Pharmacology of

#Hydroxyurea.
Hydroxyurea acts in the S phase of cell cycle (CCS drug).
Hydroxyurea interferes with the conversion of ribonucleotide to deoxyribonucleotide by inhibiting ribonucleoside diphosphate reductase.
This results in inhibition of DNA synthesis. It is used mainly in CML, polycythaemia vera and #psoriasis.
The common side effects are bone marrow suppression with #leucopenia, anaemia and thrombocytopenia.