For 18 months I’ve been treated at Dana Farber for stage 4 melanoma using a checkpoint inhibitor like in the video. So far, so good. It doesn’t work for everyone, but it gives us a chance to live longer fuller lives with a disease that used to end badly and rather quickly. Thanks for putting this video together, it’s actually very helpful for explaining to family and friends what is going on. Bravo!
Impressed by the cute and vivid drawings applied in the video to state what is immunotherapy and how does it work to fight cancers. Besides with cancers, such therapy is also studied on other diseases like CLL.
i got stage 4 lung cancer and no PD-1 in my blood. Started the clinical trial recently and in just 2 months, the cancer has significantly shrunk via CT scans. Not sure how this is working without PD-1 but it is. Working with M.D. Anderson clinic in Houston.
Gary, my 38 year old brother was just diagnosed with stage III B. Please keep up posted on your journey. We are considering immunotherapy since he does have PD-L1.
From what I understand, PD-1 has to be expressed on the T cells that are already inside the tumor in your lung, not necessarily those floating around in your blood. The T cells sitting inside the tumor (known as Tumor Infiltrating Lymphocytes or TIL) have the ability to destroy the tumor but because of PD-1 /PD-L1 interaction between T cells and cancer cells, they are effectively paralyzed. The checkpoint drug prevents or blocks that interaction and the T cells then get to work killing the tumor.
*How is immunotherapy used to fight cancer?* If you take the brakes off the immune system, you can unleash an attack on cancer cells. That's the theory behind PD-1/PD-L1, a vitally important immunotherapy discovery illustrated in this video. bit.ly/1fk8rSQ #DanaFarber #Cancer #immunotherapy #precsionmedicine #checkpointinhibitors
1:58 I think Atezolizumab binds to PD-L1 receptors to keep the T-cells active right, the video shows that Atezolizumab is bound to PD1. Correct me if i'm wrong.
My father after diagnosed with melanoma of advanced stage started immunotherapy and on his 4th day after the first application passed away. Before applying it, please take in consideration that there are many cases that show that this treatment can be life threatening because of its side effects. The immune system while rebooted can attach other organs and cause death.
Sorry to hear that. It's often the only viable option. Is for me. They say they can catch any adverse side effects including autoimmune reactions in bloodwork and reverse them with other drugs.
Seriously? You must be alot of fun to hang out with (rolling my eyes.) This is a cartoon on how these therapies work. Get over your gender issues. This is to help patients understand the basics of T-cells and PD-1/PD-L1. It's a cartoon.
Aw..I am sorry that the bigoted Dana-Farber Institute wasn't being inclusive enough. I hope that in future illustrations an adequate number of scientists are portrayed as gay or trans too.
For 18 months I’ve been treated at Dana Farber for stage 4 melanoma using a
checkpoint inhibitor like in the video. So far, so good. It doesn’t work for everyone, but it gives us a chance to live longer fuller lives with a disease that used to end badly and rather quickly. Thanks for putting this video together, it’s actually very helpful for explaining to family and friends what is going on. Bravo!
Awesome breakdown for regular non-doctor people
Impressed by the cute and vivid drawings applied in the video to state what is immunotherapy and how does it work to fight cancers. Besides with cancers, such therapy is also studied on other diseases like CLL.
i got stage 4 lung cancer and no PD-1 in my blood. Started the clinical trial recently and in just 2 months, the cancer has significantly shrunk via CT scans. Not sure how this is working without PD-1 but it is. Working with M.D. Anderson clinic in Houston.
Gary Stumpf Great news !
Gary, my 38 year old brother was just diagnosed with stage III B. Please keep up posted on your journey. We are considering immunotherapy since he does have PD-L1.
From what I understand, PD-1 has to be expressed on the T cells that are already inside the tumor in your lung, not necessarily those floating around in your blood. The T cells sitting inside the tumor (known as Tumor Infiltrating Lymphocytes or TIL) have the ability to destroy the tumor but because of PD-1 /PD-L1 interaction between T cells and cancer cells, they are effectively paralyzed. The checkpoint drug prevents or blocks that interaction and the T cells then get to work killing the tumor.
Fabulous. I'm about to have my 2nd infusion here in Chicago. Used to live by MD Anderson, and you are in great hands.
Any updates on anyone who commented on here? How are you all doing now. Did the treatment work?
Creative illustration about how Immunotherapy works!
Amazing video, so appreciative
Thanks!
Thanks for this great explanation
Thank you very much! You made that very understandable!
This is wholesome thank you
Thank you !
*How is immunotherapy used to fight cancer?*
If you take the brakes off the immune system, you can unleash an attack on cancer cells. That's the theory behind PD-1/PD-L1, a vitally important immunotherapy discovery illustrated in this video. bit.ly/1fk8rSQ
#DanaFarber #Cancer #immunotherapy #precsionmedicine #checkpointinhibitors
Thanks for the video
1:58 I think Atezolizumab binds to PD-L1 receptors to keep the T-cells active right, the video shows that Atezolizumab is bound to PD1.
Correct me if i'm wrong.
Really interesting, thanks!
How about for kidney failure patients, pls advise
No, oncology patients (certain tumor types) only right now to my knowledge.
Really usefull, thank you
Good info, tq
background music is waaay to distracting
My father after diagnosed with melanoma of advanced stage started immunotherapy and on his 4th day after the first application passed away. Before applying it, please take in consideration that there are many cases that show that this treatment can be life threatening because of its side effects. The immune system while rebooted can attach other organs and cause death.
I am sorry to hear that. Did he die from adverse reaction to the immunotherapy drug or from the cancer ?
Sorry to hear that. It's often the only viable option. Is for me. They say they can catch any adverse side effects including autoimmune reactions in bloodwork and reverse them with other drugs.
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-.- hm
Some of the scientists involved in this research are female. I'd never know it from your illustrations.
Seriously? You must be alot of fun to hang out with (rolling my eyes.) This is a cartoon on how these therapies work. Get over your gender issues. This is to help patients understand the basics of T-cells and PD-1/PD-L1. It's a cartoon.
Aw..I am sorry that the bigoted Dana-Farber Institute wasn't being inclusive enough. I hope that in future illustrations an adequate number of scientists are portrayed as gay or trans too.
I absolutely agree - it would be great to include more than old white men as scientists. I hope your message is taken seriously by the creators.
@@DoubleGauss Sério isso?
Não seria por competência?
Acorda povo meu!!!
@@432_nine Cadê os jovens cientistas? Usando outros químicos? Gostaria de vê-los em destaque por merecimento, competência!!! Gratidão
Indian hospital posdullty immuno tharpy