Gastrointestinal | Liver Circulation & Portal Hypertension
HTML-код
- Опубликовано: 4 май 2018
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about liver circulation including the hepatic portal vein, common hepatic artery, hepatic artery proper, and many more important structures that are involved in the liver vasculature. We also talk about hepatic portal hypertension going into detail on pathologies such as Caput Medusae, and esophageal varices. We hope you enjoy this lecture and be sure to support us below!
Join this channel to get access to perks:
/ @ninjanerdofficial
APPAREL |
We are switching merchandise suppliers.
DONATE
PATREON | / ninjanerdscience
PAYPAL | www.paypal.com/paypalme/ninja...
SOCIAL MEDIA
FACEBOOK | / ninjanerdlectures
INSTAGRAM | / ninjanerdlectures
TWITTER | / ninjanerdsci
@NinjaNerdSci
DISCORD | / discord
#ninjanerd #LiverCirculation #Gastrointestinal
When he said trust me for this, I'm like I trust you with whole of my both atrium and ventricles 🥺
😃
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
both Atria* ☝🤓
It's incredible that you can talk for 45 minutes straight with few mistakes and little to no editing. Thanks for this video!
You deserve a large portion of my tuition, thank you for recognizing your gift and sharing it with others.
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
best channel in the world
Ninja nerd team out here saving med students' lives. God bless yall :"D
I wish this channel was available way back undergrad day☹️. Anyways, I am sitting for a professional exam and this video makes me cover a one week reading for instance, in just a few hours. I have never understood anatomy like I do now after watching your videos! I now enjoy studying anatomy. You were born with a rare gift, thank you so much for sharing with the world.
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
As a medical student, this was super helpful, especially as we're discussing Schistosomiasis in our current case study. God bless you bro.
It would have made my life a lot easier if this videos had been available when I attended medical school. Always had doubts over certain subjects (I missed school time because of disease and for the death of my son). You explained everything better than anyone. So clearly... You are quite amazing.
Same here, studying for a professional exam, enjoying all aspects of medicine combining these lectures with papers...he is brilliant and sends so much energy and empathy through his eyes. I will be definitely taking some of the courses he offers. The universe loves you ninja 🤓!
You are a truly gifted teacher. …even I can follow you without getting too lost….my nurse training was many moons ago and wasn’t so detailed or well taught! Bless you! Thank you!
Great demonstration this guy reminds me of my health teacher in high school, I learned more from him than any other teacher thanks so much.
This is fabulous 😊 I recently got a job as a Research Nurse in Hepatology.. new field for me . Although I may not “need “ this understanding to do my job , technically speaking , I am feeling lost without this basic understanding of how the liver works .I so appreciate your help. You are an awesome teacher. Thank-you
You're the reason I passed my biochemistry exam. Thanks very much for sharing the informative videos💯💟
Incredibly informative. The best tutoring video. I'm fortunate to have found his channel. Thank you so, so much.
I need to give you my entire tuition 🥺🥺🥺you know your stuff so well and you give it your all when teaching. Thank you so much 🙏🏾
I love your passion and how you simplify ! I am watching this because my BF has portal hypertension and kidney failure -Was total he has esophageal varices as well. Thank you!!!!!! I subscribed!
Professor Zach thank you so much you are the best thing to ever happen to a med student. Magnificent explanation
I'm a nursing lecturer and your videos are my go to. Thank you sir 🙏
best teacher Ive had so far
perfect teacher, perfect video, perfect understanding & knowledge !!!
Thank you so much sir for your wonderful lecture, it is so useful and helpful to me.I couldn't understand this portion when I learnt from lecturers in our medical college, but once i listen to your lectures everything becomes crystal clear.You are really doing such a great service through these selfless efforts.I wish you good luck and all the courage to do more wonderful videos like this always in future.
I am a fan of Ninja Nerds, from Sri Lanka
You really know how deliver! Search for info on Portal Hypertention and stumbled upon your video. I can now review the medical write-up with greater understanding. Thank you!👏👏
Superb as always. So impressed with your knowledge but also your ability to explain and articulate it all so well. This video was such a revelation to me. I had always assumed all returning blood from all organs was via the inferior vena cava but had no idea of this very clever portal to the liver. God or nature is so brilliant in its designs.
Wonderful Work as always ,thanks to all the team :)
Usually I get bored with long videos but yours I can't even think if I will get bored ,I wish you explain all medical lectures ,then I won't have any thing other to do rather than watching your videos,Dr Zach .
31:47 (Clinical Part)
By far you are the best I’ve seen! Thank you so much for your exceptional and detailed video! 🙏🏽👏🏽👍🏽😌God bless you!
I wish you were my teacher!! You explain everything sooo well! Thank you!
OMG IM SO GLAD I FOUND YOU... explained in a very well stepwise manner... Thank you so much...
AWSOME VIDEO, Thank you so much. I'm a Board Certified Internist and didn't recall how the basic flow throught the liver went any more. So appreciate this fantastic video. I'm currently visiting Sweden (am a dual citizen) from Cal and parked myself here at a lovely Medical library. Finished watching your video here. Loved it!
Thank you for providing a comprehensive, in-depth analysis of the Liver. You have given me a new appreciation of the liver, I am even tempted to give up alcohol to protect this hard-working filtering system.
The most amazing and clear vidoes I have come across yet. This is sth that i had not understood since med school and it all makes so much sense now. Thank you so much :) :) :) :)
Khushboo Singh you completed ..medical
Plz recommended some more channels for hepatology.
Always makes learning so much easier ! Love this channel and thanks Zack for the great explanations !!
Great video. Really liked your gesticulations when describing sagital and coronal views - very easy to understand.
Best tutor ever. thank you so much for all this lectures!!!
Sooooo good…. Teaching is his calling/niché
Loved this lecture. I have watched many many and this is one of the best one. TY
Hi! I just discovered your channel and found it's truly very useful with your clear explanation and drawing! very much appreciated!
Thanks Zack. Texting you straight from Punjab in India.
Can’t explain the effect your teaching had on me. So satisfying.
God bless you bro. ❤️
I like it when you say alright and take a deep breath,I feel lovely❤️
This is a great video for a patient like me. I have PBC. Your diagrams are really easy to understand thank you. I am waiting for the result on my portal Doppler scan.
Thank you to the greatest medical teaching King of all time 👑 👌
Incredible! What a bright shining lamp you are! Sir you are like the lamp which burns itself to illuminate the medical world. You explained so nicely in short time that was not possible for me to understand even after trying for many days. God bless you. Our good wishes are always with you.
Perfect explanation of liver circulation!
Understand the hepatic portal Sys much better.
Sir, thank you for the thorough explanation...salute!
Thank you for the knowledge shared. As it gives me more understanding about my diagnoses. And how things work❤
This has helped me during my pathophysioly class! Thank you ! 😊
I've been diagnosed with non-alcoholic fatty liver disease, high blood pressure, and high cholesterol I'm just here trying to learn as much as I can about my liver, I never gave it much thought before I always thought the heart, brain, or lungs where you're most important organ but now I know the liver is actually the most important organ thank you Doctor.
This video just changed my life THANK YOU SO MUCH
Artistic presentation, really clear explanation thanks to you guys
I actually came here came here not knowing the gross anatomy and now im leaving knowing the whole circulation thank you sooo much🙏🙏
One of the best tutor!!
Thank you very much
This channel is a blessing!
how do u remember so many things.u r a gift of god to all of us. u r simply great.where were u since so many years.we missed u .
such a great teacher you are...your efforts should be really appreciated...
Excellent information & very well spoken. In Gastric bypass surgery most common to see Vitamin -A deficiency ( fat soluble Vitamin absorbed from stomach ) from Ophthalmology standpoint & patients have to take Vitamin -A regularly as a medicine. Thanks
This is the best explanation I've ever gotten about this stuff, Im a RADIOGRAPHER by profession, this explanation makes sense
I feel Bad for the I reported on sonograms before knowing this
Thank you. Now I'm more interested in medicine than before because of your lessons
This guy is so good, he requires to teach at my university 🙌
Amazing ! Thanks a lot. Best explanation ever.
you are the best teacher in the world
Excellent explanation...hat's off to the effort taken
Thank you so much it's amazing how you make everything so much easier ❤️❤️❤️
Excellent! Thank you so much for an informative presentation. I have liver disease and appreciated this video.
Thank you, Professor!
Yesterday I can’t remember this topic when I studied with book suddenly I remember everything about liver after this miraculous video 📼 hats off bro u r hulk
So well explained. God bless you
Thanks for helping me understand how this works. My mom’s doctor is suggesting that speaking with a specialist about getting her TIPS procedure. This is scary stuff! 😔
you are a PHENOMENON bro!
its like watching my memory working in live action ....awesome job. I always used colored pens/pencils to draw similar thoughts
Wow! so clear teaching, you are the best, thank you.
My 62 year old hubby has cirrhosis of the liver, a swollen spleen, a hernia, low blood platelets , low white blood cells and very high bilirubin and asceites (?). His hematologist doctor wants to put him on water pills or drain belly, do a bone marrow biopsy. She told him he needed a liver transplant. We asked her what role diet & nutrition plays in this. She said “NOTHING.” SO……We quit cold Turkey all alcohol, all processed foods, cut down drastically on sugar and salt. No pain meds, no prescriptions. He’s lost 33 lbs since diagnosed in August 22. I’ve only lost 9 ( Damnit). He says he feels so much better. We will - in the short term at least- continue to get blood tests and exam of belly ( CT Scan?) WE believe we can reverse this.
Incredible, am really grate. You increased my efficiency amidst the work load of medical school.
Thank you so much you literally answered 5 questions of my homework ❤
I have no words 😭😭😭😭, thank you so much. 🙏
You are amazing zack , all love and respect ❤️
Thank you so much sir for such a well explained video!
Wonderful GI ninja technique!!
Love you man ❤ ur awesome you make everything easy make every concept clear now I know reason of Caput Medusa
Thank you very Mach sir ..... stay happy and God bless you .....
If I have to choose one channel on RUclips for life time, it is gonna be this one. ❤️❤️
even tho this is a year ago. you sound sick. hope you feel better xD thanks for powering thru and teaching us under the weather
Iam a nurse student, l really enjoy this advanced knowledge on portal circulation and hypertension. Thank you so much
Never understood anything better than this!!!
I have a major test tomorrow glad you uploaded this video. 😋
Aww while teaching hus expressions were so cute.. gosh I am in love with him :(
😆😆😆😆😆😆😆
I have a crush on him, too!!
It's awesome.. really very informative..thank u so much for u efforts...I highly appreciate ur simple diagrams...keep going
Sensei you are amezing love from india 🇮🇳, just the way you teaching us is great...
Thanks u made life easier on that topic 🙏🙏
You Sir, are bringing the swag into anatomy/physiology.
This is what happens when passion and competence are nicely blended.
If this is your way of studying/reviewing for yourself you are going to know your stuff!
Exams are a walk in the park for you, me thinks.
Also , way better source for me to recap GI-Liver basics before starting a PhD in this field.
Screw dull paper courses, this is the future!
Love this, stellar presentation!
You are amazing. I always learn so much from you. 🙏🙏
This is amazing, you are a wonderful teacher!!
you are fantastic..... such a good teacher!!!
My daughter passed away at 31 from Cirrhosis of the Liver. Thanks for helping me understand more about what happened.
We are sorry for your loss. We couldn't begin to understand your loss, but hopefully the understanding you've gained can bring you some closure.
i don't how anatomy could be without you
I so much appreciate and enjoy your videos. Great teacher
thank you so much for giving us this content in free
Very clear and fantastic explanation
Very well demonstrated 👍
Finally, someone who can explain this subject.