Is ADHD a Mitochondrial Disease?
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- Опубликовано: 29 май 2023
- In the last few years, a host of mental health conditions (schizophrenia, depression, autism, dementia) have been attributed to mitochondrial dysfunction. While mitochondrial dysfunction has been proposed to have a role in ADHD, we have somewhat less data than we do for some other conditions. Nevertheless, preliminary evidence has found signs of oxidative stress, mitochondrial dysfunction and genetic evidence to support a role for mitochondria in contributing to ADHD. We also have some very limited evidence that antioxidants (omega-3 fatty acids, pycnogenol, N-acetyl cysteine) can play a positive role in treating ADHD.
References:
Attention deficit-hyperactivity disorder suffers from mitochondrial dysfunction.
Verma P, Singh A, Nthenge-Ngumbau DN, Rajamma U, Sinha S, Mukhopadhyay K, Mohanakumar KP.
www.ncbi.nlm.nih.gov/pmc/arti...
Mitochondrial Dysfunction in Attention Deficit Hyperactivity Disorder
www.eajm.org/Content/files/sa...
Oxidative Stress and ADHD: A Meta-Analysis
www.ncbi.nlm.nih.gov/pmc/arti...
Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder
www.ncbi.nlm.nih.gov/pmc/arti...
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
www.nature.com/articles/s4138...
Hey! Great presentation. Btw, did you talk with Andrew Huberman for his recent podcast? A lot of the stuff he said sounded like stuff I remember you saying.
You've been listening closely! Yes, I talked with him before his presentation, and we've discussed that I may be on his podcast in a few months.
@@dr.johnkruse6708 that would be great since you talk about ADHD related stuff that no one talks about!
Hello John, I hope you are better meanwhile after Covid! Thanks a lot for this video. I'm a neuropsychologist from Germany who got ill with "Long Covid" in 2020 and hasn't recovered since then. Mitochondrial damage and oxidative stress seems to be implicated in the pathogenesis of many post-viral syndromes like Long Covid or ME/CFS. Some data, as well as anecdotal evidence and observations within the LC and ME/CFS community suggest an overrepresentation of individuals diagnosed with ADHD or ASD prior to developing Long Covid. Mitochondrial dysfunction would be an interesting link to explore and could account for people with ADHD and ASD being more vulnerable to post-infectious syndromes.
Thanks for passing on that information, I hadn't heard of that connection between ADHD and Long COVID previously. I hope that you have complete recovery.
Thank you so much for sharing your knowledge on RUclips, Dr Kruse! I have been learning as much as possible after our family developed long Covid and newly diagnosed ADHD several months after our initial Covid infections. Fish oil, NAC, nattokinase, pycnogenol and surprisingly an antihistamine (Zyrtec in our case), have helped so much. I am trying to understand how possible MTHFR snips might affect mitochondria, making us more prone to ADHD, especially during/after illness? Where my kids had perhaps mild (undiagnosed) ADHD and anxiety before, post Covid, it was off the charts. I would love to hear your thoughts on any MTHFR/mitochondria/ADHD links. Thank you!
I don't have a good answer regarding MTHR/mitochondria/ADHD, and I'm not sure I would start with such a narrow focus. The improvement with cetirizine catches my eye, which strongly implicates an inflammatory/immune component to what is going on.
Glycene / Glynac? Dr Kruse, it would be helpful for you to provide links to studies.
I'm starting to do this, and will be adding more links in the future.
Amazing info, sir. Thank you! Are there any non-dietary lifestyle modifications that can help one reduce oxidative stress?
Exercise is one good way. www.ncbi.nlm.nih.gov/pmc/articles/PMC5908316/#:~:text=An%20acute%20level%20of%20exercise,antioxidant%20defense%20system%20%5B137%5D.
Love your work.
This is awesome. How do you not have more subscribers????
Unless it's your microphone/echo.
1. I didn't hear coQ10 mentioned...
I find huge difference if I suppliment with 1200+ mg of it in a day, to energy etc.
I mean I'd take 1500-3000 but that gets costly.
Bleeding/bruising? well I eat natto, for the Vitamin K2 (MK7) after a round on fluroquinone antibiotics that had me asking myself "is this Leukaemia" from the explosive bruises.
Which settled that down very quick.
2. What about the autoimmune link with mitochondrial function?
DEFINITELY when that side of things flares, I definitely feel mentally wrong.
I mean there are Journal articles that pose the question "why do asthmatics have extraordinary rates of depression and anxiety"
is is mere concern over their illness, or are inflammatory molecules crossing the blood-brain barrier?
I remember finding a journal elucidating some connection between the leukotriene pathway and dopamine and other neurotransmitters...
I was curious about the uhhh feelings/effect from leukotriene inhibition (montelukast).
It does has a black box warning.
I mean it's not all bad, just more of a tendency towards being an a-hole.
**
Well apparently catecholamines apparently suppress leukotriene release.
Montelukast and Aspirin have dopaminergic neuron protective effects.
One study showed a 38% reduction in Parkinson's amongst high dose montelukast users.
The more time goes on the more I'd love to chat with someone who specialises in the crossover and relatively new field between psychiatry and immunology.
I'm working on the presentation. The content I think is pretty useful and clear. And what I have seen on social media is that people follow the people who already have large audience.
@@dr.johnkruse6708 You have great info but I think it would help if you got a basic mic and looked in the camera when you talk. With all due respect you look like a cat that can see ghosts. All I can think about is what is he looking at? Also if you made some basic graphs or diagrams to cut to when you are explaining how these things work any visual would help. I really want a better understanding of this but I have ADHD and cant follow this video. Sorry to be blunt, this is great work please keep it up! Hire a small graphics and editing team and you will have millions of views.
@@user-gt3yz4tb8g I appreciate the candor, and am working with someone to improve the quality of videos. Part of it going forward will be doing more pre-recorded videos and fewer live presentations, because RUclips doesn't have an easy way to include graphics in the live mode.
Love the information but it is very difficult to hear you