Glad the video was helpful. The question you ask is an important one. It is best to use the amount of diluent information provided in the package as it already accounts for the powder volume. Without knowing the drug powder volume it is difficult to accurately determine the volume of diluent. The one exception is if the powder volume is negligible in which case your diluent volume will be equal to the volume that gives the desired drug concentration. Hope this helps. Thank you broashley for watching and for the comment.
Hi for pcn questions why didnt we use the formula you taught us? 400,000units/(500,000units/ml)=total volume 0.8ml. isnt this a total volume which includes diluent volume+drug volume?
Add 3ml dilute to 1g to give 280mg/ml how many ml should be used to prepare Want/got 250/280×3 250×2 (q12hrs)=500mg/ml/day/total.=250mg =0.25×4ml=1ml (q12hrs), hence how 4ml was used in the new equation at the bottom, but order is for 250mg q12hr = 0.50 ml, 1ml is given as the closest and the rate of waste of medicine dynamic in the body through metabolism. 1g=1000mg/280×3ml dilute 3.57ml-3=0.57ml powder volume (New) Qty of drug/final concentration = volume dilute +powder 1000mg (qty of drug)/250(final concentration)=×+0.57 4ml (volume dilute)=x + 0.57ml(powder volume) ×=4-0.57ML=3.43ML
True solution before injection, reconstitution a dry powder is completely dissolved using a diluted. Calculate powder volume the space of volume occupied by the powder in a powdered drug preparation. Calculate the volume Final volume =Volume of diluent+Powder Volume Equations Quantity of Drug/Final Concentration =Volume of dilute+Powder Volume
@@PharmaceuticalCalculationsEasy Welcome! Just refreshing my memory of things and your channel seemed to be close to what I am use too and some other things.
Dr. D. there is no proof i can found in the literature to set up the equation of amount/ concentration = volume+ volume, though it may give a correct answer
Thank you TK for watching and for the comment. It is unlikely you will find the (Quantity of Drug/ Final Concentration) = volume of Diluent + Powder volume in literature because it is a derived equation. The original equation is Final volume = volume of Diluent + Powder volume. However, to find Final volume you first have to divide the Quantity of Drug by the Final Concentration. So instead of using two separate equations, the (Quantity of Drug/ Final Concentration) = volume of Diluent + Powder volume equation allows you to do it all in one step. It is a useful equation I teach students to ensure they perform these calculations accurately and expeditiously.
400,000 units Penicillin G to 1 liter of D5W is a vial containing 500,000 units Volume will be added to the D5W bag. 8ml to get 500000 unit/ml Want/got 400,000/500,000 ×1ml =0.8ml to be added. (The answer is in the problem)
What is the powder volume of alteplase 2 mg (Cathflo Activase)? You reconstitute with 2.2ml water for injection and you get 1mg/1ml? Is the powder volume is negative?
Thank you Ibrahim for watching and for the comment. It appears there is an issue with the question. First of all, when you divide the amount of alteplase (2 mg) by the volume of water (2.2 mL) you get 0.91 mg/mL. So if the drug is contributing some powder volume then the resulting concentration should be less than 0.91 mg/mL. Hence, the 1 mg/mL concentration mentioned in the question is not possible based on the other information in the question. And no, the powder volume cannot be negative. Hope this helps.
Thank you Rubendra for watching and for the question. The 8 mL is the volume of diluent that you need to add to the dry powder so you end up with the required concentration of 500,000 units/mL. The volume of diluent is important when you need to determine powder volume, final volume or final concentration. However, it is not needed in the calculations for this question since we are looking for the volume of the reconstituted solution for a specified dose and the final concentration was already given. Hope this helps.
Can u pls solve this for me During the end of the swing shift, another technician has poured 16oz. Of D5NS and 16oz. Of D10NS into a 1 L Erlenmeyer flask for a custom compounding. What solution has this tech concocted? And can u tell me what kind of problem it is.
Thank Siris Home Cookbook for watching and for the comment. Your question was solved in our Pharmaceutical Calculations Solve Along livestream: jo.my/pcsal1 . It was the last question solved.
Best video I have seen for explaining these confusing calculations
Awesome and quite logical .It is such an easy flow. Thank you for transforming the world of education .
Glad you liked the video Olapeju! Thank you for watching and for being an active member of the pharmaceutical calculations community.
He sound very Ghanaian.... Thank you
Elegantly done. Thank you so much Dr. D.
Glad you liked the video Svalson. Welcome to the pharmaceutical calculations community!
Thanks very much...you saved my life 😊
You are most welcome Lily White. Thank you for watching and for the kind comment.
Thank you so much! I finally understand this topic 😅
Glad you liked the video. Thank you Rebecca for watching and for the comment.
awesome 😇
Thanks 🤗
1g ceftazidine dilute 3ml what is the powder volume Ceftazidine 280mg/ml
Final volume=Volume +powder volume
Qty drug/final concentration =vol dilute + Powder volume
1g=1000mg/280mg/ml=3.57=3ml dilute 3.57-3= 0.57ml
This is a great presentation. I'm struggling with a way to figure how much diluent to add without reading off the package. Will you explain this?
Glad the video was helpful. The question you ask is an important one. It is best to use the amount of diluent information provided in the package as it already accounts for the powder volume.
Without knowing the drug powder volume it is difficult to accurately determine the volume of diluent. The one exception is if the powder volume is negligible in which case your diluent volume will be equal to the volume that gives the desired drug concentration. Hope this helps. Thank you broashley for watching and for the comment.
Hi for pcn questions why didnt we use the formula you taught us? 400,000units/(500,000units/ml)=total volume
0.8ml. isnt this a total volume which includes diluent volume+drug volume?
Add 3ml dilute to 1g to give 280mg/ml how many ml should be used to prepare
Want/got 250/280×3
250×2 (q12hrs)=500mg/ml/day/total.=250mg =0.25×4ml=1ml (q12hrs), hence how 4ml was used in the new equation at the bottom, but order is for 250mg q12hr = 0.50 ml, 1ml is given as the closest and the rate of waste of medicine dynamic in the body through metabolism.
1g=1000mg/280×3ml dilute
3.57ml-3=0.57ml powder volume
(New) Qty of drug/final concentration = volume dilute +powder
1000mg (qty of drug)/250(final concentration)=×+0.57
4ml (volume dilute)=x + 0.57ml(powder volume)
×=4-0.57ML=3.43ML
True solution before injection, reconstitution a dry powder is completely dissolved using a diluted.
Calculate powder volume the space of volume occupied by the powder in a powdered drug preparation.
Calculate the volume
Final volume =Volume of diluent+Powder Volume
Equations
Quantity of Drug/Final Concentration =Volume of dilute+Powder Volume
Thank you for watching and for contributing this content. Welcome to the pharmaceutical calculations community.
@@PharmaceuticalCalculationsEasy Welcome! Just refreshing my memory of things and your channel seemed to be close to what I am use too and some other things.
Please I need some clarification on the preparation of simple syrup bp given the formula, where the water is given in kg
Dr. D. there is no proof i can found in the literature to set up the equation of amount/ concentration = volume+ volume, though it may give a correct answer
Thank you TK for watching and for the comment. It is unlikely you will find the (Quantity of Drug/ Final Concentration) = volume of Diluent + Powder volume in literature because it is a derived equation. The original equation is Final volume = volume of Diluent + Powder volume. However, to find Final volume you first have to divide the Quantity of Drug by the Final Concentration. So instead of using two separate equations, the (Quantity of Drug/ Final Concentration) = volume of Diluent + Powder volume equation allows you to do it all in one step. It is a useful equation I teach students to ensure they perform these calculations accurately and expeditiously.
400,000 units Penicillin G to 1 liter of D5W is a vial containing 500,000 units
Volume will be added to the D5W bag.
8ml to get 500000 unit/ml
Want/got 400,000/500,000 ×1ml =0.8ml to be added. (The answer is in the problem)
Nice 👌
What is the powder volume of alteplase 2 mg (Cathflo Activase)?
You reconstitute with 2.2ml water for injection and you get 1mg/1ml?
Is the powder volume is negative?
Thank you Ibrahim for watching and for the comment. It appears there is an issue with the question. First of all, when you divide the amount of alteplase (2 mg) by the volume of water (2.2 mL) you get 0.91 mg/mL. So if the drug is contributing some powder volume then the resulting concentration should be less than 0.91 mg/mL. Hence, the 1 mg/mL concentration mentioned in the question is not possible based on the other information in the question.
And no, the powder volume cannot be negative. Hope this helps.
dr. what is the use of 8ml of example 2 calculation?
Thank you Rubendra for watching and for the question. The 8 mL is the volume of diluent that you need to add to the dry powder so you end up with the required concentration of 500,000 units/mL.
The volume of diluent is important when you need to determine powder volume, final volume or final concentration. However, it is not needed in the calculations for this question since we are looking for the volume of the reconstituted solution for a specified dose and the final concentration was already given. Hope this helps.
Thanks, it's helpful.💯
Thanks Wedi for watching and for the comment.
Can u pls solve this for me
During the end of the swing shift, another technician has poured 16oz. Of D5NS and 16oz. Of D10NS into a 1 L Erlenmeyer flask for a custom compounding. What solution has this tech concocted?
And can u tell me what kind of problem it is.
Thank Siris Home Cookbook for watching and for the comment. Your question was solved in our Pharmaceutical Calculations Solve Along livestream: jo.my/pcsal1 . It was the last question solved.
Thank u
Thank you so much!
You are welcome. Thanks for watching and for the comment.