Dear Doctor, what if you thake those with Lion's mane (fruitbody and mycelium)? I heard its helps well for the NGF. Wich supplementen can help the bloodbarior to active the NGF? Thank you
Thank you for the information. I too wonder if there is a way to see how high dose biotin effects RR MS. In an age where we are starting to treat harder earlier to try and slow disease progression, what are its effects in that regard? At my MS diagnosis, my neurologist suggested I take a high dose biotin. I of course complied, but it would be neat to hear a breakdown if there have been studies for RR effects as well.Does it only help with certain functions? Does it assist with slower overall progression? Faster recovery times or more function retained after a flare? Maybe a future video idea if they ever release a study. Thank you so much for the content 😊
As far as I know, there is no major study in relapsing MS. I think at the time biotin was being first studied, very few medications had evidence in progressive MS, so they wanted to pursue treatments of SPMS and PPMS. It's very unclear both if and how biotin works in MS.
I have a brief question re Biotin - you say it is recommended to stop before getting blood tests - just to be sure: should one stop taking biotin before an MRI scan? That is, can biotin interact with the contrast in any way? Thank you!
Isn't Biotin basically an energy catalyst? Shouldn't there have been some assessment of what exercising the subjects were doing during the trial? Perhaps those who worked harder exercising may have had better results?
Great review. Thanks again for the information. Can you comment on the evidence for using serum neurofiliment light chain levels to guage MS therapies?
There is definitely strong evidence on the group level that serum neurofilament is correlated with central nervous system injury and that disease modifying therapies can reduce serum neurofilament. However, my opinion is that on the individual level, there is so much variability that it isn't very useful. it is hard to define a level at which treatment escalation is warranted.
Are there any RRMS studies done? I wonder if it maybe just effects nerve function (like for instance Ampyradine), or if it has function on the progression of MS (so its more of a DMT).
As far as I know, there are no studies in RRMS. Professor Gavin Giovannoni wrote an interesting blog awhile ago where he talks about how it is unclear whether biotin is a symptomatic therapy or disease modifying therapy: multiple-sclerosis-research.org/2015/04/aan-2015-my-take-on-the-biotin-the-story/
Well, pharmaceutical companies aren't going to invest in making something natural and inexpensive look effective, are they? That said, how about a video about LDN? (I find it a life saver!!)
Actually, the company Qizenday was trying to develop the product MD1003 (biotin 300mg), but their trial was unsuccessful. I may do a video on LDN at some point. I'm not sure there is a lot of published data on LDN in MS despite its popularity.
@@DrBrandonBeaber Of COURSE not; as above!! But I attribute to it having calmed down a great deal, and a good night's sleep (if with some weird dreams 🤭). Just the idea of HOW it works is interesting.
@@freethinkeralways Yep, 4.5, shows as the ideal dose. I can have it cooked up privately for about $1 per capsule, if I can find a doctor who knows what I want from his life when I ask him for a prescription. And no, it's NOT just a placebo. Anti-inflammatory, rumor has it that no one who takes it has gotten Corona! Happy and healthy New Year from Jerusalem!!
@@Jerusalem_Warrior Thank you! Happy New Year! I think I pay more... Smth in range of $130 for 90 compounded pills in clear capsules. I heard capsules with red dye are a little cheaper.
Dr. I have mild ms I used aubagio for 7 month and quit it because I want healing my self naturally ,now I'm doing ketogenic diet but without any dairy product.. what's your opinion please? ☹
Hi doctor! I was wondering if you could make a video in regards to progression in cases where no new lesions are present. I was on ocrevus for a little over 1 year and in that year I progressed heavily. My edss score had a jump 4 points and every other symptom because significantly worse. My doctor said I have RRMS and affording to my latest scan there are no active leisons or signs of active disease. They didn’t compare my scan with my scan from 1 year ago ( I had to change doctors due to a move), so I’m not sure if there was any progression seen over the year yet. All I know is: I had a ALOT of decline and it was new. I recorded atleast 2 episodes of new symptoms emerging or old ones progressing every month for the last 1 year. My scans are telling a different story than what’s visible. My doctor said ocrevus won’t be given to me ever again due to this but he wasn’t too clear on anything in terms of treatment plans, progression or any of this. If you don’t mind, I’d love to see your take on the matter.
It is unfortunately very common for people with MS to have worsening symptoms despite a stable MRI scan. This is very typical of progressive MS but also occurs in relapsing MS. There is a newer term called PIRA (progression independent of relapse activity) which I talk about in this video: ruclips.net/video/duwSGmbHa0E/видео.html A change in the EDSS by 4 points without a relapse in 1 year is unusual, but I can't comment on your specific situation. I wish you the best of luck.
Dr. Brandon Beaber thank you for your reply doctor. Unfortunately, not much is known about MS so there is so much conflicting info and so many grey areas. Not sure what’s going on with my system. I have had Ms for 10 years now and I’m 19 now. I have noticed a lot of different patterns. I know 1 thing as a fact: I have progressed. And I have recorded dates when stuff would get worse too. I was on ocrevus whole time so not sure. I probably just have disappearing leisons. Hopefully it all gets better for me and I have clarity soon. Thank you for taking the time to reply Dr. I appreciate it a lot.
![Multiple Sclerosis is Becoming Milder [Data Presented by Neurologist]](http://i.ytimg.com/vi/GlZdHnTFcwQ/mqdefault.jpg)
I would be interested to know as to the thinking behind the dose of 300mg? Why not less or more? Would a 100mg per day provide some benefit?
Dear Doctor, what if you thake those with Lion's mane (fruitbody and mycelium)? I heard its helps well for the NGF. Wich supplementen can help the bloodbarior to active the NGF?
Thank you
Thank you for the information. I too wonder if there is a way to see how high dose biotin effects RR MS. In an age where we are starting to treat harder earlier to try and slow disease progression, what are its effects in that regard? At my MS diagnosis, my neurologist suggested I take a high dose biotin. I of course complied, but it would be neat to hear a breakdown if there have been studies for RR effects as well.Does it only help with certain functions? Does it assist with slower overall progression? Faster recovery times or more function retained after a flare?
Maybe a future video idea if they ever release a study.
Thank you so much for the content 😊
As far as I know, there is no major study in relapsing MS. I think at the time biotin was being first studied, very few medications had evidence in progressive MS, so they wanted to pursue treatments of SPMS and PPMS. It's very unclear both if and how biotin works in MS.
I have a brief question re Biotin - you say it is recommended to stop before getting blood tests - just to be sure: should one stop taking biotin before an MRI scan? That is, can biotin interact with the contrast in any way? Thank you!
Very interesting, but WHY Biotin? Why not vitamin B12, or any other vitamin?
Thank you doctor 💜💜🙏
No problem. I'm glad you enjoyed it.
Isn't Biotin basically an energy catalyst? Shouldn't there have been some assessment of what exercising the subjects were doing during the trial? Perhaps those who worked harder exercising may have had better results?
Would you recommend taking a B12 supplement if you are also taking a biotin supplement? Great video! Thank you.
B12 isn't specifically related to high dose biotin as far as I know.
Great review. Thanks again for the information. Can you comment on the evidence for using serum neurofiliment light chain levels to guage MS therapies?
There is definitely strong evidence on the group level that serum neurofilament is correlated with central nervous system injury and that disease modifying therapies can reduce serum neurofilament. However, my opinion is that on the individual level, there is so much variability that it isn't very useful. it is hard to define a level at which treatment escalation is warranted.
Are there any RRMS studies done? I wonder if it maybe just effects nerve function (like for instance Ampyradine), or if it has function on the progression of MS (so its more of a DMT).
As far as I know, there are no studies in RRMS. Professor Gavin Giovannoni wrote an interesting blog awhile ago where he talks about how it is unclear whether biotin is a symptomatic therapy or disease modifying therapy: multiple-sclerosis-research.org/2015/04/aan-2015-my-take-on-the-biotin-the-story/
@@DrBrandonBeaber thank you doc.
Well, pharmaceutical companies aren't going to invest in making something natural and inexpensive look effective, are they? That said, how about a video about LDN? (I find it a life saver!!)
Actually, the company Qizenday was trying to develop the product MD1003 (biotin 300mg), but their trial was unsuccessful. I may do a video on LDN at some point. I'm not sure there is a lot of published data on LDN in MS despite its popularity.
@@DrBrandonBeaber Of COURSE not; as above!! But I attribute to it having calmed down a great deal, and a good night's sleep (if with some weird dreams 🤭). Just the idea of HOW it works is interesting.
@@Jerusalem_Warrior Same here :) At 4.5 mg
@@freethinkeralways Yep, 4.5, shows as the ideal dose. I can have it cooked up privately for about $1 per capsule, if I can find a doctor who knows what I want from his life when I ask him for a prescription. And no, it's NOT just a placebo. Anti-inflammatory, rumor has it that no one who takes it has gotten Corona! Happy and healthy New Year from Jerusalem!!
@@Jerusalem_Warrior Thank you! Happy New Year! I think I pay more... Smth in range of $130 for 90 compounded pills in clear capsules. I heard capsules with red dye are a little cheaper.
I take 3 of 10,000 mcg biotin per day. Do you think that this is sufficient? Also thank you so much for making such informative videos! 😊
This would be 30mg/day which is about 1/10th of the dose used in the clinical studies. I can't comment on how effective this dose might be.
Dr. I have mild ms I used aubagio for 7 month and quit it because I want healing my self naturally ,now I'm doing ketogenic diet but without any dairy product.. what's your opinion please? ☹
I may do a video on ketosis/intermittent fasting at some point. I don't have an opinion on it right now.
@@DrBrandonBeaber ok dr thanks alot 💗🙏
Hi doctor! I was wondering if you could make a video in regards to progression in cases where no new lesions are present. I was on ocrevus for a little over 1 year and in that year I progressed heavily. My edss score had a jump 4 points and every other symptom because significantly worse. My doctor said I have RRMS and affording to my latest scan there are no active leisons or signs of active disease. They didn’t compare my scan with my scan from 1 year ago ( I had to change doctors due to a move), so I’m not sure if there was any progression seen over the year yet. All I know is:
I had a ALOT of decline and it was new. I recorded atleast 2 episodes of new symptoms emerging or old ones progressing every month for the last 1 year. My scans are telling a different story than what’s visible. My doctor said ocrevus won’t be given to me ever again due to this but he wasn’t too clear on anything in terms of treatment plans, progression or any of this. If you don’t mind, I’d love to see your take on the matter.
It is unfortunately very common for people with MS to have worsening symptoms despite a stable MRI scan. This is very typical of progressive MS but also occurs in relapsing MS. There is a newer term called PIRA (progression independent of relapse activity) which I talk about in this video: ruclips.net/video/duwSGmbHa0E/видео.html A change in the EDSS by 4 points without a relapse in 1 year is unusual, but I can't comment on your specific situation. I wish you the best of luck.
Dr. Brandon Beaber thank you for your reply doctor. Unfortunately, not much is known about MS so there is so much conflicting info and so many grey areas. Not sure what’s going on with my system. I have had Ms for 10 years now and I’m 19 now. I have noticed a lot of different patterns. I know 1 thing as a fact: I have progressed. And I have recorded dates when stuff would get worse too. I was on ocrevus whole time so not sure. I probably just have disappearing leisons. Hopefully it all gets better for me and I have clarity soon. Thank you for taking the time to reply Dr. I appreciate it a lot.
Is biotin safe to use along with your dmt?
I'm not aware of any specific interaction with disease modifying therapy, but this is not something which has actually been studied.