pH microclimate in drug absorption

📚 Description:
Explore the fascinating world of pH microclimates and their impact on drug absorption in this comprehensive video. We delve into the definition of pH microclimates, their location in the intestine, and the factors shaping them-such as the mucus layer, cellular metabolism, and specific secretions.
Discover the pH partition hypothesis and how deviations from it challenge our understanding of drug absorption. Uncover the role of pH microclimates in altering drug ionization states and influencing transporter activity.
In the segment on evidence, we present studies in rats and humans showcasing the existence of pH microclimates, their variation along the intestine, and the vital role played by the mucus layer and cellular metabolism in maintaining them.
🔬Key Topics:
Definition and location of pH microclimates
Factors influencing pH microclimates
pH partition hypothesis and its deviations
Role of pH microclimates in drug absorption
Evidence for pH microclimates in rats and humans
Variation in pH microclimate along the intestine
The role of mucus layer and cellular metabolism
🔍 Studies and Research:
Explore groundbreaking studies revealing the pH microclimate's presence in rats and humans, its variation in different intestinal sections, and the intriguing impact of substances like glucose and sodium.
💡 Insights into Drug Absorption:
Gain insights into how pH microclimates impact drug absorption, altering ionization states, and influencing transporter activity.
📊 Scientific Findings:
Delve into pH measurements across various intestinal sections, including the intriguing findings of acidic microclimates even in the human stomach.
Thanks for joining us on this scientific exploration! If you enjoyed the video, don't forget to like, share, and subscribe for more insightful content. Have a fantastic day!
#pHMicroclimates #DrugAbsorption #ScienceExplained #Research #MedicalScience #RUclipsScience #Pharmacology
📚 Reference Book:
"Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition" by Alex Avdeef.
Thanks for watching, and remember-science is the key to understanding our complex world! 🌐🔬✨
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[@jaishreevg4209]

very informative video. expect more of this video

[@WorldOfEduPharma]

Glad you liked it