Please confirm that last part. Did you mean which of the 3 candidate MTDs is most effective? or did you mean which can be an overall MTD (uber MTD)? Since there isn't any effective/efficacy stuff yet.
We are selecting one dose to be the MTD. The MTD is the dose level (candidate MTD) that has an observed toxicity rate closest to the pre-specified target DLT rate. The observed toxicity rate is estimated with isotonic regression. Hope that helps!
👉unknow 🤗😊😂
Please confirm that last part. Did you mean which of the 3 candidate MTDs is most effective? or did you mean which can be an overall MTD (uber MTD)? Since there isn't any effective/efficacy stuff yet.
We are selecting one dose to be the MTD. The MTD is the dose level (candidate MTD) that has an observed toxicity rate closest to the pre-specified target DLT rate. The observed toxicity rate is estimated with isotonic regression. Hope that helps!
@@alysestaley yes it does. Thanks much. Very nice presentation. I wish I knew about boin much earlier.