This was great. I came across a term called liquid liquid phase separation in a paper, didn't understand but thanks to this video I now have some insight. Thank you.
Fantastic talk! Just a small detail I'd like to add: I wouldn't define the Golgi apparatus as 'a funny name', it comes from Camillo Golgi, an italian scientist who discovered this organelle.
You have to admit, it's a little funny that he's known for his little apparatus. Seriously, mad props to the pioneers of cellular biology! And whatever it takes to memorize all of this crazy crazy stuff!
Cross pollination between physics and biochemistry is so very exciting!!! Thanks for opening our eyes to these exciting developments. Question is what will the future bring? Thanks Dr. Brangwynne.
28:38 You said that with a low interaction parameter (high temperature) the system remains in a high entropy/mixed state. And as you raise the interaction parameter, the system will favor phase separation. But the sign on the y-axis is indicating the opposite. In other words, based on the graph, it appears that a low interaction parameter drives the system into phase separation, and so on... Could it be that the interaction parameter is relative? (ie. low interaction between heterogenous molecules (phase separation) vs. low interaction between homogenous molecules (mixed state))?
I wonder when biology is finally going to admit and understand that without a "spirit" / "IS-BE" there is no life animating-organizing force behind life-forms
This was great. I came across a term called liquid liquid phase separation in a paper, didn't understand but thanks to this video I now have some insight. Thank you.
Fantastic talk!
Just a small detail I'd like to add: I wouldn't define the Golgi apparatus as 'a funny name', it comes from Camillo Golgi, an italian scientist who discovered this organelle.
You have to admit, it's a little funny that he's known for his little apparatus. Seriously, mad props to the pioneers of cellular biology!
And whatever it takes to memorize all of this crazy crazy stuff!
This is indeed helpful to understand LLPS (liquid-liquid phase separation) from a physics point of view.
Cross pollination between physics and biochemistry is so very exciting!!! Thanks for opening our eyes to these exciting developments. Question is what will the future bring? Thanks Dr. Brangwynne.
Very nice talk. Finally I landed here after hearing the talk of Tony hyman, Frank Julicher and Eric Dufresne.
membraneless organelle will change many the molecule biology concepts, thanks Cliff Brangwynne
Very great lecture. Looking forward to more videos.
Thank you SO much for your clarity and for the generosity of your time. I am fascinated.
This video was fantastic. Great explanations and great lecturing.
Hi Cliff, fantastic talk! . thank you
Excellent Lecture. Thanks for clearing the basic concept.
These are novel and important idea. Thanks for nice intro.
Loved it. Thank u Prof. Brangwynne!
Macromolecules as liquids. (15:30)
7:17 21:51 Organelles without (phospholipid) borders.
Very helpful for a beginner like me. Thanks.
this talk was super good
Thanks for the great talk!
Great stuff!!
28:38
You said that with a low interaction parameter (high temperature) the system remains in a high entropy/mixed state. And as you raise the interaction parameter, the system will favor phase separation. But the sign on the y-axis is indicating the opposite. In other words, based on the graph, it appears that a low interaction parameter drives the system into phase separation, and so on... Could it be that the interaction parameter is relative? (ie. low interaction between heterogenous molecules (phase separation) vs. low interaction between homogenous molecules (mixed state))?
What effect does milli meter microwave raditation have on liquid phase seperation, given it can increase hydroxy radicals in water?
thanks
Everbody gangsta until the phase change
wish I could give 1000 thumb up
Coo
You're a soft squishy robot, not me
I wonder when biology is finally going to admit and understand that without a "spirit" / "IS-BE" there is no life animating-organizing force behind life-forms
See “intended evolution”- there is a “life force” as the substrate to physics and chemistry.
Huh?