Conversion of Phytonadione into menaquinone-4: 1. Phytonadione into menadione 1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase. 1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units. 2. Menadione into menaquinone-4 2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). 2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4. Is this process incorrect or not?
Conversion of Phytonadione into menaquinone-4: 1. Phytonadione into menadione 1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase. 1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units. 2. Menadione into menaquinone-4 2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). 2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4. Is this process incorrect or not?
I wish this channel was available way back undergrad day☹️. Anyways, I am sitting for a professional exam and this video makes me cover a one week reading for instance, in just a few hours. I have never understood anatomy like I do now after watching your videos! I now enjoy studying anatomy. You were born with a rare gift, thank you so much for sharing with the world.
Conversion of Phytonadione into menaquinone-4: 1. Phytonadione into menadione 1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase. 1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units. 2. Menadione into menaquinone-4 2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). 2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4. Is this process incorrect or not?
It would have made my life a lot easier if this videos had been available when I attended medical school. Always had doubts over certain subjects (I missed school time because of disease and for the death of my son). You explained everything better than anyone. So clearly... You are quite amazing.
Same here, studying for a professional exam, enjoying all aspects of medicine combining these lectures with papers...he is brilliant and sends so much energy and empathy through his eyes. I will be definitely taking some of the courses he offers. The universe loves you ninja 🤓!
This is the best explanation I've ever gotten about this stuff, Im a RADIOGRAPHER by profession, this explanation makes sense I feel Bad for the I reported on sonograms before knowing this
I've been diagnosed with non-alcoholic fatty liver disease, high blood pressure, and high cholesterol I'm just here trying to learn as much as I can about my liver, I never gave it much thought before I always thought the heart, brain, or lungs where you're most important organ but now I know the liver is actually the most important organ thank you Doctor.
Usually I get bored with long videos but yours I can't even think if I will get bored ,I wish you explain all medical lectures ,then I won't have any thing other to do rather than watching your videos,Dr Zach .
Superb as always. So impressed with your knowledge but also your ability to explain and articulate it all so well. This video was such a revelation to me. I had always assumed all returning blood from all organs was via the inferior vena cava but had no idea of this very clever portal to the liver. God or nature is so brilliant in its designs.
This is fabulous 😊 I recently got a job as a Research Nurse in Hepatology.. new field for me . Although I may not “need “ this understanding to do my job , technically speaking , I am feeling lost without this basic understanding of how the liver works .I so appreciate your help. You are an awesome teacher. Thank-you
My 62 year old hubby has cirrhosis of the liver, a swollen spleen, a hernia, low blood platelets , low white blood cells and very high bilirubin and asceites (?). His hematologist doctor wants to put him on water pills or drain belly, do a bone marrow biopsy. She told him he needed a liver transplant. We asked her what role diet & nutrition plays in this. She said “NOTHING.” SO……We quit cold Turkey all alcohol, all processed foods, cut down drastically on sugar and salt. No pain meds, no prescriptions. He’s lost 33 lbs since diagnosed in August 22. I’ve only lost 9 ( Damnit). He says he feels so much better. We will - in the short term at least- continue to get blood tests and exam of belly ( CT Scan?) WE believe we can reverse this.
I love your passion and how you simplify ! I am watching this because my BF has portal hypertension and kidney failure -Was total he has esophageal varices as well. Thank you!!!!!! I subscribed!
You Sir, are bringing the swag into anatomy/physiology. This is what happens when passion and competence are nicely blended. If this is your way of studying/reviewing for yourself you are going to know your stuff! Exams are a walk in the park for you, me thinks. Also , way better source for me to recap GI-Liver basics before starting a PhD in this field. Screw dull paper courses, this is the future!
You are a truly gifted teacher. …even I can follow you without getting too lost….my nurse training was many moons ago and wasn’t so detailed or well taught! Bless you! Thank you!
You really know how deliver! Search for info on Portal Hypertention and stumbled upon your video. I can now review the medical write-up with greater understanding. Thank you!👏👏
The most amazing and clear vidoes I have come across yet. This is sth that i had not understood since med school and it all makes so much sense now. Thank you so much :) :) :) :)
AWSOME VIDEO, Thank you so much. I'm a Board Certified Internist and didn't recall how the basic flow throught the liver went any more. So appreciate this fantastic video. I'm currently visiting Sweden (am a dual citizen) from Cal and parked myself here at a lovely Medical library. Finished watching your video here. Loved it!
Incredible! What a bright shining lamp you are! Sir you are like the lamp which burns itself to illuminate the medical world. You explained so nicely in short time that was not possible for me to understand even after trying for many days. God bless you. Our good wishes are always with you.
Thank you so much sir for your wonderful lecture, it is so useful and helpful to me.I couldn't understand this portion when I learnt from lecturers in our medical college, but once i listen to your lectures everything becomes crystal clear.You are really doing such a great service through these selfless efforts.I wish you good luck and all the courage to do more wonderful videos like this always in future. I am a fan of Ninja Nerds, from Sri Lanka
Thank you for providing a comprehensive, in-depth analysis of the Liver. You have given me a new appreciation of the liver, I am even tempted to give up alcohol to protect this hard-working filtering system.
This is a great video for a patient like me. I have PBC. Your diagrams are really easy to understand thank you. I am waiting for the result on my portal Doppler scan.
Thanks for helping me understand how this works. My mom’s doctor is suggesting that speaking with a specialist about getting her TIPS procedure. This is scary stuff! 😔
Excellent information & very well spoken. In Gastric bypass surgery most common to see Vitamin -A deficiency ( fat soluble Vitamin absorbed from stomach ) from Ophthalmology standpoint & patients have to take Vitamin -A regularly as a medicine. Thanks
I was diagnosed with portal hypertension of the liver. I've several nodules also but nothing more. This was very imformative and made me feel better about the outcome about the stunt placement. My only worry now are the nodules.
Yesterday I can’t remember this topic when I studied with book suddenly I remember everything about liver after this miraculous video 📼 hats off bro u r hulk
I'm learning more about this my son had got hospitalized because bad liver but u mo god is good and a lot of prayers I dont wish no kind of sickness like all these now days glaucoma cataracts this that and the other but ithank everyone for their prayers
I find this video so valuable as I am a patient currently with GI tract bleeding. I have this bleeding from about 3 months after the whipple surgery till now, a total of 4 times getting in the hospital but the doctors still not be able to find the source or the root cause of the GI tract bleeding. I have some blood clot in the portal vein which I am now thinking it is the main cause of my bleeding. Thank you so much.
You deserve a large portion of my tuition, thank you for recognizing your gift and sharing it with others.
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
It's incredible that you can talk for 45 minutes straight with few mistakes and little to no editing. Thanks for this video!
best channel in the world
When he said trust me for this, I'm like I trust you with whole of my both atrium and ventricles 🥺
😃
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
both Atria* ☝🤓
I wish this channel was available way back undergrad day☹️. Anyways, I am sitting for a professional exam and this video makes me cover a one week reading for instance, in just a few hours. I have never understood anatomy like I do now after watching your videos! I now enjoy studying anatomy. You were born with a rare gift, thank you so much for sharing with the world.
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
It would have made my life a lot easier if this videos had been available when I attended medical school. Always had doubts over certain subjects (I missed school time because of disease and for the death of my son). You explained everything better than anyone. So clearly... You are quite amazing.
Ninja nerd team out here saving med students' lives. God bless yall :"D
And nursing students 😭
As a medical student, this was super helpful, especially as we're discussing Schistosomiasis in our current case study. God bless you bro.
Iam a nurse student, l really enjoy this advanced knowledge on portal circulation and hypertension. Thank you so much
Same here, studying for a professional exam, enjoying all aspects of medicine combining these lectures with papers...he is brilliant and sends so much energy and empathy through his eyes. I will be definitely taking some of the courses he offers. The universe loves you ninja 🤓!
You're the reason I passed my biochemistry exam. Thanks very much for sharing the informative videos💯💟
i don't how anatomy could be without you
This is the best explanation I've ever gotten about this stuff, Im a RADIOGRAPHER by profession, this explanation makes sense
I feel Bad for the I reported on sonograms before knowing this
I've been diagnosed with non-alcoholic fatty liver disease, high blood pressure, and high cholesterol I'm just here trying to learn as much as I can about my liver, I never gave it much thought before I always thought the heart, brain, or lungs where you're most important organ but now I know the liver is actually the most important organ thank you Doctor.
you are the best teacher in the world
Best tutor ever. thank you so much for all this lectures!!!
Sooooo good…. Teaching is his calling/niché
my comment maybe late but i think you are a little bit sick we really appreciate your hard work, these videos have helped alot
Finally, someone who can explain this subject.
I'm a nursing lecturer and your videos are my go to. Thank you sir 🙏
Usually I get bored with long videos but yours I can't even think if I will get bored ,I wish you explain all medical lectures ,then I won't have any thing other to do rather than watching your videos,Dr Zach .
Superb as always. So impressed with your knowledge but also your ability to explain and articulate it all so well. This video was such a revelation to me. I had always assumed all returning blood from all organs was via the inferior vena cava but had no idea of this very clever portal to the liver. God or nature is so brilliant in its designs.
I need to give you my entire tuition 🥺🥺🥺you know your stuff so well and you give it your all when teaching. Thank you so much 🙏🏾
This is fabulous 😊 I recently got a job as a Research Nurse in Hepatology.. new field for me . Although I may not “need “ this understanding to do my job , technically speaking , I am feeling lost without this basic understanding of how the liver works .I so appreciate your help. You are an awesome teacher. Thank-you
best teacher Ive had so far
Great demonstration this guy reminds me of my health teacher in high school, I learned more from him than any other teacher thanks so much.
My 62 year old hubby has cirrhosis of the liver, a swollen spleen, a hernia, low blood platelets , low white blood cells and very high bilirubin and asceites (?). His hematologist doctor wants to put him on water pills or drain belly, do a bone marrow biopsy. She told him he needed a liver transplant. We asked her what role diet & nutrition plays in this. She said “NOTHING.” SO……We quit cold Turkey all alcohol, all processed foods, cut down drastically on sugar and salt. No pain meds, no prescriptions. He’s lost 33 lbs since diagnosed in August 22. I’ve only lost 9 ( Damnit). He says he feels so much better. We will - in the short term at least- continue to get blood tests and exam of belly ( CT Scan?) WE believe we can reverse this.
I love your passion and how you simplify ! I am watching this because my BF has portal hypertension and kidney failure -Was total he has esophageal varices as well. Thank you!!!!!! I subscribed!
Incredibly informative. The best tutoring video. I'm fortunate to have found his channel. Thank you so, so much.
Thanks Zack. Texting you straight from Punjab in India.
Can’t explain the effect your teaching had on me. So satisfying.
God bless you bro. ❤️
Hi from India, sir is great
You Sir, are bringing the swag into anatomy/physiology.
This is what happens when passion and competence are nicely blended.
If this is your way of studying/reviewing for yourself you are going to know your stuff!
Exams are a walk in the park for you, me thinks.
Also , way better source for me to recap GI-Liver basics before starting a PhD in this field.
Screw dull paper courses, this is the future!
You are a truly gifted teacher. …even I can follow you without getting too lost….my nurse training was many moons ago and wasn’t so detailed or well taught! Bless you! Thank you!
You really know how deliver! Search for info on Portal Hypertention and stumbled upon your video. I can now review the medical write-up with greater understanding. Thank you!👏👏
The most amazing and clear vidoes I have come across yet. This is sth that i had not understood since med school and it all makes so much sense now. Thank you so much :) :) :) :)
Khushboo Singh you completed ..medical
Plz recommended some more channels for hepatology.
I wish you were my teacher!! You explain everything sooo well! Thank you!
The best channel in the world
I like it when you say alright and take a deep breath,I feel lovely❤️
I actually came here came here not knowing the gross anatomy and now im leaving knowing the whole circulation thank you sooo much🙏🙏
AWSOME VIDEO, Thank you so much. I'm a Board Certified Internist and didn't recall how the basic flow throught the liver went any more. So appreciate this fantastic video. I'm currently visiting Sweden (am a dual citizen) from Cal and parked myself here at a lovely Medical library. Finished watching your video here. Loved it!
If I have to choose one channel on RUclips for life time, it is gonna be this one. ❤️❤️
This guy is so good, he requires to teach at my university 🙌
Sensei you are amezing love from india 🇮🇳, just the way you teaching us is great...
OMG IM SO GLAD I FOUND YOU... explained in a very well stepwise manner... Thank you so much...
Professor Zach thank you so much you are the best thing to ever happen to a med student. Magnificent explanation
Incredible! What a bright shining lamp you are! Sir you are like the lamp which burns itself to illuminate the medical world. You explained so nicely in short time that was not possible for me to understand even after trying for many days. God bless you. Our good wishes are always with you.
Thank you so much sir for your wonderful lecture, it is so useful and helpful to me.I couldn't understand this portion when I learnt from lecturers in our medical college, but once i listen to your lectures everything becomes crystal clear.You are really doing such a great service through these selfless efforts.I wish you good luck and all the courage to do more wonderful videos like this always in future.
I am a fan of Ninja Nerds, from Sri Lanka
Thank you for providing a comprehensive, in-depth analysis of the Liver. You have given me a new appreciation of the liver, I am even tempted to give up alcohol to protect this hard-working filtering system.
This video just changed my life THANK YOU SO MUCH
Incredible, am really grate. You increased my efficiency amidst the work load of medical school.
you are the best teacher in this entire universe..... I wanna meet you but staying in the other corner of the world..
This is a great video for a patient like me. I have PBC. Your diagrams are really easy to understand thank you. I am waiting for the result on my portal Doppler scan.
perfect teacher, perfect video, perfect understanding & knowledge !!!
gold standard for humanity right here
Thank you. Now I'm more interested in medicine than before because of your lessons
My daughter passed away at 31 from Cirrhosis of the Liver. Thanks for helping me understand more about what happened.
We are sorry for your loss. We couldn't begin to understand your loss, but hopefully the understanding you've gained can bring you some closure.
Thanks for helping me understand how this works. My mom’s doctor is suggesting that speaking with a specialist about getting her TIPS procedure. This is scary stuff! 😔
How can someone be so so so brilliant ❤
One of the best tutor!!
Thank you very much
This has helped me during my pathophysioly class! Thank you ! 😊
It hurts that your voice is weak... Great teacher💓
Aww while teaching hus expressions were so cute.. gosh I am in love with him :(
😆😆😆😆😆😆😆
I have a crush on him, too!!
I am not a student and I enjoy your explanations.
This video is an answer to prayer! Thanks!!
Thank you for the knowledge shared. As it gives me more understanding about my diagnoses. And how things work❤
Perfect explanation of liver circulation!
you are a PHENOMENON bro!
Excellent! Thank you so much for an informative presentation. I have liver disease and appreciated this video.
Excellent information & very well spoken. In Gastric bypass surgery most common to see Vitamin -A deficiency ( fat soluble Vitamin absorbed from stomach ) from Ophthalmology standpoint & patients have to take Vitamin -A regularly as a medicine. Thanks
ma man right here doing God's work, dude you deserve to lecture at Harvard
I was diagnosed with portal hypertension of the liver. I've several nodules also but nothing more. This was very imformative and made me feel better about the outcome about the stunt placement.
My only worry now are the nodules.
Hope you get better soon
Mere papa ko cld h stage 4 portal hypertension h medicines chal rhi h...unki life ko danger to nhi h?
Understand the hepatic portal Sys much better.
Sir, thank you for the thorough explanation...salute!
Wow! so clear teaching, you are the best, thank you.
Yesterday I can’t remember this topic when I studied with book suddenly I remember everything about liver after this miraculous video 📼 hats off bro u r hulk
Wonderful Work as always ,thanks to all the team :)
I'm learning more about this my son had got hospitalized because bad liver but u mo god is good and a lot of prayers I dont wish no kind of sickness like all these now days glaucoma cataracts this that and the other but ithank everyone for their prayers
its like watching my memory working in live action ....awesome job. I always used colored pens/pencils to draw similar thoughts
Excellent explanation...hat's off to the effort taken
thank you so much for giving us this content in free
such a great teacher you are...your efforts should be really appreciated...
Never understood anything better than this!!!
Loved this lecture. I have watched many many and this is one of the best one. TY
I find this video so valuable as I am a patient currently with GI tract bleeding. I have this bleeding from about 3 months after the whipple surgery till now, a total of 4 times getting in the hospital but the doctors still not be able to find the source or the root cause of the GI tract bleeding. I have some blood clot in the portal vein which I am now thinking it is the main cause of my bleeding. Thank you so much.
how do u remember so many things.u r a gift of god to all of us. u r simply great.where were u since so many years.we missed u .
It's awesome.. really very informative..thank u so much for u efforts...I highly appreciate ur simple diagrams...keep going
This channel is a blessing!
Love you man ❤ ur awesome you make everything easy make every concept clear now I know reason of Caput Medusa
thank you sir. you are the best on youtube
you are fantastic..... such a good teacher!!!
So well explained. God bless you
Artistic presentation, really clear explanation thanks to you guys
You are amazing zack , all love and respect ❤️
Great video. Really liked your gesticulations when describing sagital and coronal views - very easy to understand.
Thank you so much you literally answered 5 questions of my homework ❤
Thanks u made life easier on that topic 🙏🙏
By far you are the best I’ve seen! Thank you so much for your exceptional and detailed video! 🙏🏽👏🏽👍🏽😌God bless you!
May you have a long and healthy life
Lots of love from india❤️❤️❤️🇮🇳🇮🇳
Good information and making it understandable!
You are amazing. I always learn so much from you. 🙏🙏
Best channel in the world 🌍
31:47 (Clinical Part)