Virology course #2 Structure of viruses

في هذه المحاضرة مواضيع تخص تركيب الفايروس وتشمل
-Viral nucleic acids (DNA or RNA)( Single straded or double stranded) (linear or circular)(Haploid or diplid) (Single molecule or inseveral pieces)
-Viral capsid?
-Nucleocapsid?
-Viral envelope?
-Viral proteins? (capsid, enzymes, matrex proteins, regulatory proteins and surface proteins)
-Tegument

[@wadhaalbadri11]

عاشت الأيادي دكتور 👏

[@ahmedhusseinmahdialzurfi8500]

دكتور ممكن معرفه شنو سبب الفعاليه العاليه للفيروسات naked عن فعاليه envelop

[@DrAhmedAlobaidy]

مو واضح السؤال

[@ahmedhusseinmahdialzurfi8500]

اذكر مره دكتور كلت انو فعاليه او pathogensis الخاصه للفيروسات غير المحاطه بغلاف اللي هيه من نوع naked viruses تكون اعلى و اخطر و مقاومتها تكون اعلى

[@ahmedhusseinmahdialzurfi8500]

@@DrAhmedAlobaidy حديثك في بدايه دوره المختبر دكتور ذكرت هذا الموضوع فما لكيت الاسباب الواضحه لهذا الموضوع غير لكيت الفرق بالتركيب بين ال naked و envelop

[@DrAhmedAlobaidy]

Non-enveloped viruses are typically more virulent
Non-enveloped viruses (also known as naked viruses) are typically more virulent than enveloped viruses. This is because they usually cause host cell lysis. This is one of the major differences between non-enveloped and enveloped viruses; let’s understand the reasoning behind that. Since non-enveloped viruses don’t have that extra lipid membrane, cell lysis is the most common exit mode from the host cell. During this event, the viruses violate the integrity of the cell membrane, causing cell death and significant tissue damage to the host organism. Non-enveloped viruses are more resistant to extreme pH, heat, dryness, and simple disinfectants. Some examples of non-enveloped viruses are norovirus, enterovirus, adenovirus, and rhinovirus.

[@DrAhmedAlobaidy]

Enveloped viruses are typically less virulent
On the other hand, enveloped viruses are typically less virulent than non-enveloped viruses. This is because they don’t always cause cell lysis during cell exit, although cell death often follows as a consequence of virus replication. Since enveloped viruses contain an outer membrane that surrounds the capsid, during virus assembly and exit from host cells, these viruses can use the host cell membrane itself to assemble their membrane, known as an envelope. This process avoids cell lysis and helps enveloped viruses escape the host’s immune system.
Enveloped viruses also tend to be more sensitive to extreme pH, heat, dryness, and simple disinfectants. Examples of enveloped viruses include: influenza, human cytomegalovirus (HCMV), HIV, respiratory syncytial virus (RSV), vaccinia virus, and human coronaviruses (such as NL63, 229E, OC43, and SARS-CoV-2).