Conquer Cholesterol with Bempedoic Acid: Mechanism of action │ Pharmacology

Among patients who couldn’t take a statin because of unacceptable side effects, the use of bempedoic acid reduced the relative risk of the primary endpoint of death from cardiovascular causes, nonfatal MI, nonfatal stroke, or coronary revascularization by 13% compared with placebo. In this video, we’ll look into the unique way bempedoic acid tames cholesterol levels, current applications, and potential downsides.
References:
1. Chandramahanti S, Farzam K. Bempedoic Acid. In: StatPearls. Treasure Island (FL): StatPearls Publishing; July 21, 2023.
2. Goldberg AC, Leiter LA, Stroes ESG, et al. Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial [published correction appears in JAMA. 2020 Jan 21;323(3):282]. JAMA. 2019;322(18):1780-1788.
3. Ray KK, Bays HE, Catapano AL, et al. Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol. N Engl J Med. 2019;380(11):1022-1032.
4. Di Minno A, Lupoli R, Calcaterra I, et al. Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2020;9(15):e016262.
5. Nissen SE, Lincoff AM, Brennan D, et al. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023;388(15):1353-1364. doi:10.1056/NEJMoa2215024
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