A friend of mine once tasted phenolphthalein in school and found out it was very bitter even when heavily diluted. She wasn't supposed to but stuck her finger in a big bottle with a little bit of phenolphthalein and licked it because she was curious about its taste. The teacher told her to stop tasting stuff but nothing really came of it. She kinda has a reputation of tasting stuff and is now studying geology
I once crystallized 10g of quinine sulfate from cinchona bark. I have like 3 total taste buds so I would convince ppl to taste it by sprinkling some on my tongue first. Now I have no friends. I went through those 10g within a few years just making super strong gin and tonics. Dont calculate that please
Blonde homie has NileRed tongue or something. Took forever to taste PTC, but eventually could. Thought denatonium "wasn't that bad". Dude could chug vodka and not flinch.
i accidentally licked my finger after using 100% acetone nail polish remover and didn’t know they had recently added denatonium to the formula. i literally could not swallow. my body wouldn’t let me.
I used to work at a company that used TSDA1 denatured ethanol, which is an EU/UK specification for 99.99% pure ethanol denatured with denatonium benzoate. Everybody failed to thoroughly clean their hands before lunch exactly once during their time there.
Word on the street Guy Fierri uses Quinine on his frosted tips to prevent fans from nibbling on his hair…. Similar to hot sauce on ya bushes/plants to keep critters from eating em yup
Wonder how I'd react to all of this? I'm a hypertaster for bitter, and those bitter test strips are roughly the equivalent of getting punched in the face.
Denatonium benzoate reminds me of when you try to swallow a pill and it gets caught in your throat only then to be slowly dissolved then refluxed back into your mouth. Just dry, bitter, and irritating.
@andrefiliks well you know what they say, "repress your bad memories until a youtube comment reminds you of an unending bitterness" idk i pulled that out my ass but sun tzu probably said that shit first
Denatoniumbenzoat is a hell of a bitter drug. I got 20g to make an solution to put on my cats tail where he continued to bite open a wound. It worked well, to well. Even if I took all precautions I could tasted this awful taste for a week when I touched something that has touched something that had slight contact with the Denatoniumbenzoat.
That's not surprising, I remember reading somewhere that even extremely diluted the bitter taste persists. The article mentioned an Olympic size swimming pool, not sure I believe that, but maybe? If so it would be one heck of a mean prank to play, that would probably get you sued if discovered, despite being very safe to do... XD Edit: This stuff is said to be "unbearably bitter" to humans in a solution at ten parts per million, so 20g is massive overkill. Then again I guess cats are less sensitive to some flavors, maybe that applies to bitter as well?
I was properly trained, so when I decided to check the switch cartridge thing, I only touched it the minimal amount. It was enough. Can't imagine going with full crystals of this shit xD
@@lefthandedspanner MSG by itself doesn't taste umami to me. It definitely makes the food I cook with more umami, but by itself, it's hard to describe. Vaguely salty?
@@That_Chemist what about sour taste ? it got me to read few abstracts. I seems that the pKa isn't the main contributor to the sour taste. Weak acid would taste more sour as strong acid would be mostly dissociated. Also, organic acids taste more sour as mineral ones diffuse less in the cell (or something like that, i don't know what a cell is)
I remember in my anatomy and physiology class in high school we were studying genetics so he had those PTU test strips handed out to see if we had the gene to taste it. Let me say that I've never been so happy to be born a mutant that can't taste it because everyone in class started wretching. Then again, I also have the gene that makes cilantro taste like soap so I think it evens out 😂
Imagine working at the bar they’re in for the very end segment, and you’re watching a group of people openly take mystery crystals out of a vial, but they’re all just talking about bitterness and genetics. I would have spent the rest of my shift thinking about whether they were taking drugs or not
to be fair that is exactly why the PTC test strips were used - even ImKibitz was like "you wanna bring a container of white powder to a restaurant" when I wanted to show our friends neotame in the past lol
I remember using phenyl thiourea for my research, the old bottle smells like forbidden cheetos, smells like it would taste extremely dry and umami, thank god my intrusive thoughts didn't win
@@That_Chemist Greetings from Finland. Not many things entertain us more than seeing foreigners try Salmiakki (Ammonium Chloride) as we literally eat it as candy, ice cream, potato chips, powder, vodka and even condoms flavored with it. I am not kidding.
Concerning caffeine. You should try to synthesize anhydrous "caffeine citrate", by combining caffeine in anhydrous chloroform, and anhydrous citric acid in anhydrous ethanol, run it on the rotavap and test it out. Did once and it was so bitter it even got out of the fume hood, through the vacuum pump/rotavap... Overwhelming bitterness. Much more than any other bitter compound I've ever sampled, involuntary or otherwise. Also deliquescent so store under vacuum. Decomposes into "regular" caffeine citrate in water after some time and looses it's bitterness. Couldn't find the paper describing the synthesis and the effects but if you see this and respond I'll try.
Yhea I remember that bitter and soapy taste also way too good even got grose bumbs just remebering it 😖😣 my go too discripption Was always tasts like the child of shit and Washing Puder 😅
Ha, yeah when it sticks up your nose and slowly drips down into the back of the throat…, fucking gross, especially with your sense getting more sensitive by the second lmao
@@aqdrobertI am currently listening to an extracurricular Lecture on Natural Chemicals and the professer said that he knows of good account that you cannot poison anyone with strychnine because it's so powerful that if you take a singular bite you just start puking.
@@wrenophelia @wrenophelia3400 you're not wrong, most ssris probably taste pretty disgusting (as well as lots of other meds, even though most arent too unpleasant imo), but escitalopram is next level bad. It's so bitter it becomes metallic tasting & astringent and sticks around forever - and that was just when you failed to swallow the tablet immediately. And that fzcker was just 10 mg! Much much worse than my usual 100mg sertraline! Anyway uhh Thanks for coming to my Ted talk And those tablets are just 10mg and taste
@@wrenophelia sure, most are somewhat bitter but pretty tolerable imo Ssris are generally pretty disgusting but the few times I had escitalopram 10(!)mg I found it to be orders of magnitude worse than sertraline 100mg. it was strongly astringent, intensely metallic and lingering
By very very far the most bitter substance I have ever tasted is TUDCA. It is pure bile. And it is the most optimal form of bile. Because it is an water soluble form of bile salt. One uses it as a supplement to optimize what bile does in the body. Dissolve fat and help the body metabolize such substances. It is also used in lots of other parts of the body as kind of a nutrient for various parts of the cells. Many who used it supplement with it to get their liver bile flow work properly. If your own bile and bile flow get sluggish, it impairs lots of function in the liver and the body. That the use of TUDCA many times can resolve. And it works great to improve your health. BUT it if you ever get any of it lose in your mouth.......it is so incredible extremely bitter and the taste just doesn't go away for a good while, no matter what you try to rinse it down or out with.
When I was a kid my parents tried a denatonium solution on me to stop sucking my thumb, I acclimatized myself to it, and to this day, I can take the pure powder with ease. Its strong, but it can be beaten.
My parents used to put something on my nails to stop me biting them. I don't know if it had denatonium in it (i'd learn about denatonium by name roughly 10 years afterwards), but i too acclimatized to the weird goo lol.
That" do it "a 7:00 was too similar to "do the roar" 😂 Ive accidentally licked the finger after changing my remote battery for my bedroom lights and oh my God it's disgusting. I then got curious and licked the battery itself, dumbest decision I've made when it comes to being curious about the taste of something 😂
I grew up drinking "Bitter Lemon" in the US and it's now virtually unfindable. My daily beverage is Diet Grapefruit Dry. It's always there and no one else will drink it :D
Good thing that kitchen(?) sink is nearby in case you 🤮. Denatonium Benzoate was at one time (maybe still is) used to prevent thumb sucking. And I would have thought that it would have been taste-tested last, as it's the worse one. Not saying you're wrong, but I've always heard Quinine being pronounced as "KWAI-nine".
So i lost the ability to taste bitter about 10 years ago. Made a 120,000 ppm solution of denatonium once thinking "eh i was overzealous with the PPE last time i did this and i cant taste bitter anyway" So thats how everything tasted like hint of splenda dirt for a few days
Every time I get my switch out I lick one to see if it's as bad as I remember. It's worse. It's always worse. I'm really sensitive to the stuff so it doesn't even taste bitter, honestly. It just tastes like pain :(
around 4:15 someone mentions that only 25% of people can taste PTC, but that’s not true! being a taster is dominant over nontaster, so ~75% of people can taste it while ~25% can’t! (a club i’m in runs an experiment where we genotype students’ TAS2R38 genes)
Do you know if any of your test subjects have the gene to be a "supertaster"? For supertasters, their bitterness perception is amplified compared to typical people. I'm guessing you and the pukey frog might be supertasters. TAS2R38 is the gene if you have had your own sequenced and want to check it. I found out I have it, and I've always wondered if it was the reason why I was an absolute fiend for baker's chocolate when I was very young. Like I would wake up before everyone in the house and climb and explore cabinets, just a nightmare of a child, and my mom could not hide her baker's chocolate, I found it multiple times. I also used to eat instant coffee by the spoonful... That was all when I was like 3 or 4. Quinine is fascinating, it has quite the history. For a long time, control of supply of it was a Big Deal globally. The tree whose bark it comes from would only grow on some high-altitude hill, and mosquito-born diseases like malaria literally led to rise and fall of entire empires. You definitely should have had some 'miracle fruit' berries on hand for when you guys finished up... would make all that stuff taste sweet!
In school we tasted the first one (or something else genetically bitter or not) and only me and the teacher couldn't taste it. Looking back, she totally just liked to watch the kids cringe lmao
Thank you. I was looking for this. I needed an extremely bitter ingredient for a "social experiment." Yeah. A social experiment. Mhm. Not a prank. Yup. Definitely not gonna bake cookies with these chemicals. Trust me. Yeah. (this is a joke im not actually going to bake those cookies XD) (very bad idea)
I am simultaneously shocked and impressed you lot took denatonium. Props for that Your reaction is absolutely priceless and i show it to everyone for instant entertainment 😁
is it bad that the chemical that which is sprayed onto the back of nintendo cartridges tastes kinda good? like its not bitter for me and similar to how copper or nickel tastes. slightly.
The first one sounds funny, you can only taste it if you have a certain gene. Sounds like a great drinking game, get a bunch of those chemicals which some can taste and which some cannot taste and drink a shot when you could taste it.
I can't remember ever hearing about umami in school, just bitter, acid, sweet, and salt. I wonder if your friend has the reverse of whatever I have, to him denatonium is fine but I can't stand even cauliflower.
Havong barely passed statisitics, i feel fully justified in sayingnthay technically a minimum of 10 poeple for normal results, though id argue 30 should be the minimum becasue id do a t test
I don’t know what difference it does adding denatonium to antifreeze. All you need is a good gulp of it to mess you up for the (very short) rest of your life, bitterness might make you vomit but then you’d take another swig if you’re really dedicated, or seek help if you’re not. I lived through it and mine wasn’t denatonium’d. It would not have made a difference if it was. Dedication means a lot
I once used topical bittering agent designed to stop nail biting, many years ago. The very first (and last) time I applied it, I left my house and started eating a sandwich, a bit of it got on my sandwich from my finger and I freaked out because it was so strong and disgustingly evil! - I instinctively began clawing at my tongue using my nails to try to get it off (i know), which resulted in a mega-dose. I instantly began vomiting violently on a phone box, in public.... yeah Needless to say I still bite the shit out of my nails to this day
One of the worst things I've ever tasted is eszopiclone (Lunesta), a prescription sleep aid. It made everything I ate/drank taste metallic and bitter the whole morning after I would take it. I remember gagging on water ☹️
The amount of efforts deployed to avoid referencing drugs is remarkable! I'd like to know why someone wanted to taste sucrose octaacetate in the first place. Like, "i wonder how many acetylation does it take to make sucrose not sweet ?" ?
I mean anything that isn't a pure substance is likely to have multiple types of flavor compounds. If you mean like an asian style herbal energy shot then yeah the primary flavor would probably be bitter, but a western red bull or monster would probably be primarily sweet.
It's time. Explosions&Fire once did the chloride salts test if any of them were as good as sodium chloride (they were not!) and now you did this. It's time. You must do an artificial sweetener collab with him. Dewit!
quinine is the worst bitter for me there is. on sip on any drink containing tonic water and i wishing i could amputate my tongue for an hour maybe there also is a genetic factor
A friend of mine once tasted phenolphthalein in school and found out it was very bitter even when heavily diluted. She wasn't supposed to but stuck her finger in a big bottle with a little bit of phenolphthalein and licked it because she was curious about its taste. The teacher told her to stop tasting stuff but nothing really came of it. She kinda has a reputation of tasting stuff and is now studying geology
rock licker origin stories
average Kazakh
Hahaha it was my first thought when you said she couldn't stop herself : geologist xD
Geologists not beating the rock licker allegations
I am a geologist, everything checks out
Quinine:
- safely edible
- fluoresces under UV light
- used in drinks for bitter taste
- treats malaria
gigachad alkaloid
I once crystallized 10g of quinine sulfate from cinchona bark. I have like 3 total taste buds so I would convince ppl to taste it by sprinkling some on my tongue first. Now I have no friends. I went through those 10g within a few years just making super strong gin and tonics. Dont calculate that please
@@kibnob now I want gin, thanks 👍😂
Thank god I got my taste buds to differentiate a slightly overripe cucumber from tasty lead acetate.
:(
Forbidden sugar
Forbidden vinegar
Would you prefer your pickles premium or unleaded?
@@jebediahkerman3826 cocaine
Blonde homie has NileRed tongue or something. Took forever to taste PTC, but eventually could. Thought denatonium "wasn't that bad". Dude could chug vodka and not flinch.
Some people just don't taste certain flavors as good
i accidentally licked my finger after using 100% acetone nail polish remover and didn’t know they had recently added denatonium to the formula. i literally could not swallow. my body wouldn’t let me.
My stomach turned and I felt like I was going to vomit from the crystals
Kentucky Fried Nail Polish Remover is finger licking good. It contains the Colonel's secret blend of eleven oxidizers and solvents.
Why though? Are people drinking nail polish remover now?
@@jackstone8074 it's probably a safety reason for toddlers
I haaaate nail polish with bitrex in it, it just makes my hands taste disgusting for hours. I'm an adult, I'm not going to chug it out of the bottle!
The friend on the (audience) left has Neil Red levels of taste perception. XD
What or who is "Neil Red"?
@@Fitzrovialitter Chemistry Yoububer (although I missremembered his name. It's NileRed)
I used to work at a company that used TSDA1 denatured ethanol, which is an EU/UK specification for 99.99% pure ethanol denatured with denatonium benzoate. Everybody failed to thoroughly clean their hands before lunch exactly once during their time there.
Sneak these chemicals onto the set of Hell's Kitchen. Wonder how long it will take Gordon Ramsay to notice why the salt tastes funny.
Word on the street Guy Fierri uses Quinine on his frosted tips to prevent fans from nibbling on his hair…. Similar to hot sauce on ya bushes/plants to keep critters from eating em yup
Wonder how I'd react to all of this? I'm a hypertaster for bitter, and those bitter test strips are roughly the equivalent of getting punched in the face.
Denatonium benzoate reminds me of when you try to swallow a pill and it gets caught in your throat only then to be slowly dissolved then refluxed back into your mouth. Just dry, bitter, and irritating.
So true.... I hate that
Oh god, please don't remind me of this
@andrefiliks well you know what they say, "repress your bad memories until a youtube comment reminds you of an unending bitterness" idk i pulled that out my ass but sun tzu probably said that shit first
Denatoniumbenzoat is a hell of a bitter drug. I got 20g to make an solution to put on my cats tail where he continued to bite open a wound. It worked well, to well. Even if I took all precautions I could tasted this awful taste for a week when I touched something that has touched something that had slight contact with the Denatoniumbenzoat.
That's not surprising, I remember reading somewhere that even extremely diluted the bitter taste persists.
The article mentioned an Olympic size swimming pool, not sure I believe that, but maybe? If so it would be one heck of a mean prank to play, that would probably get you sued if discovered, despite being very safe to do... XD
Edit: This stuff is said to be "unbearably bitter" to humans in a solution at ten parts per million, so 20g is massive overkill. Then again I guess cats are less sensitive to some flavors, maybe that applies to bitter as well?
Denatonium Benzocat
Trade name is Bitrex. It's added to many chemical so that kids won't accidentally swallow them. It's really one of the worst substances ever.
20g is a hell of a lot. You can just use bitter apple spray for the same effect. That stuff is designed to stop pets from biting themselves.
sure you mean 20g, and not 20mg?
The instant stomach ache and mouth feel when he said “caffeine pill”
This is the perfect marriage of youtube edutainment and a stoner movie.
Nice of you to jump on this one so we don't have to.
I was properly trained, so when I decided to check the switch cartridge thing, I only touched it the minimal amount.
It was enough. Can't imagine going with full crystals of this shit xD
So if there’s a most bitter chemical does that mean there’s a most umami chemical?
We need this study
There should be, although it’s been challenging for me to identify any affordable suppliers for some of the umamiants
monosodium glutamate is a strong contender
@@lefthandedspanner MSG by itself doesn't taste umami to me. It definitely makes the food I cook with more umami, but by itself, it's hard to describe. Vaguely salty?
@@That_Chemist what about sour taste ? it got me to read few abstracts. I seems that the pKa isn't the main contributor to the sour taste.
Weak acid would taste more sour as strong acid would be mostly dissociated. Also, organic acids taste more sour as mineral ones diffuse less in the cell (or something like that, i don't know what a cell is)
I remember in my anatomy and physiology class in high school we were studying genetics so he had those PTU test strips handed out to see if we had the gene to taste it. Let me say that I've never been so happy to be born a mutant that can't taste it because everyone in class started wretching. Then again, I also have the gene that makes cilantro taste like soap so I think it evens out 😂
Imagine working at the bar they’re in for the very end segment, and you’re watching a group of people openly take mystery crystals out of a vial, but they’re all just talking about bitterness and genetics. I would have spent the rest of my shift thinking about whether they were taking drugs or not
to be fair that is exactly why the PTC test strips were used - even ImKibitz was like "you wanna bring a container of white powder to a restaurant" when I wanted to show our friends neotame in the past lol
@@That_Chemist Lol, good call, I’m glad! Your content is too entertaining for you to get arrested as a result of public bitterness testing
just 3 bros sitting around eating random chemicals, as we do.
I remember using phenyl thiourea for my research, the old bottle smells like forbidden cheetos, smells like it would taste extremely dry and umami, thank god my intrusive thoughts didn't win
i love how deep this vid goes into the chemistry and jargon i dont understand but still appreciate
Explosions and fire did a video where he got his friends to try different salts.
he sure did - eventually I might subject my friends to the alkali metal chlorides as well
@@That_Chemist I want to say rubidium was their favorite
@@That_Chemist Greetings from Finland. Not many things entertain us more than seeing foreigners try Salmiakki (Ammonium Chloride) as we literally eat it as candy, ice cream, potato chips, powder, vodka and even condoms flavored with it.
I am not kidding.
Concerning caffeine. You should try to synthesize anhydrous "caffeine citrate", by combining caffeine in anhydrous chloroform, and anhydrous citric acid in anhydrous ethanol, run it on the rotavap and test it out. Did once and it was so bitter it even got out of the fume hood, through the vacuum pump/rotavap... Overwhelming bitterness. Much more than any other bitter compound I've ever sampled, involuntary or otherwise. Also deliquescent so store under vacuum. Decomposes into "regular" caffeine citrate in water after some time and looses it's bitterness. Couldn't find the paper describing the synthesis and the effects but if you see this and respond I'll try.
I don't understand half of these videos but I am absolutely here for it.
happy to have you aboard :)
my brother and i have a tradition of licking nintendo switch cartridges every time we buy a new switch game.
it's a really shitty, stupid tradition.
MDMA is a disgustingly bitter compound that sticks to your tongue, probably the most bitter chemical I’ve personally encountered.
Can confirm it's only slightly less nasty than denatrononium benzoate.
Yhea I remember that bitter and soapy taste also way too good even got grose bumbs just remebering it 😖😣 my go too discripption Was always tasts like the child of shit and Washing Puder 😅
5-MAPB was way worse than mdma for me, adds a bit of disgusting sourness to the mix 🤮
Ha, yeah when it sticks up your nose and slowly drips down into the back of the throat…, fucking gross, especially with your sense getting more sensitive by the second lmao
how would you know what ecstasy tastes like
you forgot(probably not because duh) the GOAT. The one and only strychnine
Okay but strychnine is poisonous. This is just bitter stuff that won’t kill you.
Toriel: You are determined! I shall make you strychnine pie.
@@aqdrobertI am currently listening to an extracurricular Lecture on Natural Chemicals and the professer said that he knows of good account that you cannot poison anyone with strychnine because it's so powerful that if you take a singular bite you just start puking.
One of the most bitter, sour tasting chemical I've had the displeasure of tasting would have to be Phenibut. It's similarly disgusting to DXM syrup.
it aint that bad. 4-flouro phenibut is much worse.
@@morningfox_ I am indeed an adult
Escitalopram also has to be up there for disgusting bitterness
Most meds are v bitter
@@wrenophelia @wrenophelia3400 you're not wrong, most ssris probably taste pretty disgusting (as well as lots of other meds, even though most arent too unpleasant imo), but escitalopram is next level bad. It's so bitter it becomes metallic tasting & astringent and sticks around forever - and that was just when you failed to swallow the tablet immediately.
And that fzcker was just 10 mg! Much much worse than my usual 100mg sertraline!
Anyway uhh
Thanks for coming to my Ted talk
And those tablets are just 10mg and taste
@@wrenophelia sure, most are somewhat bitter but pretty tolerable imo
Ssris are generally pretty disgusting but the few times I had escitalopram 10(!)mg I found it to be orders of magnitude worse than sertraline 100mg.
it was strongly astringent, intensely metallic and lingering
By very very far the most bitter substance I have ever tasted is TUDCA. It is pure bile.
And it is the most optimal form of bile.
Because it is an water soluble form of bile salt.
One uses it as a supplement to optimize what bile does in the body.
Dissolve fat and help the body metabolize such substances.
It is also used in lots of other parts of the body as kind of a nutrient for various parts of the cells.
Many who used it supplement with it to get their liver bile flow work properly. If your own bile and bile flow get sluggish, it impairs lots of function in the liver and the body.
That the use of TUDCA many times can resolve.
And it works great to improve your health. BUT it if you ever get any of it lose in your mouth.......it is so incredible extremely bitter and the taste just doesn't go away for a good while, no matter what you try to rinse it down or out with.
When I was a kid my parents tried a denatonium solution on me to stop sucking my thumb, I acclimatized myself to it, and to this day, I can take the pure powder with ease. Its strong, but it can be beaten.
My parents used to put something on my nails to stop me biting them. I don't know if it had denatonium in it (i'd learn about denatonium by name roughly 10 years afterwards), but i too acclimatized to the weird goo lol.
There's no way you didn't smoke up before this lmao
I mean they are based in Vancouver so
ah yes i too like putting my hand on the burner to see what happens
That" do it "a 7:00 was too similar to "do the roar" 😂
Ive accidentally licked the finger after changing my remote battery for my bedroom lights and oh my God it's disgusting. I then got curious and licked the battery itself, dumbest decision I've made when it comes to being curious about the taste of something 😂
I think Victor lost his taste buds long ago 😂 or he has a super hero like self control.
I grew up drinking "Bitter Lemon" in the US and it's now virtually unfindable. My daily beverage is Diet Grapefruit Dry. It's always there and no one else will drink it :D
Gotta find one of those international grocery stores
@@bsnow304 $7.50 for bitter lemon is ultimately unacceptable when 4 for $11 of Grapefruit dry at stop & shop :P
Good thing that kitchen(?) sink is nearby in case you 🤮.
Denatonium Benzoate was at one time (maybe still is) used to prevent thumb sucking. And I would have thought that it would have been taste-tested last, as it's the worse one.
Not saying you're wrong, but I've always heard Quinine being pronounced as "KWAI-nine".
Damn, that's inhumane。Thumb sucking is a natural thing
So i lost the ability to taste bitter about 10 years ago. Made a 120,000 ppm solution of denatonium once thinking "eh i was overzealous with the PPE last time i did this and i cant taste bitter anyway"
So thats how everything tasted like hint of splenda dirt for a few days
Dream Chem Tasting Rotation
17:20 your pressure cooker is done by the way
It was actually the dishwasher :P
@@That_Chemist hahaha darn it! I guessed wrong. My dishwasher makes a similar noise but my instant pot pressure cooker makes the exact same noise 😁
i licked a switch cartridge because of this video
he wasnt kidding about the switch cartridge, i liked one watching this it of curiosity, do not do that its horrible.
Every time I get my switch out I lick one to see if it's as bad as I remember. It's worse. It's always worse.
I'm really sensitive to the stuff so it doesn't even taste bitter, honestly. It just tastes like pain :(
I hardly tasted anything . But my kid nearly chucked
Denatonium benzoate - it's in Nintendo Switch cartridges, it's a S tier.
S for Switch
around 4:15 someone mentions that only 25% of people can taste PTC, but that’s not true! being a taster is dominant over nontaster, so ~75% of people can taste it while ~25% can’t!
(a club i’m in runs an experiment where we genotype students’ TAS2R38 genes)
I remember tasting that one in a science class once. I can't taste it lol
3:10 and they said it the correct way around in the video
" it was 8 " say the person who cant taste bitter
This video reminds me of the RUclips channels in like 2007 that would just post videos of themselves smoking salvia
You couldn't pay me to intentionally put denatonium in my mouth. That taste lingers FOREVER
I did it for free dawg
the taste test at the end makes me think about that thing where whether or not cilantro tastes like soap to you is genetic
Dude on the left is either simply swag as hell or drunk/high lol
Yes, bitter chemistry is super cool. Great video
thanks!
Do you know if any of your test subjects have the gene to be a "supertaster"? For supertasters, their bitterness perception is amplified compared to typical people. I'm guessing you and the pukey frog might be supertasters. TAS2R38 is the gene if you have had your own sequenced and want to check it. I found out I have it, and I've always wondered if it was the reason why I was an absolute fiend for baker's chocolate when I was very young. Like I would wake up before everyone in the house and climb and explore cabinets, just a nightmare of a child, and my mom could not hide her baker's chocolate, I found it multiple times. I also used to eat instant coffee by the spoonful... That was all when I was like 3 or 4.
Quinine is fascinating, it has quite the history. For a long time, control of supply of it was a Big Deal globally. The tree whose bark it comes from would only grow on some high-altitude hill, and mosquito-born diseases like malaria literally led to rise and fall of entire empires.
You definitely should have had some 'miracle fruit' berries on hand for when you guys finished up... would make all that stuff taste sweet!
In school we tasted the first one (or something else genetically bitter or not) and only me and the teacher couldn't taste it. Looking back, she totally just liked to watch the kids cringe lmao
Thank you. I was looking for this. I needed an extremely bitter ingredient for a "social experiment."
Yeah. A social experiment. Mhm. Not a prank. Yup. Definitely not gonna bake cookies with these chemicals. Trust me. Yeah.
(this is a joke im not actually going to bake those cookies XD)
(very bad idea)
👀
if you put in too much baking soda, it actually goes bitter as well 👀
@@maru9094it somehow tastes sour-ish to me. I mean, I don't distinguish between bitter and off-putting sour well, so it may explain the situation
@@nabra97 Might as well add that too. But it's not like I'm gonna bake bitter cookies.
@@maru9094 I will NOT keep that in mind because I'm NOT gonna bake bitter cookies and put them in a jar.
Reminds me when explosions and fire did a taste test on all the salts 😂
I am simultaneously shocked and impressed you lot took denatonium. Props for that
Your reaction is absolutely priceless and i show it to everyone for instant entertainment 😁
How much devil's lettuce was involved in the creation of this video?
Not much
The jazz cabbage
Electric lettuce
Pure MDMA HCl and concentrated syrian rue extract are both almost denatronium nasty.
Everyone forgets their sense of balance, the 6th sense.
we have way more than six. heat (tongue), heat (skin), cold (you get it). and so on.
is it bad that the chemical that which is sprayed onto the back of nintendo cartridges tastes kinda good? like its not bitter for me and similar to how copper or nickel tastes. slightly.
I feel the same about it. If nothing else you’re not the only one.
Aw. I wanted to hear what he was trying to say about willow bark. 😞
Me too!
ain't no way bro asigned bitter to broccoli ☠
Broc-coli is evil. It is e-coli disguised.
Funnily enough Denatonium Benzoate doesn't taste that bitter to me, haven't tasted pure but I've tasted it in denatured ethanol and also on the carts.
AP chemistry prank: "Today we are making food safe Denatonium Benzoate!"
The first one sounds funny, you can only taste it if you have a certain gene. Sounds like a great drinking game, get a bunch of those chemicals which some can taste and which some cannot taste and drink a shot when you could taste it.
miss opportunity to have your other friends taste the S tier bitter compound XD
you should do a part 2 of this tier list. Ive heard that strychnidin-10-one is very bitter
I can't remember ever hearing about umami in school, just bitter, acid, sweet, and salt.
I wonder if your friend has the reverse of whatever I have, to him denatonium is fine but I can't stand even cauliflower.
I licked my DOOM Nintendo switch thingy after this.
DOOM cartride... good taste! (Pun intended) 😅
the "clean your room" shirt 😭
Is it possible that one friend who can't taste anything has Covid or smokes a lot? lol
The next one is lipid tier list? Or food acids?
the next tasting one is artificial sweeteners, and that video should be released in the next month or so
THIS IS THE ‘HANGOVER’ OF CHEMISTRY
Do a taste ranking of different salts. Potassium chloride, lithium chloride etc.
When the camera stops rolling they gon be taste testin other chemicals if yk what i mean 😂
Thank you I really needed to see this video today
Theobromine contains neither bromine nor gods
Havong barely passed statisitics, i feel fully justified in sayingnthay technically a minimum of 10 poeple for normal results, though id argue 30 should be the minimum becasue id do a t test
Bro, it's a RUclips video, not a research paper
homie on the left has like,,, the brussel sprouts gene i swear
I used to drink liquid sanitizer (regularly), which is denatured with denatonium benzoate.
I do not recommend it.
Are you one of those third worlder alcoholics?
This one time i drank hand sanitizer that's denatured with glycerol (no methanol).
Wasn't much worse than vodka tbh. Wouldn't do it again though lmao.
my grandfather was part of the group at MacFarlan Smith that originally developed denatonium !!!
That’s awesome :)
the thumbnail looks like you're in a hospital bed
I don’t know what difference it does adding denatonium to antifreeze. All you need is a good gulp of it to mess you up for the (very short) rest of your life, bitterness might make you vomit but then you’d take another swig if you’re really dedicated, or seek help if you’re not. I lived through it and mine wasn’t denatonium’d. It would not have made a difference if it was. Dedication means a lot
Naringin, respect to the guy who named it. Its found in citrus fruits which in sanskrit were called Nāranga. Nice
I once used topical bittering agent designed to stop nail biting, many years ago.
The very first (and last) time I applied it, I left my house and started eating a sandwich, a bit of it got on my sandwich from my finger and I freaked out because it was so strong and disgustingly evil! - I instinctively began clawing at my tongue using my nails to try to get it off (i know), which resulted in a mega-dose.
I instantly began vomiting violently on a phone box, in public.... yeah
Needless to say I still bite the shit out of my nails to this day
One of the worst things I've ever tasted is eszopiclone (Lunesta), a prescription sleep aid. It made everything I ate/drank taste metallic and bitter the whole morning after I would take it. I remember gagging on water ☹️
Yup, it tastes like a mixture of soluble copper or cobalt (don’t ask…) salts, gross af
Poor baby! (Mom sympathy here!)
That was the day I found out, science hurts
The amount of efforts deployed to avoid referencing drugs is remarkable!
I'd like to know why someone wanted to taste sucrose octaacetate in the first place.
Like, "i wonder how many acetylation does it take to make sucrose not sweet ?" ?
It's because they are authies
The worst that I've tasted is from chewing a benadryl. I don't know if it's the dph or something else they add, but my god is it terrible.
It tastes so bitter
What does he mean you shouldnlt taste distilled water???
Do one more episode with the most Sour!
There are a lot more to test(taste)) - paracetamol, for example) try chewing a tablet, after this ordinary water tastes sweet)
Bro your disclaimer 2:41 😂😂😂 DONT TRY THIS SHIT PLEASE
4:22 nvm
where's Strychnine ?
There was four friends….
Somebody tell left guy when his hair sticks out.
fyi ya'll - taste zones of the tongue are a myth
Denatonium doesn’t taste like much to me which is weird since I am clinically sensitive to taste. I wonder if some people are immune.
"Supertasters" have a different and more nuanced response to very bitter things. Makes me curious, do you like the taste of baker's chocolate?
@@revenevan11 I fucking love cacao nibs and I assume it’s similar. I can taste the bitterness. It’s just that I like it. Why do you ask?
is broccoli bitter?
If we are talking bitterness, would an Energy drink go into that sector or not?
It's very very weak 😂
I mean anything that isn't a pure substance is likely to have multiple types of flavor compounds. If you mean like an asian style herbal energy shot then yeah the primary flavor would probably be bitter, but a western red bull or monster would probably be primarily sweet.
It's time. Explosions&Fire once did the chloride salts test if any of them were as good as sodium chloride (they were not!) and now you did this. It's time. You must do an artificial sweetener collab with him. Dewit!
quinine is the worst bitter for me there is. on sip on any drink containing tonic water and i wishing i could amputate my tongue for an hour
maybe there also is a genetic factor