People who freak out about the gut health bs about artificial sweetners always seem to neglect that being fat is profoundly worse than having some problems with gut bacteria. Get your weight down as a priority, then worry about gut biome and micros and shit. Its orders of magnitudes more important to get weight under control. You got it right :P
@@x3r0h0ur I have gut problems at the moment . I am also quite overweight , eat alot of crap and drink way too much . Do you think if I changed my lifestyle ate healthly exercised lost the weight and quit the booze my issues would fix
I did my bachelor's thesis about Rats' gut microbiota. Sure, it was only bachelor's thesis, but the key point I understood while doing it, was that we know very little about gut microbiota overall - especially within humans.
Don’t discount your hard work and research because of an authority based fallacy. You don’t need to have a bachelors or a Masters degree to be able to put together objective based research and facts. Your opinion matters!
Ending my junior year in undergrad Dietetics, taking a Nutrition Research and Methodology class this semester and it feels awesome being able to (somewhat) understand the scientific research lingo finally! Your no BS, honest approach to relaying information is refreshing.
I've been "taught" to fear sucralose for years. That chart you put up shows such little variance between the control and sucralose groups, that I think I can let that go now. Thanks Layne!
Sucralose raises blood sugar. I work in a nursing home and a diabetic resident snacks on sucralose candy every night. His blood sugar is in the 300s in the morning before he eats anything.
Discovered your channel through your appearance on Spencer Cornelia's channel. Going through a backlog of your videos and really like what you're doing. Pumping the algo.
Since sucralose is not metabolized and is excreted in feces, they should do a study on whether sucralose makes poop taste sweet. If confirmed, I will make low cal poopsicles for my next family function!
Stunning open-mindedness and impartial scrutiny - Norton once again demonstrates his ability to hear, consider, and be open and professional. 👌 This requires a spine and integrity!
Whenever you conduct a study and find no differences between groups... you pretty much have to make up something so journals pick it up for publication. As you said: "If you torture the data enough, it will confess to whatever you want."
What many readers don’t understand is if you compare the effect of your intervention on 100 different variables to a 5% confidence level you will get ~5 variables showing a significant difference due to just random variation. To me (without reading the study), the differences they found between water & Sucralose consumption groups sounds like random variations. In my experience, if something is physiologically significant you’ll see large, consistent differences across time in many of the tested variables. This study didn’t have that!
Intelligently put. A lot of people don't understand that "statistically significant" means there was only a 5% chance of seeing the result. That's a pretty decent change. If you try to find a needle in a haystack, you'll probably find it after a lot of digging and manipulation of data
This study looks to be one of those that was farming factors to find anything that had a significant difference. Run analysis on enough factors, especially with a small sample size, and you will always find something that has a significant difference, even if it's trivial, and often just noise in the data set. This is a common, and deceptive, tactic used in many studies these days because the researchers don't want to run a study where they found nothing of interest.
@@defeqel6537 dose dependency in human placebo trials is not a factor in determining causative outcomes. Every body is different and receives the same dose of the substance/placebo. Impossible to determine dose dependency and it isn't important either. This isn't a drug that's being tested, and all diets are variable. Dose response curves to food do not exist because of individual variability
I have been subscribed. I love the use of artificial sweeteners in moderation like everything else in my diet. It is just one of many tools I use to loose or maintain my weight.
@@bobbyadkins6983 Probably only 6 a day depending on what I'm doing. If I'm making low cal desserts, more. If I'm just just drinking diet soda, a lot less.
I'm listening to one interview you've given and really appreciating your info. Keep up the good work! And, yes, I'm commenting for the algorithm, too.😂🎉
You are not wrong about Dr. Layne. If you look through the list of authors and their previous work, not a single microbiologist or someone with extensive experience with studying microbiome. Calling a simple asymptomatic change in microbiome composition "dysmicrobiosis" is a stretch. These changes happen even with menstrual cycle, season of the year etc. So many possible confounders. I would just state that there was a significant difference between the groups at the end of the experiment and discuss possible causing factors, but wouldn't call it a dysmicrobiosis.
Artificial sweeteners help keep me from consuming actual sugar. As someone with insulin resistance, SUGAR messes my body up. Artificial sweeteners help keep me from binging on said sugar. Anyway, when I have different artificial sweeteners that I don't have often, such as allulose, it definitely causes gut issues b/c my body isn't used to ingesting it. Just like when I suddenly eat sugar again after not having it for a while, it gives me a stomach ache, headache and overall makes me feel ill.
its the same like i now smoke e-cigarettes so i dont smoke nikotin... you just fool yourself... sweeteners are in no way healthy or usefull, they are maybe a good solution for weak people that look for excuses...
Thank you for your work sir! I used to be so afraid of artificial sweeteners because I didn't know better and the fear mongering amongst my friends who went to the gym didn't help. Also, commenting for the algorithm XD
it makes sense the 15 minute timepoint was different, artificial sweeteners linger compared to sucrose - also what gives diet products that characteristic aftertaste. It really is not a problem in any way.
5. Conclusions This clinical trial demonstrates, for the first time, that consumption of 48 mg of sucralose every day for ten weeks induces gut dysbiosis by increasing Blautia coccoides and decreasing Lactobacillus acidophilus in healthy non-insulin-resistant young adults. As far as we know, this is one of the first long-term clinical trials showing that sucralose amounts, far lower than the suggested ADI, alter the balance of the gut microbiome, while also being associated with significant elevations in AUCG and serum insulin in response to glucose loads.
@@catea2551 If I took ten kids and stuck them in a room and only fed them macaroni and cheese laced with lead paint chips, would adding more kids to the room make the lead paint chips less dangerous?
The man who can admit when he is wrong is the better man, not that you’ve been proven wrong but the fact you’re open to accepting you’re wrong shows a massive character trait that many men and women lack. Critical thinking at its finest. Great video
Since finding laynes content in Jan, I no longer obsess and purchase crazy expensive/fancy ‘pure stevia’ products …. The other sweeteners were paramount in helping me loose 2.5 stone the other year after all!
Layne, I must commend you for keeping abreast of so many areas of research and staying sharp with your research analytical skills so many years after completing your PhD. And you're not working in academia, right? Not that one has to be in academia to remain a critical thinker, but hey, you know what I mean! Good job man!
I appreciate your focus and emphasis on sucralose rather than the entire group of artificial sweeteners. There are far too many chemical differences to group them together. Question to you, is there work being done with other A.S. to determine if they have a negative impact on insulin resistance? Also, comment for the algorithm boost!
Also, thank you for continuing to justify my abuse of artificial sweeteners despite the fact common sense, regardless of lack of studies, tells me they are probably not great for me. i appreciate it bro.
I eat healthy, exercise daily but my gut has been screwed up for awhile. I figured out recently that sucrulose was in my protein drink, my preworkout and bcaas. Ditched it all and feel so much better. I do miss the preworkout in the morning but not worth the messed up gut issues.
Wow I have herd people talk and talk about how artificial sweets destroy the gut biome One RUclipsr said that the pink pack sugar was like an atomic bomb to your gut biome. I have believed for years now that that stuff is poison. Also recently subscribed to your channel and have learned a lot . Keep up the good work.
So this is one of those studies that was fishing for any post hoc factor that had a significant difference. I can't remember the name of this but if you have a small sample size and the number of factors you examine is greater than your sample size you will always find something that is significant.
Greate video great educational content i wish more poeple start to think critically and dont cherry pick studies and conclusions that they want to hear
I have never had issues with foods or health whatsoever. Around 40 (6 yrs now) I started having gut issues slowly but consistently. I have never been overweight even for years after 3 kids. (Last child was at age 25) my husband went on a diet about (my age) 37. We switched to Splenda at that time. Only change I personally made. I drink coffee daily. I use 2 packets per cup. I made a month meal log and Splenda never concerned the doctor. Perhaps because by the time I started the log I was only drinking 2 cups max. They did every test possible but no idea why my gut seems to be acting up. It's so bad my stomach swells like I'm 5 months pregnant. Horrible pain lasting days. Linzess helps a ton but I still can't eat many things...mainly fatty meat or green veggies and certainly no tomatoes which is very sad. 😢 perhaps it's age...perhaps it was Splenda. Lol. Who knows.
If you do enough studies you can pretty much find anything is bad for some people. I think it's about time people stopped worrying about artificial sweeteners.
I'm trying to interpret European research on microbiotics and low calorie sweeteners. That's not just artificial sweeteners but includes also plant based low calorie sweeteners. Can sweeteners like cyclamates in the EU+Canada and Allulose in the US+Mexico contribute to antibiotic resistance for the gut microorganisms that cause pneumonia meningitis and urinary tract infections?
Artificial sweeteners helped me loose 70 pounds,along with CICO- I'd be pretty pissed if my zero A&W left the shelf... Commenting for the algorithm ✌️
People who freak out about the gut health bs about artificial sweetners always seem to neglect that being fat is profoundly worse than having some problems with gut bacteria. Get your weight down as a priority, then worry about gut biome and micros and shit. Its orders of magnitudes more important to get weight under control. You got it right :P
Well done!
Congrats
@@x3r0h0ur I have gut problems at the moment . I am also quite overweight , eat alot of crap and drink way too much . Do you think if I changed my lifestyle ate healthly exercised lost the weight and quit the booze my issues would fix
@@markcoughlan2233 Virtually everything will improve if you do that.
I did my bachelor's thesis about Rats' gut microbiota. Sure, it was only bachelor's thesis, but the key point I understood while doing it, was that we know very little about gut microbiota overall - especially within humans.
Agreed. It’s a whole different universe.
Don’t discount your hard work and research because of an authority based fallacy. You don’t need to have a bachelors or a Masters degree to be able to put together objective based research and facts. Your opinion matters!
Way ahead of me. I dropped out and went to mechanics for the Army.
I understand you are saying, "we are not rats."
one thing we do know however is that rodents process artificial sweeteners very differently from humans
HOLD THE PHONE!! A study just proved that your gut biome changes a bit when you change your diet a bit? MIND-BLOWING
Ending my junior year in undergrad Dietetics, taking a Nutrition Research and Methodology class this semester and it feels awesome being able to (somewhat) understand the scientific research lingo finally! Your no BS, honest approach to relaying information is refreshing.
I've been "taught" to fear sucralose for years. That chart you put up shows such little variance between the control and sucralose groups, that I think I can let that go now. Thanks Layne!
Sucralose raises blood sugar. I work in a nursing home and a diabetic resident snacks on sucralose candy every night. His blood sugar is in the 300s in the morning before he eats anything.
@@CM7777...so? If you eat food your blood sugar will rise, and in healthy humans it will drop later, oh and.... sugar doesnt cause diabetes
This is the best science based fitness channel out there.
I'm curious what a study comparing water vs sucralose vs sucrose would show
I teach this too
Have you seen renaissance periodization? They’re even more nerdy
Took me only 1 minute and he makes already a lot more sense than most fitness youtubers
Discovered your channel through your appearance on Spencer Cornelia's channel. Going through a backlog of your videos and really like what you're doing. Pumping the algo.
Thank you for educating people on how to actually interpret research papers
Since sucralose is not metabolized and is excreted in feces, they should do a study on whether sucralose makes poop taste sweet. If confirmed, I will make low cal poopsicles for my next family function!
🤣🤣🤣🤣
Mmm, centipops.
“Poopsicles”... Sir, you’ve won the internets today!!! 🤣🤣🤣👊👍
Hmmm maybe thats why Mr Hanky the Christmas Poo is so nice lol.
naturally sweetened fecal microbiota transplants.
Commenting for the algorithm because I love these videos.
Stunning open-mindedness and impartial scrutiny - Norton once again demonstrates his ability to hear, consider, and be open and professional. 👌 This requires a spine and integrity!
Thanks for the info Layne. Your channel is refreshingly objective.
Big fan, love how you approach fitness, I hope your channel keeps growing bcuz you definitely deserve more recognition & views!
Whenever you conduct a study and find no differences between groups... you pretty much have to make up something so journals pick it up for publication.
As you said: "If you torture the data enough, it will confess to whatever you want."
What many readers don’t understand is if you compare the effect of your intervention on 100 different variables to a 5% confidence level you will get ~5 variables showing a significant difference due to just random variation. To me (without reading the study), the differences they found between water & Sucralose consumption groups sounds like random variations. In my experience, if something is physiologically significant you’ll see large, consistent differences across time in many of the tested variables. This study didn’t have that!
Intelligently put. A lot of people don't understand that "statistically significant" means there was only a 5% chance of seeing the result. That's a pretty decent change. If you try to find a needle in a haystack, you'll probably find it after a lot of digging and manipulation of data
@@Collinpawns See also: xkcd 882 and 1478.
This study looks to be one of those that was farming factors to find anything that had a significant difference. Run analysis on enough factors, especially with a small sample size, and you will always find something that has a significant difference, even if it's trivial, and often just noise in the data set. This is a common, and deceptive, tactic used in many studies these days because the researchers don't want to run a study where they found nothing of interest.
large, consistent and dose dependent
@@defeqel6537 dose dependency in human placebo trials is not a factor in determining causative outcomes. Every body is different and receives the same dose of the substance/placebo. Impossible to determine dose dependency and it isn't important either. This isn't a drug that's being tested, and all diets are variable. Dose response curves to food do not exist because of individual variability
Great video. You are so dissective in your comments....👏👏👏
I have been subscribed. I love the use of artificial sweeteners in moderation like everything else in my diet. It is just one of many tools I use to loose or maintain my weight.
How many packets do you use per day?
@@bobbyadkins6983 Probably only 6 a day depending on what I'm doing. If I'm making low cal desserts, more. If I'm just just drinking diet soda, a lot less.
Coach Greg needs to see this.
Thank you as always for sharing your expertise!
great video! digested the info to the T! thanks for your videos i love them!
I'm listening to one interview you've given and really appreciating your info. Keep up the good work!
And, yes, I'm commenting for the algorithm, too.😂🎉
Great discussion.
Appreciate these breakdowns chief
I hope you'll one day reach 1mill subs
Great explanation and information
More knowledge = smarter gains. Thanks for putting in the work again.
More good content thanks always love to see your videos
You are not wrong about Dr. Layne. If you look through the list of authors and their previous work, not a single microbiologist or someone with extensive experience with studying microbiome. Calling a simple asymptomatic change in microbiome composition "dysmicrobiosis" is a stretch. These changes happen even with menstrual cycle, season of the year etc. So many possible confounders. I would just state that there was a significant difference between the groups at the end of the experiment and discuss possible causing factors, but wouldn't call it a dysmicrobiosis.
Good stuff as always!
For the algo. But also artificial sweeteners are a huge part of my diet - thanks for this
Artificial sweeteners help keep me from consuming actual sugar. As someone with insulin resistance, SUGAR messes my body up. Artificial sweeteners help keep me from binging on said sugar.
Anyway, when I have different artificial sweeteners that I don't have often, such as allulose, it definitely causes gut issues b/c my body isn't used to ingesting it. Just like when I suddenly eat sugar again after not having it for a while, it gives me a stomach ache, headache and overall makes me feel ill.
its the same like i now smoke e-cigarettes so i dont smoke nikotin... you just fool yourself... sweeteners are in no way healthy or usefull, they are maybe a good solution for weak people that look for excuses...
Thank you for your work sir! I used to be so afraid of artificial sweeteners because I didn't know better and the fear mongering amongst my friends who went to the gym didn't help. Also, commenting for the algorithm XD
Biolayne has a growth mindset. Very nice
it makes sense the 15 minute timepoint was different, artificial sweeteners linger compared to sucrose - also what gives diet products that characteristic aftertaste. It really is not a problem in any way.
5. Conclusions
This clinical trial demonstrates, for the first time, that consumption of 48 mg of sucralose every day for ten weeks induces gut dysbiosis by increasing Blautia coccoides and decreasing Lactobacillus acidophilus in healthy non-insulin-resistant young adults. As far as we know, this is one of the first long-term clinical trials showing that sucralose amounts, far lower than the suggested ADI, alter the balance of the gut microbiome, while also being associated with significant elevations in AUCG and serum insulin in response to glucose loads.
what if you regularly eat yogurt and kimchi. would additional lactobacillus acidophilus help your microbiome?
Since sucralose is mixed with other ingredients in a packet of Splenda, how many packets would it take to consume 48 grams of sucralose?
@@bobbyadkins6983 A packet of Splenda has 12mg of Sucralose, so 4 packets is equal to 48mg.
@@catea2551 If I took ten kids and stuck them in a room and only fed them macaroni and cheese laced with lead paint chips, would adding more kids to the room make the lead paint chips less dangerous?
@@bobbyadkins6983 4 packets of Splenda would equate to 48mg of sucralose. A very common daily amount.
Great video as always
Great video as always sir, much appreciated.
The man who can admit when he is wrong is the better man, not that you’ve been proven wrong but the fact you’re open to accepting you’re wrong shows a massive character trait that many men and women lack. Critical thinking at its finest. Great video
Thanks for the info really appreciate it!
I love these new research videos!!
I'm watching this while sipping my diet Pepsi
Wow. Thanks for the info.👍🏾
I enjoy your information. Keep up your no bs way. Too little of it around
💗🙏🏻 for the algorithm and your channel✨
Man, I love these non controversial videos.
Doc NBS m….thank you…I appreciate how you do the hard work for us that really want to know the truth.
Love ur stuff and wow I use ur food tracker !!! F eeeen amazing app thx u !!!!
You mean nutrition coaching app 😬
Thank you.
Since finding laynes content in Jan, I no longer obsess and purchase crazy expensive/fancy ‘pure stevia’ products …. The other sweeteners were paramount in helping me loose 2.5 stone the other year after all!
2.5 stone?
Layne sure does love his diet sodas
Thank you
Ok Jeez, I subscribed after that begging part.
Layne, I must commend you for keeping abreast of so many areas of research and staying sharp with your research analytical skills so many years after completing your PhD. And you're not working in academia, right? Not that one has to be in academia to remain a critical thinker, but hey, you know what I mean! Good job man!
Thank you for continuing to rescue data from being tortured.
Yes! TY!
I appreciate your focus and emphasis on sucralose rather than the entire group of artificial sweeteners. There are far too many chemical differences to group them together.
Question to you, is there work being done with other A.S. to determine if they have a negative impact on insulin resistance?
Also, comment for the algorithm boost!
Also, thank you for continuing to justify my abuse of artificial sweeteners despite the fact common sense, regardless of lack of studies, tells me they are probably not great for me. i appreciate it bro.
My thoughts and prayers go out to the algorithm.
Thanks
This is gotta be one of the worst cases of confirmation bias I’ve ever seen
Not sick of artificial sweetener content! For the algorithm!
Whenever I have sucralose I become sick for days and have serious hayfever symptoms.
Subscribed!
For the algorithm! Thanks for all.
I really like your videos! Keep up the work!
Can you make a Video about which supplements you can take? Except creatine, I'm taking it for years☺️
I eat healthy, exercise daily but my gut has been screwed up for awhile. I figured out recently that sucrulose was in my protein drink, my preworkout and bcaas. Ditched it all and feel so much better. I do miss the preworkout in the morning but not worth the messed up gut issues.
Same for me
Good stuff.
The heading is the hypothesis, reading the paper provides the conclusion.
for the dang alg!!! biolaynee for lifeee.
I wonder how much any of this matters if you’re also eating plenty of fiber.
Once you cut out sugar completely you recalibrate your sensitivity to sweetness. Fruit is like a lolly to me now.
Wow I have herd people talk and talk about how artificial sweets destroy the gut biome One RUclipsr said that the pink pack sugar was like an atomic bomb to your gut biome. I have believed for years now that that stuff is poison. Also recently subscribed to your channel and have learned a lot . Keep up the good work.
What about aspartame and acesulfam-k ?
So this is one of those studies that was fishing for any post hoc factor that had a significant difference. I can't remember the name of this but if you have a small sample size and the number of factors you examine is greater than your sample size you will always find something that is significant.
p hacking
@@biolayne1 Thanks!
The title of this video should say sucralose instead of artificial sweeteners because there is a whole lot of different artificial sweeteners
6:44 do mice and humans have the same type of bacteria in the gut?
Thanks, I don't feel so guilty now having had Sucralose-sweetened cheese cakes all those weekends.
Good stuff
would you say then also Erythritol is generally safe too?
I’m curious what studies will say if they repeated this experiment with other forms of artificial sweeteners
For the algorithm!! Great Video!
You're a beast Layne
Any research on natural sweeteners?
Greate video great educational content i wish more poeple start to think critically and dont cherry pick studies and conclusions that they want to hear
Allergies anc autoimmune diseases have gone up. What are the reasons? Layne thinks it's not leaky gut and it's not sucrose - what are the reasons?
Subscribed and comment for the algorithm.
I have never had issues with foods or health whatsoever. Around 40 (6 yrs now) I started having gut issues slowly but consistently. I have never been overweight even for years after 3 kids. (Last child was at age 25) my husband went on a diet about (my age) 37. We switched to Splenda at that time. Only change I personally made. I drink coffee daily. I use 2 packets per cup. I made a month meal log and Splenda never concerned the doctor. Perhaps because by the time I started the log I was only drinking 2 cups max. They did every test possible but no idea why my gut seems to be acting up. It's so bad my stomach swells like I'm 5 months pregnant. Horrible pain lasting days. Linzess helps a ton but I still can't eat many things...mainly fatty meat or green veggies and certainly no tomatoes which is very sad. 😢 perhaps it's age...perhaps it was Splenda. Lol. Who knows.
whatever it does its a hell of a lot less than the equivalent level of sugar
Literally subbed 3 times now - RUclips keeps unsubbing me :(
Typical
If you do enough studies you can pretty much find anything is bad for some people. I think it's about time people stopped worrying about artificial sweeteners.
Is erythritol safe for the gut please?
love it... FOR THE ALGORITHM
No. Being wrong is never beautiful. It is only to be avoided.
0:43 Real science described in one sentence.
Tbe majority of artificial sweeteners used is aspartame not sucralose aka splenda.
Hello Layne
Artificial sweeteners have helped my keep off 70 pounds for almost 12 years. Love my Diet Mt Dew and I have never felt better.
@Bex I didn’t swap any bad habits.
Ya, so that is sucralose. What about all the other ones?
I'm trying to interpret European research on microbiotics and low calorie sweeteners. That's not just artificial sweeteners but includes also plant based low calorie sweeteners.
Can sweeteners like cyclamates in the EU+Canada and Allulose in the US+Mexico contribute to antibiotic resistance for the gut microorganisms that cause pneumonia meningitis and urinary tract infections?