCORP1ONF1RE Год назад

      shes a super-genius. and because of that, she can see through his BS from a mile away!

    • @spookavision
      @spookavision Год назад

      @@SCORP1ONF1RE No she's not. She's smart, but she's far from a genius.

  • @LucGendrot
    @LucGendrot 2 года назад +14

    I obviously don't know Mayim, but it does seem that Jonathan hit the nail on the head when he implied that her negative reaction to David's research had more to do with her own struggles with aging in her family than any particular problem with the science.
    The thing she said that frustrated me the most was when she was talking about people in nursing homes and how spending more time there would be awful. Obviously that's true, and yet David's entire point is that a longer healthspan would reduce the amount of time people spend in those places. I think Mayim completely missed the mark here, to be honest.

  • @eszternagyszollosi3001
    @eszternagyszollosi3001 2 года назад +10

    Thankful for David Sinclair to exist. He is a brilliant minded human with a healthy ‘heart’ and pure intentions leading Humanity into the next chapter that might look more hopeful. Hopefully we as a species will grow up to use our time on Earth (and the benefits that better health gives us) more wisely as a response to this leap!
    The lovely lady leading the interview seems to represent the wounded part in us that is afraid of this opportunity as, yes, our traumas first need to be healed enough for us to want to move on and want to live longer. Health also has this aspect, which even science cannot solve fully. This is for another whole bunch of disciplines to work on! Xx

    • @fsr1391
      @fsr1391 Год назад

      Thank you so much. David Sinclair is one of my favorite people on the planet.
      I read the book and it instilled great strength in me. Am in my 70’s and I am reversing my age through art activities,
      reading, walking and I love makeup!!!
      Grandchildren are awesome and creative. Mayim, I knew you were a star as Blossom. You and Jonathon are lived and so needed on the planet. Thanks to both of you for sharing your brilliance and your neshama with us out here in the world at large. 💌🌷💥☃️

  • @nozhki-busha
    @nozhki-busha 2 года назад +41

    Woohoo more healthy lifespan, sign me up! Ending age related diseases for longer healthy lives is something humankind should get behind 100%. David is absolutely correct in the personal and societal benefits of healthy longevity.

  • @karenkingrey6142
    @karenkingrey6142 2 года назад +16

    I have been a compulsive overeater for as long as I can remember. When I discovered my current eating plan coupled with IF, it truly helped me far more than any other program. I’ve lost 90 lbs, and now I can enjoy waking/exercising. Now look, I am not quite as extreme, I have a 5/6 hr eating window. And I’ve never had more energy, my Lupus symptoms have all but vanished, my BP Med has been cut in half….among other things. I really believe he’s on to something very encouraging. (I’m 55, 3 (grown) kids, menopausal, full time job & a part time job) I need allllll the energy!! Lol. Wonderful podcast full of hope for our future!!! Thanks Mayim!

    • @ThisIsNotMyHome
      @ThisIsNotMyHome 2 года назад

      Can I ask what your current eating plan is, please?

  • @kimcremer9910
    @kimcremer9910 2 года назад +5

    I love this guy! I’m all on board! I’m reading his book right now. I do love that she challenges him and doesn’t just bow down to him like many podcast hosts do. She knows science and best practice. I also massively appreciate Mayim’s social awareness. I’m loving this!

  • @fishhead1982
    @fishhead1982 2 года назад +8

    Mayim seems to have missed one of the main point David makes in his book. It's not juts about the length of life but the quality of it. It's not going to end up with people in nursing homes for 60 years because their "healthspan" is right up until the end of life.

  • @m_brokenleg
    @m_brokenleg 2 года назад +32

    For all those Spanish speaking people watching here: Dr. Sinclair’s book is also in Spanish and in Amazon. And is a GREAT ONE! Quite interesting and informative. Even if disagreeing in some ethic attitudes.

    • @emiliaumana272
      @emiliaumana272 2 года назад +3

      Gracias!

    • @m_brokenleg
      @m_brokenleg 2 года назад +1

      @@emiliaumana272 De nada!

    • @MrCoconutcat
      @MrCoconutcat 2 года назад +1

      I watch the full episodes commercials and everything from start to beginning

    • @kennylo8423
      @kennylo8423 2 года назад

      Thanks for the advice ! 🙏🏼 i will give it in spanish to my mom , cuz she docent read English 📚

    • @lauradoctorf6415
      @lauradoctorf6415 2 года назад

      Exacto. De hecho la version en Spanish version kindle es mas economica que la version en Ingles!

  • @BarsandNightclubsAU
    @BarsandNightclubsAU 2 года назад +6

    Please people listen to other David Sinclair videos where he is interviewed by someone who isn't mentally unhealthy. This should give so many people the inspiration to stsrt something new (as it did for me).

  • @marydama8357
    @marydama8357 2 года назад +4

    Mayim, could you please get serious. This doctor is brilliant!!!

  • @TeruMaldi
    @TeruMaldi 2 года назад +56

    To say we can't address longevity and aging because there are societal issues is like saying we can't fight covid when cancer is such a rampant problem. They aren't exclusive and fighting aging related health issues might even be the way out of poverty for a lot of people. Sure there is suffering, but it shouldn't prevent us from fighting for a good cause.
    Also at times it felt like the host was almost attacking David through the humorous but snarky comments, which - considering his stance throughout this podcast - was uncalled for.

    • @lucyphillips2217
      @lucyphillips2217 2 года назад +8

      This is such an important comment and should have been stated in the video. This was my first time listening to the hosts, and the only reason I watched was because I admire David Sinclair. He is attempting to tackle many issues already, we should not expect him to address social-economic issues that dedicated economists and politicians can’t even handle. ALSO, if people have an OPTION to choose his tactics as an alternative to many other expensive and/or time consuming procedures to promote healthy living, LET THEM CHOOSE. If people don’t want a longer life, then don’t take the advice or pill that David is promoting.
      Since I have never listened to the hosts, I have no idea what their personalities are like, but Jonathan’s approach to the topic was far more enjoyable to listen to.

    • @kallazjopatsu6846
      @kallazjopatsu6846 2 года назад +1

      Even Joe Rogan saw David as more interesting than neurotic.

  • @yuliya9885
    @yuliya9885 2 года назад +25

    The host and her questions were really questionable. But David was so good.

    • @Richard-eg6fw
      @Richard-eg6fw 2 года назад +2

      The host is not open-minded. She didn’t learned anything from talking to Dr Sinclair. Drinking sugar and self pity.

    • @LucindaSchumann
      @LucindaSchumann 2 года назад

      I could only watch bec of David but that chic.... Ey man. Really?

    • @jenm1
      @jenm1 2 года назад

      Dr. Sinclair is a charlatan. He has no science backing his claims and his advice has sent people to the hospital.

    • @jenm1
      @jenm1 2 года назад +3

      @@LucindaSchumann She's not some "chick". She's a scientist with a PhD in neuroscience.

    • @LucindaSchumann
      @LucindaSchumann 2 года назад

      @@jenm1 omg you just made me watch her again for 5 secs and I literally could not do it

  • @get2sri
    @get2sri 2 года назад +5

    I am so disappointed at Mayim. I loved her in BBT episodes way better. Her body language, her terrible way of reading his book a little, hand gestures, her artificial demeaning laughs were very disrespectful and no idea what she has become. This is my first seeing her outside of the show and it's gone totally south. David has been so cool with such a worse host, probably his first. Her problem has a conflict of interest like for example, she hates fasting, loves food.
    David is a very smart, probably the only person if allowed, will correct the biggest problem, aging, we slow down, and we are useless for the society and become a burden. Instead, we can take his steps on lifestyle and NMN regime to be active and contribute to the society and live our passion for rest half of our life.
    Thank you, David, please keep going 🙏🏼 👍🏼.
    For all others, please view his other interviews that are much better and peaceful to listen to, concentrated on the subject.

  • @sheridixon190
    @sheridixon190 2 года назад +13

    I find her negative and I don’t like the ads. I just like David Sinclair. I’m here for him. He’s the real deal.

    • @robz.3225
      @robz.3225 2 года назад +2

      The ads are really annoying

  • @jennifermoran2884
    @jennifermoran2884 2 года назад +27

    The way I receive David in this interview is him spreading a message of hope based on years of experience and dedication. David and every other researcher/professor can better the lives of people all over the world. I am all for extending a persons life by giving them more options/chances/avenues to do so. Although, quality of life needs to be taken into consideration.
    I don't think this is an 'either/or' situation but a 'both/and" situation. Meaning, all parts of an individual need to be taken into consideration before making any decision as no two people on the planet are the same.

  • @roncenti
    @roncenti 2 года назад +51

    WOW. Weird mindset. I sometimes do not understand people. It was a great episode but the "breakdown" at the end I don't understand.
    I should not take cold showers because there are people who can not afford hot water?
    I should not do fasting because there are people who can not afford meals?
    I should not live longer because my grandparents suffered through horrible tragedies?
    I think politicians would make better decisions if they lived a 1000 years cause the changes would influence them. On the other hand dictators would never leave.... so I am torn.
    We need to find out how things work and fix it... Then we deal with society. If we would live 1000 years we just can not give birth to 100 children but there is a solution. A shitty year does not seem as bad if you had 1000 more. You could have several careers cause you have time to learn. You can fix more problems cause you can study something for a long time and not get old and die and the next guy has to understand what you did and add or modify it.
    Why do we have to fight every idea? Even one like this? I just do not understand.

    • @ChemistrywithDonya
      @ChemistrywithDonya 2 года назад +2

      100% agree with you

    • @FlowerGirl8
      @FlowerGirl8 2 года назад

      First episode and the negative pushback you mentioned confused me too. Sinclair is highly regarded for his evidence-based research and I love his positivity and drive to improve quality of life, and health longevity by delaying the aging process. I feel she missed the point entirely.

  • @LucretiaYeh
    @LucretiaYeh 2 года назад +2

    I’m not sure I want a longer life, but do want a healthy life up to the end

  • @nicolenichol3820
    @nicolenichol3820 2 года назад +39

    I was thinking the same thing as Mayiam. Not everyone has the same access to goods/services/shelter ect. It's definitely easier in theory than practice to live in the way he does. Corruption is a major problem that prevents us from advancement.

    • @nohjuan3048
      @nohjuan3048 2 года назад +6

      Longevity isn't a blessing to people who live in extreme pain. My mom's friend Jeff just died after living 58 years with a very painful congenital disease of the heart and joints. Even people with emotional pain might not choose to live a long time. And what do we do for the extra housing, food, fuel, and other resources that would be required to extend life expectancy another 20 to 30 years? We can barely cover the average lifespan now. Living longer requires more than just a pill, we'd have to change our entire culture to make it work.

    • @Danuxsy
      @Danuxsy 2 года назад +1

      @@nohjuan3048 which we will have to do anyway, technology will just keep moving forward, we are forced to adapt.

    • @abnerperry5297
      @abnerperry5297 2 года назад

      @nichole You too are a fool. Not everyone is equal. Is it fair? No. Is life fair? No. Get over it. Do you want equality or freedom? You can't have both and that is the truth.
      "Human beings are born with different capacities. If they are free, they are not equal. And if they are equal, they are not free.”
      ― Aleksandr Solzhenitsyn

  • @begoniatabriz6828
    @begoniatabriz6828 2 года назад +36

    I am sorry, @Mayim Bialik that you don't understand many of the things the guy was talking about. One meal a day, intermittent fasting, and longer fasting are pure health to the body, especially when you have obesity (like you and I have), diabetes, and many other conditions. Nobody said this was for children or for malnourished people, but fasting is very healthy for most of us. We should eat only when our body (not mind!) is really hungry. The same about the anti-aging pill, Jonathan was right in all he was saying at the end, it is not necessarily about living 1000 years, it is also about the quality of life and health. Also, everybody in America should think about what he said about Australia (and this is true also for Western Europe; maybe Canada, too?): in that part of the world, people don't get to be extremely poor and not have what to eat!

    • @mishdude
      @mishdude 2 года назад +4

      Agreed. This video is great re intermittent fasting.
      ruclips.net/video/RuOvn4UqznU/видео.html
      So are Dr. Fung's videos. Amanda Rose, PhD helped me lose 97# with free info re intermittent fasting and low carb food. Autophagy is such a great benefit and I have put my diabetes in remission. I'm surprised she didn't research that more!

    • @angelatakano6072
      @angelatakano6072 2 года назад

      I don’t think Mayim has obesity, only some extra kgs, but agree that the only way to get rid of those extra kgs is to try to find a “diet” or regimen that would actually work for you, because all people are different and their bodies respond differently

  • @marisamartinezolivera
    @marisamartinezolivera 2 года назад +7

    SO TOUCHED by Mayim’s words at the end of the episode. A knot in my throat..Empathy and empathic people as Mayim are most needed in this selfish world! THANK YOU! 💜💜 But such absolutely interesting topic! I’ve read his book about aging well! (as my granpa “said it’s not the years of life but the life of years”) Now I’m 65 and do hard alpin sky, walk 60 km/week & hubby is quite past 76, a known doc here still fully active who rides 7,000 km/year through mountain roads with his bike. Good genetics? Yes. Mediterranean diet? Of course. Active life even struggling with awful things? Always!
    Dear Mayim and Jonathan, how the hell this podcast is improving its content, guests, and topics as every episode is broadcasted! You rock, guys! 👏🏻👏🏻

  • @angelamiller391
    @angelamiller391 Год назад +2

    people are so judgemental... thank you for sharing your emotional response at the end. I appreciate you Mayim! Living longer with only what I know and how I respond to life now would be sad and redundant! That's one reason that I'll keep watching your podcast and keep learning how to improve not only my way of living but my perspective. You are also teaching me to be of service to others, for that I am grateful!

  • @10bleph
    @10bleph 2 года назад +33

    Just a shame you didn't really give David the room to talk without all the sidetrack .. Jonathon asked some great questions.

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад

      Sinclair has a VERY limited repertoire. It was interesting to hear someone challenge him as he rarely accepts any challenge.

    • @lauriegreinert8672
      @lauriegreinert8672 2 года назад

      What about 5G?? Does he address that in the book?? I'm 64, and caring for my elderly mother who has late stage vascular dementia and diabetes. I'm interested in his book, but not sure it's on my level of understanding. I'm a Christian and I am daily trying to figure out what God is trying to tell me when reading certain Books of the Bible, chapters, verses.

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад

      @@lauriegreinert8672 His book isn't exactly a page-turner. I think a pamphlet would have been just as effective.

    • @thatwasprettyneat
      @thatwasprettyneat 2 года назад

      @@lauriegreinert8672 it doesn’t take a college degree to understand it. It’s not an easy book necessarily, but it’s extremely interesting and it kept my interest and Sinclair is pretty good with using analogies

    • @thatchessguy7072
      @thatchessguy7072 2 года назад +1

      @@rosevanderreijden3216 I listen to a good deal of Sinclair podcasts, and I’ve noticed it’s mostly the same old same old each interview. Somehow I expect to not find much new information in his new book that I couldn’t gather from his podcasts.

  • @peter_bazinet
    @peter_bazinet 2 года назад +80

    At the end, Jonathan made more sense by not getting emotional. Mayim made references to practices that no longer exist, though valid in their time, and they didn't make sense for the current conversation. Also, her "live forever" was a bit much. The ability to live "forever" will never exist. Jonathan's comment of just living "healthier" was the qualifier. I understand Mayim's concern about people only having one meal of day, only having cold water, etc, etc. But if Mr. Sinclair and his methods didn't exist, some people would still have only one meal a day and cold water. That's a separate issue to be worked on by all of us. The beauty of longevity is that nobody will be forced to do it. It will be a personal choice. For anyone who has ever said "there just aren't enough hours in the day", this could possibly make reaching goals attainable. I certainly do not want to live forever, but if I could stretch out this lifetime with the chance of seeing all the beautiful places and people I've only dreamed of, then I welcome it.

    • @larrywayne6254
      @larrywayne6254 2 года назад +9

      I agree with you. However, emotions do hold value in a conversation. Science is applicable to all aspects of our lives. Emotions such as compassion, empathy, and sadness are important tools to bring to any conversation, including conversations of Science that directly impact our lives (all science). For example: Breonna's Law that was not too long ago passed in many states. Emotions are important in governing a society. I applaud Dr. Bialik's emotions. It's needed.

    • @derekjetter4039
      @derekjetter4039 2 года назад +6

      ​@@larrywayne6254 She talks about suffering as a way to self identity and feel important. The bit about women consistently marrying old men is made up and really has no relevance to today anyways. She talked about women not voting while ignoring that most men never voted but still had to live in the military. She talks about the tragedy of parents not becoming too attached to kids who would frequently die in young yet she is pro abortion. How tragic does she view baby deaths when she supports a mothers right to impose it? How compassionate is she about people born in unfortunate situations when she is pro zionist, ie pro apartheid. I think she is fake.

    • @spadaacca
      @spadaacca 2 года назад +3

      Hi couldn't agree more. There was a fair bit of conflation and hyperbole which took away from a reasonable conclusion to the video.

    • @Pakistan-Icecream
      @Pakistan-Icecream 2 года назад

      @@larrywayne6254 Bialik is a doctor?

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад

      Yes, us women tend to have emotions but we don't start wars and we tend not to rape the Earth of resources for power. So much for the impassive logic of men.

  • @KenOtwell
    @KenOtwell 2 года назад +9

    OMG I always thought Mayim was a reasonably intelligent person, but I'm disgusted with her attitude here. This is the last video of hers I will watch. Guests deserve so much better treatment.

  • @mattbaumgart3621
    @mattbaumgart3621 2 года назад +22

    I love when two academics get together and are able to discuss a topic. They each ask and answer questions in a way that seems like mental chess. I wish I could interact with most of society in this way without them resorting to name calling or just shutting down the conversation. This is how both sides can disagree but still learn new ideas.

    • @Pakistan-Icecream
      @Pakistan-Icecream 2 года назад

      I thought Marin is an actress and not an academic.

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад +2

      @@Pakistan-Icecream She's both. She has a degree in neurobiology.

    • @ImAbbyNormal
      @ImAbbyNormal 2 года назад +1

      Majoring in neuroscience with a minor in Hebrew and Jewish studies, Bialik earned her bachelor's degree in 2000 from the California university. She researched obsessive-compulsive disorder (OCD) in adolescents with Prader-Willi syndrome for her Ph. D. at UCLA, which she received in 2007.Oct 7, 2021

    • @abnerperry5297
      @abnerperry5297 2 года назад +2

      @matt Two academics? You put Mayim in a class with David Sinclair? She is ridiculous. Has an opportunity to interview someone like David Sinclair and she thinks we want to hear about her natural childbirth and nursing her babies? Really!? Useless woman.

    • @86sineadw
      @86sineadw 2 года назад

      So because she is ALSO something else (an actress) as well as having a PHD that means she isn't an academic? That's a ridiculous argument. Go again.

  • @edjones8815
    @edjones8815 2 года назад +18

    What an intense, passionate, informative and thought provoking interview. Thank you. As with most situations in life, there always is someone better and worse off than am I. Prolonging life is not a driver for me (I’m not ready to go anywhere now though), but whatever I can do under my current circumstance to improve my condition (and those of others) now and into the future interests me. I share your concern about the pain that exists. The hopeful part of me makes me remember the quote from War and Peace, “where there is life, there is hope.” For things to get better, it takes effort and compassion, and in this episode I saw both. Great job!

    • @Ehralur
      @Ehralur 2 года назад

      This is exactly it. People always jump on David's ideas as if his goal is to make people live longer, but his goal is to make people age more slowly and therefore live more healthily. Living longer will just be a side-effect of that.

  • @collscollscolls
    @collscollscolls Год назад +1

    Mayim, your empathy and attachment to real pain, struggle, suffering resonated with me. I’m a therapist! But I still feel the exact pain you emote.

  • @yayangtapir4130
    @yayangtapir4130 2 года назад +3

    My favourite scientist on planet earth right now- David Sinclair! I get so excited and motivated listening to him.

  • @aug8478
    @aug8478 2 года назад +40

    I really enjoyed this podcast even though I did not really understand Mayim's reaction... I seem to think more like Jonathan, and I am Canadian. Definitely getting David's book next.

    • @gerihenry2261
      @gerihenry2261 2 года назад +10

      I think what's she's sharing is there is so much inequality currently that needs to be repaired before we can extend the life of humans. Those who can afford it will continue to live the priveleged life, and those who want a better life who can't afford it will either go without and die sooner, or somehow save their change for years and live longer in poverty and disadvantage due to inequalities. And that's sad, thus the tears. At least that's my take.

    • @versuch8239
      @versuch8239 2 года назад +4

      Sure, we will just keep watching our parents and grandparents and eventually ourselves grow frail, forgetful and die until we somehow solve the rest of the world's problems first.

    • @gerihenry2261
      @gerihenry2261 2 года назад

      @@versuch8239 good point but I don't think that's why here emotions were strong enough to bring tears. There's so much hurt in the world in so many forms, inside and outside ourselves, so to each their own, I guess.

    • @versuch8239
      @versuch8239 2 года назад +3

      @@gerihenry2261 Ignoring the pain of the people growing old around you - their bodies failing them more and more with each year - just because other people suffer too is neither noble, nor a situation fitting of saying "to each their own".

    • @breannemattson5847
      @breannemattson5847 2 года назад

      @@versuch8239 I think that's her point though.... It's not a "rest of the world" problem. It's a bigger problem in the USA than people want to believe. Sinclair even talked about it in the beginning when compared to Australia and other countries with universal health care. Also when he mentions metformin is available in other countries OTC for cheap but you have to have a prescription in the US and it's more expensive with that prescription.

  • @permaxsun
    @permaxsun 2 года назад +24

    I think Jonathan's final remarks are spot on, the viewing angles were quite different between David and Mayim, but they are not mutually exclusive. Medical science advances and equality in society can (and did) benefits each other. Jonathan at least tried to help Mayim to see from David's view point.

  • @flipmcflop2
    @flipmcflop2 2 года назад +24

    When he said he was 52 I nearly fell off my seat. I thought he was 25!

    • @sandramcinnis-fibreinsanity
      @sandramcinnis-fibreinsanity 2 года назад +4

      Yes he does look very youthful for his age, but he definitely had a filter on in this "zoom" screen. His real-life photos are more realistic. Even so, he looks young in real life. This stuff is all working for him!

    • @joannaurban2418
      @joannaurban2418 2 года назад +1

      He does look 52 in his photos.

    • @abnerperry5297
      @abnerperry5297 2 года назад

      @@joannaurban2418 Are you unaware his BIOMARKERS peg his age at 31?

    • @simplynej
      @simplynej 2 года назад

      Right?!?!?!

  • @AtoZDesign
    @AtoZDesign 2 года назад +13

    I am an intermittent faster - It wasn't a "thing" when I started in my teens and my mother worried about me and had loads of conversations with her friends about it until it recently became a "thing". I LOVE my food but both early breakfast and late dinner never agreed with me in one way or another so I moved them much closer together and was happier for it. It's not for everyone and it shouldn't be, our bodies and minds all have different needs.

  • @cayceesmith2650
    @cayceesmith2650 11 месяцев назад

    As someone who grew up in extreme poverty (and I'm only speaking to my own experience), I'm incredibly grateful to have grown up that way. Knowing what I can survive and even flourish in has made me a much stronger and more confident person.

  • @roxannetracy2931
    @roxannetracy2931 2 года назад +8

    Oh Mayim. I watched till the end as usual and I love your heart. I get it. I have the same heart. Now, what we have to do, is pull up our bootstraps as my Papa would say and merge the hell out of our hearts and Sinclair's science. Bless your heart.

  • @xmanboby
    @xmanboby 2 года назад +3

    If you want to know more about fasting invite Jason Fung, you could have a nice conversation with him as well , great show

    • @robz.3225
      @robz.3225 2 года назад

      Better yet, Alan Goldhammer

    • @xmanboby
      @xmanboby 2 года назад

      @@robz.3225 why not both :D

    • @mishdude
      @mishdude 2 года назад

      Fung us great. And this doc: ruclips.net/video/RuOvn4UqznU/видео.html

  • @MuhammadTaimoour
    @MuhammadTaimoour 2 года назад +7

    David is a loving legend lots of prayers for him and his theory is right live healthy following from long time

  • @MS-rc6ii
    @MS-rc6ii 2 года назад +2

    Mayim, great humor. He’s talking about living longer and being HEALTHY:)

  • @joslyngail
    @joslyngail 2 года назад +14

    I love you, Mayim. Everything you said is what I was thinking and it's reassuring to see your empathy and compassion pouring through tough conversations like these.

  • @maankanimoda
    @maankanimoda 2 года назад +22

    It's also socio-cultural, Mayim.. In the Philippines, we don't send our aging population away. There are homes for the aged for those who have no relatives who can take care of them, but the great majority of families remain intact even in the poorer quarters.

    • @_richie_manila5371
      @_richie_manila5371 2 года назад +2

      Tama. You can see aged people just roaming in the streets begging for food especially here in Manila.

    • @sethseth9059
      @sethseth9059 2 года назад

      If philippino's had the money then the old would be in palliative care homes. Let's not pretend the philipino's are these angels. You're poor as dirt and couldn't sent grandma away even if you wanted to.

    • @christiancarigaba5941
      @christiancarigaba5941 2 года назад +1

      @@sethseth9059 nope, we have enough, but would not send my mother or father to rott on care homes. being the eldest, they are my responsibility.

    • @sethseth9059
      @sethseth9059 2 года назад +1

      @@christiancarigaba5941 Yep you philipinos do. Philipinos behave exactly like everyone else here in Canada. I don't give a fuck what you claim to do with no way of verifying it. Nice try clown.

  • @sweingold5686
    @sweingold5686 2 года назад +1

    Mayim has such a big heart. I was crying along with her. I share her empathetic viewpoint and concerns for disadvantaged communities. I grew up poor so I know how it feels. Our Healthcare system needs big changes. The science in this book is intriguing. I know people taking Metformin (sp?).

  • @blueskye2790
    @blueskye2790 Год назад +1

    Mayim is so admirable. She's the most feeling-human I've encountered. And she's right. We never think about the global scale suffering the way she does. Unfortunately, even if I consider myself empathic/sympathetic, I don't always feel as deeply as she did, and I wish more people did, because we clearly have PROBLEMS. And it's true that so many of these ideas tend to overlook people who are forced into these situations (only have cold water - been there); don't have enough to eat (been there).

  • @pureforn9218
    @pureforn9218 2 года назад +121

    I don't think this man is gonna shove longevity pills down anyone's throat. If you're not keen on prolonging your miserable life - you're safe. But let's not expect him to solve world problems.
    I'm no way rich person and I'm taking Trans-Resveratrols and looking and feeling 10 years younger. How doctor Sinclair endured this weird interview with such patience and grace is admirable...

    • @misterogers9423
      @misterogers9423 2 года назад +10

      I agree. I do think there will be resistance to following this kind of life style since it is inherently uncomfortable and goes against antiquated ingrained beliefs, such as the importance of eating breakfast. Humans also desire to be comfortable temperature wise, but the science states we must go away from that to slow down aging. Clearly, it is not for everyone, and that is ok.

    • @thatwasprettyneat
      @thatwasprettyneat 2 года назад +2

      I'm taking resveratrol in powder form in yogurt, just the way he recommended. I don't feel any younger but I feel like it might be helping so I continue to take it. There are things he talks about that I won't do, because I feel they're counterproductive. I'm not going to subject myself to cold showers or be cold all the time or whatever just to achieve hormesis, for one.

    • @carolbrooks9161
      @carolbrooks9161 2 года назад +1

      I love this show. My first time watching. I love that Mayim gets so emotional. I get emotional about that stuff too. ❤️

    • @WilleH1
      @WilleH1 2 года назад +5

      @@misterogers9423 Everyone isnt uncomfortable eating only one meal a day, like me for example. My body thrives on OMAD. I feel more energentic, dont get huge blood sugar spikes, dont feel unnecessary hunger every 2-3 hours when my body doesnt even need food. Also my inflammation levels have gone down so much my psoriasis is healing itself better than when I used hydrocortison. I also like cold exposure, I feel so good afterwards and I'm very warm blooded as well, so cold feels really good.

    • @LucindaSchumann
      @LucindaSchumann 2 года назад +1

      EXACTLY That is not the point. This women thinks it's a debate!!

  • @spadaacca
    @spadaacca 2 года назад +22

    I genuinely respect honesty and openness in interviews etc. but I'm not sure his content warranted her reaction. It felt like the science and the value therein got muddied with too much conflation and personal background, which shouldn't take away from the importance of this work.

    • @abnerperry5297
      @abnerperry5297 2 года назад +1

      I for one didn't need or have the least speck of interest in her personal background.

  • @seancregomusic
    @seancregomusic 2 года назад +29

    This was a tough episode for me to watch. I am sure Sinclair is well-respected, but he is sooooo stuck in the science mind bubble that he couldn't begin to process what Mayim was trying to say, even though he experienced it himself! (It's like he left that all behind him.) I agree with Mayim, of course, that it takes all kinds in the world, but it was still really, really difficult to listen to this guy.
    But, Mayim's epilogue to this episode made the entire episode worth it! I am very glad that I stuck around to the end. I could just only wish I could have been with Mayim in person to discuss and support her in her reaction to everything.

    • @davidadams2395
      @davidadams2395 2 года назад +2

      I have never subscribed to Sinclair's claims, to the point where I don't care for the guy. I don't believe I can watch this episode.

    • @Danuxsy
      @Danuxsy 2 года назад

      What exactly was she trying to say?

    • @abnerperry5297
      @abnerperry5297 2 года назад

      @sean Garbage. Let her share her wealth with all those poor people she pretends to worry about.

  • @ohmydevorahrose
    @ohmydevorahrose 2 года назад +4

    Omad is incredible and genuinely changed my life. I have lost 50 lbs and gained sharp mental focus, probably reverse 15 years, and overall healthy feeling. I love listening to David Sinclair and absorbing everything he says. This interview was a step-in-the Twilight Zone, with Mayim Crying and Sobbing...is she OK? Does she need therapy? David Sinclair should be celebrated, and his teaching should be spread to the people of a growing demographic like me who want to change and improve life quality on the next stage. Instead, this interview was a total downer with the hunger of the world and missed information. Would you please donate to charity to help solve world hunger, but please let the Great David Sinclair speak to us?

  • @daddyshoneygirlusa7030
    @daddyshoneygirlusa7030 2 года назад +3

    Just, "wow", I thought I kinda like Mayim, but just too much negativity toward scientific research that may keep people healthier, more productive and free up resources currently going towards "health care", when we do not even fully understand what "health" means. I have been intermittingly fasting, avoiding sugars, etc.. for over a year, and it seems helpful vis a vi my autoimmune condition. Thanks so much Dr. Sinclair, for your insightful research!

    • @artten5002
      @artten5002 2 года назад

      The stance about not taking cold showers and one meal a day bc others are suffering will never make sense
      Those 2 things amongst others helped me beat alot of my depression and inflammations.
      Getting diabetes, getting sick bc my immune system isn't getting stronger by avoiding those and depression isn't the price I will take just to make feel better about the poor.

  • @angiedamian681
    @angiedamian681 2 года назад +2

    Yes, Dr. Sinclair is our new hero. He knows why we should be alive longer so we could love more.

  • @bradenmonroe3818
    @bradenmonroe3818 10 месяцев назад +1

    Mayims enormous heart is everything. She made me cry 😂

  • @cah94pa
    @cah94pa 2 года назад +42

    I cried with Mayim the first time I heard the podcast, it was very moving. Two days later, I understand her point of view less and less. How can someone think it wouldn't be great if people didn't have to die from cancer anymore, or go blind, have chronic diseases, degenerative diseases etc? Why is it that that can't be a reality just because other tragedies are? Mayim is vegan by choice (which for sure will make her live longer than meat-eaters btw) but there are people who eat only grains and cheap vegetables because it's all they can afford. How is this different from the one-meal-a-day thing, or the cold shower thing? She makes a ton of money from her acting career and yet chooses to have 8-10 minutes of sponsored content on the podcast every time, which makes her even richer, while there are people who can't even afford to drink clean water. Why is that ok?
    I'm not saying that it isn't but it's the same logic. To me, it almost sounded like she doesn't want medicine and science to advance. And I hate this expression and its overuse but "check your privilege" feels almost appropriate here.

    • @arir8655
      @arir8655 2 года назад +3

      If we are truly worried about people living longer, not getting as many physical or mental illness, and longevity we need to address poverty and the inequity in our society and in our world. It's not that there is anything wrong with David's research but adapting David's take on longevity without addressing the glaring inequalities that cut peoples lives short and cause many people not to even want to live longer is pointless. A homeless person or someone living in poverty could take all David's advice but it's not likely to extend their lives without addressing the other issues.

    • @cah94pa
      @cah94pa 2 года назад +7

      @@arir8655 advancements in longevity go hand in hand with cures to diseases and body limitations. Forget about living 120 years instead of 90 for a second and let’s think of this: a little kid goes blind; a toddler is diagnosed with a terminal disease; a 30 year old loses their legs in a car crash. Do they not deserve a second chance without being dragged into a conversation about inequalities? Why do they have to carry the weight of the world on their shoulders?

    • @pragmaticvfx
      @pragmaticvfx 2 года назад +5

      Not only that, but she is also peddling absolute snake oil to scam people just to make some money. Talk about hypocrisy!

    • @robz.3225
      @robz.3225 2 года назад +2

      great comment

    • @robz.3225
      @robz.3225 2 года назад +2

      @@pragmaticvfx well said

  • @arir8655
    @arir8655 2 года назад +35

    Also Jonathan, poor people regularly go with one meal a day and/or changes in temperature/"cold therapy" but they still aren't living longer. Quite the opposite. No amount of cold therapy or meal skipping will change someone's longevity if they're still suffering in poverty.

    • @shaunessymckay3021
      @shaunessymckay3021 2 года назад

      ☝️☝️☝️this ❤️❤️

    • @marisamartinezolivera
      @marisamartinezolivera 2 года назад

      Exactly!

    • @mishdude
      @mishdude 2 года назад +1

      Intermittent fasting works...when the one meal you are eating is full of nutritious foods/ingredients You can't do that if you live in poverty.

    • @abnerperry5297
      @abnerperry5297 2 года назад

      Life isn't fair, get over it. "Human beings are born with different capacities. If they are free, they are not equal. And if they are equal, they are not free.”
      ― Aleksandr Solzhenitsyn
      Would you give up freedom for equality? Not me. I'm not wealthy, but I'm free. I'll take it.

  • @nkelemogobe8359
    @nkelemogobe8359 2 года назад +4

    I love David Sinclair! My hero.

  • @stellaskopal
    @stellaskopal 2 года назад +38

    So this scientist working on improving our overall health should first solve WORLD HUNGER AND POVERTY?!? 🤔
    How is that his job? Why was he even confronted with that issue? This man is only doing his job.
    Mayim, why are you filming sitcoms when there is so much sadness and poverty in this world? And why do we go to doctor when we're sick and ask for latest medicine even if it's just plain cold?

    • @robz.3225
      @robz.3225 2 года назад

      Exactly

    • @sleepsmartsmashstress740
      @sleepsmartsmashstress740 2 года назад +4

      In one way by asking the food bingers to skip meals he is trying to do that. Or in the end if people who overeat cut back there would be surplus food left for others who face HUNGER AND POVERTY. He is a bit of a maniac a man on a mission so he does a lot more than just enough for his job to get his paycheck. Most researchers and scientists work that way. They are addicted to work.

  • @heathercade9645
    @heathercade9645 2 года назад +1

    Just searched for his book at my local library, and I'll be reading it shortly! I like David Sinclair. I didn't think I would, but I do. His ideas around the aging process are extremely radical, and his intentions are good, even a little altruistic. On the plus side he has research to back up those ideas, so there's hope there. Those types of changes won't happen over night, but they are certainly worth exploring. I am decidedly a breakfast person, so no intermittent fasting for me, thanks. Mayim, thank you for allowing yourself to be so vulnerable, I was right there with you. Jonathan, as always, you are the yin to her yang, and balance things out when needed. This podcast has given me so much, and at all the right times. :)

  • @karlalomeli9273
    @karlalomeli9273 2 года назад +15

    I am with Mayim on this, 100%

    • @rturney6376
      @rturney6376 2 года назад

      ruclips.net/video/RuOvn4UqznU/видео.html&feature=share

  • @mykaong7778
    @mykaong7778 2 года назад +11

    I just cannot understand Mayim's emotional response to David and Jonathan's arguments. One of the proofs that you should not allow emotions destroy logic.

    • @miliesomethingdo4379
      @miliesomethingdo4379 2 года назад

      We are emotional beings, therefore it should be part of the equation.
      Especially since, as she eloquently explained, living longer doesn’t make the life of the people struggling today better.
      Cutting down on life’s pleasures to live longer is bonkers.

    • @mykaong7778
      @mykaong7778 2 года назад +1

      @@miliesomethingdo4379 it's not just about living longer but improving humans' overall health. Diseases and sickness, physical and mental, would be prevented, provided the medicine really works. Long-term, this yields positive results.
      Sinclair thinks long-term, Mayim as what she mentioned, lives for the present. Both are operating from different perspectives. But between the two, I prefer Sinclair and his vision for the future.

    • @mykaong7778
      @mykaong7778 2 года назад

      @@miliesomethingdo4379 also commenting on your first clause, humans are also thinking beings. We have the ability to think about thinking, and think about emotions. It's definitely one thing that differentiates us from other species. We don't just act on impulse or just because our emotions are triggered.

    • @miliesomethingdo4379
      @miliesomethingdo4379 2 года назад

      One can cogitate as much as they want about why they feel the way they do. That’s why people go to therapy. Rationalising your emotions and feelings doesn’t necessarily mean you gain control of them tho. As she pointed out, we are not equal when it comes to brain chemistry too.
      It doesn’t sound appealing to me. I don’t think medicine can overcome social issues… Living longer is not going to affect the individualistic and exploitative logic of capitalism…

    • @abnerperry5297
      @abnerperry5297 2 года назад

      @@miliesomethingdo4379 So what would you do? 'From each according to his ability, to each according to his needs' Do you propose you (and everyone else) work as hard as your ability allows and throw it all in a big pot to be divided according to need so that all would be equal? Life isn't fair and I hope it is never equal. Do you not like being an individual? Do you not like freedom? Capitalism is far far from perfect but I prefer it to equality.
      ""Human beings are born with different capacities. If they are free, they are not equal. And if they are equal, they are not free.”
      ― Aleksandr Solzhenitsyn
      Life isn't fair. Or equal. Some will always struggle. Get over it.

  • @Victoria_Loves_Jesus
    @Victoria_Loves_Jesus 2 года назад +4

    David Sinclair is brilliant. Why not live a healthier life? yes, plz & thank you 🙏🏻

  • @lwalt7120
    @lwalt7120 2 года назад +7

    The past does not equal the future. Open the mind to unknown possibilities.

  • @aidinmurtha5544
    @aidinmurtha5544 2 года назад +40

    I'm going to be honest, I respect Mayim for stating her mind so clearly, but I hate to say that I can't at all understand the conflation of issues going on. Obviously, societal issues need to be addressed, but I don't see how this conflicts with that view. From a personal standpoint, I have not lived a privileged existence: I came from an extremely poor and abusive home and have to deal with the consequences of that every day. As an adult man, I still all the time feel like a scared and helpless little boy trying to wake his drug addict father up to make him some dinner. I've had suicidal thoughts and ideation at various points in my life. Still, if someone told me in 10 years they'd have a pill that'd make me not have to worry about aging and I would just stay young until my death, I would be overjoyed. It would be among the greatest pieces of news I could receive. If I went homeless, if I was without work or food, if this was available to me, I would still personally gladly accept it at every opportunity. My life and my youth are precious to me and I think to pretend aging is anything but evil is cowardice.
    I was raised for the good part of my childhood by my grandparents. At the beginning of this year, my Grandmother passed away at 86. It was natural, it was old age - and it was a suffering I would wish on no one. I had to see this strong, independent woman who I always had thought of as young and full of life despite her age suddenly begin failing. She fell and within 6 months she was reduced to almost nothing. I often think about the fact that I fed her her last bite of solid food ever, a bite of carrot cake, the day before she died. I think of my mom and her siblings gathered around their mother in tears knowing how little time she had left, lost children struggling for an answer.
    There is nothing just about aging and nothing fair or right about this, just like there is no justice or fairness in the types of suffering Mayim speaks of, and I think that to not act to end this is as irresponsible as our unwillingness to end poverty, to take action on climate change, to strive for a more equitable world, etc., and I think the only reason people are so comfortable with it is because they don't think it will ever be them. Because when I imagine in 60, 70 years finding myself in my grandmother's position, there is no way a rational human could find it desirable or just.

    • @Mark_Trail
      @Mark_Trail 2 года назад +4

      Thank you so much for sharing this. I am a big fan of longevity research, and I found Mayim’s take fascinating. I love my life and want my healthy years expanded as long as possible. But to hear people say they don’t want to live an extra 50 years because they are suffering and don’t want that suffering to be extended is heartbreaking. Longevity extension won’t fix all the issues of or planet, but it is a step in the right the direction.

    • @carriedrake892
      @carriedrake892 2 года назад +2

      Yes, I am not sure why fasting is such a trigger for her, I've noticed she is very averse to it. However, the science supports that it works to improve our emotional and physical health. I eased into it slowly a few years back and it wasn't difficult or detrimental at all!

  • @lovev9904
    @lovev9904 2 года назад +1

    I'm an Independent Latino, Thank You Mayim! Also thank you to Joe Rogan and many, many, many cool "Independent News Media" like the Breaking Points, The Hill, Lex Fridman, Dark Horse, Sam Harris, Russel Brand, Valuetaiment with Patrick.

  • @sailingsam3815
    @sailingsam3815 2 года назад +4

    Dr. Sinclair is amazing...thanks for the anti aging tips.

  • @jeanne553
    @jeanne553 2 года назад +27

    Instead of spending so much of our energy on the injustices of the past, we need to put our energy into changing the system. Medicare for All!!!

    • @JustMe_OhWell
      @JustMe_OhWell 2 года назад +1

      I believe we are learning so much about the past so we can move forward properly. Make a better future.

    • @giancolabird
      @giancolabird 2 года назад +3

      No universal healthcare...it drops healthcare to the lowest denominator. Turns healthcare into crap

    • @christianblack6916
      @christianblack6916 2 года назад +2

      Who’s paying for Medicare for all?

    • @christianblack6916
      @christianblack6916 2 года назад +1

      @@freddykruger3320 so essentially we are paying for it. I definitely don’t agree with Medicare for all and definitely less government involvement and taxes. I pay way more than my fare share of those and we all know the government misuses money.

    • @christianblack6916
      @christianblack6916 2 года назад

      @@freddykruger3320 problem is with runway capitalism that isn’t happening and with socialism it isn’t either. I’ll pass

  • @galpalsal
    @galpalsal 2 года назад +14

    I was crying with you, Mayim, Who would want to live any longer than necessary if the world's ails aren't improved? Never gave much thought or desire for increased longevity. We've got so much to improve now.

    • @cathiehealey4608
      @cathiehealey4608 2 года назад +3

      Maybe that's how we address the world's ails, we have a larger group of experienced, wise people working on solutions.

    • @Danuxsy
      @Danuxsy 2 года назад +6

      So let me refute your silly argument, by extending lifespan and healthspan we are directly improving the human condition, we would have more time and experience in solving complex problems, imagine if Isaac Newton or Richard Feynman was still alive today, what contributions would they be able to muster up in our modern era? Doesn't people without illness have the right to live longer? Who determine how long we should live? What does "live any longer than necessary" even mean? People should be able to live for as long as they wish, aren't we spending billions of dollars curing diseases, cancers and so on?
      H+

  • @kellymeighan3405
    @kellymeighan3405 2 года назад +7

    Wow...he's 52!! Whatever the is doing is working for him! I live with a hopeful perspective and would love to live a healthier, longer life! It's not about how much money you have, it's how you choose to live your life. If all you think about is all the bad stuff in the world and living in the past, I don't see you living a happy life. And not even being open to living longer and healthier because all you think about is the negative, idk but that's sad. I grew up a poor farm kid, but we were happy. I don't think being poor automatically makes you a sad person who has a bad life. There's a lot of fun things to do even if you don't have much money. All he is saying is he wants people to have an opportunity to live longer and healthier and took a turn down a totally different path about poor people and how some people live not such great lives, well he isn't talking about changing human behavior and just because people may have had a bad past... does that mean they automatically don't want to live longer and healthier going forward 🤷

    • @nedkelly2035
      @nedkelly2035 2 года назад +2

      Look at Frank Zane at age 52. He does about the opposite of what this guy says, and he looked better at 52. Now he is 78, but showed no age until about 75. Was on the cover of a muscle magazine in posing trunks at age 65., and looked about 40.

    • @kellymeighan3405
      @kellymeighan3405 2 года назад

      @@nedkelly2035 Frank Zane is a body builder, which he does look young, but not sure it's the same type of research, idk

    • @MK67934
      @MK67934 2 года назад

      @@nedkelly2035 he looked 65 in face

  • @bridiemacdonald9436
    @bridiemacdonald9436 2 года назад +3

    What a wonderful and nuanced conversation. Fasting for some is really well-tolerated and pretty easy. There is loads of science-based studies to support that our bodies have evolved for intermittent fasting and the (fairly recent availability) of food all of the time actually really negatively impacts our health. I do appreciate the conversation about "great health" without a "good life" which is well needed when most of the conversations around this I've listened to breezily focus on just biological markers as an indication of "wellness". David Sinclar comes across as a kind and thoughtful person and I really do appreciate him sharing his story about his mom as the driver for his work and for your care and questions.

  • @mjoscifi
    @mjoscifi 2 года назад +3

    We all should be able to personally choose whether or not we would like to live thousands of years. The option should be on the table for everyone. I personally am a slow learner, so extra time would allow me to develop more talents and contribute to the world. When I think of longevity, I think of the desire to contribute to, learn more about, and even explore the universe, and the personal option to be a part of that. Great interview 👍.

  • @toby-xo6rb
    @toby-xo6rb 2 года назад +10

    My god - for a scientist, Mayim is so closed to the possibility of technology making the future better. She's like "why live 1000 years?" because she incorrectly assumes everything else will stay the same. It doesn't have to be like that. Change is the answer. Mayim needs to stop being so emotional and look at the facts. As things get better, her emotions won't need to be so negative and painful.

  • @ayahslife8773
    @ayahslife8773 2 года назад +3

    Excellent show, excellent guest. Perfect bear poking. As a 61 year old vegan caring for my 56 year old dying husband, I’m all ears. For 17 years I’ve watched him damage his body and reduce his lifespan. On intermittent fasting I’ve found that yes I feel better but It triggers obsessive compulsive eating behavior. Definitely getting the book

    • @AndreaAvila78
      @AndreaAvila78 2 года назад +2

      😢I'm sorry about your husband. I've been doing intermittent fasting or time restricted eating for a year now. I feel like I have a lot of energy. It's been great for me. I'm also plant based.

    • @ayahslife8773
      @ayahslife8773 2 года назад

      @@AndreaAvila78 Hi Andrea, thank you. It’s wonderful you’ve been doing it and reaping the benefits. It’s a goal of mine. I’ve struggled with obsessive compulsive eating disorders all my life. Intermittent fasting makes me have to plan thus triggering the obsessive part. Due to a genetic blood disorder (that plant based has managed well!) I have meds to take AM and PM. I have to take with food. So I think I’ll have to modify intermittent to allow the small meal when I take them. Like a 1/2 banana with a few almonds. What do you think?

    • @KellyC12070
      @KellyC12070 2 года назад

      @Ayah. I’m so sorry to hear about your husband. I was doing int fasting until recently( have to intake something in the morning hours due to some health probs) but hopefully can go back to it at some point. I realized with the IF that I was rarely hungry but just felt better overall. I am also vegan(wfpb). Sending you caring thoughts and best wishes.

  • @elisabethryan1906
    @elisabethryan1906 2 года назад +1

    I am impressed with all parties involved in this interview. Mayim’s compassion for the suffering of others is admirable. While I see how it’s more helpful to turn every ailment of the “other” into an opportunity to be grateful, I still see the value in loving each person. Feeling for each person who goes without, who’s basic needs aren’t met.

  • @ruthrodriguez3099
    @ruthrodriguez3099 2 года назад +6

    My brother-in-law nearly died from a reaction to Metformin. It's a rare occurrence but he had been on it for many many years so it was a huge surprise. Had a hard time listening to this guy after he said it won't hurt you.

    • @sethseth9059
      @sethseth9059 2 года назад +3

      It won't. If you take what is prescribed. Take a gram of it a day or more and it will hurt you and maybe even kill you. But, but, but my brother in law said. Yeah I'm sure he lied when he didn't tell you about the overdose he took. Yes he did overdose. The first clue is the fact you said he had been on it for years.

    • @ruthrodriguez3099
      @ruthrodriguez3099 2 года назад

      @@sethseth9059 you really don't know what you are talking about... as I said, it's rare but happens. Not a case of "he said" since I was at the hospital for days and spoke with his doctor and nurses. No drug is 100% safe, which is why testing needs to be done before any medication is subscribed for a particular use.

    • @sethseth9059
      @sethseth9059 2 года назад +1

      @@ruthrodriguez3099 Shut the fuck up Ruth. The fact he was taking it for years was plenty of time for his body to react to it. No one ever anywhere but clowns like you would say something like drugs are 100% safe even if used as prescribed. You really needed to speak to a specialists not a general practitioner or a nurse; they are not qualified. You're the one who hasn't a fucking clue.

    • @12345tlynne
      @12345tlynne 2 года назад

      I agree. I'm grateful that my liver damage was found before it was too late. It took 10 years to heal. It can be VERY dangerous, especially just telling people to take it for no reason. I'm shocked at the lack of responsibility from him here.

  • @thehealthpromotion7024
    @thehealthpromotion7024 2 года назад

    Mayim do not mind the few in the comments calling you out. You are great and this video was very respectful and your point of view is always appreciate

  • @nicholeburt7021
    @nicholeburt7021 2 года назад +15

    That was pretty difficult to watch. I could definitely sense that Mayim had some disagreements about what he had written and what he had to say. I value both perspectives and I appreciate when I can tune into such intense philosophical conversations and take away from both sides. Thank you to all three of you 💕

    • @derekjetter4039
      @derekjetter4039 2 года назад +7

      she is a wealthy celebrity making money on her podcast while complaining about people who can afford hot water but chose to do cold showers. I dont see how anybody sees this a legitimate. You can even hear her ego in the way she talks to david and makes it about herself.

    • @rosevanderreijden3216
      @rosevanderreijden3216 2 года назад

      @@derekjetter4039 He is a wealthy scientist who makes money at god-knows-what.

    • @ImAbbyNormal
      @ImAbbyNormal 2 года назад +1

      @@derekjetter4039 She's much more than a celebrity. She's earned that ego.

    • @abnerperry5297
      @abnerperry5297 2 года назад +1

      @@derekjetter4039 I agree completely. She's a hypocrite.

  • @bethdejuan8909
    @bethdejuan8909 2 года назад +1

    My grandmother lived to a 100 and 6 months with her health never been to a doctors no meds. Lived alone until 99 yrs. she went blind because of old aged and didn't want to had eyes surgery. We felt she gave up and deteriorated fast. Its in her genes because her siblings lived to over a 100yrs. We hope we have it too.

  • @phoenixthundertarot3738
    @phoenixthundertarot3738 2 года назад +1

    this is legit i stopped my aging process 2 years ago. my cousin same age looks like my dad now and i still look just like i did when i was a child. am Sage soul though deep mystic alchemist type weirdo but now am working on reversing the process and no not to the state of childhood but to peak perfection dna work deep long focus

  • @ginacirelli1581
    @ginacirelli1581 2 года назад +17

    I think that Mayim was triggered by something either before or during this conversation and I wish her well. To me, it just looked like she was having a hard time due to something not immediately relevant to the conversation.

    • @PFLEONARDI0906
      @PFLEONARDI0906 2 года назад +1

      @@rafaelmateodev Spot on, she’s an actress plying her wares for click bait just like Oprah did….

  • @crissw2471
    @crissw2471 2 года назад

    Some people are conflict oriented. They pile on, conflate issues, and exaggerate. They blame others for their problems and when they feel bad about themselves they fall back on bad habits and scoff at others who don't have that response to the stress of self loathing. They challenge well meaning people like this guy. I love how he's just not having it. His response....if it's too hard for you...don't do it. If you don't believe me...don't. I'm not going to fight with you.

  • @roxannetracy2931
    @roxannetracy2931 2 года назад +4

    When this podcast first started I asked you a question about Neuroplasticity. Hey now. This is what I am talking about. CELLS!

  • @momcatx2
    @momcatx2 2 года назад +18

    I find it interesting that a flogging of Mr Sinclair, and his choice (based on research) of single meal days and cold therapy is acceptable. Along with your emotional outburst because, you know, covid and people with no choice.
    Meanwhile, just a few days ago you laughed and blew right past privileged funny man Andy Richter's comment about his excess and weight gain during COVID. Equating it to "drinking gravy." No blow back, no tears, no "He just doesn't get it, Johnathan."

  • @christiancarigaba5941
    @christiancarigaba5941 2 года назад +1

    shes talking about the experience outside the body which is why she looks emotional, doctor is talking about the body and how it works. really good doctor for trying to hard to connect. she should interview politicians. she will make them cry.

  • @luzmarinamann
    @luzmarinamann 2 года назад +2

    Sorry for this Mayim, is just my opinion, I'm a big fan of you, but I'm not agree with your opinion about David's research. This kind of research is looking forward to approach a long and healthy lifespan. However the example that you gave us about your grand parents it's sad, but isn't a valid argument (in my opinion), they were sick and certainly nobody wants to live in pain and misery, but in many cases this happen for our ignorance about our own health (poor health decisions, bad nutrition, lack of physical activity, bad genes or even fortuitous events). Having that said, I know David's research for years, and he definitely wants to address that, he is being spreading his knowledge to others, and if he is successful, people who wants to live longer could have excellent wellness until the end of their lives. Anyway I really enjoyed this episode, Thank you Mayim and Johnathan, in this episode more agreed with Johnathan, but I loved the discussion.

  • @LourdesGzz
    @LourdesGzz 2 года назад +4

    I want quality of life for me and everyone who wants it, and to live the longest possible the healthiest possible, if we had that maybe we could fix the rest.
    I say yes to spend 1 more year together with my beloved dog that passed away last year, but both of us beung healthy, I wouldn't mind living in a third world country like I am, time is the most valuable and precious thing. If we had time we could take care of everything else I think.

    • @kellymeighan3405
      @kellymeighan3405 2 года назад +1

      I didn't even think about animals!! I think everyone would definitely want their dog or any pet, to live longer and healthier!! I know I would want my dog to live longer!!

  • @sandrasmith7065
    @sandrasmith7065 2 года назад +10

    Thank you Mayim, yes sometimes cold showers are the only option sometimes one meal is all we get and THAT is where Dr. Sinclair misses the mark for me; we are not mice. Thank you for being HUMAN.

    • @sandrasmith7065
      @sandrasmith7065 2 года назад +2

      @@thanoskoumpanis9699 you also missed the mark.

    • @kelsqi-books4835
      @kelsqi-books4835 2 года назад +2

      @@thanoskoumpanis9699 what did you think you were replying to? This person didn't criticize using mice for testing at all. 🤨🧐

  • @scottpreston5074
    @scottpreston5074 2 года назад +1

    I appreciate his candor.

  • @maureenmckillop3622
    @maureenmckillop3622 2 года назад +5

    Perhaps repeating the Serenity Prayer would have helped. I know being a 12 stepper that it's a good reminder to do your part, not everyone else's.

  • @LionelLaCorbiere
    @LionelLaCorbiere 2 года назад +2

    This was an amazing podcast! I started with something posted about what you said on a TikTok, hitting that link from Yahoo and then catching my eye on something involving an SRT (Sitting-Rising Test) to an imbedded post about this! Mind blown, but in a very informative, and good way!
    I’ve always been a fan of intelligent conversation and listening to this, while doing the dishes, is damned good entertainment! 👏🏽 👏🏽👏🏽👏🏽.
    To also note, Mayim, my heart strings of compassion and a yearning for a better world were pulled too! Just saying.

  • @alexperassolo4104
    @alexperassolo4104 2 года назад

    6 to 12 burpees without pushup and with or without jump or more.
    6 to 20 goblet squats
    6 to 20 Romanian deadlifts
    2x or 3x
    30 to 60 jumping jacks or more.
    6 to 20 pushup or dumbbell chest press.
    6 to 20 dumbbell back rows.
    2x or 3x
    10 to 20 180 degree pivots or jumps.
    6 to 20 dumbbell bicep curls.
    6 to 20 dumbbell shoulder press.
    2x or 3x
    Situps variations your choice
    Do situps on upper body day.

  • @bigghomie24
    @bigghomie24 2 года назад +4

    Having 300 years to work on your career and life instead of 30 would be way better. Access is needed, yes, but with 1000yr lifetimes the greatest minds would have so much more time to figure things out and observe and make corrections

  • @nicolemaddison2945
    @nicolemaddison2945 2 года назад +4

    I feel the fact that apart from selling his Book, David is not selling anything except his scientific findings. His science has made a HUGE difference to my depressed (to the point of Suicide) husband. I love that you can agree to disagree. I love that you are so passionate and put the human perspective. Our indigenous First Nations people who live with Poverty and generational trauma are so at risk and every factor limits their life expectancy. So many ethical questions- Thank you for such honesty

  • @yud2006yud
    @yud2006yud 2 года назад +2

    I was touched by your actual breakdown at the end. I GET IT - I am strangling with over weight and getting closer to my 50's - but I do think that David has a point (not sure it's for everyone but I started thinking of making a change towards what he has described) - I did not get the point you were trying to make - how people that can't afford one meal a day, are impacted by David's suggestion for the worse? - I mean, if we consume less food, supply and demand dictates that the cost of food would get cheaper - which would make it MORE affordable for everyone else - No?
    I live in Israel - where healthcare is a right - as we have mandatory healthcare - that does not mean that the private health sector suffers - quite the opposite - those who can afford it - can get quicker care that is true - but by doing so - they are not taking a spot from those who can't afford private care.
    It's all about BALANCE I think.

  • @loislane488
    @loislane488 2 года назад +26

    I loved the content, but Mayim’s condescending stance toward David and Johnathon is a real turnoff… a comedienne she is not. Her pseudo jokes/confrontations are not remotely funny. They reek of arrogance and conceit. I’ll read the book and skip the commentary here. As a fellow highly sensitive person, I cringe at the semantic daggers she shoots in the guise of wit.

    • @lolasbananas
      @lolasbananas 2 года назад +8

      Thank you!!! This was torture to watch because of all of that you just said!

    • @mykaong7778
      @mykaong7778 2 года назад +4

      I agree with this

    • @robz.3225
      @robz.3225 2 года назад +3

      Couldn't agree more.

    • @abnerperry5297
      @abnerperry5297 2 года назад

      So well said.

  • @karendiehl2963
    @karendiehl2963 11 месяцев назад

    Thank you so much for your knowlesge and compasión. Much love to you both

  • @nicolewilliams2468
    @nicolewilliams2468 2 года назад +1

    Wow. Mayim & I could not be more different in many ways - more so in how we would choose solutions versus on what the actual problem is - but I have so much respect for her work & her vulnerability here. Hat tip to you, madam - well done, once again. ♥️♥️♥️

  • @bettyglick2679
    @bettyglick2679 2 года назад +3

    This medication sounds nice, but eating whole food plant based, avoiding most processed non-organic food and enjoying life, moving your body, spending time with loved ones…. Is how we can all live to 90-100 healthily. See ‘Blue Zones’, work by Dr. Barnard, Dr. Dean Ornish, Rich Roll’s podcast.. the book ‘How Not to Die’ was revolutionary for me and my family.

    • @robz.3225
      @robz.3225 2 года назад +1

      Big fan of Dr. Greger and his books. I follow the Starch Solution.